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Pnk1 (human)

Overview Pnk1 polynucleotide kinase 3'-phosphatase. May be involved in double-strand break repair by non-homologous end joining. Required for normal response to DNA damage by gamma-radiation or camptothecin in S. pombe. Note: This description may include information from UniProtKB. Protein type: EC 2.7.1.78; EC 3.1.3.32; Kinase, other; Phosphatase (non-protein); DNA binding protein Cellular Component: nucleolus; nucleus Molecular Function: ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; purine nucleotide binding; polynucleotide 3'-phosphatase activity; endonuclease activity; double-stranded DNA binding; damaged DNA binding; nucleotide kinase activity; ATP binding Biological Process: response to radiation; dephosphorylation; nucleotide-excision repair, DNA damage removal; DNA damage response, detection of DNA damage; response to oxidative stress; DNA-dependent DNA replication; DNA repair; nucleotide phosphorylation Reference #:  Q96T60 (UniProtKB) Alt. Names/Synonyms: 2'(3')-polynucleotidase; Bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); PNK; PNKP; Polynucleotide 3'-phosphatase; Polynucleotide 5'-hydroxyl-kinase; polynucleotide kinase 3'-phosphatase; polynucleotide kinase 3-prime-phosphatase; Polynucleotide kinase-3'-phosphatase Gene Symbols: PNKP Molecular weight: 57,076 Da Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states

Select Structure to View Below Pnk1 2BRF - A=1-110 (human) 2W3O - A/B=1-110 (human) 1UJX - A=1-106 (mouse) 1YJ5 - A/B=140-522, C=1-143 (mouse) 1YJM - A/B/C=1-110 (mouse) 3U7E - B=142-522 (mouse) 3U7F - B=142-522 (mouse) 3U7G - A=144-522 (mouse) 3U7H - B=142-522 (mouse) 3ZVL - A=111-522 (mouse) 3ZVM - A/B=111-522 (mouse) 3ZVN - A=111-522 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2BRF 2W3O  |  ENZYME 2.7.1.78 3.1.3.32  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		T109-p	LTLRWEEtRtPEsQP
0	13		T111-p	LRWEEtRtPEsQPDt
2	31		S114-p	EEtRtPEsQPDtPPG
0	122		T118-p	tPEsQPDtPPGtPLV
0	97		T122-p	QPDtPPGtPLVsQDE
2	21		S126-p	PPGtPLVsQDEKRDA
0	5		N144	KKRMRKSNPGWENLE
0	1		E151	NPGWENLEKLLVFTA
0	2		K183-a	LITTRSGkVFPTGPS
0	1		G188	SGkVFPTGPSDWRIL
0	1		K233	KLPAEEFKAKVEAVV
0	1		K242	KVEAVVEKLGVPFQV
0	1		S364-p	SRALLSAsPEVVVAV
0	1		K484-u	MVMYGYRkQFEAPTL

	mouse
L109	LTLRWEELSTSGsQP
T111	LRWEELSTSGsQPDA
S114-p	EELSTSGsQPDAPPD
A118	TSGsQPDAPPDtPGD
T122-p	QPDAPPDtPGDPEEG
P126	PPDtPGDPEEGEDTE
S143-p	KKRVRKSsLGWESLk
K150-u	sLGWESLkKLLVFTA
K182	LITTRSGKVFPTsPS
S187-p	SGKVFPTsPSDWRIL
K232-a	KLPAEVFkGKVEAVL
K241-a	KVEAVLEkLGVPFQV
N363	SSSLLSPNPEVVVAV
K483	MVMFSYRKQFEPPTL

	rat
I109	LTLRWEEISTPGSPP
T111	LRWEEISTPGSPPDT
S114	EEISTPGSPPDTPPG
T118	TPGSPPDTPPGNPVD
N122	PPDTPPGNPVDPEEG
P126	PPGNPVDPEEGKDTE
S143	KKRMRKSSPGWESFK
K150	SPGWESFKQLLVFTA
K182	LITTRSGKVFPTSPS
S187	SGKVFPTSPSDWRIL
K232	KLPAEVFKAKVEAVL
K241	KVEAVLEKLGVPFQV
N363	SSFLLSPNPEVVVAV
K483	MVMFSYRKQFEPPTL

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