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Protein Page:
VTI1A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VTI1A V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; cytoplasmic membrane-bound vesicle; integral to membrane
Molecular Function: SNAP receptor activity
Biological Process: intracellular protein transport; retrograde transport, endosome to Golgi
Reference #:  Q96AJ9 (UniProtKB)
Alt. Names/Synonyms: MVti1; SNARE Vti1a-beta protein; Vesicle transport through interaction with t-SNAREs homolog 1A; vesicle transport through interaction with t-SNAREs homolog 1A (yeast); Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2; VTI1A
Gene Symbols: VTI1A
Molecular weight: 25,218 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VTI1A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MSsDFEGYEQ
0 2 K43-ub QMVANVEkQLEEAKE
0 3 S66-p VREIPPQsRGMYSNR
0 2 S76-p MYSNRMRsYKQEMGK
0 1 S91-p LETDFKRsRIAySDE
0 1 Y95-p FKRsRIAySDEVRNE
0 1 S110-p LLGDDGNsSENQRAH
0 2 T122-p RAHLLDNtERLERSS
0 15 Y136-p SRRLEAGyQIAVETE
0 1 T170-p ARERLREtDANLGkS
0 2 K176-ub EtDANLGkSSRILTG
0 1 S213-p ILMAITFsVRRH___
  mouse

 
S3 _____MSSDFEGYEQ
K43-ub QMVANVEkQLEEARE
S66-p VREIPPQsRGMYSNR
S76 MYSNRMRSYKQEMGK
S91 LETDFKRSRIAYSDE
Y95 FKRSRIAYSDEVRNE
S110 LLGDAGNSSENQRAH
T122 RAHLLDNTERLERSS
Y136 SRRLEAGYQIAVETE
A170 ARDRLRDADANLGkS
K176-ub DADANLGkSSRILTG
F213 ILTAIAFFVKGH___
  rat

 
A3 _____MSADFEGYEQ
K43 QMVANVEKQLEEARE
S66 VREIPPQSRGMYSNR
S76 MYSNRMRSYKQEMGK
S91 LETDFKRSRIAYSDE
Y95 FKRSRIAYSDEVRNE
S110 LLGDAGNSSENQLIK
T129 RAHLLDNTERLERSS
Y143 SRRLEAGYQIAVETE
T177 ARERLRETDANLGKS
K183 ETDANLGKSSRILTG
F220 ILTAITFFVRGH___
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