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HDAC7 (human)

Overview HDAC7 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. 10 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 3.5.1.98; Hydrolase Cellular Component: cytoplasm; histone deacetylase complex; nucleus Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); protein kinase C binding; transcription activator binding; NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); transcription corepressor activity; protein kinase binding Biological Process: intercellular junction assembly; Notch signaling pathway; transcription, DNA-dependent; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; vasculogenesis; negative regulation of interleukin-2 production Reference #:  Q8WUI4 (UniProtKB) Alt. Names/Synonyms: DKFZp586J0917; FLJ99588; HD7; HD7a; HDAC7; HDAC7A; Histone deacetylase 7; Histone deacetylase 7A Gene Symbols: HDAC7 Molecular weight: 102,927 Da Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  Crosstalk between PTMs  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HDAC7 2NVR - A/B/C=482-903 (human) 2PQO - A/B/C=483-903 (human) 2PQP - A/B/C=483-903 (human) 3C0Y - A/C/B=482-903 (human) 3C0Z - A/C/B=482-903 (human) 3C10 - A/C/B=482-903 (human) 3ZNR - A/C/B=482-903 (human) 3ZNS - A/C/B=482-903 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2NVR 2PQO 2PQP 3C0Y 3C0Z 3C10 3ZNR 3ZNS  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S155‑p, S358‑p, S486‑p cell motility, altered: S155‑p, S358‑p, S486‑p cytoskeletal reorganization: S155‑p, S358‑p, S486‑p transcription, altered: S155‑p, S358‑p, S486‑p intracellular localization: S155‑p, S358‑p, S486‑p phosphorylation: S155‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S49-p	SVEPMRLsMDTPMPE
0	2		T104-p	QQAALERtVHPNsPG
0	11		S109-p	ERtVHPNsPGIPyRT
0	4		Y114-p	PNsPGIPyRTLEPLE
0	1		T153-p	EHFPLRKtVsEPNLK
7	37		S155-p	FPLRKtVsEPNLKLR
2	19		S181-p	NPLLRKEsAPPSLRR
0	1		S207	SSSSTPASGCSSPND
0	1		T247-p	VAPFALPtVSLLPAI
0	5		T255-p	VSLLPAItLGLPAPA
0	24		S283-p	PRGPILGsPHtPLFL
0	29		T286-p	PILGsPHtPLFLPHG
0	4		T301-p	LEPEAGGtLPSRLQP
0	1		S354-p	SGLHWPLsRtRsEPL
0	9		T356-p	LHWPLsRtRsEPLPP
5	21		S358-p	WPLsRtRsEPLPPSA
0	1		S364	RsEPLPPSAtAPPPP
0	1		T366-p	EPLPPSAtAPPPPGP
0	40		S405-p	PRLRQIPsAEDLETd
0	1		D412-ca	sAEDLETdGGGPGQV
0	1		S482	QGGHRPLSRAQssPA
0	1		A484	GHRPLSRAQssPAAP
6	66		S486-p	RPLSRAQssPAAPAs
0	17		S487-p	PLSRAQssPAAPAsL
0	3		S493-p	ssPAAPAsLSAPEPA
0	12		S507-p	ASQARVLssSEtPAR
0	3		S508-p	SQARVLssSEtPARt
0	2		T511-p	RVLssSEtPARtLPF
0	2		T515-p	sSEtPARtLPFTTGL
0	2		Y524-p	PFTTGLIyDSVMLkH
0	1		K530-u	IyDSVMLkHQCSCGD
0	1		S595-p	LYGTNPLsRLKLDNG
0	1		K603-u	RLKLDNGkLAGLLAQ
0	1		S903-p	GCMQRLAsCPDsWVP
0	1		S907-p	RLAsCPDsWVPRVPG

	mouse
S72	SAEPMRLSMDPPMPE
T127	QQAALERTVHPSsPS
S132-p	ERTVHPSsPSIPYRT
Y137	PSsPSIPYRTLEPLD
T176	EHFPLRKTVsEPNLK
S178-p	FPLRKTVsEPNLKLR
S204-p	NPLLRKEsAPPSLRR
S230-p	SSSSTPAsGCSSPND
-	gap
-	gap
N269	PRGPVLGNPHAPLFL
A272	PVLGNPHAPLFLHHG
T287	LEPEAGGTLPSRLQP
N340	SGLHRPLNRtRsEPL
T342-p	LHRPLNRtRsEPLPP
S344-p	RPLNRtRsEPLPPsA
S350-p	RsEPLPPsATASPLL
T352	EPLPPsATASPLLAP
S398-p	PRLRQIPsAEDLETD
D405	sAEDLETDGGGVGPM
S475-p	QVGHRPLsRtQssPA
T477-p	GHRPLsRtQssPAAP
S479-p	RPLsRtQssPAAPVS
S480-p	PLsRtQssPAAPVSL
S486	ssPAAPVSLLSPEPT
N500	TCQTQVLNSSETPAT
S501	CQTQVLNSSETPATG
T504	QVLNSSETPATGLVY
-	gap
Y511	TPATGLVYDSVMLKH
K517	VYDSVMLKHQCSCGD
S582-p	LYGTNPLsRLKLDNG
K590	RLKLDNGKLTGLLAQ
S890	GCMQRLASCPDSWLP
S894	RLASCPDSWLPRVPG

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