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FIP1L1 (human)

Overview FIP1L1 a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. A fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA) is the cause of some cases of hypereosinophilic syndrome (HES), a disorder characterized by overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: RNA processing Cellular Component: nucleolus; mRNA cleavage and polyadenylation specificity factor complex; nucleus Molecular Function: RNA binding Biological Process: mRNA processing Reference #:  Q6UN15 (UniProtKB) Alt. Names/Synonyms: DKFZp586K0717; Factor interacting with PAP; FIP1; FIP1 like 1; FIP1 like 1 (S. cerevisiae); FIP1-like 1 protein; FIP1L1; FLJ33619; hFip1; Pre-mRNA 3'-end-processing factor FIP1; Rearranged in hypereosinophilia; RHE Gene Symbols: FIP1L1 Molecular weight: 66,526 Da Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states

Select Structure to View Below FIP1L1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 607685 607686  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	12		Y27-p	DEEEEWLyGGPWDVH
0	1		S37-p	PWDVHVHsDLAKDLD
0	1		S57	RPEEENASANPPSGI
0	1		S62	NASANPPSGIEDETA
0	12		S85-p	VTETEDDsDsDsDDD
0	12		S87-p	ETEDDsDsDsDDDED
0	10		S89-p	EDDsDsDsDDDEDDV
1	6		Y110-p	IKTGAPQyGsyGTAP
0	1		S112-p	TGAPQyGsyGTAPVN
0	35		Y113-p	GAPQyGsyGTAPVNL
0	2		K123-u	APVNLNIkTGGRVyG
0	8		Y129-p	IkTGGRVyGTTGTKV
0	1		D158-ca	PLLEVDLdSFEDKPW
0	4		Y175-p	PGADLSDyFNYGFNE
0	1		K186-a	GFNEDTWkAYCEKQK
0	4		T221-p	EDCTMEVtPGAEIQD
0	1		T253-g	KETALPStKAEFtsP
0	1		T258-p	PStKAEFtsPPSLFK
0	36		S259-p	StKAEFtsPPSLFKT
0	2		S274-p	GLPPSRNstssQsQt
0	1		T275-g	LPPSRNstssQsQtS
0	1		S276-g	PPSRNstssQsQtSt
0	3		S277-p	PSRNstssQsQtStA
0	5		S279-p	RNstssQsQtStASR
0	2		T281-p	stssQsQtStASRKA
0	1		T283-p	ssQsQtStASRKANS
0	1		S285	QsQtStASRKANSSV
0	1		S285	QsQtStASRKANSSV
0	2		K294-a	KANSSVGkWQDRYGR
0	15		S304-p	DRYGRAEsPDLRRLP
0	46		Y426-p	RSARAFPyGNVAFPH
0	4		S440-p	HLPGSAPsWPsLVDT
0	1		S443-p	GSAPsWPsLVDTSKQ
0	3		Y453-p	DTSKQWDyyARREKD
0	12		Y454-p	TSKQWDyyARREKDR
0	3		T482-p	RDRERERtRERERER
0	75		S492-p	RERERDHsPtPsVFN
0	44		T494-p	RERDHsPtPsVFNsD
0	26		S496-p	RDHsPtPsVFNsDEE
0	43		S500-p	PtPsVFNsDEERyRY
0	4		Y505-p	FNsDEERyRYREyAE
0	4		Y510-p	ERyRYREyAERGyER
0	3		Y515-p	REyAERGyERHRASR
0	5		S548-p	HKSSRSNsRRRHEsE
0	75		S554-p	NsRRRHEsEEGDsHR
0	3		S559-p	HEsEEGDsHRRHKHK
0	17		T591-p	EQESTEAtPAE____

	mouse
Y26	DEEEEWLYGGPWDVH
S36	PWDVHVHSDLAKDLD
S56-p	RPEEENAsANPPsGI
S61-p	NAsANPPsGIEEEAA
S84-p	VTETEDDsDsDsDDD
S86-p	ETEDDsDsDsDDDED
S88-p	EDDsDsDsDDDEDDV
Y109	IKTGAPQYGSYGTAP
S111	TGAPQYGSYGTAPVN
Y112	GAPQYGSYGTAPVNL
K122-u	APVNLNIkAGGRVYG
Y128	IkAGGRVYGNTGTKV
D157	PLLEVDLDSFEDKPW
Y174	PGADLSDYFNYGFNE
K185	GFNEDTWKAYCEKQK
-	gap
T229	KEAALPSTKAEFtsP
T234-p	PSTKAEFtsPPSLFK
S235-p	STKAEFtsPPSLFKT
S250	GLPPSRNSTSsQSQT
T251	LPPSRNSTSsQSQTS
S252	PPSRNSTSsQSQTST
S253-p	PSRNSTSsQSQTSTA
S255	RNSTSsQSQTSTAsR
T257	STSsQSQTSTAsRKA
T259	SsQSQTSTAsRKASS
S261-p	QSQTSTAsRKASSSV
S261-g	QSQTSTAsRKASSSV
K270	KASSSVGKWQDRYGR
S280-p	DRYGRAEsPDLRRLP
Y411	RSARAFPYGNVAFPH
S425	HLTSSAPSWPSLVDT
S428	SSAPSWPSLVDTTKQ
Y438	DTTKQWDYYARREKD
Y439	TTKQWDYYARREKDR
T469-p	RDRERERtRERERER
S479-p	RERERDHsPtPsVFN
T481-p	RERDHsPtPsVFNsD
S483-p	RDHsPtPsVFNsDEE
S487-p	PtPsVFNsDEERyRY
Y492-p	FNsDEERyRYREYAE
Y497	ERyRYREYAERGYER
Y502	REYAERGYERHRASR
S535-p	HKSSRSNsRRRHEsE
S541-p	NsRRRHEsEEGDsHR
S546-p	HEsEEGDsHRRHKHK
A578	EQESTEAAPAE____

	rat
Y26	DEEEEWLYGGPWDVH
S36	PWDVHVHSDLAKDLD
S56	RPEEENASANPPSGI
S61	NASANPPSGIEEEAA
S84	VTETEDDSDSDSDDD
S86	ETEDDSDSDSDDDED
S88	EDDSDSDSDDDEDDV
Y109	IKTGAPQYGSYGTAP
S111	TGAPQYGSYGTAPVN
Y112	GAPQYGSYGTAPVNL
K122	APVNLNIKAGGRVYG
Y128	IKAGGRVYGNTGTKV
D157	PLLEVDLDSFEDKPW
Y174	PGADLSDYFNYGFNE
K185	GFNEDTWKAYCEKQK
-	gap
T229	KEAALPSTKAEFTSP
T234	PSTKAEFTSPPSLFK
S235	STKAEFTSPPSLFKT
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	under review
-	gap
-	under review
-	gap
-	gap
Y366	RSARAFPYGNVAFPH
S380	HLTSSAPSWPSLVDT
S383	SSAPSWPSLVDTTKQ
Y393	DTTKQWDYYARREKD
Y394	TTKQWDYYARREKDR
T424	RDRERERTRERERER
S434-p	RERERDHsPtPSVFN
T436-p	RERDHsPtPSVFNsD
S438	RDHsPtPSVFNsDEE
S442-p	PtPSVFNsDEERYRY
Y447	FNsDEERYRYREYAE
Y452	ERYRYREYAERGYER
Y457	REYAERGYERHRASR
S490	HKSSRSNSRRRHEsE
S496-p	NSRRRHEsEEGDSHR
S501	HEsEEGDSHRRHKHK
A533	EQESTEAAPAE____

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