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SKIL (human)

Overview SKIL May have regulatory role in cell division or differentiation in response to extracellular signals. Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Belongs to the SKI family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: nucleoplasm; PML body; cytoplasm; nucleus Molecular Function: protein domain specific binding; protein binding; DNA binding; protein complex binding; nucleotide binding; chromatin binding; SMAD binding; transcription corepressor activity Biological Process: transcription initiation from RNA polymerase II promoter; skeletal muscle development; transcription, DNA-dependent; blastocyst formation; negative regulation of transcription from RNA polymerase II promoter; response to antibiotic; regulation of apoptosis; negative regulation of cell differentiation; transforming growth factor beta receptor signaling pathway; positive regulation of axonogenesis; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; cell cycle arrest; lymphocyte homeostasis Reference #:  P12757 (UniProtKB) Alt. Names/Synonyms: SKI-like oncogene; Ski-like protein; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SKIL; SNO; SnoA; SnoI; SnoN Gene Symbols: SKIL Molecular weight: 76,976 Da Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SKIL 3EQ5 - F/A/J/K/E/B/H/C/D/I/G/L=137-238 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T6-p	__MENLQtNFSLVQG
0	1		T42	DIHANGKTINKVPTV
2	0		K50-s	INKVPTVkKEHLDDY
0	1		K249-u	NGSVLPAkSSLAQLK
0	1		K352	KIILEEMKEKFSMRS
2	0		K383-s	QSWYPVIkQEGDHVS
0	1		K423-u	TSAVSQSkELtKTEA
0	1		T426-p	VSQSkELtKTEASkS
0	1		K432-a	LtKTEASkSISRQSE
0	1		K440-a	SISRQSEkAHSSGkL
1	0		K440-u	SISRQSEkAHSSGkL
1	0		K446-u	EkAHSSGkLQkTVsY
1	0		K449-u	HSSGkLQkTVsYPDV
0	8		S452-p	GkLQkTVsYPDVSLE
0	1		K463-a	VSLEEQEkMDLKTSR

	mouse
S6	__MENLQSKFSLVQG
T42-p	DIHANGKtLTKVKKE
K47	GKtLTKVKKEHLDDY
K246	NGSILPAKSSLAQLK
K349-u	KIILEEMkEKFSMRN
K380	PSWYPVIKQEGDHVP
K420	TSAASQSKEATKAET
T423	ASQSKEATKAETSKS
K429	ATKAETSKSTSKQSE
K437	STSKQSEKPHESSQH
K437	STSKQSEKPHESSQH
Q443	EKPHESSQHQKTVSY
K446	HESSQHQKTVSYPDV
S449	SQHQKTVSYPDVSLE
K460	VSLEEQEKMDLKTSR

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