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Lyric (human)

Overview Lyric a protein of unknown function. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Membrane protein, integral Cellular Component: nuclear body; intercellular canaliculus; endoplasmic reticulum membrane; nuclear membrane; tight junction; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; apical plasma membrane; integral to membrane; nucleolus; nucleus Molecular Function: NF-kappaB binding; protein binding; transcription coactivator activity Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; negative regulation of apoptosis; activation of NF-kappaB transcription factor Reference #:  Q86UE4 (UniProtKB) Alt. Names/Synonyms: 3D3; 3D3/LYRIC; AEG-1; AEG1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC/3D3; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; MTDH; Protein LYRIC Gene Symbols: MTDH Molecular weight: 63,837 Da Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Lyric

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	10		S84-p	GARKKRRsPPRKREE
0	5		A97	EEAAAVPAAAPDDLA
0	29		K107-u	PDDLALLkNLRsEEQ
0	3		S111-p	ALLkNLRsEEQKKKN
0	1		K121-u	QKKKNRKkLSEkPkP
0	2		K125-u	NRKkLSEkPkPNGRT
0	1		K127-u	KkLSEkPkPNGRTVE
0	9		T143-p	AEGEAVRtPQsVTAk
0	1		S146-p	EAVRtPQsVTAkQPP
0	15		K150-u	tPQsVTAkQPPEIDK
0	1		K170-a	KKNKKKSkSDAkAVQ
0	1		K174-a	KKSkSDAkAVQNssR
0	2		K174-u	KKSkSDAkAVQNssR
0	1		S179-p	DAkAVQNssRHDGkE
0	1		S180-p	AkAVQNssRHDGkEV
0	18		K185-u	NssRHDGkEVDEGAW
0	2		K248-u	PVGSKKNkGDSHLNV
0	1		K261-m1	NVQVSNFkSGKGDST
0	2		K289-u	NGGGWNEkSVkLssQ
0	2		K292-u	GWNEkSVkLssQIsA
0	2		S294-p	NEkSVkLssQIsAGE
0	3		S295-p	EkSVkLssQIsAGEE
0	25		S298-p	VkLssQIsAGEEkWN
0	1		K303-u	QIsAGEEkWNsVsPA
0	2		S306-p	AGEEkWNsVsPAsAG
0	9		S308-p	EEkWNsVsPAsAGkR
0	3		S311-p	WNsVsPAsAGkRKTE
0	13		K314-a	VsPAsAGkRKTEPSA
0	5		S339-p	NGKDWGRsWsDRsIF
0	3		S341-p	KDWGRsWsDRsIFSG
0	3		S344-p	GRsWsDRsIFSGIGS
0	1		S357-p	GSTAEPVsQSTtsDy
0	1		T361-p	EPVsQSTtsDyQWDV
0	3		S362-p	PVsQSTtsDyQWDVs
0	45		Y364-p	sQSTtsDyQWDVsRN
0	2		S369-p	sDyQWDVsRNQPYID
0	3		S415-p	ERASLLKsQEPIPDD
0	2		P420	LKsQEPIPDDQKVsD
0	28		S426-p	IPDDQKVsDDDKEKG
0	1		K441-a	EGALPTGkSKKKKKK
0	1		S457	KKQGEDNStAQDTEE
0	1		T458-p	KQGEDNStAQDTEEL
0	2		K491-u	QEKAFSLktIsTSDP
0	1		T492-p	EKAFSLktIsTSDPA
0	2		S494-p	AFSLktIsTSDPAEV
0	3		K510-u	VKNSQPIkTLPPATS
0	1		T511	KNSQPIkTLPPATST
0	1		S521	PATSTEPSVILSKSD
0	1		S529	VILSKSDSDKSSSQV
0	1		T543	VPPILQETDKSKsNt
0	2		S548-p	QETDKSKsNtKQNSV
0	1		T550-p	TDKSKsNtKQNSVPP
0	1		S554	KsNtKQNSVPPsQtK
0	2		S558-p	KQNSVPPsQtKSETS
0	2		T560-p	NSVPPsQtKSETSWE
0	23		S568-p	KSETSWEsPKQIKKK
0	19		T582-p	KKKARREt_______

	Lyric iso3
S84	GSRKKRRSPPRKREE
A97	EEAAAVPAAAPDDLA
K107	PDDLALLKNLRSEEQ
S111	ALLKNLRSEEQKKKN
K121	QKKKNRKKLSEKPKP
K125	NRKKLSEKPKPNGRT
K127	KKLSEKPKPNGRTVE
T143	AEGEAVRTPQSVTAK
S146	EAVRTPQSVTAKQPP
K150	TPQSVTAKQPPEIDK
K170	KKNKKKSKSDAKAVQ
K174	KKSKSDAKAVQNSSR
K174	KKSKSDAKAVQNSSR
S179	DAKAVQNSSRHDGKE
S180	AKAVQNSSRHDGKEV
K185	NSSRHDGKEVDEGAW
K248	PVGSKKNKGDSHLNV
K261	NVQVSNFKSGKGDST
K289	NGGGWNEKSVKLSSQ
K292	GWNEKSVKLSSQISA
S294	NEKSVKLSSQISAGE
S295	EKSVKLSSQISAGEE
S298	VKLSSQISAGEEKWN
K303	QISAGEEKWNSVSPA
S306	AGEEKWNSVSPASAG
S308	EEKWNSVSPASAGKR
S311	WNSVSPASAGKRKAE
K314	VSPASAGKRKAEPSA
S339	NGKDWGRSWSDRSIF
S341	KDWGRSWSDRSIFSG
S344	GRSWSDRSIFSGIGS
S357	GSTAEPVSQSTTSDY
T361	EPVSQSTTSDYQWDV
S362	PVSQSTTSDYQWDVS
Y364	SQSTTSDYQWDVSRN
S369	SDYQWDVSRNQPYID
S415	ERASLLKSQEPIPDD
P420	LKSQEPIPDDQKVSD
S426	IPDDQKVSDDDKEKG
K441	EGALPTGKSKKKKKK
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	mouse
S84	GARKKRRSPPRKREE
T96-p	REEAAPPtPAPDDLA
K106-u	PDDLAQLkNLRsEEQ
S110-p	AQLkNLRsEEQKKKN
K120	QKKKNRKKLPEKPKP
K124	NRKKLPEKPKPNGRT
K126	KKLPEKPKPNGRTVE
N142	PEDEVVRNPRSITAK
S145	EVVRNPRSITAKQAP
K149	NPRSITAKQAPETDK
K169	KKNKKKSKSDAKAVQ
K173	KKSKSDAKAVQNSSR
K173	KKSKSDAKAVQNSSR
S178	DAKAVQNSSRHDGkE
S179	AKAVQNSSRHDGkEV
K184-u	NSSRHDGkEVDEGAW
K247-u	PVGSKKNkGDSHLNV
K260	NVQVSNFKSGKGDST
K288-u	NGGGWSEkSVKLssQ
K291	GWSEkSVKLssQLsE
S293-p	SEkSVKLssQLsEEK
S294-p	EkSVKLssQLsEEKW
S297-p	VKLssQLsEEKWNSV
K300	ssQLsEEKWNSVPPA
S303	LsEEKWNSVPPAsAG
P305	EEKWNSVPPAsAGKR
S308-p	WNSVPPAsAGKRKTE
K311	VPPAsAGKRKTEPSA
N336	NGKDWGRNWSDRSIF
S338	KDWGRNWSDRSIFSG
S341	GRNWSDRSIFSGIGS
S354	GSTAEPVSQSTTSDY
T358	EPVSQSTTSDYQWDV
S359	PVSQSTTSDYQWDVS
Y361	SQSTTSDYQWDVSRN
S366	SDYQWDVSRNQPYID
S412	DRASLLKSQEPIsND
S417-p	LKSQEPIsNDQKVsD
S423-p	IsNDQKVsDDDKEKG
K438	EGALPTGKSKKKKKK
S454-p	KKQGEDNsHTQDTED
H455	KQGEDNsHTQDTEDL
K488	QEKACSLKTMSTSDP
T489	EKACSLKTMSTSDPA
S491	ACSLKTMSTSDPAEV
K507	IKNSQPVKtLPPAIS
T508-p	KNSQPVKtLPPAISA
S518-p	PAISAEPsITLSKGD
S526-p	ITLSKGDsDNSSSQV
T540-p	VPPMLQDtDKPKsNA
S545-p	QDtDKPKsNAKQNsV
A547	tDKPKsNAKQNsVPP
S551-p	KsNAKQNsVPPsQtK
S555-p	KQNsVPPsQtKSETN
T557-p	NsVPPsQtKSETNWE
S565-p	KSETNWEsPKQIKKK
T579-p	KKKARREt_______

	rat
S84	GARKKRRSPPRKREE
T96	REEVTPPTPAPEDPA
K106	PEDPAQLKNLRSEEQ
S110	AQLKNLRSEEQKKKN
K120	QKKKNRKKLPEKPKP
K124	NRKKLPEKPKPNGRT
K126	KKLPEKPKPNGRTVE
T142	PEDEVVRTPRSITAK
S145	EVVRTPRSITAKQPP
K149	TPRSITAKQPPETDK
K169	KKNKKKSKSDAKAVQ
K173	KKSKSDAKAVQNSSR
K173	KKSKSDAKAVQNSSR
S178	DAKAVQNSSRHDGKE
S179	AKAVQNSSRHDGKEV
K184	NSSRHDGKEVDEGAW
K247	PVGSKKNKGDSHLNV
K260	NVQVSNFKSGKGDST
K288	NGGGWSEKSVKLSSQ
K291	GWSEKSVKLSSQLsA
S293	SEKSVKLSSQLsAGE
S294	EKSVKLSSQLsAGEE
S297-p	VKLSSQLsAGEEKWN
K302	QLsAGEEKWNSVPPA
S305	AGEEKWNSVPPASAG
P307	EEKWNSVPPASAGKR
S310	WNSVPPASAGKRKTE
K313	VPPASAGKRKTEQSA
N338	NGKDWGRNWSDRSIF
S340	KDWGRNWSDRSIFSG
S343	GRNWSDRSIFSGIGS
S356	GSTAEPVSQSTTSDY
T360	EPVSQSTTSDYQWDG
S361	PVSQSTTSDYQWDGS
Y363	SQSTTSDYQWDGSRN
S368	SDYQWDGSRNQPHID
S414	DRASLLKSQEPISND
S419	LKSQEPISNDQKDsD
S425-p	ISNDQKDsDDDKEKG
K440	EGALPTGKSKKKKKK
S456-p	KKQGEDNsITQDTED
I457	KQGEDNsITQDTEDL
K490	QEKACSLKTMSTSDP
T491	EKACSLKTMSTSDPV
S493	ACSLKTMSTSDPVEV
K509	IKNSQPIKTLPPAIS
T510	KNSQPIKTLPPAISA
S520	PAISAEPSVTLSKGD
S528	VTLSKGDSDKSSSQV
T542	VPPMLQDTDKPKSNA
S547	QDTDKPKSNAKQNSV
A549	TDKPKSNAKQNSVPP
S553	KSNAKQNSVPPSQTK
S557	KQNSVPPSQTKSETN
T559	NSVPPSQTKSETNWE
S567-p	KSETNWEsPKQIKKK
T581	KKKARRET_______

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