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MCM2 (human)

Overview MCM2 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Note: This description may include information from UniProtKB. Protein type: EC 3.6.4.12; DNA binding protein Cellular Component: nucleoplasm; MCM complex; nuclear origin of replication recognition complex; chromatin; nucleus Molecular Function: protein binding; DNA binding; histone binding; metal ion binding; DNA replication origin binding; helicase activity; ATP binding Biological Process: DNA unwinding during replication; nucleosome assembly; DNA replication initiation; M/G1 transition of mitotic cell cycle; DNA strand elongation during DNA replication; mitotic cell cycle; S phase of mitotic cell cycle; cell cycle; DNA replication; cell cycle checkpoint; G1/S transition of mitotic cell cycle Reference #:  P49736 (UniProtKB) Alt. Names/Synonyms: BM28; CCNL1; cdc19; CDCL1; cell devision cycle-like 1; cyclin-like 1; D3S3194; DNA replication licensing factor MCM2; KIAA0030; MCM2; MCM2 minichromosome maintenance deficient 2, mitotin; MGC10606; minichromosome maintenance complex component 2; minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance protein 2 homolog; MITOTIN; Nuclear protein BM28 Gene Symbols: MCM2 Molecular weight: 101,896 Da Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MCM2

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	Sites Implicated In
cell cycle regulation: S27‑p, S41‑p, S139‑p cell growth, altered: S40‑p, S53‑p chromatin organization, altered: S13‑p, S27‑p, S40‑p, S41‑p, S53‑p, S108‑p, S139‑p activation: S27‑p, S41‑p, S139‑p intracellular localization: S5‑p molecular association, regulation: S13‑p, S27‑p, S40‑p, S41‑p, S53‑p, S108‑p, S139‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
2	1		S4-p	____MAEssEsFtMA
2	1		S5-p	___MAEssEsFtMAs
2	1		S7-p	_MAEssEsFtMAssP
0	1		T9-p	AEssEsFtMAssPAQ
0	4		S12-p	sEsFtMAssPAQRRR
2	17		S13-p	EsFtMAssPAQRRRG
0	15		N21	PAQRRRGNDPLtssP
0	25		T25-p	RRGNDPLtssPGRss
0	49		S26-p	RGNDPLtssPGRssR
3	98		S27-p	GNDPLtssPGRssRR
1	4		S31-p	LtssPGRssRRtDAL
0	5		S32-p	tssPGRssRRtDALt
0	4		T35-p	PGRssRRtDALtssP
0	21		T39-p	sRRtDALtssPGRDL
5	30		S40-p	RRtDALtssPGRDLP
4	49		S41-p	RtDALtssPGRDLPP
7	14		S53-p	LPPFEDEsEGLLGtE
1	12		T59-p	EsEGLLGtEGPLEEE
0	1		Y81-p	GDGMERDyRAIPELD
0	2		Y90-p	AIPELDAyEAEGLAL
0	8		T106-p	DEDVEELtAsQREAA
7	89		S108-p	DVEELtAsQREAAER
0	111		Y137-p	RMRRGLLyDsDEEDE
4	341		S139-p	RRGLLyDsDEEDEER
0	13		D140	RGLLyDsDEEDEERP
0	4		T158-p	RRQVERAtEDGEEDE
0	1		K178-u	IENLEDLkGHSVREW
0	1		K216-u	SHGHNVFkERIsDMC
0	1		K216-a	SHGHNVFkERIsDMC
2	0		S220-p	NVFkERIsDMCkENR
0	1		K224-u	ERIsDMCkENREsLV
0	1		S229-p	MCkENREsLVVNYED
0	3		S381-p	QRIRIQEsPGKVAAG
0	1		Y418-p	EIELTGIyHNNyDGS
0	1		Y422-p	TGIyHNNyDGSLNTA
0	1		K462-u	ELTDEDVkMITSLSk
0	10		K469-u	kMITSLSkDQQIGEk
0	1		K476-u	kDQQIGEkIFASIAP
0	1		K492-u	IYGHEDIkRGLALAL
0	1		T527-p	LLCGDPGtAkSQFLK
0	1		K529-u	CGDPGtAkSQFLKYI
0	5		K538-u	QFLKYIEkVSSRAIF
0	1		K591-u	CLIDEFDkMNDQDRT
0	14		K613-u	QQSISISkAGIVTSL
0	1		K742-a	LNQMDQDkVAKMYSD
0	2		S754-p	YSDLRKEsMAtGSIP
0	1		T757-p	LRKEsMAtGSIPItV
0	1		T763-p	AtGSIPItVRHIEsM
0	1		S769-p	ItVRHIEsMIRMAEA
0	1		S801-p	AIRVMLEsFIDTQKF
0	2		T857-p	RFGAQQDtIEVPEKD
0	1		K868-u	PEKDLVDkARQINIH
0	1		K896-a	NKFSHDLkRKMILQQ

	MCM2 iso4
S4	____MAESSESFTMA
S5	___MAESSESFTMAS
S7	_MAESSESFTMASSP
T9	AESSESFTMASSPAQ
S12	SESFTMASSPAQRRR
S13	ESFTMASSPAQRRRG
N21	PAQRRRGNDPLTSSP
T25	RRGNDPLTSSPGRSS
S26	RGNDPLTSSPGRSSR
S27	GNDPLTSSPGRSSRR
S31	LTSSPGRSSRRTDAL
S32	TSSPGRSSRRTDALT
T35	PGRSSRRTDALTSSP
T39	SRRTDALTSSPGRDL
S40	RRTDALTSSPGRDLP
S41	RTDALTSSPGRDLPP
S53	LPPFEDESEGLLGTE
T59	ESEGLLGTEGPLEEE
Y81	GDGMERDYRAIPELD
Y90	AIPELDAYEAEGLAL
T106	DEDVEELTASQREAG
S108	DVEELTASQREAGRG
Y118	EAGRGLLYDSDEEDE
S120	GRGLLYDSDEEDEER
D121	RGLLYDSDEEDEERP
T139	RRQVERATEDGEEDE
K159	IENLEDLKGHSVREW
K197	SHGHNVFKERISDMC
K197	SHGHNVFKERISDMC
S201	NVFKERISDMCKENR
K205	ERISDMCKENRESLV
S210	MCKENRESLVVNYED
S362	QRIRIQESPGKVAAG
Y399	EIELTGIYHNNYDGS
Y403	TGIYHNNYDGSLNTA
K443	ELTDEDVKMITSLSK
K450	KMITSLSKDQQIGEK
K457	KDQQIGEKESSRNAS
K542	IYGHEDIKRGLALAL
T577	LLCGDPGTAKSQFLK
K579	CGDPGTAKSQFLKYI
K588	QFLKYIEKVSSRAIF
K641	CLIDEFDKMNDQDRT
K663	QQSISISKAGIVTSL
K792	LNQMDQDKVAKMYSD
S804	YSDLRKESMATGSIP
T807	LRKESMATGSIPITV
T813	ATGSIPITVRHIESM
S819	ITVRHIESMIRMAEA
S851	AIRVMLESFIDTQKF
T907	RFGAQQDTIEVPEKD
K918	PEKDLVDKARQINIH
K946	NKFSHDLKRKMILQQ

	mouse
S4	____MAESSESLSAs
S5	___MAESSESLSAss
S7	_MAESSESLSAssPA
S9	AESSESLSAssPARQ
S11-p	SSESLSAssPARQRR
S12-p	SESLSAssPARQRRR
S21-p	ARQRRRIsDPLtssP
T25-p	RRIsDPLtssPGRsS
S26-p	RIsDPLtssPGRsSR
S27-p	IsDPLtssPGRsSRR
S31-p	LtssPGRsSRRADAL
S32	tssPGRsSRRADALt
A35	PGRsSRRADALtssP
T39-p	SRRADALtssPGRDL
S40-p	RRADALtssPGRDLP
S41-p	RADALtssPGRDLPP
S53-p	LPPFEDEsEGLLGTE
T59	EsEGLLGTEGPMEEE
Y81	GDGMERDYRPIPELD
Y90	PIPELDVYEAEGLAL
T106	DEDVEELTAsQREAA
S108-p	DVEELTAsQREAAER
Y137-p	RMRRGLLyDssEEDE
S139-p	RRGLLyDssEEDEER
S140-p	RGLLyDssEEDEERP
T158	RRHVERATEDGEEDE
K178	IENLEDLKGHSVREW
K216	SHGHNVFKERISDMC
K216	SHGHNVFKERISDMC
S220	NVFKERISDMCKENR
K224	ERISDMCKENREsLV
S229-p	MCKENREsLVVNYED
S381	QRIRIQESPGKVAAG
Y418	EIELTGIYHNNYDGS
Y422	TGIYHNNYDGSLNTA
K462	ELTDEDVKMITGLSK
K469	KMITGLSKDQQIGEK
K476	KDQQIGEKIFASIAP
K492	IYGHEDIKRGLALAL
T527	LLCGDPGTAKSQFLK
K529	CGDPGTAKSQFLKYI
K538	QFLKYIEKVSSRAIF
K591	CLIDEFDKMNDQDRT
K613	QQSISISKAGIVTSL
K742	LNQMDQDKVARMYSD
S754	YSDLRKESMATGSIP
T757	LRKESMATGSIPITV
T763	ATGSIPITVRHIESM
S769	ITVRHIESMIRMAEA
S801	AIRVMMESFIDTQKF
T857	RFGAQQDTIEIPEKD
K868	PEKDLMDKARQINIH
K896	NKFSRDLKRKLILQQ

	rat
S4	____MAESSESFSAA
S5	___MAESSESFSAAS
S7	_MAESSESFSAASSP
S9	AESSESFSAASSPAP
S12	SESFSAASSPAPQRR
S13	ESFSAASSPAPQRRR
S22-p	APQRRRIsDPLTssP
T26	RRIsDPLTssPGRSS
S27-p	RIsDPLTssPGRSSR
S28-p	IsDPLTssPGRSSRR
S32	LTssPGRSSRRADAL
S33	TssPGRSSRRADALT
A36	PGRSSRRADALTSsP
T40	SRRADALTSsPGRDL
S41	RRADALTSsPGRDLP
S42-p	RADALTSsPGRDLPP
S54	LPPFEDESEGLLGTE
T60	ESEGLLGTEGPVEEE
Y82	GDGMERDYRPIPELD
Y91	PIPELDVYEAEGLAL
T107	DEDVEELTASQREAA
S109	DVEELTASQREAAER
Y138	RMRRGLLYDsDEEDE
S140-p	RRGLLYDsDEEDEER
D141	RGLLYDsDEEDEERP
T159	RRHIERATEDGEEDE
K179	IENLEDLKGHSVREW
K217	SHGHNVFKERISDMC
K217	SHGHNVFKERISDMC
S221	NVFKERISDMCKENR
K225	ERISDMCKENRESLV
S230	MCKENRESLVVNYED
S382	QRIRIQESPGKVAAG
Y419	EIELTGIYHNNYDGS
Y423	TGIYHNNYDGSLNTT
K463	ELTDEDVKMITSLSK
K470	KMITSLSKDQQIGEK
K477	KDQQIGEKIFASIAP
K493	IYGHEDIKRGLALAL
T528	LLCGDPGTAKSQFLK
K530	CGDPGTAKSQFLKYI
K539	QFLKYIEKVSSRAIF
K592	CLIDEFDKMNDQDRT
K614	QQSISISKAGIVTSL
K743	LNQMDQDKVARMYSD
S755	YSDLRKESMATGSIP
T758	LRKESMATGSIPITV
T764	ATGSIPITVRHIESM
S770	ITVRHIESMIRMAEA
S802	AIRVMLESFIDTQKF
T858	RFGAQQDTIEIPEKD
K869	PEKDLMDKARQINIH
K897	NKFSRDLKRKLILQQ

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