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Protein Page:
TSC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TSC1 tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: TSC1-TSC2 complex; growth cone; protein complex; membrane; intracellular membrane-bound organelle; lamellipodium; cytoplasm; actin filament; cell cortex; cytosol
Molecular Function: protein binding; chaperone binding; GTPase activating protein binding; protein N-terminus binding; GTPase regulator activity
Biological Process: myelination; regulation of cell cycle; protein heterooligomerization; regulation of cell-matrix adhesion; cell-matrix adhesion; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; regulation of phosphoprotein phosphatase activity; cardiac muscle cell differentiation; response to insulin stimulus; regulation of translation; negative regulation of cell proliferation; positive regulation of focal adhesion formation; cell projection organization and biogenesis; synapse organization and biogenesis; cell cycle arrest; kidney development; potassium ion transport; negative regulation of TOR signaling pathway; protein stabilization; hippocampus development; activation of Rho GTPase; rRNA export from nucleus; regulation of stress fiber formation; negative regulation of translation; neural tube closure; insulin receptor signaling pathway; cerebral cortex development; regulation of protein kinase activity
Reference #:  Q92574 (UniProtKB)
Alt. Names/Synonyms: Hamartin; KIAA0243; LAM; MGC86987; TSC; TSC1; tuberous sclerosis 1; Tuberous sclerosis 1 protein; tumor suppressor
Gene Symbols: TSC1
Molecular weight: 129,767 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TSC1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: T417‑p
intracellular localization: T417‑p
molecular association, regulation: T310‑p, T417‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 P17 LLAMLDSPMLGVRDD
0 1 M18 LAMLDSPMLGVRDDV
0 1 R22 DSPMLGVRDDVTAVF
0 1 Y79-p LLDRINEyVGKAATR
0 1 S91-p ATRLSILsLLGHVIR
0 1 S108-p PSWKHKLsQAPLLPs
0 1 S115-p sQAPLLPsLLKCLKM
0 1 S205-p NFVSFLRsHYSMKEN
0 1 T267-p AKISLDPtEAsyEDG
0 1 S270-p SLDPtEAsyEDGySV
0 1 Y271-p LDPtEAsyEDGySVS
0 1 Y275-p EAsyEDGySVSHQIs
0 1 S282-p ySVSHQIsARFPHRS
0 1 S295-p RSADVTTsPyADTQN
0 6 Y297-p ADVTTsPyADTQNsy
0 1 S303-p PyADTQNsyGCATSt
0 2 Y304-p yADTQNsyGCATStP
1 0 T310-p syGCATStPySTSRL
0 5 Y312-p GCATStPySTSRLML
0 4 N321 TSRLMLLNMPGQLPQ
1 2 T357-p SMVCGMTtPPtSPGN
0 2 T360-p CGMTtPPtSPGNVPP
0 1 T386 TTAGGKGTPLGtPAt
0 2 L388 AGGKGTPLGtPAtSP
1 0 T390-p GKGTPLGtPAtSPPP
0 1 T393-p TPLGtPAtSPPPAPL
0 6 S394 PLGtPAtSPPPAPLC
0 2 Y406-p PLCHSDDyVHISLPQ
2 0 T417-p SLPQATVtPPRKEER
0 2 S427-p RKEERMDsARPCLHR
0 1 S468-p GFLGDLAsEEDsIEK
0 1 S472-p DLAsEEDsIEKDkEE
0 1 K477-ub EDsIEKDkEEAAIsR
0 1 S483-p DkEEAAIsRELsEIT
2 6 S487-p AAIsRELsEITTAEA
0 65 S505-p VPRGGFDsPFyRDsL
0 7 Y508-p GGFDsPFyRDsLPGs
4 14 S511-p DsPFyRDsLPGsQRK
0 1 P513 PFyRDsLPGsQRKTH
0 9 S515-p yRDsLPGsQRKTHsA
0 1 T519 LPGsQRKTHsAASSS
0 2 S521-p GsQRKTHsAASSSQG
0 1 C559 FTPIDLPCGSADESP
0 2 S565 PCGSADESPAGDREC
1 0 S584-p ETSIFTPsPCKIPPP
0 5 G595 IPPPTRVGFGsGQPP
0 4 S598-p PTRVGFGsGQPPPyD
0 1 Y604-p GsGQPPPyDHLFEVA
0 1 S644 EDGVPSTSPMEVLDR
0 3 S682-p DWTHFGGsPPSDEIR
0 1 K725-ub RLLRKVIkAAALEEH
0 1 K751-ac EKDIQMWkVSLQKEQ
0 1 S871-p EQLQNKHsDttKEVE
0 1 T873-p LQNKHsDttKEVEMM
0 1 T874-p QNKHsDttKEVEMMK
0 1 T1020-p GHNGETKtPRPssAR
0 1 S1024-p ETKtPRPssARGssG
0 1 S1025-p TKtPRPssARGssGS
0 1 S1029-p RPssARGssGSRGGG
0 1 S1030-p PssARGssGSRGGGG
0 2 S1046-p SSSSSELstPEKPPH
1 21 T1047-p SSSSELstPEKPPHQ
0 2 S1080 SIPTTVGSLPSSKSF
0 1 S1083 TTVGSLPSSKSFLGM
0 1 S1084 TVGSLPSSKSFLGMK
0 21 S1100-p RELFRNKsEsQCDED
0 8 S1102-p LFRNKsEsQCDEDGM
0 1 S1114-p DGMTSSLsEsLKTEL
0 1 S1116-p MTSSLsEsLKTELGK
0 1 P1132 LGVEAKIPLNLDGPH
0 1 N1134 VEAKIPLNLDGPHPs
0 1 S1141-p NLDGPHPsPPtPDSV
0 1 P1142 LDGPHPsPPtPDSVG
0 1 T1144-p GPHPsPPtPDSVGQL
  mouse

► Hide Isoforms
 
S17-p LLSMLDSstLGVRDD
T18-p LSMLDSstLGVRDDV
R22 DSstLGVRDDVTAIF
Y79 LLDKINEYVGKAATR
S91 ATRLSILSLLGHVVR
S108 PSWKHKLSQAPLLPS
S115 SQAPLLPSLLKCLKM
S205 NFVSFLRSHYSMKEN
T267 AKISLDPTEASYEDG
S270 SLDPTEASYEDGYSV
Y271 LDPTEASYEDGYSVS
Y275 EASYEDGYSVSHQLS
S282 YSVSHQLSACFPYRS
S295 RSADVTTSPYVDTQN
Y297 ADVTTSPYVDTQNSY
S303 PYVDTQNSYGGSTST
Y304 YVDTQNSYGGSTSTP
T310 SYGGSTSTPSSSSRL
S312 GGSTSTPSSSSRLML
S321-p SSRLMLFsPPGQLPQ
T357-p SAVCGMTtPPtSPGN
T360-p CGMTtPPtSPGNVPA
T386-p TTAGGKGtPsGTPAT
S388-p AGGKGtPsGTPATsP
T390 GKGtPsGTPATsPPP
T393 tPsGTPATsPPPAPP
S394-p PsGTPATsPPPAPPC
C406 PPCPQDDCVHGSAAQ
T417 SAAQASATAPRKEER
S427-p RKEERADsSRPYLHR
S465 DFLGDLASEEDSIEK
S469 DLASEEDSIEKDKEE
K474 EDSIEKDKEEAAISK
S480 DKEEAAISKELsEIT
S484-p AAISKELsEITTAEA
S502-p VPRGGFDsPFyRDsL
Y505-p GGFDsPFyRDsLsGs
S508-p DsPFyRDsLsGsQRK
S510-p PFyRDsLsGsQRKtH
S512-p yRDsLsGsQRKtHSA
T516-p LsGsQRKtHSAASGT
S518 GsQRKtHSAASGTQG
S556-p FTPIDPPsGSADVsP
S562-p PsGSADVsPAGDRDR
S581 ETSILTPSPCKIPPQ
S592-p IPPQRGVsFGSGQLP
S595 QRGVsFGSGQLPPYD
Y601 GSGQLPPYDHLFEVA
S641-p EDCVPSTsPMEVLDR
S679-p DWTHFGGsPPSDELR
R722 RLLRKVIRAAALEEH
K748 EKDIQMWKVSLQKEQ
P868 EQLQSKHPDTTKEVE
T870 LQSKHPDTTKEVEMM
T871 QSKHPDTTKEVEMMK
T1017 GHNGETRTSRPGGTR
G1021 ETRTSRPGGTRASCG
G1022 TRTSRPGGTRASCGG
S1026 RPGGTRASCGGRVTG
C1027 PGGTRASCGGRVTGG
S1043 SSSSSELStPEKPPS
T1044-p SSSSELStPEKPPSQ
S1074-p SIPTTVGsLPssKSF
S1077-p TTVGsLPssKSFLGM
S1078-p TVGsLPssKSFLGMK
S1094-p RELFRNKsEsQCDED
S1096-p LFRNKsEsQCDEDSV
S1111 TMSSSSLSETLKTEL
T1113 SSSSLSETLKTELGK
S1129-p SGTENKTsLsLDAPH
S1131-p TENKTsLsLDAPHPS
S1138 sLDAPHPSsPNSDNV
S1139-p LDAPHPSsPNSDNVG
N1141 APHPSsPNSDNVGQL
  TSC1 iso2  
S17 LLSMLDSSTLGVRDD
T18 LSMLDSSTLGVRDDV
R22 DSSTLGVRDDVTAIF
Y79 LLDKINEYVGKAATR
S91 ATRLSILSLLGHVVR
S108 PSWKHKLSQAPLLPS
S115 SQAPLLPSLLKCLKM
S205 NFVSFLRSHYSMKEN
T267 AKISLDPTEASYEDG
S270 SLDPTEASYEDGYSV
Y271 LDPTEASYEDGYSVS
Y275 EASYEDGYSVSHQLS
S282 YSVSHQLSACFPYRS
S295 RSADVTTSPYVDTQN
Y297 ADVTTSPYVDTQNSY
S303 PYVDTQNSYGGSTST
Y304 YVDTQNSYGGSTSTP
T310 SYGGSTSTPSSSSRL
S312 GGSTSTPSSSSRLML
S321 SSRLMLFSPPGQLPQ
T357 SAVCGMTTPPTSPGN
T360 CGMTTPPTSPGNVPA
T385 GTTGGKGTPsGTPAT
S387-p TGGKGTPsGTPATsP
T389 GKGTPsGTPATsPPP
T392 TPsGTPATsPPPAPP
S393-p PsGTPATsPPPAPPC
C405 PPCPQDDCVHGSAAQ
T416 SAAQASATAPRKEER
S426 RKEERADSSRPYLHR
S464 DFLGDLASEEDSIEK
S468 DLASEEDSIEKDKEE
K473 EDSIEKDKEEAAISK
S479 DKEEAAISKELSEIT
S483 AAISKELSEITTAEA
S501 VPRGGFDSPFYRDSL
Y504 GGFDSPFYRDSLSGS
S507 DSPFYRDSLSGSQRK
S509 PFYRDSLSGSQRKTH
S511 YRDSLSGSQRKTHSA
T515 LSGSQRKTHSAASGT
S517 GSQRKTHSAASGTQG
S555 FTPIDPPSGSADVSP
S561 PSGSADVSPAGDRDR
S580 ETSILTPSPCKIPPQ
S591 IPPQRGVSFGSGQLP
S594 QRGVSFGSGQLPPYD
Y600 GSGQLPPYDHLFEVA
S640 EDCVPSTSPMEVLDR
S678 DWTHFGGSPPSDELR
R721 RLLRKVIRAAALEEH
K747 EKDIQMWKVSLQKEQ
P867 EQLQSKHPDTTKEVE
T869 LQSKHPDTTKEVEMM
T870 QSKHPDTTKEVEMMK
T1016 GHNGETRTSRPGGTR
G1020 ETRTSRPGGTRASCG
G1021 TRTSRPGGTRASCGG
S1025 RPGGTRASCGGRVTG
C1026 PGGTRASCGGRVTGG
S1042 SSSSSELSTPEKPPS
T1043 SSSSELSTPEKPPSQ
S1073 SIPTTVGSLPSSKSF
S1076 TTVGSLPSSKSFLGM
S1077 TVGSLPSSKSFLGMK
S1093 RELFRNKSESQCDED
S1095 LFRNKSESQCDEDSV
S1110 TMSSSSLSETLKTEL
T1112 SSSSLSETLKTELGK
S1128 SGTENKTSLSLDAPH
S1130 TENKTSLSLDAPHPS
S1137 SLDAPHPSSPNSDNV
S1138 LDAPHPSSPNSDNVG
N1140 APHPSSPNSDNVGQL
  rat

 
S17 LLSMLDSSTLGVrDD
T18 LSMLDSSTLGVrDDV
R22-m1 DSSTLGVrDDVTTIF
Y79 LLDKMNEYVGKAATR
S91 ATRLSILSLLGHVVR
S108 PSWKHKLSQAPLLPS
S115 SQAPLLPSLLKCLKM
S205 NFVSFLRSHYSMKEN
T267 AKISLDPTEASYEDG
S270 SLDPTEASYEDGDAV
Y271 LDPTEASYEDGDAVS
D275 EASYEDGDAVSHQLS
S282 DAVSHQLSACFPHRS
S295 RSADVTTSSYVDTQN
Y297 ADVTTSSYVDTQNSY
S303 SYVDTQNSYGGATST
Y304 YVDTQNSYGGATSTP
T310 SYGGATSTPSSTSRL
S312 GGATSTPSSTSRLML
S321 TSRLMLFSTPGQLPQ
T357 SAVCGMTTPPTSPGN
T360 CGMTTPPTSPGNVPA
T386 TTTGGKGTPSGTPAT
S388 TGGKGTPSGTPATSP
T390 GKGTPSGTPATSPPP
T393 TPSGTPATSPPPAPP
S394 PSGTPATSPPPAPPC
C406 PPCPQDDCAHGPASQ
T417 PASQASATPPRKEER
S427 RKEERADSSRPYLPR
S468 DFLGDLASEEDSIEK
S472 DLASEEDSIEKDKEE
K477 EDSIEKDKEEAAISK
S483 DKEEAAISKELSEIT
S487 AAISKELSEITTAEA
S505-p APRGGFDsPFYRDSL
Y508 GGFDsPFYRDSLSGS
S511 DsPFYRDSLSGSQRK
S513 PFYRDSLSGSQRKTH
S515 YRDSLSGSQRKTHSA
T519 LSGSQRKTHSAASGT
S521 GSQRKTHSAASGTQG
S559 FTPIDPPSGSADASP
S565 PSGSADASPAGDRDR
S584 ETSILTPSPCKIPPQ
S595 IPPQRGVSFGSGQLP
S598 QRGVSFGSGQLPPYD
Y604 GSGQLPPYDHLFEVA
S644 EDCVPSTSPMEVLDR
S682 DWTHFGGSPPSDEIR
R725 RLLRKVIRAAALEEH
K751 EKDIQMWKVSLQKEQ
P871 EQLQSKHPDTTKEVE
T873 LQSKHPDTTKEVEMM
T874 QSKHPDTTKEVEMMK
T1020 GHNGETRTSRPGGTR
G1024 ETRTSRPGGTRASCG
G1025 TRTSRPGGTRASCGG
S1029 RPGGTRASCGGRVTG
C1030 PGGTRASCGGRVTGG
S1046 SSSSSELSTPEKPPN
T1047 SSSSELSTPEKPPNQ
S1077 SIPTTVGSLPSSKSF
S1080 TTVGSLPSSKSFLGM
S1081 TVGSLPSSKSFLGMK
S1097 RELFRNKSESQCDED
S1099 LFRNKSESQCDEDGM
S1112 GMTMSSFSETLKTEL
T1114 TMSSFSETLKTELGK
- gap
S1133 MENKTPPSLDAPHPS
S1140 SLDAPHPSSPSSDSM
S1141 LDAPHPSSPSSDSMG
S1143 APHPSSPSSDSMGQL
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