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Protein Page:
HDAC7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC7 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. 10 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.5.1.98
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: nucleoplasm; cytoplasm; histone deacetylase complex; nucleus
Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; protein kinase C binding; transcription activator binding; NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); transcription corepressor activity; protein kinase binding
Biological Process: intercellular junction assembly; Notch signaling pathway; transcription, DNA-dependent; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; vasculogenesis; negative regulation of interleukin-2 production
Reference #:  Q8WUI4 (UniProtKB)
Alt. Names/Synonyms: DKFZp586J0917; FLJ99588; HD7; HD7a; HDAC7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A
Gene Symbols: HDAC7
Molecular weight: 102,927 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HDAC7

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: S155‑p, S358‑p, S486‑p
cell motility, altered: S155‑p, S358‑p, S486‑p
cytoskeletal reorganization: S155‑p, S358‑p, S486‑p
transcription, altered: S155‑p, S358‑p, S486‑p
intracellular localization: S155‑p, S358‑p, S486‑p
phosphorylation: S155‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S49-p SVEPMRLsMDTPMPE
0 4 T104-p QQAALERtVHPNsPG
0 15 S109-p ERtVHPNsPGIPyRT
0 5 Y114-p PNsPGIPyRTLEPLE
0 1 T153-p EHFPLRKtVsEPNLK
7 53 S155-p FPLRKtVsEPNLKLR
2 27 S181-p NPLLRKEsAPPSLRR
0 1 S207 SSSSTPASGCSSPND
0 1 T247-p VAPFALPtVSLLPAI
0 5 T255-p VSLLPAItLGLPAPA
0 25 S283-p PRGPILGsPHtPLFL
0 29 T286-p PILGsPHtPLFLPHG
0 4 T301-p LEPEAGGtLPSRLQP
0 1 S354-p SGLHWPLsRtRsEPL
0 10 T356-p LHWPLsRtRsEPLPP
5 24 S358-p WPLsRtRsEPLPPsA
0 3 S364-p RsEPLPPsAtAPPPP
0 1 T366-p EPLPPsAtAPPPPGP
0 1 S391-p HVQVIKRsAKPSEKP
0 65 S405-p PRLRQIPsAEDLETd
0 1 D412-ca sAEDLETdGGGPGQV
0 2 S482-p QGGHRPLsRAQssPA
0 1 A484 GHRPLsRAQssPAAP
6 81 S486-p RPLsRAQssPAAPAs
0 21 S487-p PLsRAQssPAAPAsL
0 4 S493-p ssPAAPAsLSAPEPA
0 15 S507-p ASQARVLssSEtPAR
0 3 S508-p SQARVLssSEtPARt
0 2 T511-p RVLssSEtPARtLPF
0 2 T515-p sSEtPARtLPFTTGL
0 2 Y524-p PFTTGLIyDSVMLkH
0 1 K530-ub IyDSVMLkHQCSCGD
0 3 S595-p LYGTNPLsRLKLDNG
0 2 K603-ac RLKLDNGkLAGLLAQ
0 1 K603-ub RLKLDNGkLAGLLAQ
0 1 S903-p GCMQRLAsCPDsWVP
0 1 S907-p RLAsCPDsWVPRVPG
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  HDAC7 iso3  
S49 SVEPMRLSMDTPMPE
T104 QQAALERTVHPNSPG
S109 ERTVHPNSPGIPYRT
Y114 PNSPGIPYRTLEPLE
T153 EHFPLRKTVSEPNLK
S155 FPLRKTVSEPNLKLR
S181 NPLLRKESAPPSLRR
S207 SSSSTPASGCSSPND
- gap
- gap
S246 PRGPILGSPHTPLFL
T249 PILGSPHTPLFLPHG
T264 LEPEAGGTLPSRLQP
S317 SGLHWPLSRTRSEPL
T319 LHWPLSRTRSEPLPP
S321 WPLSRTRSEPLPPSA
S327 RSEPLPPSATAPPPP
T329 EPLPPSATAPPPPGP
S354 HVQVIKRSAKPSEKP
S368 PRLRQIPSAEDLETD
D375 SAEDLETDGGGPGQV
S445 QGGHRPLSRAQSSPA
A447 GHRPLSRAQSSPAAP
S449 RPLSRAQSSPAAPAS
S450 PLSRAQSSPAAPASL
S456 SSPAAPASLSAPEPA
S470 ASQARVLSSSETPAR
S471 SQARVLSSSETPART
T474 RVLSSSETPARTLPF
T478 SSETPARTLPFTTGL
Y487 PFTTGLIYDSVMLKH
K493 IYDSVMLKHQCSCGD
S558 LYGTNPLSRLKLDNG
K566 RLKLDNGKLAGLLAQ
K566 RLKLDNGKLAGLLAQ
S866 GCMQRLASCPDSWVP
S870 RLASCPDSWVPRVPG
  HDAC7 iso5  
S88 SVEPMRLSMDTPMPE
T143 QQAALERTVHPNSPG
S148 ERTVHPNSPGIPYRT
Y153 PNSPGIPYRTLEPLE
T192 EHFPLRKTVSEPNLK
S194 FPLRKTVSEPNLKLR
S220 NPLLRKESAPPSLRR
S246 SSSSTPASGCSSPND
T286 VAPFALPTVSLLPAI
T294 VSLLPAITLGLPAPA
S322 PRGPILGSPHTPLFL
T325 PILGSPHTPLFLPHG
T340 LEPEAGGTLPSRLQP
S393 SGLHWPLSRTRSEPL
T395 LHWPLSRTRSEPLPP
S397 WPLSRTRSEPLPPSA
S403 RSEPLPPSATAPPPP
T405 EPLPPSATAPPPPGP
S430 HVQVIKRSAKPSEKP
S444 PRLRQIPSAEDLETD
D451 SAEDLETDGGGPGQV
S521 QGGHRPLSRAQSSPA
A523 GHRPLSRAQSSPAAP
S525 RPLSRAQSSPAAPAS
S526 PLSRAQSSPAAPASL
S532 SSPAAPASLSAPEPA
S546 ASQARVLSSSETPAR
S547 SQARVLSSSETPART
T550 RVLSSSETPARTLPF
T554 SSETPARTLPFTTGL
Y563 PFTTGLIYDSVMLKH
K569 IYDSVMLKHQCSCGD
S634 LYGTNPLSRLKLDNG
K642 RLKLDNGKLAGLLAQ
K642 RLKLDNGKLAGLLAQ
S942 GCMQRLASCPDSWVP
S946 RLASCPDSWVPRVPG
  HDAC7 iso7  
S88 SVEPMRLSMDTPMPE
T143 QQAALERTVHPNSPG
S148 ERTVHPNSPGIPYRT
Y153 PNSPGIPYRTLEPLE
T192 EHFPLRKTVSEPNLK
S194 FPLRKTVSEPNLKLR
S220 NPLLRKESAPPSLRR
S246 SSSSTPASGCSSPND
- under review  
- under review  
S285 PRGPILGSPHTPLFL
T288 PILGSPHTPLFLPHG
T303 LEPEAGGTLPSRLQP
S356 SGLHWPLSRTRSEPL
T358 LHWPLSRTRSEPLPP
S360 WPLSRTRSEPLPPSA
S366 RSEPLPPSATAPPPP
T368 EPLPPSATAPPPPGP
S393 HVQVIKRSAKPSEKP
S407 PRLRQIPSAEDLETD
D414 SAEDLETDGGGPGQV
S484 QGGHRPLSRAQSSPA
A486 GHRPLSRAQSSPAAP
S488 RPLSRAQSSPAAPAS
S489 PLSRAQSSPAAPASL
S495 SSPAAPASLSAPEPA
S509 ASQARVLSSSETPAR
S510 SQARVLSSSETPART
T513 RVLSSSETPARTLPF
T517 SSETPARTLPFTTGL
Y526 PFTTGLIYDSVMLKH
K532 IYDSVMLKHQCSCGD
S597 LYGTNPLSRLKLDNG
K605 RLKLDNGKLAGLLAQ
K605 RLKLDNGKLAGLLAQ
S905 GCMQRLASCPDSWVP
S909 RLASCPDSWVPRVPG
  mouse

 
S72 SAEPMRLSMDPPMPE
T127 QQAALERTVHPSsPS
S132-p ERTVHPSsPSIPYRT
Y137 PSsPSIPYRTLEPLD
T176 EHFPLRKTVsEPNLK
S178-p FPLRKTVsEPNLKLR
S204-p NPLLRKEsAPPSLRR
S230-p SSSSTPAsGCSSPND
- gap
- gap
N269 PRGPVLGNPHAPLFL
A272 PVLGNPHAPLFLHHG
T287 LEPEAGGTLPSRLQP
N340 SGLHRPLNRtRsEPL
T342-p LHRPLNRtRsEPLPP
S344-p RPLNRtRsEPLPPsA
S350-p RsEPLPPsATASPLL
T352 EPLPPsATASPLLAP
P384 AISPPQRPAKPSEKP
S398-p PRLRQIPsAEDLETD
D405 sAEDLETDGGGVGPM
S475-p QVGHRPLsRtQssPA
T477-p GHRPLsRtQssPAAP
S479-p RPLsRtQssPAAPVS
S480-p PLsRtQssPAAPVSL
S486 ssPAAPVSLLSPEPT
N500 TCQTQVLNSSETPAT
S501 CQTQVLNSSETPATG
T504 QVLNSSETPATGLVY
- gap
Y511 TPATGLVYDSVMLKH
K517 VYDSVMLKHQCSCGD
S582-p LYGTNPLsRLKLDNG
K590 RLKLDNGKLTGLLAQ
K590 RLKLDNGKLTGLLAQ
S890 GCMQRLASCPDSWLP
S894 RLASCPDSWLPRVPG
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  rat

 
S50 SAEPMRLSMDPPLPE
T105 QQAALERTVHPSSPS
S110 ERTVHPSSPSIPYRT
Y115 PSSPSIPYRTLEPLD
T154 EHFPLRKTVsEPNLK
S156-p FPLRKTVsEPNLKLR
S182-p NPLLRKEsAPPSLRR
S208 SSSSTPASGCSSPND
T248 LAPFALPTVSLLPAI
T256 VSLLPAITLGLPAPA
N284 PRGPVLGNPHAPLFL
A287 PVLGNPHAPLFLHHG
T302 LEPEAGGTLPSRLQP
N355 SGLHRPLNRTRSEPL
T357 LHRPLNRTRSEPLPP
S359 RPLNRTRSEPLPPSA
S365 RSEPLPPSATASPLL
T367 EPLPPSATASPLLGP
P399 AISPPQRPAKPSEKP
S413-p PRLRQIPsAEDLETD
D420 sAEDLETDGGGVGPM
S490 QIGHRPLSRTQSSPA
T492 GHRPLSRTQSSPAAP
S494 RPLSRTQSSPAAPVS
S495 PLSRTQSSPAAPVSL
S501 SSPAAPVSLLSPEPT
N515 TCQTQVLNSSEAPAT
S516 CQTQVLNSSEAPATG
A519 QVLNSSEAPATGLVY
- gap
Y526 APATGLVYDSVMLKH
K532 VYDSVMLKHQCSCGD
S597-p LYGTNPLsRLKLDNG
K605-ac RLKLDNGkLTGLLAQ
K605 RLKLDNGKLTGLLAQ
S905 GCMQRLASCPDPWLP
P909 RLASCPDPWLPRVPG
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