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Protein Page:
hnRNP D0 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP D0 a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP). Implicated in the regulation of mRNA stability. Has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. Four alternatively spliced transcript variants have been described. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; RNA splicing
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: nucleoplasm; nucleolus; ribonucleoprotein complex; cytosol; nucleus
Molecular Function: protein binding; RNA binding; nucleotide binding; telomeric DNA binding
Biological Process: positive regulation of translation; transcription, DNA-dependent; RNA splicing; positive regulation of transcription, DNA-dependent; RNA catabolic process; regulation of circadian rhythm; regulation of mRNA stability; mRNA metabolic process; nuclear mRNA splicing, via spliceosome; RNA processing; regulation of transcription, DNA-dependent; RNA metabolic process; gene expression
Reference #:  Q14103 (UniProtKB)
Alt. Names/Synonyms: ARE-binding protein AUFI, type A; AU-rich element RNA-binding protein 1; AUF1; AUF1A; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; HNRNPD; hnRNPD0; HNRPD; P37
Gene Symbols: HNRNPD
Molecular weight: 38,434 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

hnRNP D0

Protein Structure Not Found.


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Sites Implicated In
RNA stability, altered: S83‑p, S87‑p
transcription, induced: S87‑p
transcription, inhibited: S83‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S60 SGGTEGGSAESEGAK
0 1 D69-ca ESEGAKIdAskNEED
0 8 S71-p EGAKIdAskNEEDEG
0 1 K72-ub GAKIdAskNEEDEGH
0 33 S80-p NEEDEGHsNssPRHs
0 40 S82-p EDEGHsNssPRHsEA
3 62 S83-p DEGHsNssPRHsEAA
3 8 S87-p sNssPRHsEAAtAQR
0 2 T91-p PRHsEAAtAQREEWK
0 1 S105-p KMFIGGLsWDTTkkD
0 2 K110-ac GLsWDTTkkDLkDYF
0 18 K110-ub GLsWDTTkkDLkDYF
0 1 K111-ac LsWDTTkkDLkDYFS
0 21 K111-ub LsWDTTkkDLkDYFS
0 1 K114 DTTkkDLKDYFSkFG
0 2 K114-ub DTTkkDLkDYFSkFG
0 1 K114-sc DTTkkDLkDYFSkFG
0 1 K119-ac DLkDYFSkFGEVVDC
0 7 K119-ub DLkDYFSkFGEVVDC
0 21 T127-p FGEVVDCtLkLDPIT
0 2 K129-ac EVVDCtLkLDPITGR
0 61 K129-ub EVVDCtLkLDPITGR
0 1 K153 KESESVDKVMDQkEH
0 1 K158-ac VDKVMDQkEHKLNGk
0 3 K165-ac kEHKLNGkVIDPKRA
0 1 T177 KRAKAMKTKEPVKkI
0 1 K183-ub KTKEPVKkIFVGGLs
0 24 S190-p kIFVGGLsPDtPEEk
1 31 T193-p VGGLsPDtPEEkIRE
0 11 K197-ac sPDtPEEkIREYFGG
0 37 K197-ub sPDtPEEkIREYFGG
0 1 K218-ac IELPMDNkTNKRRGF
0 3 K218-ub IELPMDNkTNKRRGF
0 9 K231-ac GFCFITFkEEEPVKk
0 1 K237 FkEEEPVKkIMEKKy
0 2 K238-ac kEEEPVKkIMEKKyH
0 4 Y244-p KkIMEKKyHNVGLSk
0 1 K251-ac yHNVGLSkCEIKVAM
0 2 K251-ub yHNVGLSkCEIKVAM
0 1 Y263-p VAMSKEQyQQQQQWG
0 1 S271-p QQQQQWGsrGGFAGr
0 52 R272-m1 QQQQWGsrGGFAGrA
0 6 R272-m2 QQQQWGsrGGFAGrA
0 43 R278-m1 srGGFAGrArGRGGG
0 5 R278-m2 srGGFAGrArGRGGG
0 14 R280-m1 GGFAGrArGRGGGPS
0 6 R280-m2 GGFAGrArGRGGGPS
0 14 R282 FAGrArGRGGGPSQN
0 6 R282 FAGrArGRGGGPSQN
0 7 Y339 YSNQQSGYGKVSRrG
0 7 K341 NQQSGYGKVSRrGGH
0 2 R344 SGYGKVSRrGGHQNS
0 29 R345-m1 GYGKVSRrGGHQNSY
0 22 R345-m2 GYGKVSRrGGHQNSY
0 1 K353-ac GGHQNSYkPY_____
  hnRNP D0 iso2  
S60 SGGTEGGSAESEGAK
D69 ESEGAKIDASKNEED
S71 EGAKIDASKNEEDEG
K72 GAKIDASKNEEDEGK
- gap
- gap
- gap
- gap
- gap
S86 KMFIGGLSWDTTKKD
K91 GLSWDTTKKDLKDYF
K91 GLSWDTTKKDLKDYF
K92 LSWDTTKKDLKDYFS
K92 LSWDTTKKDLKDYFS
K95 DTTKKDLKDYFSKFG
K95 DTTKKDLKDYFSKFG
K95 DTTKKDLKDYFSKFG
K100 DLKDYFSKFGEVVDC
K100 DLKDYFSKFGEVVDC
T108 FGEVVDCTLKLDPIT
K110 EVVDCTLKLDPITGR
K110 EVVDCTLKLDPITGR
K134 KESESVDKVMDQKEH
K139 VDKVMDQKEHKLNGK
K146 KEHKLNGKVIDPKRA
T158 KRAKAMKTKEPVKKI
K164 KTKEPVKKIFVGGLS
S171 KIFVGGLSPDTPEEK
T174 VGGLSPDTPEEKIRE
K178 SPDTPEEKIREYFGG
K178 SPDTPEEKIREYFGG
K199 IELPMDNKTNKRRGF
K199 IELPMDNKTNKRRGF
K212 GFCFITFKEEEPVKK
K218 FKEEEPVKKIMEKKY
K219 KEEEPVKKIMEKKYH
Y225 KKIMEKKYHNVGLSK
K232 YHNVGLSKCEIKVAM
K232 YHNVGLSKCEIKVAM
Y244 VAMSKEQYQQQQQWG
S252 QQQQQWGSRGGFAGR
R253 QQQQWGSRGGFAGRA
R253 QQQQWGSRGGFAGRA
R259 SRGGFAGRARGRGGG
R259 SRGGFAGRARGRGGG
R261 GGFAGRARGRGGGPS
R261 GGFAGRARGRGGGPS
R263 FAGRARGRGGGPSQN
R263 FAGRARGRGGGPSQN
Y320 YSNQQSGYGKVSRRG
K322 NQQSGYGKVSRRGGH
R325 SGYGKVSRRGGHQNS
R326 GYGKVSRRGGHQNSY
R326 GYGKVSRRGGHQNSY
K334 GGHQNSYKPY_____
  hnRNP D0 iso3  
S60 SGGTEGGSAESEGAK
D69 ESEGAKIDASKNEED
S71 EGAKIDASKNEEDEG
K72 GAKIDASKNEEDEGH
S80 NEEDEGHSNSsPRHs
S82 EDEGHSNSsPRHsEA
S83-p DEGHSNSsPRHsEAA
S87-p SNSsPRHsEAATAQR
T91 PRHsEAATAQREEWK
S105 KMFIGGLSWDTTKKD
K110 GLSWDTTKKDLKDYF
K110 GLSWDTTKKDLKDYF
K111 LSWDTTKKDLKDYFS
K111 LSWDTTKKDLKDYFS
K114 DTTKKDLKDYFSKFG
K114 DTTKKDLKDYFSKFG
K114 DTTKKDLKDYFSKFG
K119 DLKDYFSKFGEVVDC
K119 DLKDYFSKFGEVVDC
T127 FGEVVDCTLKLDPIT
K129 EVVDCTLKLDPITGR
K129 EVVDCTLKLDPITGR
K153 KESESVDKVMDQkEH
K158-ac VDKVMDQkEHKLNGK
K165 kEHKLNGKVIDPKRA
T177 KRAKAMKTKEPVKKI
K183 KTKEPVKKIFVGGLS
S190 KIFVGGLSPDtPEEK
T193-p VGGLSPDtPEEKIRE
K197 SPDtPEEKIREYFGG
K197 SPDtPEEKIREYFGG
K218 IELPMDNKTNKRRGF
K218 IELPMDNKTNKRRGF
K231 GFCFITFKEEEPVKK
K237 FKEEEPVKKIMEKKY
K238 KEEEPVKKIMEKKYH
Y244 KKIMEKKYHNVGLSK
K251 YHNVGLSKCEIKVAM
K251 YHNVGLSKCEIKVAM
Y263 VAMSKEQYQQQQQWG
S271 QQQQQWGSrGGFAGr
R272 QQQQWGSRGGFAGrA
R272-m2 QQQQWGSrGGFAGrA
R278 SrGGFAGRArGrGGD
R278-m2 SrGGFAGrArGrGGD
R280-m1 GGFAGrArGrGGDQQ
R280-m2 GGFAGrArGrGGDQQ
R282-m1 FAGrArGrGGDQQSG
R282-m2 FAGrArGrGGDQQSG
Y290-p GGDQQSGyGkVSRRG
K292-ac DQQSGyGkVSRRGGH
R295 SGyGkVSRRGGHQNS
R296 GyGkVSRRGGHQNSY
R296 GyGkVSRRGGHQNSY
K304 GGHQNSYKPY_____
  mouse

► Hide Isoforms
 
S60-p AGGTEGGsAEAEGAK
D69 EAEGAKIDAsKNEED
S71-p EGAKIDAsKNEEDEG
K72 GAKIDAsKNEEDEGH
S80-p NEEDEGHsNssPRHT
S82-p EDEGHsNssPRHTEA
S83-p DEGHsNssPRHTEAA
T87 sNssPRHTEAAAAQR
A91 PRHTEAAAAQREEWK
S105 KMFIGGLSWDTTkKD
K110 GLSWDTTKKDLkDYF
K110-ub GLSWDTTkKDLkDYF
K111 LSWDTTkKDLkDYFS
K111 LSWDTTkKDLkDYFS
K114-ac DTTkKDLkDYFSkFG
K114-ub DTTkKDLkDYFSkFG
K114 DTTkKDLKDYFSkFG
K119 DLkDYFSKFGEVVDC
K119-ub DLkDYFSkFGEVVDC
T127 FGEVVDCTLkLDPIT
K129 EVVDCTLKLDPITGR
K129-ub EVVDCTLkLDPITGR
K153-ub KESESVDkVMDQKEH
K158 VDkVMDQKEHKLNGk
K165-ac KEHKLNGkVIDPKRA
T177-p KRAKAMKtKEPVKKI
K183 KtKEPVKKIFVGGLs
S190-p KIFVGGLsPDtPEEk
T193-p VGGLsPDtPEEkIRE
K197-ac sPDtPEEkIREYFGG
K197-ub sPDtPEEkIREYFGG
K218 IELPMDNKTNKRRGF
K218-ub IELPMDNkTNKRRGF
K231 GFCFITFKEEEPVkK
K237-ub FKEEEPVkKIMEKKY
K238 KEEEPVkKIMEKKYH
Y244 kKIMEKKYHNVGLSk
K251 YHNVGLSKCEIKVAM
K251-ub YHNVGLSkCEIKVAM
Y263 VAMSKEQYQQQQQWG
S271 QQQQQWGSrGGFAGr
R272-m1 QQQQWGSrGGFAGrA
R272-m2 QQQQWGSrGGFAGrA
R278-m1 SrGGFAGrArGrGGG
R278 SrGGFAGRArGrGGG
R280-m1 GGFAGrArGrGGGPS
R280 GGFAGrARGrGGGPS
R282-m1 FAGrArGrGGGPSQN
R282 FAGrArGRGGGPSQN
Y339 YSNQQSGYGKVSrrG
K341 NQQSGYGKVSrrGGH
R344-m2 SGYGKVSrrGGHQNS
R345-m1 GYGKVSrrGGHQNSY
R345-m2 GYGKVSrrGGHQNSY
K353 GGHQNSYKPY_____
  hnRNP D0 iso3  
S60 AGGTEGGSAEAEGAK
D69 EAEGAKIDASKNEED
S71 EGAKIDASKNEEDEG
K72 GAKIDASKNEEDEGH
S80 NEEDEGHSNSSPRHT
S82 EDEGHSNSSPRHTEA
S83 DEGHSNSSPRHTEAA
T87 SNSSPRHTEAAAAQR
A91 PRHTEAAAAQREEWK
S105 KMFIGGLSWDTTKKD
K110 GLSWDTTKKDLKDYF
K110 GLSWDTTKKDLKDYF
K111 LSWDTTKKDLKDYFS
K111 LSWDTTKKDLKDYFS
K114 DTTKKDLKDYFSKFG
K114 DTTKKDLKDYFSKFG
K114 DTTKKDLKDYFSKFG
K119 DLKDYFSKFGEVVDC
K119 DLKDYFSKFGEVVDC
T127 FGEVVDCTLKLDPIT
K129 EVVDCTLKLDPITGR
K129 EVVDCTLKLDPITGR
K153 KESESVDKVMDQKEH
K158 VDKVMDQKEHKLNGK
K165 KEHKLNGKVIDPKRA
T177 KRAKAMKTKEPVKKI
K183 KTKEPVKKIFVGGLS
S190 KIFVGGLSPDTPEEK
T193 VGGLSPDTPEEKIRE
K197 SPDTPEEKIREYFGG
K197 SPDTPEEKIREYFGG
K218 IELPMDNKTNKRRGF
K218 IELPMDNKTNKRRGF
K231 GFCFITFKEEEPVKK
K237 FKEEEPVKKIMEKKY
K238 KEEEPVKKIMEKKYH
Y244 KKIMEKKYHNVGLSK
K251 YHNVGLSKCEIKVAM
K251 YHNVGLSKCEIKVAM
Y263 VAMSKEQYQQQQQWG
S271 QQQQQWGSrGGFAGr
R272-m1 QQQQWGSrGGFAGrA
R272 QQQQWGSRGGFAGrA
R278-m1 SrGGFAGrArGrGGD
R278 SrGGFAGRArGrGGD
R280-m1 GGFAGrArGrGGDQQ
R280 GGFAGrARGrGGDQQ
R282-m1 FAGrArGrGGDQQSG
R282-m2 FAGrArGrGGDQQSG
Y290 GGDQQSGYGKVSrRG
K292 DQQSGYGKVSrRGGH
R295-m2 SGYGKVSrRGGHQNS
R296 GYGKVSrRGGHQNSY
R296 GYGKVSrRGGHQNSY
K304 GGHQNSYKPY_____
  rat

► Hide Isoforms
 
S58 AGGTEGGSTEAEGAK
D67 EAEGAKIDASKNEED
S69 EGAKIDASKNEEDEG
K70 GAKIDASKNEEDEGH
S78-p NEEDEGHsNssPRHT
S80-p EDEGHsNssPRHTEA
S81-p DEGHsNssPRHTEAA
T85 sNssPRHTEAATAQR
T89 PRHTEAATAQREEWK
S103 KMFIGGLSWDTTkKD
K108 GLSWDTTKKDLkDYF
K108-ub GLSWDTTkKDLkDYF
K109 LSWDTTkKDLkDYFS
K109 LSWDTTkKDLkDYFS
K112-ac DTTkKDLkDYFSKFG
K112 DTTkKDLKDYFSKFG
K112 DTTkKDLKDYFSKFG
K117 DLkDYFSKFGDVVDC
K117 DLkDYFSKFGDVVDC
T125 FGDVVDCTLKLDPIT
K127 DVVDCTLKLDPITGR
K127 DVVDCTLKLDPITGR
K151 KESESVDKVMDQKEH
K156 VDKVMDQKEHKLNGk
K163-ac KEHKLNGkVIDPKRA
T175 KRAKAMKTKEPVKKI
K181 KTKEPVKKIFVGGLs
S188-p KIFVGGLsPDTPEEk
T191 VGGLsPDTPEEkIRE
K195-ac sPDTPEEkIREYFGG
K195 sPDTPEEKIREYFGG
K216 IELPMDNKTNKRRGF
K216 IELPMDNKTNKRRGF
K229 GFCFITFKEEEPVKK
K235 FKEEEPVKKIMEKKY
K236 KEEEPVKKIMEKKYH
Y242 KKIMEKKYHNVGLSK
K249 YHNVGLSKCEIKVAM
K249 YHNVGLSKCEIKVAM
Y261 VAMSKEQYQQQQQWG
S269 QQQQQWGSrGGFAGr
R270-m1 QQQQWGSrGGFAGrA
R270 QQQQWGSRGGFAGrA
R276-m1 SrGGFAGrARGRGGG
R276 SrGGFAGRARGRGGG
R278 GGFAGrARGRGGGPS
R278 GGFAGrARGRGGGPS
R280 FAGrARGRGGGPSQN
R280 FAGrARGRGGGPSQN
Y337 YSNQQSGYGKVSRrG
K339 NQQSGYGKVSRrGGH
R342 SGYGKVSRrGGHQNS
R343-m1 GYGKVSRrGGHQNSY
R343 GYGKVSRRGGHQNSY
K351 GGHQNSYKPY_____
  hnRNP D0 iso2  
S58 AGGTEGGSTEAEGAK
D67 EAEGAKIDASKNEED
S69 EGAKIDASKNEEDEG
K70 GAKIDASKNEEDEGK
- under review  
- under review  
- under review  
- under review  
- under review  
S84 KMFIGGLSWDTTKKD
K89 GLSWDTTKKDLKDYF
K89 GLSWDTTKKDLKDYF
K90 LSWDTTKKDLKDYFS
K90 LSWDTTKKDLKDYFS
K93 DTTKKDLKDYFSKFG
K93 DTTKKDLKDYFSKFG
- under review  
K98 DLKDYFSKFGDVVDC
K98 DLKDYFSKFGDVVDC
T106 FGDVVDCTLKLDPIT
K108 DVVDCTLKLDPITGR
K108 DVVDCTLKLDPITGR
K132 KESESVDKVMDQKEH
K137 VDKVMDQKEHKLNGK
K144 KEHKLNGKVIDPKRA
T156 KRAKAMKTKEPVKKI
K162 KTKEPVKKIFVGGLS
S169 KIFVGGLSPDTPEEK
T172 VGGLSPDTPEEKIRE
K176 SPDTPEEKIREYFGG
K176 SPDTPEEKIREYFGG
K197 IELPMDNKTNKRRGF
K197 IELPMDNKTNKRRGF
K210 GFCFITFKEEEPVKK
K216 FKEEEPVKKIMEKKY
K217 KEEEPVKKIMEKKYH
Y223 KKIMEKKYHNVGLSK
K230 YHNVGLSKCEIKVAM
K230 YHNVGLSKCEIKVAM
Y242 VAMSKEQYQQQQQWG
S250 QQQQQWGSRGGFAGR
R251 QQQQWGSRGGFAGRA
R251 QQQQWGSRGGFAGRA
R257 SRGGFAGRARGRGGG
R257 SRGGFAGRARGRGGG
R259 GGFAGRARGRGGGPS
R259 GGFAGRARGRGGGPS
R261 FAGRARGRGGGPSQN
R261 FAGRARGRGGGPSQN
Y318 YSNQQSGYGKVSRRG
K320 NQQSGYGKVSRRGGH
R323 SGYGKVSRRGGHQNS
R324 GYGKVSRRGGHQNSY
R324 GYGKVSRRGGHQNSY
K332 GGHQNSYKPY_____
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