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SAP18 (human)

Overview SAP18 Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Belongs to the SAP18 family. Note: This description may include information from UniProtKB. Cellular Component: cytoplasm; histone deacetylase complex; plasma membrane; nucleolus; nucleus Molecular Function: protein binding; transcription corepressor activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent Reference #:  O00422 (UniProtKB) Alt. Names/Synonyms: 18 kDa Sin3-associated polypeptide; 2HOR0202; cell growth inhibiting protein 38; Cell growth-inhibiting gene 38 protein; cell growth-inhibiting protein 38; histone deacetlyase complex subunit SAP18; Histone deacetylase complex subunit SAP18; MGC27131; SAP18; SAP18P; Sin3-associated polypeptide p18; sin3-associated polypeptide, 18 kDa; sin3-associated polypeptide, p18; Sin3A-associated protein, 18kDa Gene Symbols: SAP18 Molecular weight: 17,561 Da Basal Isoelectric point: 9.38  Predict pI for various phosphorylation states CST Pathways:  Protein Acetylation

Select Structure to View Below SAP18 2HDE - A=6-149 (human) 4A6Q - A=6-143 (mouse) 4A8X - C=14-143 (mouse) 4A90 - A/B=1-143 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T25-p	KPIDREKtCPLLLRV
0	1		T35-p	LLLRVFTtNNGRHHR
0	1		S47-p	HHRMDEFsRGNVPSS
0	6		K74-u	KELTSLVkEVYPEAR
0	1		T85-p	PEARKKGtHFNFAIV
0	1		T94-p	FNFAIVFtDVKRPGy
0	1		Y101-p	tDVKRPGyRVkEIGs
0	3		K104-u	KRPGyRVkEIGsTMS
0	1		S108-p	yRVkEIGsTMSGRkG
0	1		K114-a	GsTMSGRkGtDDsMt
0	1		K114-u	GsTMSGRkGtDDsMt
0	2		T116-p	TMSGRkGtDDsMtLQ
0	1		S119-p	GRkGtDDsMtLQSQk
0	1		T121-p	kGtDDsMtLQSQkFQ
0	1		K126-u	sMtLQSQkFQIGDyL
0	4		Y132-p	QkFQIGDyLDIAITP

	mouse
T44	KPIDREKTCPLLLRV
T54	LLLRVFTTNNGRHHR
S66	HHRMDEFSRGNVPSS
K93-u	KELTSLVkEVYPEAR
T104	PEARKKGTHFNFAIV
M113	FNFAIVFMDLKRPGY
Y120	MDLKRPGYRVKEIGS
K123	KRPGYRVKEIGSTMS
S127	YRVKEIGSTMSGRKG
K133	GSTMSGRKGTDDSMT
K133	GSTMSGRKGTDDSMT
T135	TMSGRKGTDDSMTLQ
S138	GRKGTDDSMTLQSQK
T140	KGTDDSMTLQSQKFQ
K145	SMTLQSQKFQIGDYL
Y151	QKFQIGDYLDIAITP

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