Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
RS1 (human)

Overview
RS1 a highly conserved extracellular protein essential for proper retinal structure. Must interact with L-type voltage-gated calcium channels (L-VGCCs) correctly so that the photoreceptor cells in the eye can function properly. Genetic mutations in RS1 cause X-linked retinoschisis (XLRS) and early onset of macular degeneration. Interacts with the L-VGCCa1D subunit, regulating its activity. The expression and secretion of retinoschisin are modulated by circadian rhythms, peaking at night and diminishing during the day. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extrinsic to plasma membrane; extracellular space
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylserine binding; phosphatidylinositol-5-phosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol 3-phosphate binding
Biological Process: visual perception; multicellular organismal development; adaptation of rhodopsin mediated signaling; cell adhesion
Reference #:  O15537 (UniProtKB)
Alt. Names/Synonyms: Retinoschisin; retinoschisin 1; retinoschisis (X-linked, juvenile) 1; RS; RS1; X-linked juvenile retinoschisis protein; XLRS1
Gene Symbols: RS1
Molecular weight: 25,592 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Select Structure to View Below

RS1

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S105-p ANKARLNsQGFGCAW
0 1 S114-p GFGCAWLsKFQDsSQ
0 1 S119-p WLsKFQDsSQWLQID
0 1 Y177-p TGNNRVFyGNSDRtS
0 1 T183-p FyGNSDRtSTVQNLL
  mouse

 
S105 ANKARLNSQGFGCAW
S114 GFGCAWLSKYQDSSQ
S119 WLSKYQDSSQWLQID
Y177 TGNNRVFYGNSDRSS
S183 FYGNSDRSSTVQNLL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.