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PDHX
a mitochondrial protein required for anchoring dihydrolipoamide dehydrogenase (E3) to the pyruvate dehydrogenase complexes (PDHC) of eukaryotes. This specific binding is essential for a PDHC function. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3), and protein X bound by non-covalent bonds. Belongs to the 2-oxoacid dehydrogenase family. Contains 1 lipoyl-binding domain. Note: This description may include information from UniProtKB.
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| Protein type: Mitochondrial |
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Cellular Component: mitochondrial matrix
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Molecular Function: transferase activity, transferring acyl groups
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Biological Process: regulation of acetyl-CoA biosynthetic process from pyruvate; pyruvate metabolic process
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Reference #:
O00330 (UniProtKB)
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| Alt. Names/Synonyms: Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; DLDBP; E3-binding protein; E3BP; Lipoyl-containing pyruvate dehydrogenase complex component X; ODPX; OPDX; PDHX; PDX1; proX; pyruvate dehydrogenase complex, component X; pyruvate dehydrogenase complex, E3-binding protein subunit; pyruvate dehydrogenase complex, lipoyl-containing component X; Pyruvate dehydrogenase protein X component, mitochondrial |
| Gene Symbols: PDHX |
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Molecular weight: 54,122 Da
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Basal Isoelectric point: 8.8
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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