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Protein Page:
PDHX (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PDHX a mitochondrial protein required for anchoring dihydrolipoamide dehydrogenase (E3) to the pyruvate dehydrogenase complexes (PDHC) of eukaryotes. This specific binding is essential for a PDHC function. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3), and protein X bound by non-covalent bonds. Belongs to the 2-oxoacid dehydrogenase family. Contains 1 lipoyl-binding domain. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial
Cellular Component: mitochondrial matrix
Molecular Function: transferase activity, transferring acyl groups
Biological Process: cellular metabolic process; regulation of acetyl-CoA biosynthetic process from pyruvate; pyruvate metabolic process
Reference #:  O00330 (UniProtKB)
Alt. Names/Synonyms: Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; DLDBP; E3-binding protein; E3BP; Lipoyl-containing pyruvate dehydrogenase complex component X; ODPX; OPDX; PDHX; PDX1; proX; pyruvate dehydrogenase complex, component X; pyruvate dehydrogenase complex, E3-binding protein subunit; pyruvate dehydrogenase complex, lipoyl-containing component X; Pyruvate dehydrogenase protein X component, mitochondrial
Gene Symbols: PDHX
Molecular weight: 54,122 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below

PDHX

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y16-p CDPRLLRyLVGFPGR
0 1 S162-p KPSEPRPsPEPQIsI
0 1 S168-p PsPEPQIsIPVKKEH
0 3 K194-a AARNILEkHSLDASQ
0 2 R485 VDDELATRFLkSFkA
0 4 K488-a ELATRFLkSFkANLE
0 45 K491-a TRFLkSFkANLENPI
  mouse

 
Y16 CNQPLLRYLLGFSSR
S163-p PPAPTQPsPQPQIPC
P169 PsPQPQIPCPARKEH
K194-a AARNILEkHSLDASQ
R485 VDDELATRFLETFKA
E488 ELATRFLETFKANLE
K491 TRFLETFKANLENPM
  rat

 
- gap
S40 PPAPPQPSPQTQTPC
P46 PSPQTQTPCPARKER
K73 AARNILEKHSLDASQ
K364-a VDDELATkFLETFKA
E367 ELATkFLETFKANLE
K370 TkFLETFKANLENPM
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