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VEGFC (human)

Overview VEGFC Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family. Note: This description may include information from UniProtKB. Protein type: Secreted, signal peptide; Cytokine; Motility/polarity/chemotaxis; Cell cycle regulation; Secreted Cellular Component: extracellular space; membrane; extracellular region Molecular Function: protein binding; growth factor activity; vascular endothelial growth factor receptor 3 binding; chemoattractant activity Biological Process: response to drug; substrate-bound cell migration; platelet activation; positive regulation of neuroblast proliferation; positive regulation of blood vessel endothelial cell migration; signal transduction; positive regulation of protein amino acid autophosphorylation; induction of positive chemotaxis; organ morphogenesis; platelet degranulation; morphogenesis of embryonic epithelium; positive chemotaxis; positive regulation of protein secretion; positive regulation of cell division; regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell proliferation; angiogenesis; negative regulation of blood pressure; vascular endothelial growth factor receptor signaling pathway; blood coagulation; positive regulation of epithelial cell proliferation Reference #:  P49767 (UniProtKB) Alt. Names/Synonyms: Flt4 ligand; FLT4 ligand DHM; Flt4-L; Vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGF-C; VEGFC; VRP Gene Symbols: VEGFC Molecular weight: 46,883 Da Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below VEGFC 2X1W - A/D/C/B=112-215 (human) 2X1X - E=112-215 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2X1W 2X1X  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S101-p	REQANLNsRTEEtIK
0	1		T106-p	LNsRTEEtIKFAAAH

	mouse
T97	WQQPTLNTRTGDSVK
S102	LNTRTGDSVKFAAAH

	rat
M97	WQQPSLNMRTGDTVK
T102	LNMRTGDTVKLAAAH

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