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Protein Page:
NCL (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NCL the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and preribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-RNA transcription and ribosome assembly. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Helicase; Nuclear receptor co-regulator; RNA binding protein
Cellular Component: nucleoplasm; nucleolus; cell cortex; ribonucleoprotein complex; nucleus
Molecular Function: protein C-terminus binding; protein binding; RNA binding; nucleotide binding; telomeric DNA binding
Biological Process: angiogenesis
Reference #:  P19338 (UniProtKB)
Alt. Names/Synonyms: C23; FLJ45706; FLJ59041; NCL; NUCL; Nucleolin; Protein C23
Gene Symbols: NCL
Molecular weight: 76,614 Da
Basal Isoelectric point: 4.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NCL
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
1 53 K9-a VKLAKAGkNQGDPkk
1 51 K15-a GkNQGDPkkMAPPPK
0 4 K16-a kNQGDPkkMAPPPKE
0 28 S28-p PKEVEEDsEDEEMsE
1 24 S34-p DsEDEEMsEDEEDDs
0 12 D40 MsEDEEDDssGEEVV
0 25 S41-p sEDEEDDssGEEVVI
0 13 S42-p EDEEDDssGEEVVIP
0 1 T59 KGKKAAATSAkkVVV
0 7 K62-a KAAATSAkkVVVsPt
1 0 K63-a AAATSAkkVVVsPtk
1 52 S67-p SAkkVVVsPtkkVAV
0 29 T69-p kkVVVsPtkkVAVAt
1 56 K70-a kVVVsPtkkVAVAtP
0 1 K70-u kVVVsPtkkVAVAtP
0 9 K71-a VVVsPtkkVAVAtPA
0 1 K71-u VVVsPtkkVAVAtPA
1 26 T76-p tkkVAVAtPAkkAAV
1 26 K79-a VAVAtPAkkAAVtPG
0 1 K79-u VAVAtPAkkAAVtPG
1 0 K80-a AVAtPAkkAAVtPGk
0 7 T84-p PAkkAAVtPGkkAAA
1 76 K87-a kAAVtPGkkAAAtPA
1 3 K88-a AAVtPGkkAAAtPAk
0 10 T92-p PGkkAAAtPAkKtVt
0 4 K95-a kAAAtPAkKtVtPAk
0 1 T97-p AAtPAkKtVtPAkAV
0 18 T99-p tPAkKtVtPAkAVtt
2 30 K102-a kKtVtPAkAVttPGk
0 2 T105-p VtPAkAVttPGkkGA
0 6 T106-p tPAkAVttPGkkGAt
1 35 K109-a kAVttPGkkGAtPGk
1 8 K110-a AVttPGkkGAtPGkA
0 1 K110-u AVttPGkkGAtPGkA
0 5 T113-p tPGkkGAtPGkALVA
2 32 K116-a kkGAtPGkALVAtPG
2 31 T121-p PGkALVAtPGkkGAA
1 186 K124-a ALVAtPGkkGAAIPA
0 1 K124-u ALVAtPGkkGAAIPA
1 1 K125-a LVAtPGkkGAAIPAk
0 3 K132-a kGAAIPAkGAkNGKN
1 1 K135-a AIPAkGAkNGKNAKK
0 103 S145-p KNAKKEDsDEEEDDD
0 62 S153-p DEEEDDDsEEDEEDD
0 40 E157 DDDsEEDEEDDEDED
1 34 S184-p AAAAAPAsEDEDDED
1 42 S206-p DDDEEDDsEEEAMEt
0 2 T213-p sEEEAMEttPAKGKK
0 5 T214-p EEEAMEttPAKGKKA
0 1 K294-a QKAAPEAkKQKVEGt
0 5 T301-p kKQKVEGtEPttAFN
0 2 T304-p KVEGtEPttAFNLFV
0 3 T305-p VEGtEPttAFNLFVG
0 1 K318-a VGNLNFNkSAPELkT
0 4 K318-u VGNLNFNkSAPELkT
0 11 K324-u NkSAPELkTGISDVF
0 1 K333-a GISDVFAkNDLAVVD
0 27 K333-u GISDVFAkNDLAVVD
0 1 I343 LAVVDVRIGMTRkFG
0 1 M345 VVDVRIGMTRkFGyV
0 1 K348 VRIGMTRKFGyVDFE
0 2 K348-u VRIGMTRkFGyVDFE
0 1 Y351-p GMTRkFGyVDFEsAE
0 3 S356-p FGyVDFEsAEDLEKA
0 2 T367-p LEKALELtGLkVFGN
0 8 K370-a ALELtGLkVFGNEIk
0 37 K370-u ALELtGLkVFGNEIk
0 1 K377-a kVFGNEIkLEKPkGK
0 1 K377-u kVFGNEIkLEKPkGK
0 1 K382-u EIkLEKPkGKDSkkE
0 2 K387-a KPkGKDSkkERDART
0 1 K388-a PkGKDSkkERDARTL
0 8 K398-a DARTLLAkNLPykVt
0 3 K398-u DARTLLAkNLPykVt
0 13 P401 TLLAkNLPykVtQDE
0 6 Y402-p LLAkNLPykVtQDEL
0 6 K403-a LAkNLPykVtQDELk
0 20 K403-u LAkNLPykVtQDELk
0 15 T405-p kNLPykVtQDELkEV
0 2 K410-u kVtQDELkEVFEDAA
0 1 S423-p AAEIRLVsKDGKskG
0 1 S428-p LVsKDGKskGIAyIE
0 1 K429-u VsKDGKskGIAyIEF
0 1 Y433-p GKskGIAyIEFkTEA
0 1 K437-a GIAyIEFkTEADAEk
0 1 K444-a kTEADAEkTFEEkQG
1 3 K449-a AEkTFEEkQGTEIDG
0 1 K449 AEkTFEEKQGTEIDG
0 6 S458-p GTEIDGRsIsLyytG
0 2 S460-p EIDGRsIsLyytGEk
1 63 Y462-p DGRsIsLyytGEkGQ
0 3 Y463-p GRsIsLyytGEkGQN
0 2 T464-p RsIsLyytGEkGQNQ
0 3 K467-a sLyytGEkGQNQDyR
0 45 K467-u sLyytGEkGQNQDyR
0 20 Y473-p EkGQNQDyRGGkNSt
0 8 K477-u NQDyRGGkNStWSGE
0 1 T480-p yRGGkNStWSGESkt
0 1 K486-u StWSGESktLVLSNL
0 1 T487-p tWSGESktLVLSNLS
0 1 T498-p SNLSYSAtEETLQEV
0 4 E499 NLSYSAtEETLQEVF
0 4 K508-u TLQEVFEkATFIkVP
0 1 K513-a FEkATFIkVPQNQNG
0 60 K513-u FEkATFIkVPQNQNG
0 7 K521-u VPQNQNGkSkGyAFI
0 20 K523-u QNQNGkSkGyAFIEF
0 3 Y525-p QNGkSkGyAFIEFAs
0 8 S532-p yAFIEFAsFEDAkEA
0 6 K537-u FAsFEDAkEALNsCN
0 1 S542-p DAkEALNsCNkREIE
0 17 K545-a EALNsCNkREIEGRA
0 11 K545-u EALNsCNkREIEGRA
0 15 S563-p ELQGPRGsPNARSQP
0 1 K572-a NARSQPSkTLFVkGL
0 11 K572-u NARSQPSkTLFVkGL
0 2 K577-a PSkTLFVkGLsEDTT
0 15 K577-u PSkTLFVkGLsEDTT
0 10 S580-p TLFVkGLsEDTTEET
0 8 K589-u DTTEETLkESFDGSV
0 17 T602-p SVRARIVtDREtGSS
0 1 T606-p RIVtDREtGSSkGFG
0 8 K610-u DREtGSSkGFGFVDF
0 15 S619-p FGFVDFNsEEDAKAA
0 1 K627 EEDAKAAKEAMEDGE
0 1 K639-u DGEIDGNkVtLDWAk
1 1 T641-p EIDGNkVtLDWAkPK
0 5 K646-a kVtLDWAkPKGEGGF
2 0 R656-m2 GEGGFGGrGGGrGGF
0 12 R656-m1 GEGGFGGrGGGrGGF
2 0 R660-m2 FGGrGGGrGGFGGrG
0 9 R660-m1 FGGrGGGrGGFGGrG
2 0 R666-m2 GrGGFGGrGGGrGGr
2 0 R670-m2 FGGrGGGrGGrGGFG
2 0 R673-m2 rGGGrGGrGGFGGRG
1 0 R679 GrGGFGGRGrGGFGG
1 0 R681 GGFGGRGRGGFGGrG
0 3 R681-m1 GGFGGRGrGGFGGrG
1 0 R687 GrGGFGGRGGFRGGR
0 7 R687-m1 GrGGFGGrGGFRGGR
0 1 R691 FGGrGGFRGGRGGGG
1 0 R691 FGGrGGFRGGRGGGG
1 0 R694 rGGFRGGRGGGGDHK
0 4 R694 rGGFRGGRGGGGDHK
0 3 K705 GDHKPQGKKtKFE__
1 0 T707-p HKPQGKKtKFE____
  mouse

 
K9-a VKLAKAGkTHGEAkk
K15-a GkTHGEAkkMAPPPK
K16-a kTHGEAkkMAPPPKE
S28-p PKEVEEDsEDEEMsE
S34-p DsEDEEMsEDEDDss
S40-p MsEDEDDssGEEEVV
S41-p sEDEDDssGEEEVVI
G42 EDEDDssGEEEVVIP
T59-p KGKKATTtPAKKVVV
K62 KATTtPAKKVVVSQT
- under review  
S67 PAKKVVVSQTkkAAV
T69 KKVVVSQTkkAAVPt
K70-a KVVVSQTkkAAVPtP
K70 KVVVSQTKkAAVPtP
K71-a VVVSQTkkAAVPtPA
K71 VVVSQTkKAAVPtPA
T76-p TkkAAVPtPAkKAAV
K79-a AAVPtPAkKAAVtPG
K79 AAVPtPAKKAAVtPG
- under review  
T84-p PAkKAAVtPGkKAVA
K87-a KAAVtPGkKAVAtPA
K88 AAVtPGkKAVAtPAk
T92-p PGkKAVAtPAkKNIt
K95-a KAVAtPAkKNItPAk
N97 VAtPAkKNItPAkVI
T99-p tPAkKNItPAkVIPt
K102-a kKNItPAkVIPtPGK
P105 ItPAkVIPtPGKKGA
T106-p tPAkVIPtPGKKGAA
K109 kVIPtPGKKGAAQAk
K110 VIPtPGKKGAAQAkA
K110 VIPtPGKKGAAQAkA
A113 tPGKKGAAQAkALVP
K116-a KKGAAQAkALVPtPG
T121-p QAkALVPtPGkKGAA
K124-a ALVPtPGkKGAATPA
K124 ALVPtPGKKGAATPA
K125 LVPtPGkKGAATPAK
K132 KGAATPAKGAKNGKN
K135 ATPAKGAKNGKNAKK
S145-p KNAKKEDsDEDEDEE
D153 DEDEDEEDEDDsDED
S157-p DEEDEDDsDEDEDDE
S189-p AAPAAPAsEDEEDDE
S212-p DEEEEDDsEEEVMEI
I219 sEEEVMEITTAKGKK
T220 EEEVMEITTAKGKKT
K296 QKEAPEAKKQKVEGs
S303-p KKQKVEGsEPttPFN
T306-p KVEGsEPttPFNLFI
T307-p VEGsEPttPFNLFIG
K320 IGNLNPNKSVNELkF
K320-u IGNLNPNkSVNELkF
K326-u NkSVNELkFAISELF
K335 AISELFAKNDLAVVD
K335-u AISELFAkNDLAVVD
T345-p LAVVDVRtGtNRkFG
T347-p VVDVRtGtNRkFGYV
K350-a VRtGtNRkFGYVDFE
K350 VRtGtNRKFGYVDFE
Y353 GtNRkFGYVDFEsAE
S358-p FGYVDFEsAEDLEKA
T369 LEKALELTGLkVFGN
K372 ALELTGLKVFGNEIK
K372-u ALELTGLkVFGNEIK
K379 kVFGNEIKLEKPKGR
K379 kVFGNEIKLEKPKGR
K384 EIKLEKPKGRDSkKV
K389-a KPKGRDSkKVRAART
K390 PKGRDSkKVRAARTL
K400 AARTLLAKNLsFNIT
K400-u AARTLLAkNLsFNIT
S403-p TLLAkNLsFNITEDE
F404 LLAkNLsFNITEDEL
N405 LAkNLsFNITEDELK
N405 LAkNLsFNITEDELK
T407 kNLsFNITEDELKEV
K412 NITEDELKEVFEDAM
S425 AMEIRLVSQDGKSKG
S430 LVSQDGKSKGIAYIE
K431 VSQDGKSKGIAYIEF
Y435 GKSKGIAYIEFKSEA
K439 GIAYIEFKSEADAEK
K446 KSEADAEKNLEEkQG
K451 AEKNLEEKQGAEIDG
K451-u AEKNLEEkQGAEIDG
S460-p GAEIDGRsVSLyYTG
S462 EIDGRsVSLyYTGEk
Y464-p DGRsVSLyYTGEkGQ
Y465 GRsVSLyYTGEkGQR
T466 RsVSLyYTGEkGQRQ
K469 SLyYTGEKGQRQERT
K469-u SLyYTGEkGQRQERT
- gap
K478 QRQERTGKTSTWSGE
T481 ERTGKTSTWSGESKT
K487 STWSGESKTLVLSNL
T488 TWSGESKTLVLSNLS
T499 SNLSYSATkETLEEV
K500-u NLSYSATkETLEEVF
K509-u TLEEVFEkATFIKVP
K514 FEkATFIKVPQNPHG
K514 FEkATFIKVPQNPHG
K522 VPQNPHGKPKGYAFI
K524 QNPHGKPKGYAFIEF
Y526 PHGKPKGYAFIEFAS
S533 YAFIEFASFEDAKEA
K538 FASFEDAKEALNSCN
S543 DAKEALNSCNkMEIE
K546 EALNSCNKMEIEGRT
K546-u EALNSCNkMEIEGRT
- gap
K569 NSRSQPSKTLFVkGL
K569 NSRSQPSKTLFVkGL
K574 PSKTLFVKGLsEDTT
K574-u PSKTLFVkGLsEDTT
S577-p TLFVkGLsEDTTEET
K586-u DTTEETLkESFEGSV
T599 SVRARIVTDRETGSS
T603 RIVTDRETGSSkGFG
K607-u DRETGSSkGFGFVDF
S616-p FGFVDFNsEEDAKAA
K624-u EEDAKAAkEAMEDGE
K636 DGEIDGNKVTLDWAK
T638 EIDGNKVTLDWAKPK
K643 KVTLDWAKPKGEGGF
R653 GEGGFGGRGGGrGGF
R653-m1 GEGGFGGrGGGrGGF
R657 FGGrGGGRGGFGGRG
R657-m1 FGGrGGGrGGFGGRG
R663 GrGGFGGRGGGRGGR
R667 FGGRGGGRGGRGGFG
R670 RGGGRGGRGGFGGRG
R676 GRGGFGGRGRGGFGG
R678 GGFGGRGRGGFGGrG
R678 GGFGGRGRGGFGGrG
R684 GRGGFGGRGGFrGGr
R684-m1 GRGGFGGrGGFrGGr
R688-m1 FGGrGGFrGGrGGGG
R688 FGGrGGFRGGrGGGG
R691 rGGFrGGRGGGGDFK
R691-m1 rGGFrGGrGGGGDFK
K702-a GDFKPQGkKTKFE__
T704 FKPQGkKTKFE____
  rat

 
K9 VKLAKAGKTHGESKK
K15 GKTHGESKKMAPPPK
K16 KTHGESKKMAPPPKE
S28 PKEVEEDSEDEEMsE
S34-p DSEDEEMsEDEDDSS
S40 MsEDEDDSSGEEEVV
S41 sEDEDDSSGEEEVVI
G42 EDEDDSSGEEEVVIP
T59 KGKKATTTPAKKVVV
K62 KATTTPAKKVVVSQT
- under review  
S67 PAKKVVVSQTKKAAV
T69 KKVVVSQTKKAAVPT
K70 KVVVSQTKKAAVPTP
K70 KVVVSQTKKAAVPTP
K71 VVVSQTKKAAVPTPA
K71 VVVSQTKKAAVPTPA
T76 TKKAAVPTPAKKAAV
K79 AAVPTPAKKAAVTPG
K79 AAVPTPAKKAAVTPG
- under review  
T84 PAKKAAVTPGKKAAA
K87 KAAVTPGKKAAATPA
K88 AAVTPGKKAAATPAK
T92 PGKKAAATPAKKAVT
K95 KAAATPAKKAVTPAK
A97 AATPAKKAVTPAKVV
T99 TPAKKAVTPAKVVPT
K102 KKAVTPAKVVPTPGK
P105 VTPAKVVPTPGKKGA
T106 TPAKVVPTPGKKGAA
K109 KVVPTPGKKGAAQAK
K110 VVPTPGKKGAAQAKA
K110 VVPTPGKKGAAQAKA
A113 TPGKKGAAQAKALVP
K116 KKGAAQAKALVPTPG
T121 QAKALVPTPGKKGAV
K124 ALVPTPGKKGAVTPA
K124 ALVPTPGKKGAVTPA
K125 LVPTPGKKGAVTPAK
K132 KGAVTPAKGAKNGKN
K135 VTPAKGAKNGKNAKK
S145-p KNAKKEDsDEDEDEE
D153 DEDEDEEDEDDsDED
S157-p DEEDEDDsDEDEDEE
S187-p AAPAAPAsEDEDEED
S213-p EEEEEDDsEEEVMEI
I220 sEEEVMEITPAKGKK
T221 EEEVMEITPAKGKKT
K298 QKEAPEAKKQKIEGS
S305 KKQKIEGSEPTTPFN
T308 KIEGSEPTTPFNLFI
T309 IEGSEPTTPFNLFIG
K322 IGNLNPNKSVAELKV
K322 IGNLNPNKSVAELKV
K328 NKSVAELKVAISELF
K337 AISELFAKNDLAAVD
K337 AISELFAKNDLAAVD
T347 LAAVDVRTGTNRKFG
T349 AVDVRTGTNRKFGYV
K352 VRTGTNRKFGYVDFE
K352 VRTGTNRKFGYVDFE
Y355 GTNRKFGYVDFESAE
S360 FGYVDFESAEDLEKA
T371 LEKALELTGLKVFGN
K374 ALELTGLKVFGNEIK
K374 ALELTGLKVFGNEIK
K381 KVFGNEIKLEKPKGR
K381 KVFGNEIKLEKPKGR
K386 EIKLEKPKGRDSKKV
K391 KPKGRDSKKVRAART
K392 PKGRDSKKVRAARTL
K402 AARTLLAKNLSFNIT
K402 AARTLLAKNLSFNIT
S405 TLLAKNLSFNITEDE
F406 LLAKNLSFNITEDEL
N407 LAKNLSFNITEDELK
N407 LAKNLSFNITEDELK
T409 KNLSFNITEDELKEV
K414 NITEDELKEVFEDAV
S427 AVEIRLVSQDGRSKG
S432 LVSQDGRSKGIAYIE
K433 VSQDGRSKGIAYIEF
Y437 GRSKGIAYIEFKSEA
K441 GIAYIEFKSEADAEK
K448 KSEADAEKNLEEKQG
K453 AEKNLEEKQGAEIDG
K453 AEKNLEEKQGAEIDG
S462 GAEIDGRSVSLyYTG
S464 EIDGRSVSLyYTGEK
Y466-p DGRSVSLyYTGEKGQ
Y467 GRSVSLyYTGEKGQR
T468 RSVSLyYTGEKGQRQ
K471 SLyYTGEKGQRQERT
K471 SLyYTGEKGQRQERT
- gap
K480 QRQERTGKNSTWSGE
T483 ERTGKNSTWSGESKT
K489 STWSGESKTLVLSNL
T490 TWSGESKTLVLSNLS
T501 SNLSYSATEETLQEV
E502 NLSYSATEETLQEVF
K511 TLQEVFEKATFIKVP
K516 FEKATFIKVPQNPHG
K516 FEKATFIKVPQNPHG
K524 VPQNPHGKSKGYAFI
K526 QNPHGKSKGYAFIEF
Y528 PHGKSKGYAFIEFAS
S535 YAFIEFASFEDAKEA
K540 FASFEDAKEALNSCN
S545 DAKEALNSCNKMEIE
K548 EALNSCNKMEIEGRT
K548 EALNSCNKMEIEGRT
S566 ELQGPRGSPNARSQP
K575 NARSQPSKTLFVKGL
K575 NARSQPSKTLFVKGL
K580 PSKTLFVKGLSEDTT
K580 PSKTLFVKGLSEDTT
S583 TLFVKGLSEDTTEET
K592 DTTEETLKESFEGSV
T605 SVRARIVTDRETGSS
T609 RIVTDRETGSSKGFG
K613 DRETGSSKGFGFVDF
S622 FGFVDFNSEEDAKAA
K630 EEDAKAAKEAMEDGE
K642 DGEIDGNKVTLDWAK
T644 EIDGNKVTLDWAKPK
K649 KVTLDWAKPKGEGGF
R659-m2 GEGGFGGrGGGrGGF
R659-m1 GEGGFGGrGGGrGGF
R663-m2 FGGrGGGrGGFGGrG
R663-m1 FGGrGGGrGGFGGrG
R669-m2 GrGGFGGrGGGrGGr
R673-m2 FGGrGGGrGGrGGFG
R676-m2 rGGGrGGrGGFGGrG
R682-m2 GrGGFGGrGrGGFGG
R684-m2 GGFGGrGrGGFGGrG
R684 GGFGGrGRGGFGGrG
R690-m2 GrGGFGGrGGFrGGr
R690 GrGGFGGRGGFrGGr
R694 FGGrGGFRGGrGGGG
R694-m2 FGGrGGFrGGrGGGG
R697-m2 rGGFrGGrGGGGDFK
R697 rGGFrGGRGGGGDFK
K708 GDFKPQGKKTKFE__
T710 FKPQGKKTKFE____
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