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Protein Page:
COPS1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
COPS1 a protein that suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. Shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Cellular Component: signalosome; cytoplasm
Molecular Function: GTPase inhibitor activity
Biological Process: cullin deneddylation; JNK cascade; cell cycle; inactivation of MAPK activity
Reference #:  Q13098 (UniProtKB)
Alt. Names/Synonyms: COP9 signalosome complex subunit 1; COPS1; CSN1; G protein pathway suppressor 1; GPS-1; GPS1; JAB1-containing signalosome subunit 1; MGC71287; Protein MFH; SGN1; Signalosome subunit 1
Gene Symbols: GPS1
Molecular weight: 55,537 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
Select Structure to View Below

COPS1
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 - gap
0 1 - gap
0 1 - gap
0 1 - gap
0 3 - gap
0 50 - gap
0 1 - gap
0 1 - gap
0 1 T102-p HRKLSEAtRSSLREL
0 1 K144-u KALLKLEkLDTDLkN
0 2 K150-u EkLDTDLkNYkGNSI
0 1 K153-u DTDLkNYkGNSIkES
0 1 K158-u NYkGNSIkESIRRGH
0 2 K183-u GDLSNALkCYSRARD
0 8 K224-u HVLSYVSkAESTPEI
0 6 S240-p EQRGERDsQTQAILT
0 2 K248-u QTQAILTkLKCAAGL
0 1 K250 QAILTkLKCAAGLAE
0 1 K268-u RKYKQAAkCLLLASF
0 2 K337-a IFKFYESkYASCLKM
0 1 Y377-p RNRALIQyFSPYVSA
0 2 S419-p LISARVDsHskILYA
0 2 S421-p SARVDsHskILYARD
0 2 K422-u ARVDsHskILYARDV
0 3 K438-u QRSTTFEkSLLMGkE
0 3 K444-u EkSLLMGkEFQRRAK
0 1 K467-a LRNQIHVksPPREGs
0 5 K467-u LRNQIHVksPPREGs
0 26 S468-p RNQIHVksPPREGsQ
0 70 S474-p ksPPREGsQGELtPA
0 54 T479-p EGsQGELtPANsQsR
0 33 S483-p GELtPANsQsRMsTN
0 14 S485-p LtPANsQsRMsTNM_
0 1 S488-p ANsQsRMsTNM____
  COPS1 iso3  
- gap
S31-p SQDRMRDsSAPSsAS
S36-p RDsSAPSsASSsVtD
S40-p APSsASSsVtDLyCt
T42-p SsASSsVtDLyCtPH
Y45-p SSsVtDLyCtPHSsR
T47-p sVtDLyCtPHSsRSD
S51-p LyCtPHSsRSDLVLP
- gap
K129 KALLKLEKLDTDLKN
K135 EKLDTDLKNYKGNSI
K138 DTDLKNYKGNSIKES
K143 NYKGNSIKESIRRGH
K168 GDLSNALKCYSRARD
K209 HVLSYVSKAESTPEI
S225 EQRGERDSQTQAILT
K233 QTQAILTKLKCAAGL
K235 QAILTKLKCAAGLAE
K253 RKYKQAAKCLLLASF
K322 IFKFYESKYASCLKM
Y362 RNRALIQYFSPYVSA
S404 LISARVDSHSKILYA
S406 SARVDSHSKILYARD
K407 ARVDSHSKILYARDV
K423 QRSTTFEKSLLMGKE
K429 EKSLLMGKEFQRRAK
K452 LRNQIHVKSPPTSTD
K452 LRNQIHVKSPPTSTD
S453 RNQIHVKSPPTSTDL
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms 		 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T86 HRKLSEATRELQNAP
K124 KALLKLEKLDTDLKN
K130 EKLDTDLKNYKGNSI
K133 DTDLKNYKGNSIKES
K138 NYKGNSIKESIRRGH
K163-u GDLSNALkCYSRARD
K204 HVLSYVSKAESTPEI
S220-p EQRGERDsQTQAILT
K228-u QTQAILTkLkCAAGL
K230-u QAILTkLkCAAGLAE
K248 RKYKQAAKCFLLASF
K317 IFKFYESKYASCLKM
Y357 RNRALIQYFSPYVSA
S399 LINARIDSHSKILYA
S401 NARIDSHSKILYARD
K402 ARIDSHSKILYARDV
K418-u QRSTTFEkSLLMGkE
K424-u EkSLLMGkEFQRRAK
K447 LRNQIHVKsPPREGs
K447-u LRNQIHVksPPREGs
S448-p RNQIHVksPPREGsQ
S454-p ksPPREGsQGELtPA
T459-p EGsQGELtPANsQSR
S463-p GELtPANsQSRMSTN
S465 LtPANsQSRMSTNM_
S468 ANsQSRMSTNM____
  COPS1 iso4  
S8-p MRGSPAPsSASSSAS
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T141 HRKLSEATRELQNAP
K179 KALLKLEKLDTDLKN
K185 EKLDTDLKNYKGNSI
K188 DTDLKNYKGNSIKES
K193 NYKGNSIKESIRRGH
K218 GDLSNALKCYSRARD
K259 HVLSYVSKAESTPEI
S275 EQRGERDSQTQAILT
K283 QTQAILTKLKCAAGL
K285 QAILTKLKCAAGLAE
K303 RKYKQAAKCFLLASF
K372 IFKFYESKYASCLKM
Y412 RNRALIQYFSPYVSA
S454 LINARIDSHSKILYA
S456 NARIDSHSKILYARD
K457 ARIDSHSKILYARDV
K473 QRSTTFEKSLLMGKE
K479 EKSLLMGKEFQRRAK
K502 LRNQIHVKSPPREGS
K502 LRNQIHVKSPPREGS
S503 RNQIHVKSPPREGSQ
S509 KSPPREGSQGELTPA
T514 EGSQGELTPANSQSR
S518 GELTPANSQSRMSTN
S520 LTPANSQSRMSTNM_
S523 ANSQSRMSTNM____
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T86 HRKLSEATRELQNAP
K124 KALLKLEKLDTDLKN
K130 EKLDTDLKNYKGNSI
K133 DTDLKNYKGNSIKES
K138 NYKGNSIKESIRRGH
K163 GDLSNALKCYSRARD
K204 HVLSYVSKAESTPEI
S220 EQRGERDSQTQAILT
K228 QTQAILTKLKCAAGL
K230 QAILTKLKCAAGLAE
K248 RKYKQAAKCFLLASF
K317 IFKFYESKYASCLKM
Y357 RNRALIQYFSPYVSA
S399 LINARIDSHSKILYA
S401 NARIDSHSKILYARD
K402 ARIDSHSKILYARDV
K418 QRSTTFEKSLLMGKE
K424 EKSLLMGKEFQRRAK
K447 LRNQIHVKSPPREGs
K447 LRNQIHVKSPPREGs
S448 RNQIHVKSPPREGsQ
S454-p KSPPREGsQGELTPA
T459 EGsQGELTPANsQSR
S463-p GELTPANsQSRMSTN
S465 LTPANsQSRMSTNM_
S468 ANsQSRMSTNM____
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