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Protein Page:
Lyric (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Lyric a protein of unknown function. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Cellular Component: nuclear body; intercellular canaliculus; endoplasmic reticulum membrane; nuclear membrane; tight junction; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; integral to membrane; nucleolus; nucleus
Molecular Function: NF-kappaB binding; protein binding; double-stranded RNA binding; transcription coactivator activity
Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; activation of NF-kappaB transcription factor; negative regulation of apoptosis
Reference #:  Q86UE4 (UniProtKB)
Alt. Names/Synonyms: 3D3; 3D3/LYRIC; AEG-1; AEG1; Astrocyte elevated gene-1 protein; LYRIC; LYRIC/3D3; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; MTDH; Protein LYRIC
Gene Symbols: MTDH
Molecular weight: 63,837 Da
Basal Isoelectric point: 9.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Lyric

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 10 S84-p GARKKRRsPPRKREE
0 7 A97 EEAAAVPAAAPDDLA
0 29 K107-ub PDDLALLkNLRsEEQ
0 5 S111-p ALLkNLRsEEQKKKN
0 1 K121-ub QKKKNRKkLSEkPkP
0 2 K125-ub NRKkLSEkPkPNGRT
0 1 K127-ub KkLSEkPkPNGRTVE
0 12 T143-p AEGEAVRtPQsVtAk
0 3 S146-p EAVRtPQsVtAkQPP
0 1 T148-p VRtPQsVtAkQPPEI
0 15 K150-ub tPQsVtAkQPPEIDK
0 1 K170-ac KKNKKKSkSDAkAVQ
0 1 K174-ac KKSkSDAkAVQNssR
0 2 K174-ub KKSkSDAkAVQNssR
0 1 S179-p DAkAVQNssRHDGkE
0 2 S180-p AkAVQNssRHDGkEV
0 1 K185 NssRHDGKEVDEGAW
0 18 K185-ub NssRHDGkEVDEGAW
0 1 S197-p GAWETKIsHREKRQQ
0 1 S214-p RDKVLTDsGsLDSTI
0 1 S216-p KVLTDsGsLDSTIPG
0 2 K248-ub PVGSKKNkGDsHLNV
0 2 S251-p SKKNkGDsHLNVQVS
0 1 K261-m1 NVQVSNFkSGKGDST
0 2 K289-ub NGGGWNEkSVkLssQ
0 2 K292-ub GWNEkSVkLssQIsA
0 3 S294-p NEkSVkLssQIsAGE
0 5 S295-p EkSVkLssQIsAGEE
0 34 S298-p VkLssQIsAGEEkWN
0 1 K303-ub QIsAGEEkWNsVsPA
0 4 S306-p AGEEkWNsVsPAsAG
0 12 S308-p EEkWNsVsPAsAGkR
0 6 S311-p WNsVsPAsAGkRKTE
0 13 K314-ac VsPAsAGkRKTEPSA
0 1 S323-p KTEPSAWsQDTGDAN
0 6 S339-p NGKDWGRsWsDRsIF
0 3 S341-p KDWGRsWsDRsIFSG
0 3 S344-p GRsWsDRsIFSGIGS
0 1 S357-p GSTAEPVsQSTtsDy
0 1 T361-p EPVsQSTtsDyQWDV
0 3 S362-p PVsQSTtsDyQWDVs
0 40 Y364-p sQSTtsDyQWDVsRN
0 2 S369-p sDyQWDVsRNQPYID
0 5 S415-p ERASLLKsQEPIPDD
0 3 P420 LKsQEPIPDDQKVsD
0 40 S426-p IPDDQKVsDDDKEKG
0 1 K441-ac EGALPTGkSKKKKKK
0 2 S457 KKQGEDNStAQDTEE
0 1 T458-p KQGEDNStAQDTEEL
0 1 S478-p EDLPVNTsKTRPKQE
0 2 K491-ub QEKAFSLktIsTsDP
0 1 T492-p EKAFSLktIsTsDPA
0 6 S494-p AFSLktIsTsDPAEV
0 1 T495 FSLktIsTsDPAEVL
0 1 S496-p SLktIsTsDPAEVLV
0 3 K510-ub VKNSQPIkTLPPATS
0 1 T511 KNSQPIkTLPPATST
0 1 S521 PATSTEPSVILSKSD
0 2 S529-p VILSKSDsDKsSsQV
0 1 S532-p SKSDsDKsSsQVPPI
0 1 S534-p SDsDKsSsQVPPILQ
0 1 T543 VPPILQETDKsKsNt
0 1 S546-p ILQETDKsKsNtKQN
0 3 S548-p QETDKsKsNtKQNSV
0 2 T550-p TDKsKsNtKQNSVPP
0 1 S554 KsNtKQNSVPPsQtK
0 2 S558-p KQNSVPPsQtKSETs
0 2 T560-p NSVPPsQtKSETsWE
0 1 S565-p sQtKSETsWEsPKQI
0 30 S568-p KSETsWEsPKQIKKK
0 19 T582-p KKKARREt_______
  mouse

 
S84 GARKKRRSPPRKREE
T96-p REEAAPPtPAPDDLA
K106-ub PDDLAQLkNLRsEEQ
S110-p AQLkNLRsEEQKKKN
K120 QKKKNRKKLPEKPKP
K124 NRKKLPEKPKPNGRT
K126 KKLPEKPKPNGRTVE
N142 PEDEVVRNPRSITAK
S145 EVVRNPRSITAKQAP
T147 VRNPRSITAKQAPET
K149 NPRSITAKQAPETDK
K169 KKNKKKSKSDAKAVQ
K173 KKSKSDAKAVQNSSR
K173 KKSKSDAKAVQNSSR
S178 DAKAVQNSSRHDGkE
S179 AKAVQNSSRHDGkEV
K184-ac NSSRHDGkEVDEGAW
K184-ub NSSRHDGkEVDEGAW
S196 GAWETKISHREKRQQ
S213 RDKVLTDSGSLDSTI
S215 KVLTDSGSLDSTIPG
K247-ub PVGSKKNkGDSHLNV
S250 SKKNkGDSHLNVQVS
K260 NVQVSNFKSGKGDST
K288-ub NGGGWSEkSVKLssQ
K291 GWSEkSVKLssQLsE
S293-p SEkSVKLssQLsEEK
S294-p EkSVKLssQLsEEKW
S297-p VKLssQLsEEKWNsV
K300 ssQLsEEKWNsVPPA
S303-p LsEEKWNsVPPAsAG
P305 EEKWNsVPPAsAGKR
S308-p WNsVPPAsAGKRKTE
K311 VPPAsAGKRKTEPSA
T320 KTEPSAWTQDTGDTN
N336 NGKDWGRNWSDRSIF
S338 KDWGRNWSDRSIFSG
S341 GRNWSDRSIFSGIGS
S354 GSTAEPVSQSTTSDY
T358 EPVSQSTTSDYQWDV
S359 PVSQSTTSDYQWDVS
Y361 SQSTTSDYQWDVSRN
S366 SDYQWDVSRNQPYID
S412 DRASLLKSQEPIsND
S417-p LKSQEPIsNDQKVsD
S423-p IsNDQKVsDDDKEKG
K438 EGALPTGKSKKKKKK
S454-p KKQGEDNsHTQDTED
H455 KQGEDNsHTQDTEDL
S475 EELPVNTSKARPKQE
K488 QEKACSLKTMstSDP
T489 EKACSLKTMstSDPA
S491-p ACSLKTMstSDPAEV
T492-p CSLKTMstSDPAEVL
S493 SLKTMstSDPAEVLI
K507 IKNSQPVKtLPPAIS
T508-p KNSQPVKtLPPAISA
S518-p PAISAEPsITLSKGD
S526-p ITLSKGDsDNSSSQV
S529 SKGDsDNSSSQVPPM
S531 GDsDNSSSQVPPMLQ
T540-p VPPMLQDtDKPKsNA
P543 MLQDtDKPKsNAKQN
S545-p QDtDKPKsNAKQNsV
A547 tDKPKsNAKQNsVPP
S551-p KsNAKQNsVPPsQtK
S555-p KQNsVPPsQtKSETN
T557-p NsVPPsQtKSETNWE
N562 sQtKSETNWEsPKQI
S565-p KSETNWEsPKQIKKK
T579-p KKKARREt_______
  rat

 
S84 GARKKRRSPPRKREE
T96 REEVTPPTPAPEDPA
K106 PEDPAQLKNLRSEEQ
S110 AQLKNLRSEEQKKKN
K120 QKKKNRKKLPEKPKP
K124 NRKKLPEKPKPNGRT
K126 KKLPEKPKPNGRTVE
T142 PEDEVVRTPRSITAK
S145 EVVRTPRSITAKQPP
T147 VRTPRSITAKQPPET
K149 TPRSITAKQPPETDK
K169 KKNKKKSKSDAKAVQ
K173 KKSKSDAKAVQNSSR
K173 KKSKSDAKAVQNSSR
S178 DAKAVQNSSRHDGKE
S179 AKAVQNSSRHDGKEV
K184 NSSRHDGKEVDEGAW
K184 NSSRHDGKEVDEGAW
S196 GAWETKISHREKRQQ
S213 RDKVLTDSGSLDSTI
S215 KVLTDSGSLDSTIPG
K247 PVGSKKNKGDSHLNV
S250 SKKNKGDSHLNVQVS
K260 NVQVSNFKSGKGDST
K288 NGGGWSEKSVKLSSQ
K291 GWSEKSVKLSSQLsA
S293 SEKSVKLSSQLsAGE
S294 EKSVKLSSQLsAGEE
S297-p VKLSSQLsAGEEKWN
K302 QLsAGEEKWNSVPPA
S305 AGEEKWNSVPPASAG
P307 EEKWNSVPPASAGKR
S310 WNSVPPASAGKRKTE
K313 VPPASAGKRKTEQSA
T322 KTEQSAWTQDPGDTN
N338 NGKDWGRNWSDRSIF
S340 KDWGRNWSDRSIFSG
S343 GRNWSDRSIFSGIGS
S356 GSTAEPVSQSTTSDY
T360 EPVSQSTTSDYQWDG
S361 PVSQSTTSDYQWDGS
Y363 SQSTTSDYQWDGSRN
S368 SDYQWDGSRNQPHID
S414 DRASLLKSQEPISND
S419 LKSQEPISNDQKDsD
S425-p ISNDQKDsDDDKEKG
K440 EGALPTGKSKKKKKK
S456-p KKQGEDNsITQDTED
I457 KQGEDNsITQDTEDL
S477 EELPVNTSKARPKQE
K490 QEKACSLKTMSTSDP
T491 EKACSLKTMSTSDPV
S493 ACSLKTMSTSDPVEV
T494 CSLKTMSTSDPVEVL
S495 SLKTMSTSDPVEVLI
K509 IKNSQPIKTLPPAIS
T510 KNSQPIKTLPPAISA
S520 PAISAEPSVTLSKGD
S528 VTLSKGDSDKSSSQV
S531 SKGDSDKSSSQVPPM
S533 GDSDKSSSQVPPMLQ
T542 VPPMLQDTDKPKSNA
P545 MLQDTDKPKSNAKQN
S547 QDTDKPKSNAKQNSV
A549 TDKPKSNAKQNSVPP
S553 KSNAKQNSVPPSQTK
S557 KQNSVPPSQTKSETN
T559 NSVPPSQTKSETNWE
N564 SQTKSETNWEsPKQI
S567-p KSETNWEsPKQIKKK
T581 KKKARRET_______
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