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Protein Page:
IFI16 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IFI16 a nuclear protein that may function as a transcriptional repressor. Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. Binds double-stranded DNA and cell cycle regulatory factors including p53 and Rb. Loss of IFI16 activates p53 checkpoint through NBS1-DNAPK pathway. Inhibits cell growth in the Ras/Raf signaling pathway. May be involved in the senescence of prostate epithelial cells. Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast. Four alternatively spliced isoforms have been described. Isoforms-1, -2 and -3 can homo- and hetero-dimerize. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nuclear speck; nucleus; cytosol
Molecular Function: protein binding; double-stranded DNA binding; transcription factor binding
Biological Process: positive regulation of cytokine production; monocyte differentiation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of DNA binding; cellular response to glucose starvation; positive regulation of interleukin-1 beta production; cell proliferation; negative regulation of viral genome replication; negative regulation of innate immune response; positive regulation of interferon type I production; innate immune response; autophagy; regulation of autophagy; positive regulation of transcription from RNA polymerase II promoter; myeloid cell differentiation; hemopoiesis; negative regulation of transcription, DNA-dependent; inflammatory response; activation of innate immune response; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; defense response to virus
Reference #:  Q16666 (UniProtKB)
Alt. Names/Synonyms: Gamma-interferon-inducible protein 16; IF16; Ifi-16; IFI16; IFNGIP1; interferon, gamma-inducible protein 16; interferon-gamma induced protein IFI 16; Interferon-inducible myeloid differentiation transcriptional activator; MGC9466; PYHIN2
Gene Symbols: IFI16
Molecular weight: 88,256 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IFI16

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 K64-u RGDAGLGkLIKIFED
0 3 K83-u EDLAETLkKEkLKVK
0 2 K86-a AETLkKEkLKVKGPA
0 6 S95-p KVKGPALsRKRkkEV
0 3 K99-u PALsRKRkkEVDATs
0 6 K100-u ALsRKRkkEVDATsP
0 15 S106-p kkEVDATsPAPsTsS
0 1 - gap
0 1 S110-p DATsPAPsTsSTVKT
0 1 S112-p TsPAPsTsSTVKTEG
0 3 T123-p KTEGAEAtPGAQkRK
0 11 K128-a EAtPGAQkRKKsTKE
0 2 K128-u EAtPGAQkRKKsTKE
1 0 K131 PGAQkRKKsTKEKAG
1 4 S132-p GAQkRKKsTKEKAGP
0 2 S142-p EKAGPKGsKVSEEQT
0 29 S153-p EEQTQPPsPAGAGMS
0 3 T161-p PAGAGMStAMGRsPs
0 9 S166-p MStAMGRsPsPKTSL
0 5 S168-p tAMGRsPsPKTSLSA
0 3 T194-p TVAKCQVtPRRNVLQ
0 1 K214-a VKVLSTTkPFEYETP
0 3 K250-u KVLNTSLkEKFNGKK
0 14 T435-p TPQMPPTtPSSSFFT
0 4 S480-p TSIGPAEsHPHtPQM
0 4 T484-p PAEsHPHtPQMPPst
0 2 S490-p HtPQMPPstPSSSFL
0 2 T491-p tPQMPPstPSSSFLT
0 3 S536-p TSIGPAEsHPHtPQM
0 8 T540-p PAEsHPHtPQMPPsT
0 6 S546-p HtPQMPPsTPSSSFL
0 6 K561-u TTLKPRLktEPEEVS
0 1 K561-s TTLKPRLktEPEEVS
0 7 T562-p TLKPRLktEPEEVSI
0 1 S575-p SIEDSAQsDLKEVMV
0 3 K614-u ENEVFRVkVFNIDLk
0 3 K621-u kVFNIDLkEKFTPKK
0 4 S670-p KGLIRSAsVTPkINQ
0 4 K674-u RSAsVTPkINQLCSQ
0 2 K695-u NGVFEVHkKNVRGEF
0 17 K743-u TCFELAPkSGNTGEL
0 3 S775-p KDILNPDssMETsPD
0 3 S776-p DILNPDssMETsPDF
0 15 S780-p PDssMETsPDFFF__
  mouse

 
K64 PADSGLGKLIEFCEE
K83 RKRAEILKKERSEVT
R86 AEILKKERSEVTGET
S94-p SEVTGETsLEKNGQE
- gap
- gap
T106-p GQEAGPAtPtStTsH
T108-p EAGPAtPtStTsHML
T110-p GPAtPtStTsHMLAS
S112-p AtPtStTsHMLASER
T171 TSTAQEGTSTAQkRK
K176-a EGTSTAQkRKsMREE
K176 EGTSTAQKRKsMREE
S179-p STAQkRKsMREEETG
M180 TAQkRKsMREEETGV
S190 EETGVKKSKAAKEPD
C201 KEPDQPPCCEEPTAM
T206 PPCCEEPTAMCQsPI
S211-p EPTAMCQsPILHSSS
I213 TAMCQsPILHSSSSA
I239 SQPQNQNIPRGAVLH
D259 VMVLTATDPFEYESP
K295 KVFNINLKEKFTKKN
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K490 ETEFFRVKVFDTALK
K497 KVFDTALKSKFIPRN
N546 NTLRQRANATPKISY
K550 QRANATPKISYLFSQ
K571 SGEYLVNKKTERNKF
- gap
- gap
- gap
- gap
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