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Protein Page:
HSP90B (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HSP90B Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Cellular Component: signalosome; mitochondrion; basolateral plasma membrane; brush border membrane; cytoplasm; apical plasma membrane; melanosome; cytosol
Molecular Function: protein binding; GTP binding; TPR domain binding; nitric-oxide synthase regulator activity; unfolded protein binding; dATP binding; ATP binding
Biological Process: axon guidance; positive regulation of nitric oxide biosynthetic process; protein folding; innate immune response; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to unfolded protein; response to salt stress; placenta development
Reference #:  P08238 (UniProtKB)
Alt. Names/Synonyms: D6S182; FLJ26984; Heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein beta; Heat shock protein HSP 90-beta; HS90B; HSP 84; HSP 90; HSP84; HSP90-BETA; HSP90AB1; HSP90B; HSPC2; HSPCB
Gene Symbols: HSP90AB1
Molecular weight: 83,264 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSP90B
Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S226‑p, S255‑p
activation: S226‑p, S255‑p
molecular association, regulation: S226‑p, S255‑p, Y301‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 21 Y33-p SLIINTFySNkEIFL
0 3 K36-u INTFySNkEIFLREL
0 3 S45-p IFLRELIsNAsDALD
0 2 S48-p RELIsNAsDALDkIR
0 14 K53-u NAsDALDkIRyEsLT
0 39 Y56-p DALDkIRyEsLTDPS
0 11 S58-p LDkIRyEsLTDPSkL
0 51 K64-u EsLTDPSkLDSGkEL
0 3 K69-a PSkLDSGkELkIDII
0 100 K69-u PSkLDSGkELkIDII
0 8 K72-u LDSGkELkIDIIPNP
1 2 T89-p RTLTLVDtGIGMtkA
0 2 T94-p VDtGIGMtkADLINN
0 4 K95-u DtGIGMtkADLINNL
1 85 K107-u NNLGTIAkSGTkAFM
0 13 K111-u TIAkSGTkAFMEALQ
0 1 S124-p LQAGADIsMIGQFGV
0 11 K148-u EKVVVITkHNDDEQY
0 49 K180-u EPIGRGTkVILHLkE
0 75 K186-u TkVILHLkEDQTEyL
0 3 K186-a TkVILHLkEDQTEyL
0 171 Y192-p LkEDQTEyLEERRVK
1 18 K204-u RVKEVVKkHSQFIGY
0 1 T214-p QFIGYPItLyLEkER
0 1 Y216-p IGYPItLyLEkEREK
0 1 K219-a PItLyLEkEREKEIs
1 7 K219-u PItLyLEkEREKEIs
3 111 S226-p kEREKEIsDDEAEEE
0 2 K237-u AEEEKGEkEEEDKDD
4 425 S255-p PKIEDVGsDEEDDsG
0 35 S261-p GsDEEDDsGKDKKKK
0 2 K273-u KKKTKKIkEkyIDQE
0 13 K275-a KTKKIkEkyIDQEEL
1 23 K275-u KTKKIkEkyIDQEEL
0 92 Y276-p TKKIkEkyIDQEELN
0 3 K284-a IDQEELNkTkPIWTR
1 36 K284-u IDQEELNkTkPIWTR
0 3 K286-u QEELNkTkPIWTRNP
0 2 T297-p TRNPDDItQEEyGEF
1 6 Y301-p DDItQEEyGEFyksL
0 5 Y305-p QEEyGEFyksLTNDW
0 2 K306-a EEyGEFyksLTNDWE
0 24 K306-u EEyGEFyksLTNDWE
0 12 S307-p EyGEFyksLTNDWED
0 2 K319-a WEDHLAVkHFSVEGQ
0 14 K319-u WEDHLAVkHFSVEGQ
0 1 K347-m1 PFDLFENkkKkNNIk
0 3 K347-a PFDLFENkkKkNNIk
1 8 K347-u PFDLFENkkKkNNIk
0 4 K348-u FDLFENkkKkNNIkL
0 1 K348-a FDLFENkkKkNNIkL
0 1 K350-u LFENkkKkNNIkLYV
0 29 K354-u kkKkNNIkLYVRRVF
0 1 S365-p RRVFIMDsCDELIPE
0 4 S391-p EDLPLNIsREMLQQs
0 3 S398-p sREMLQQskILKVIR
1 64 K399-u REMLQQskILKVIRK
0 7 K411-u IRKNIVKkCLELFSE
0 14 K423-a FSELAEDkENYkkFY
0 40 K427-a AEDkENYkkFYEAFS
0 40 K428-a EDkENYkkFYEAFSk
0 8 K428-u EDkENYkkFYEAFSk
0 1 S434 kkFYEAFSkNLkLGI
0 6 K435-a kFYEAFSkNLkLGIH
0 7 K435-u kFYEAFSkNLkLGIH
0 10 K438-u EAFSkNLkLGIHEDs
0 1 S445-p kLGIHEDstNRRRLs
0 5 T446-p LGIHEDstNRRRLsE
0 1 S452 stNRRRLSELLRYHt
1 13 S452-p stNRRRLsELLRYHt
0 2 T459-p sELLRYHtsQSGDEM
0 1 S460-p ELLRYHtsQSGDEMT
0 1 K477-a SEYVSRMkETQksIy
1 2 K477-u SEYVSRMkETQksIy
0 1 K481-a SRMkETQksIyyITG
1 26 K481-u SRMkETQksIyyITG
0 5 S482-p RMkETQksIyyITGE
0 803 Y484-p kETQksIyyITGESk
0 24 Y485-p ETQksIyyITGESkE
0 4 K491-a yyITGESkEQVANSA
0 31 K491-u yyITGESkEQVANSA
0 1 Y512-p KRGFEVVyMTEPIDE
0 1 T514 GFEVVyMTEPIDEyC
0 9 Y520-p MTEPIDEyCVQQLkE
0 3 K526-a EyCVQQLkEFDGksL
0 1 K526-u EyCVQQLkEFDGksL
0 1 K531-a QLkEFDGksLVSVtk
0 7 K531-u QLkEFDGksLVSVtk
0 6 S532-p LkEFDGksLVSVtkE
0 1 T537-p GksLVSVtkEGLELP
0 1 K538-a ksLVSVtkEGLELPE
1 17 K538-u ksLVSVtkEGLELPE
1 1 K550-u LPEDEEEkkKMEESK
0 1 K551-u PEDEEEkkKMEESKA
0 10 K559-a KMEESKAkFENLCkL
0 43 K559-u KMEESKAkFENLCkL
0 2 K565-u AkFENLCkLMkEILD
0 13 K568-a ENLCkLMkEILDKkV
0 3 K568-u ENLCkLMkEILDKkV
0 1 K574-u MkEILDKkVEkVtIS
0 54 K577-u ILDKkVEkVtISNRL
0 1 T579-p DKkVEkVtISNRLVS
0 1 S586 tISNRLVSsPCCIVT
0 1 S587-p ISNRLVSsPCCIVTs
0 4 S594-p sPCCIVTstyGWtAN
0 12 T595-p PCCIVTstyGWtANM
0 590 Y596-p CCIVTstyGWtANME
0 3 T599-p VTstyGWtANMERIM
0 1 K607-a ANMERIMkAQALRDN
0 15 K607-m1 ANMERIMkAQALRDN
1 49 K607-u ANMERIMkAQALRDN
0 5 S615-p AQALRDNstMGyMMA
0 3 T616-p QALRDNstMGyMMAk
0 141 Y619-p RDNstMGyMMAkkHL
0 4 K623-a tMGyMMAkkHLEINP
1 13 K623-u tMGyMMAkkHLEINP
0 1 K624-a MGyMMAkkHLEINPD
0 26 K624-u MGyMMAkkHLEINPD
0 3 T637-p PDHPIVEtLRQKAEA
0 1 K685-u NRIYRMIkLGLGIDE
1 1 S718-p LEGDEDAsRMEEVD_
  mouse

 
Y33-p SLIINTFySNKEIFL
K36 INTFySNKEIFLREL
S45-p IFLRELIsNAsDALD
S48-p RELIsNAsDALDkIR
K53-u NAsDALDkIRyEsLT
Y56-p DALDkIRyEsLTDPS
S58-p LDkIRyEsLTDPSkL
K64-u EsLTDPSkLDSGkEL
K69 PSkLDSGKELkIDII
K69-u PSkLDSGkELkIDII
K72-u LDSGkELkIDIIPNP
T89 RTLTLVDTGIGMtkA
T94-p VDTGIGMtkADLINN
K95-u DTGIGMtkADLINNL
K107-u NNLGTIAkSGTkAFM
K111-u TIAkSGTkAFMEALQ
S124 LQAGADISMIGQFGV
K148 EKVVVITKHNDDEQY
K180-u EPIGRGTkVILHLkE
K186-u TkVILHLkEDQTEyL
K186 TkVILHLKEDQTEyL
Y192-p LkEDQTEyLEERRVK
K204-u RVKEVVKkHSQFIGY
T214 QFIGYPITLYLEkER
Y216 IGYPITLYLEkEREK
K219 PITLYLEKEREKEIs
K219-u PITLYLEkEREKEIs
S226-p kEREKEIsDDEAEEE
K237-u AEEEKGEkEEEDKED
S255-p PKIEDVGsDEEDDsG
S261-p GsDEEDDsGKDKKKK
K273 KKKTKKIKEkyIDQE
K275 KTKKIKEKyIDQEEL
K275-u KTKKIKEkyIDQEEL
Y276-p TKKIKEkyIDQEELN
K284 IDQEELNKTkPIWTR
K284-u IDQEELNkTkPIWTR
K286-u QEELNkTkPIWTRNP
T297 TRNPDDITQEEYGEF
Y301 DDITQEEYGEFyksL
Y305-p QEEYGEFyksLTNDW
K306 EEYGEFyKsLTNDWE
K306-u EEYGEFyksLTNDWE
S307-p EYGEFyksLTNDWED
K319 WEDHLAVKHFSVEGQ
K319 WEDHLAVKHFSVEGQ
K347 PFDLFENKkKKNNIk
K347-a PFDLFENkkKKNNIk
K347-u PFDLFENkkKKNNIk
K348-u FDLFENkkKKNNIkL
K348 FDLFENkKKKNNIkL
K350 LFENkkKKNNIkLYV
K354-u kkKKNNIkLYVRRVF
S365 RRVFIMDSCDELIPE
S391-p EDLPLNIsREMLQQs
S398-p sREMLQQskILKVIR
K399-u REMLQQskILKVIRK
K411-u IRKNIVKkCLELFSE
K423-a FSELAEDkENYkkFY
K427-a AEDkENYkkFYEAFs
K428-a EDkENYkkFYEAFsk
K428-u EDkENYkkFYEAFsk
S434-g kkFYEAFskNLkLGI
K435 kFYEAFsKNLkLGIH
K435-u kFYEAFskNLkLGIH
K438-u EAFskNLkLGIHEDs
S445-p kLGIHEDstNRRRLs
T446-p LGIHEDstNRRRLsE
S452-g stNRRRLsELLRYHt
S452-p stNRRRLsELLRYHt
T459-p sELLRYHtSQSGDEM
S460 ELLRYHtSQSGDEMT
K477 SEYVSRMKETQksIy
K477 SEYVSRMKETQksIy
K481 SRMKETQKsIyyITG
K481-u SRMKETQksIyyITG
S482-p RMKETQksIyyITGE
Y484-p KETQksIyyITGESk
Y485-p ETQksIyyITGESkE
K491 yyITGESKEQVANSA
K491-u yyITGESkEQVANSA
Y512 KRGFEVVYMtEPIDE
T514-p GFEVVYMtEPIDEyC
Y520-p MtEPIDEyCVQQLKE
K526 EyCVQQLKEFDGksL
K526 EyCVQQLKEFDGksL
K531 QLKEFDGKsLVSVTk
K531-u QLKEFDGksLVSVTk
S532-p LKEFDGksLVSVTkE
T537 GksLVSVTkEGLELP
K538 ksLVSVTKEGLELPE
K538-u ksLVSVTkEGLELPE
K550 LPEDEEEKKKMEESK
K551 PEDEEEKKKMEESKA
K559 KMEESKAKFENLCkL
K559-u KMEESKAkFENLCkL
K565-u AkFENLCkLMKEILD
K568 ENLCkLMKEILDKKV
K568 ENLCkLMKEILDKKV
K574 MKEILDKKVEKVTIS
K577 ILDKKVEKVTISNRL
T579 DKKVEKVTISNRLVs
S586-p TISNRLVsSPCCIVT
S587 ISNRLVsSPCCIVTS
S594 SPCCIVTSTyGWTAN
T595 PCCIVTSTyGWTANM
Y596-p CCIVTSTyGWTANME
T599 VTSTyGWTANMERIM
K607 ANMERIMKAQALRDN
K607-m1 ANMERIMkAQALRDN
K607-u ANMERIMkAQALRDN
S615 AQALRDNSTMGyMMA
T616 QALRDNSTMGyMMAk
Y619-p RDNSTMGyMMAkkHL
K623 TMGyMMAKkHLEINP
K623-u TMGyMMAkkHLEINP
K624 MGyMMAkKHLEINPD
K624-u MGyMMAkkHLEINPD
T637 PDHPIVETLRQKAEA
K685 NRIYRMIKLGLGIDE
S718 LEGDEDASRMEEVD_
  rat

 
Y33 SLIINTFYSNKEIFL
K36 INTFYSNKEIFLREL
S45 IFLRELISNASDALD
S48 RELISNASDALDKIR
K53 NASDALDKIRYESLT
Y56 DALDKIRYESLTDPS
S58 LDKIRYESLTDPSKL
K64 ESLTDPSKLDSGKEL
K69 PSKLDSGKELKIDII
K69 PSKLDSGKELKIDII
K72 LDSGKELKIDIIPNP
T89 RTLTLVDTGIGMTKA
T94 VDTGIGMTKADLINN
K95 DTGIGMTKADLINNL
K107-u NNLGTIAkSGTKAFM
K111 TIAkSGTKAFMEALQ
S124 LQAGADISMIGQFGV
K148 EKVVVITKHNDDEQY
K180 EPIGRGTKVILHLKE
K186 TKVILHLKEDQTEyL
K186 TKVILHLKEDQTEyL
Y192-p LKEDQTEyLEERRVK
K204 RVKEVVKKHSQFIGY
T214 QFIGYPITLYLEKER
Y216 IGYPITLYLEKEREK
K219 PITLYLEKEREKEIs
K219 PITLYLEKEREKEIs
S226-p KEREKEIsDDEAEEE
K237 AEEEKGEKEEEDKED
S255-p PKIEDVGsDEEDDsG
S261-p GsDEEDDsGKDKKKK
K273 KKKTKKIKEKYIDQE
K275 KTKKIKEKYIDQEEL
K275 KTKKIKEKYIDQEEL
Y276 TKKIKEKYIDQEELN
K284 IDQEELNKTKPIWTR
K284 IDQEELNKTKPIWTR
K286 QEELNKTKPIWTRNP
T297 TRNPDDITQEEYGEF
Y301 DDITQEEYGEFYKSL
Y305 QEEYGEFYKSLTNDW
K306 EEYGEFYKSLTNDWE
K306 EEYGEFYKSLTNDWE
S307 EYGEFYKSLTNDWED
K319 WEDHLAVKHFSVEGQ
K319 WEDHLAVKHFSVEGQ
K347 PFDLFENKKKKNNIK
K347 PFDLFENKKKKNNIK
K347 PFDLFENKKKKNNIK
K348 FDLFENKKKKNNIKL
K348 FDLFENKKKKNNIKL
K350 LFENKKKKNNIKLYV
K354 KKKKNNIKLYVRRVF
S365 RRVFIMDSCDELIPE
S391 EDLPLNISREMLQQS
S398 SREMLQQSKILKVIR
K399 REMLQQSKILKVIRK
K411 IRKNIVKKCLELFSE
K423 FSELAEDKENYKKFY
K427 AEDKENYKKFYEAFS
K428 EDKENYKKFYEAFSK
K428 EDKENYKKFYEAFSK
S434 KKFYEAFSKNLKLGI
K435 KFYEAFSKNLKLGIH
K435 KFYEAFSKNLKLGIH
K438 EAFSKNLKLGIHEDS
S445 KLGIHEDSTNRRRLs
T446 LGIHEDSTNRRRLsE
S452 STNRRRLSELLRYHT
S452-p STNRRRLsELLRYHT
T459 sELLRYHTSQSGDEM
S460 ELLRYHTSQSGDEMT
K477 SEYVSRMKETQKSIY
K477 SEYVSRMKETQKSIY
K481 SRMKETQKSIYYITG
K481 SRMKETQKSIYYITG
S482 RMKETQKSIYYITGE
Y484 KETQKSIYYITGESK
Y485 ETQKSIYYITGESKE
K491 YYITGESKEQVANSA
K491 YYITGESKEQVANSA
Y512 KRGFEVVYMTEPIDE
T514 GFEVVYMTEPIDEYC
Y520 MTEPIDEYCVQQLKE
K526 EYCVQQLKEFDGKSL
K526 EYCVQQLKEFDGKSL
K531 QLKEFDGKSLVSVTK
K531 QLKEFDGKSLVSVTK
S532 LKEFDGKSLVSVTKE
T537 GKSLVSVTKEGLELP
K538 KSLVSVTKEGLELPE
K538 KSLVSVTKEGLELPE
K550 LPEDEEEKKKMEESK
K551 PEDEEEKKKMEESKA
K559 KMEESKAKFENLCKL
K559 KMEESKAKFENLCKL
K565 AKFENLCKLMKEILD
K568 ENLCKLMKEILDKKV
K568 ENLCKLMKEILDKKV
K574 MKEILDKKVEKVTIS
K577 ILDKKVEKVTISNRL
T579 DKKVEKVTISNRLVS
S586 TISNRLVSSPCCIVT
S587 ISNRLVSSPCCIVTS
S594 SPCCIVTSTyGWTAN
T595 PCCIVTSTyGWTANM
Y596-p CCIVTSTyGWTANME
T599 VTSTyGWTANMERIM
K607 ANMERIMKAQALRDN
K607 ANMERIMKAQALRDN
K607 ANMERIMKAQALRDN
S615 AQALRDNSTMGyMMA
T616 QALRDNSTMGyMMAK
Y619-p RDNSTMGyMMAKKHL
K623 TMGyMMAKKHLEINP
K623 TMGyMMAKKHLEINP
K624 MGyMMAKKHLEINPD
K624 MGyMMAKKHLEINPD
T637 PDHPIVETLRQKAEA
K685 NRIYRMIKLGLGIDE
S718 LEGDEDASRMEEVD_
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