V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10q25.2
Cellular Component: Golgi membrane; SNARE complex; Golgi apparatus; endoplasmic reticulum membrane; synaptic vesicle; Golgi stack; cell soma; clathrin-coated vesicle; perinuclear region of cytoplasm; late endosome membrane; integral to membrane; endosome
Biological Process: intra-Golgi vesicle-mediated transport; voluntary musculoskeletal movement; ER to Golgi vesicle-mediated transport; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi
Alt. Names/Synonyms: MVti1; SNARE Vti1a-beta protein; Vesicle transport through interaction with t-SNAREs homolog 1A; vesicle transport through interaction with t-SNAREs homolog 1A (yeast); Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2; VTI1A
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.