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Protein Page:
VEGFC (human)

Overview
VEGFC Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cell cycle regulation; Secreted, signal peptide; Cytokine; Secreted
Chromosomal Location of Human Ortholog: 4q34.3
Cellular Component: extracellular space; membrane; extracellular region
Molecular Function: protein binding; growth factor activity; vascular endothelial growth factor receptor 3 binding; chemoattractant activity
Biological Process: substrate-bound cell migration; response to drug; platelet activation; positive regulation of neuroblast proliferation; positive regulation of blood vessel endothelial cell migration; signal transduction; positive regulation of protein amino acid autophosphorylation; induction of positive chemotaxis; organ morphogenesis; morphogenesis of embryonic epithelium; platelet degranulation; positive chemotaxis; positive regulation of protein secretion; regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of blood pressure; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation
Reference #:  P49767 (UniProtKB)
Alt. Names/Synonyms: Flt4 ligand; FLT4 ligand DHM; Flt4-L; Vascular endothelial growth factor C; Vascular endothelial growth factor-related protein; VEGF-C; VEGFC; VRP
Gene Symbols: VEGFC
Molecular weight: 46,883 Da
Basal Isoelectric point: 7.77  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VEGFC

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S101-p REQANLNsRTEEtIK
0 1 T106-p LNsRTEEtIKFAAAH
  mouse

 
T97 WQQPTLNTRTGDSVK
S102 LNTRTGDSVKFAAAH
  rat

 
M97 WQQPSLNMRTGDTVK
T102 LNMRTGDTVKLAAAH
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