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Protein Page:
FOXM1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXM1 a transcriptional activator factor. Contains 1 fork-head domain. May play a role in the control of cell proliferation. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Phosphorylated in M (mitotic) phase. Three splice variant isoforms have been described. Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; regulation of Ras protein signal transduction; regulation of cell cycle; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cell cycle; negative regulation of stress-activated MAPK cascade; liver development; DNA repair; regulation of cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; mitotic cell cycle; vasculogenesis; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent
Reference #:  Q08050 (UniProtKB)
Alt. Names/Synonyms: FKHL16; forkhead box M1; Forkhead box protein M1; Forkhead, drosophila, homolog-like 16; forkhead-like 16; Forkhead-related protein FKHL16; FOXM1; FOXM1B; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HFH11; HNF-3; HNF-3/fork-head homolog 11; INS-1; M-phase phosphoprotein 2; MPHOSPH2; MPM-2 reactive phosphoprotein 2; MPP-2; MPP2; PIG29; TGT3; Transcription factor Trident; TRIDENT; WIN; Winged-helix factor from INS-1 cells
Gene Symbols: FOXM1
Molecular weight: 84,283 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXM1

Protein Structure Not Found.


STRING  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB


Sites Implicated In
transcription, induced: T600‑p, T611‑p, T620‑p, T627‑p, S638‑p, S672‑p, S704‑p
protein stabilization: T600‑p, T611‑p, T620‑p, T627‑p, S638‑p, S672‑p, S704‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 1 S4-p ____MKTsPRRPLIL
1 2 S35-p SEEEPKRsPAQQESN
1 2 S191-p IQWLRKMsSDGLGSR
1 0 K201-sm GLGSRSIkQEMEEKE
1 0 K218-sm HLEQRQVkVEEPSRP
1 1 S251 MIQFAINSTERKRMT
1 1 T252 IQFAINSTERKRMTL
0 1 Y272 WIEDHFPYFKHIAkP
0 1 K278-m2 PYFKHIAkPGWkNSI
0 1 K282-m2 HIAkPGWkNSIRHNL
1 1 S306 TSANGKVSFWTIHPS
1 3 S331-p FKPLDPGsPQLPEHL
1 0 K356-sm LRRNMTIkTELPLGA
1 0 S376 PLLPRVSSYLVPIQF
1 0 K440-sm LSSAGPGkEEKLLFG
1 2 S451-p LLFGEGFsPLLPVQT
1 0 K460-sm LLPVQTIkEEEIQPG
1 0 K478-sm PHLARPIkVESPPLE
1 1 S489-p PPLEEWPsPAPSFkE
1 0 K495-p PsPAPSFkEESSHsW
0 1 S501-p FkEESSHsWEDSSQs
1 1 S508-p sWEDSSQsPtPRPKK
1 1 T510-p EDSSQsPtPRPKKSy
0 1 Y517-p tPRPKKSySGLRsPT
1 3 S522-p KSySGLRsPTRCVSE
1 1 S581 ELPFPADSSDPASQL
1 1 S582 LPFPADSSDPASQLS
2 3 T600-p EVGGPFKtPIKETLP
4 5 T611-p ETLPISStPSKSVLP
2 18 T620-p SKSVLPRtPEsWRLt
0 1 S623-p VLPRtPEsWRLtPPA
1 9 T627-p tPEsWRLtPPAKVGG
2 4 S638-p KVGGLDFsPVQTSQG
0 1 S666 LSTTPLQSAPPLEsP
1 2 S672-p QSAPPLEsPQRLLSS
0 1 S692-p ISVPFGNssPSDIDV
0 1 S693-p SVPFGNssPSDIDVP
1 3 S704-p IDVPKPGsPEPQVSG
0 3 S717-p SGLAANRsLTEGLVL
0 3 S730-p VLDTMNDsLSKILLD
0 1 S739-p SKILLDIsFPGLDED
14170 : Phospho-FoxM1 (Ser35) Antibody
  FOXM1 iso2  
S4 ____MKTSPRRPLIL
S35 SEEEPKRSPAQQESN
S191-p IQWLRKMsSDGLGSR
K201 GLGSRSIKQEMEEKE
K218 HLEQRQVKVEEPSRP
S251-p MIQFAINstERKRMT
T252-p IQFAINstERKRMTL
Y272 WIEDHFPYFKHIAKP
K278 PYFKHIAKPGWKNSI
K282 HIAKPGWKNSIRHNL
S306-p TSANGKVsFWTIHPS
- gap
K341 LRRNMTIKTELPLGA
S361-p PLLPRVSsYLVPIQF
K425 LSSAGPGKEEKLLFG
S436 LLFGEGFSPLLPVQT
K445 LLPVQTIKEEEIQPG
K463 PHLARPIKVESPPLE
S474 PPLEEWPSPAPSFKE
K480 PSPAPSFKEESSHSW
S486 FKEESSHSWEDSSQS
S493 SWEDSSQSPTPRPKK
T495 EDSSQSPTPRPKKSY
Y502 TPRPKKSYSGLRSPT
S507 KSYSGLRSPTRCVSE
S566-p ELPFPADssDPASQL
S567-p LPFPADssDPASQLS
T585 EVGGPFKTPIKETLP
T596-p ETLPISStPSKSVLP
T605 SKSVLPRTPESWRLT
S608 VLPRTPESWRLTPPA
T612 TPESWRLTPPAKVGG
S623-p KVGGLDFsPVQTSQG
S651 LSTTPLQSAPPLESP
S657 QSAPPLESPQRLLSS
S677 ISVPFGNSSPSDIDV
S678 SVPFGNSSPSDIDVP
S689 IDVPKPGSPEPQVSG
S702 SGLAANRSLTEGLVL
S715 VLDTMNDSLSKILLD
S724 SKILLDISFPGLDED
  mouse

 
S4 ____MRTSPRRPLIL
S35 SEEEAKRSPAQPEPA
S189 IQWLGKMSSDGLGPC
K199 GLGPCSVKQELEEKE
K216 HLEQNRVKVEEPSGV
S249 MIQFAINSTERKRMT
T250 IQFAINSTERKRMTL
Y270-p WIEDHFPyFKHIAKP
K276 PyFKHIAKPGWKNSI
K280 HIAKPGWKNSIRHNL
S304 TSANGKVSFWTIHPS
S329 FKPLEPGSPQSPEHL
K354 LHRNVTIKTEIPLGA
S374 PLLPRVSSYLEPIQF
K438 LPATEPPKEEKPLLG
L450 LLGGEGLLPLLPIQS
K459 LLPIQSIKEEEMQPE
K477 AHLERPIKVESPPLE
S488 PPLEEWPSPCASLKE
K494 PSPCASLKEELSNSW
S500 LKEELSNSWEDSSCS
S507 SWEDSSCSPTPKPKK
T509 EDSSCSPTPKPKKSY
Y516 TPKPKKSYCGLKSPT
S521 KSYCGLKSPTRCVSE
S578 AVELLAESSEPAPHL
S579 VELLAESSEPAPHLS
T597 EEGGPFKTPIKETLP
T608 ETLPVSSTPSKSVLS
D617 SKSVLSRDPESWRLT
S620 VLSRDPESWRLTPPA
T624 DPESWRLTPPAKVGG
S635-p KVGGLDFsPVRTPQG
S663-p LNTTPLKsGPLFDsP
S669-p KsGPLFDsPRELLNS
P689 ASDPFGSPPPPHVEG
P690 SDPFGSPPPPHVEGP
S701 VEGPKPGSPELQIPS
S714-p PSLSANRsLTEGLVL
S727-p VLDTMNDsLSKILLD
S736 SKILLDISFPGLEED
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