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Protein Page:
FIP1L1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FIP1L1 a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is the cause of some cases of hypereosinophilic syndrome (HES), a disorder characterized by overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: nucleolus; mRNA cleavage and polyadenylation specificity factor complex; nucleus
Biological Process: mRNA processing
Reference #:  Q6UN15 (UniProtKB)
Alt. Names/Synonyms: DKFZp586K0717; Factor interacting with PAP; FIP1; FIP1 like 1; FIP1 like 1 (S. cerevisiae); FIP1-like 1 protein; FIP1L1; FLJ33619; hFip1; Pre-mRNA 3'-end-processing factor FIP1; Rearranged in hypereosinophilia; RHE
Gene Symbols: FIP1L1
Molecular weight: 66,526 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
Select Structure to View Below

FIP1L1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S14-p ERLVSELsGGTGGDE
0 9 Y27-p DEEEEWLyGGPWDVH
0 1 S37-p PWDVHVHsDLAKDLD
0 4 S57-p RPEEENAsANPPsGI
0 4 S62-p NAsANPPsGIEDETA
0 1 T79-p GVPKPKVtEtEDDsD
0 1 T81-p PKPKVtEtEDDsDsD
0 17 S85-p VtEtEDDsDsDsDDD
0 17 S87-p EtEDDsDsDsDDDED
0 15 S89-p EDDsDsDsDDDEDDV
1 6 Y110-p IKTGAPQyGsyGTAP
0 3 S112-p TGAPQyGsyGTAPVN
0 33 Y113-p GAPQyGsyGTAPVNL
0 2 K123-ub APVNLNIkTGGRVyG
0 11 Y129-p IkTGGRVyGTTGTKV
0 1 S146-p VDLDAPGsINGVPLL
0 1 D158-ca PLLEVDLdSFEDKPW
0 5 Y175-p PGADLSDyFNyGFNE
0 2 Y178-p DLSDyFNyGFNEDTW
0 1 K186-ac GFNEDTWkAYCEKQK
0 5 T221-p EDCTMEVtPGAEIQD
0 1 T253-gl KETALPStKAEFtsP
0 3 T258-p PStKAEFtsPPsLFK
0 45 S259-p StKAEFtsPPsLFKT
0 5 S262-p AEFtsPPsLFKTGLP
0 2 S274-p GLPPSRNstssQsQt
0 1 T275-gl LPPSRNstssQsQtS
0 1 S276-gl PPSRNstssQsQtSt
0 3 S277-p PSRNstssQsQtStA
0 6 S279-p RNstssQsQtStASR
0 3 T281-p stssQsQtStASRKA
0 1 T283-p ssQsQtStASRKANS
0 1 S285 QsQtStASRKANSSV
0 1 S285 QsQtStASRKANSSV
0 2 K294-ac KANSSVGkWQDRYGR
0 26 S304-p DRYGRAEsPDLRRLP
0 51 Y426-p RSARAFPyGNVAFPH
0 6 S440-p HLPGSAPsWPsLVDT
0 1 S443-p GSAPsWPsLVDTSKQ
0 4 Y453-p DTSKQWDyyARREKD
0 13 Y454-p TSKQWDyyARREKDR
0 3 T482-p RDRERERtRERERER
0 89 S492-p RERERDHsPtPsVFN
0 47 T494-p RERDHsPtPsVFNsD
0 29 S496-p RDHsPtPsVFNsDEE
0 55 S500-p PtPsVFNsDEERyRY
0 5 Y505-p FNsDEERyRYREyAE
0 6 Y510-p ERyRYREyAERGyER
0 5 Y515-p REyAERGyERHRASR
0 5 S548-p HKSSRSNsRRRHEsE
0 107 S554-p NsRRRHEsEEGDsHR
0 4 S559-p HEsEEGDsHRRHKHK
0 1 S571-p KHKKSKRsKEGKEAG
0 4 S579-p KEGKEAGsEPAPEQE
0 18 T591-p EQESTEAtPAE____
  FIP1L1 iso3  
S14 ERLVSELSGGTGGDE
Y27 DEEEEWLYGDENEVE
- under review  
S42 RPEEENASANPPSGI
S47 NASANPPSGIEDETA
T64 GVPKPKVTETEDDSD
T66 PKPKVTETEDDSDSD
S70 VTETEDDSDSDSDDD
S72 ETEDDSDSDSDDDED
S74 EDDSDSDSDDDEDDV
Y95 IKTGAPQYGSYGTAP
S97 TGAPQYGSYGTAPVN
Y98 GAPQYGSYGTAPVNL
K108 APVNLNIKTGGRVYG
Y114 IKTGGRVYGTTGTKV
S131 VDLDAPGSINGVPLL
D143 PLLEVDLDSFEDKPW
Y160 PGADLSDYFNYGFNE
Y163 DLSDYFNYGFNEDTW
K171 GFNEDTWKAYCEKQK
- gap
T215 KETALPSTKAEFTsP
T220 PSTKAEFTsPPsLFK
S221-p STKAEFTsPPsLFKT
S224-p AEFTsPPsLFKTGLP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y352 RSARAFPYGNVAFPH
S366 HLPGSAPSWPSLVDT
S369 GSAPSWPSLVDTSKQ
Y379 DTSKQWDYYARREKD
Y380 TSKQWDYYARREKDR
T408 RDRERERTRERERER
S418 RERERDHSPTPSVFN
T420 RERDHSPTPSVFNSD
S422 RDHSPTPSVFNSDEE
S426 PTPSVFNSDEERYRY
Y431 FNSDEERYRYREYAE
Y436 ERYRYREYAERGYER
Y441 REYAERGYERHRASR
S474 HKSSRSNSRRRHESE
S480 NSRRRHESEEGDSHR
S485 HESEEGDSHRRHKHK
S497 KHKKSKRSKEGKEAG
S505 KEGKEAGSEPAPEQE
T517 EQESTEATPAE____
  FIP1L1 iso4  
S14 ERLVSELSGGTGGDE
Y27 DEEEEWLYGDENEVE
- gap
S42 RPEEENASANPPSGI
S47 NASANPPSGIEDETA
T64 GVPKPKVTETEDDSD
T66 PKPKVTETEDDSDSD
S70 VTETEDDSDSDSDDD
S72 ETEDDSDSDSDDDED
S74 EDDSDSDSDDDEDDV
Y95 IKTGAPQYGSYGTAP
S97 TGAPQYGSYGTAPVN
Y98 GAPQYGSYGTAPVNL
K108 APVNLNIKTGGRVYG
Y114 IKTGGRVYGTTGTKV
S131 VDLDAPGSINGVPLL
D143 PLLEVDLDSFEDKPW
Y160 PGADLSDYFNYGFNE
Y163 DLSDYFNYGFNEDTW
K171 GFNEDTWKAYCEKQK
T206 EDCTMEVTPGAEIQD
T238 KETALPSTKAEFTSP
T243 PSTKAEFTSPPSLFK
S244 STKAEFTSPPSLFKT
S247 AEFTSPPSLFKTGLP
S259 GLPPSRNSTSSQSQT
T260 LPPSRNSTSSQSQTS
S261 PPSRNSTSSQSQTST
S262 PSRNSTSSQSQTSTA
S264 RNSTSSQSQTSTASR
T266 STSSQSQTSTASRKA
T268 SSQSQTSTASRKANS
S270 QSQTSTASRKANSSV
S270 QSQTSTASRKANSSV
K279 KANSSVGKWQDRYGR
S289 DRYGRAESPDLRRLP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S13 VERLVELSGGTGGDE
Y26 DEEEEWLYGGPWDVH
S36 PWDVHVHSDLAKDLD
S56-p RPEEENAsANPPsGI
S61-p NAsANPPsGIEEEAA
T78 GVAKPKVTETEDDsD
T80 AKPKVTETEDDsDsD
S84-p VTETEDDsDsDsDDD
S86-p ETEDDsDsDsDDDED
S88-p EDDsDsDsDDDEDDV
Y109 IKTGAPQYGSYGTAP
S111 TGAPQYGSYGTAPVN
Y112 GAPQYGSYGTAPVNL
K122-ub APVNLNIkAGGRVYG
Y128 IkAGGRVYGNTGTKV
S145 VDLDAPGSINGVPLL
D157 PLLEVDLDSFEDKPW
Y174 PGADLSDYFNYGFNE
Y177 DLSDYFNYGFNEDTW
K185 GFNEDTWKAYCEKQK
- gap
T229 KEAALPSTKAEFtsP
T234-p PSTKAEFtsPPsLFK
S235-p STKAEFtsPPsLFKT
S238-p AEFtsPPsLFKTGLP
S250 GLPPSRNSTSsQSQT
T251 LPPSRNSTSsQSQTS
S252 PPSRNSTSsQSQTST
S253-p PSRNSTSsQSQTSTA
S255 RNSTSsQSQTSTAsR
T257 STSsQSQTSTAsRKA
T259 SsQSQTSTAsRKASS
S261-p QSQTSTAsRKASSSV
S261-gl QSQTSTAsRKASSSV
K270 KASSSVGKWQDRYGR
S280-p DRYGRAEsPDLRRLP
Y411 RSARAFPYGNVAFPH
S425 HLTSSAPSWPSLVDT
S428 SSAPSWPSLVDTTKQ
Y438 DTTKQWDYYARREKD
Y439 TTKQWDYYARREKDR
T469-p RDRERERtRERERER
S479-p RERERDHsPtPsVFN
T481-p RERDHsPtPsVFNsD
S483-p RDHsPtPsVFNsDEE
S487-p PtPsVFNsDEERyRY
Y492-p FNsDEERyRYREYAE
Y497 ERyRYREYAERGYER
Y502 REYAERGYERHRASR
S535-p HKSSRSNsRRRHEsE
S541-p NsRRRHEsEEGDsHR
S546-p HEsEEGDsHRRHKHK
S558 KHKKSKRSKEGKEAG
S566 KEGKEAGSEPVPEQE
A578 EQESTEAAPAE____
  rat

 
S13 VERLVELSGGTGGDE
Y26 DEEEEWLYGGPWDVH
S36 PWDVHVHSDLAKDLD
S56 RPEEENASANPPSGI
S61 NASANPPSGIEEEAA
T78 GVAKPKVTETEDDsD
T80 AKPKVTETEDDsDsD
S84-p VTETEDDsDsDsDDD
S86-p ETEDDsDsDsDDDED
S88-p EDDsDsDsDDDEDDV
Y109 IKTGAPQYGSYGTAP
S111 TGAPQYGSYGTAPVN
Y112 GAPQYGSYGTAPVNL
K122 APVNLNIKAGGRVYG
Y128 IKAGGRVYGNTGTKV
S145 VDLDAPGSINGVPLL
D157 PLLEVDLDSFEDKPW
Y174 PGADLSDYFNYGFNE
Y177 DLSDYFNYGFNEDTW
K185 GFNEDTWKAYCEKQK
- gap
T229 KEAALPSTKAEFTsP
T234 PSTKAEFTsPPSLFK
S235-p STKAEFTsPPSLFKT
S238 AEFTsPPSLFKTGLP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y366 RSARAFPYGNVAFPH
S380 HLTSSAPSWPSLVDT
S383 SSAPSWPSLVDTTKQ
Y393 DTTKQWDYYARREKD
Y394 TTKQWDYYARREKDR
T424 RDRERERTRERERER
S434-p RERERDHsPtPSVFN
T436-p RERDHsPtPSVFNsD
S438 RDHsPtPSVFNsDEE
S442-p PtPSVFNsDEERYRY
Y447 FNsDEERYRYREYAE
Y452 ERYRYREYAERGYER
Y457 REYAERGYERHRASR
S490 HKSSRSNSRRRHEsE
S496-p NSRRRHEsEEGDSHR
S501 HEsEEGDSHRRHKHK
S513 KHKKSKRSKEGKEAG
S521 KEGKEAGSEPVPEQE
A533 EQESTEAAPAE____
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