polynucleotide kinase 3'-phosphatase. May be involved in double-strand break repair by non-homologous end joining. Required for normal response to DNA damage by gamma-radiation or camptothecin in S. pombe. Note: This description may include information from UniProtKB.
Protein type: Phosphatase (non-protein); DNA binding protein; EC 22.214.171.124; Kinase, other; EC 126.96.36.199
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: membrane; nucleolus; nucleus
Molecular Function: protein binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; purine nucleotide binding; polynucleotide 3'-phosphatase activity; endonuclease activity; double-stranded DNA binding; damaged DNA binding; nucleotide kinase activity; ATP binding
Biological Process: response to radiation; dephosphorylation; nucleotide-excision repair, DNA damage removal; DNA damage response, detection of DNA damage; response to oxidative stress; DNA-dependent DNA replication; DNA repair; nucleotide phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.