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Protein Page:
SKIL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SKIL May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm; PML body; protein complex; cytoplasm; acrosome; nucleus
Molecular Function: protein domain specific binding; protein binding; DNA binding; protein complex binding; chromatin binding; SMAD binding; transcription corepressor activity
Biological Process: transcription initiation from RNA polymerase II promoter; skeletal muscle development; transcription, DNA-dependent; blastocyst formation; negative regulation of transcription from RNA polymerase II promoter; response to antibiotic; regulation of apoptosis; negative regulation of cell differentiation; response to cytokine stimulus; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of axonogenesis; spermatogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; lymphocyte homeostasis
Reference #:  P12757 (UniProtKB)
Alt. Names/Synonyms: SKI-like oncogene; Ski-like protein; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SKIL; SNO; SnoA; SnoI; SnoN
Gene Symbols: SKIL
Molecular weight: 76,976 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SKIL

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T6-p __MENLQtNFSLVQG
0 2 S26-p NGMGDDGsPPAKKMI
0 1 T42 DIHANGKTINKVPTV
2 0 K50-sm INKVPTVkKEHLDDY
0 1 K249-ub NGSVLPAkSSLAQLK
0 1 K352 KIILEEMKEKFSMRS
2 0 K383-sm QSWYPVIkQEGDHVS
0 1 K423-ub TSAVSQSkELtKTEA
0 1 T426-p VSQSkELtKTEASkS
0 1 K432-ac LtKTEASkSISRQSE
0 1 K440-ac SISRQSEkAHSSGkL
1 0 K440-ub SISRQSEkAHSSGkL
1 0 K446-ub EkAHSSGkLQkTVsY
1 0 K449-ub HSSGkLQkTVsYPDV
0 10 S452-p GkLQkTVsYPDVsLE
0 1 S457-p TVsYPDVsLEEQEkM
0 1 K463-ac VsLEEQEkMDLKTSR
0 1 S490-p NSTSKRKsESATCNL
  mouse

 
S6 __MENLQSKFSLVQG
S26 NGMEDDGSPPVKKMM
T42-p DIHANGKtLTKVKKE
K47 GKtLTKVKKEHLDDY
K246 NGSILPAKSSLAQLK
K349-ub KIILEEMkEKFSMRN
K380 PSWYPVIKQEGDHVP
K420 TSAASQSKEATKAET
T423 ASQSKEATKAETSKS
K429 ATKAETSKSTSKQSE
K437 STSKQSEKPHESSQH
K437 STSKQSEKPHESSQH
Q443 EKPHESSQHQKTVSY
K446 HESSQHQKTVSYPDV
S449 SQHQKTVSYPDVSLE
S454 TVSYPDVSLEEQEKM
K460 VSLEEQEKMDLKTSR
S487 NSTSRKKSESAVCSL
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