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FOXM1 (human)

Overview FOXM1 a transcriptional activator factor. Contains 1 fork-head domain. May play a role in the control of cell proliferation. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Phosphorylated in M (mitotic) phase. Three splice variant isoforms have been described. Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: transcription factor complex; cytoplasm; nucleolus; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; protein domain specific binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; DNA bending activity; transcription factor binding; protein kinase binding; transcription factor activity Biological Process: regulation of Ras protein signal transduction; transcription from RNA polymerase II promoter; tissue development; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cell cycle; liver development; DNA repair; negative regulation of stress-activated MAPK cascade; pattern specification process; regulation of cell proliferation; embryonic development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription factor activity; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; vasculogenesis; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent Reference #:  Q08050 (UniProtKB) Alt. Names/Synonyms: FKHL16; forkhead box M1; Forkhead box protein M1; Forkhead, drosophila, homolog-like 16; forkhead-like 16; Forkhead-related protein FKHL16; FOXM1; FOXM1B; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HFH11; HNF-3; HNF-3/fork-head homolog 11; INS-1; M-phase phosphoprotein 2; MPHOSPH2; MPM-2 reactive phosphoprotein 2; MPP-2; MPP2; PIG29; TGT3; Transcription factor Trident; TRIDENT; WIN; Winged-helix factor from INS-1 cells Gene Symbols: FOXM1 Molecular weight: 84,283 Da Basal Isoelectric point: 8  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXM1 3G73 - A/B=222-360 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
1	0		S4-p	____MKTsPRRPLIL
1	1		S35-p	SEEEPKRsPAQQESN
1	2		S191-p	IQWLRKMsSDGLGSR
1	1		S251	MIQFAINSTERKRMT
1	1		T252	IQFAINSTERKRMTL
0	1		Y272	WIEDHFPYFKHIAKP
1	1		S306	TSANGKVSFWTIHPS
1	1		S331-p	FKPLDPGsPQLPEHL
1	0		S376	PLLPRVSSYLVPIQF
1	1		S451-p	LLFGEGFsPLLPVQT
1	0		S489-p	PPLEEWPsPAPSFKE
0	1		S501-p	FKEESSHsWEDSSQs
1	0		S508-p	sWEDSSQsPtPRPKK
1	0		T510-p	EDSSQsPtPRPKKSY
1	0		S522-p	KSYSGLRsPTRCVSE
1	1		S581	ELPFPADSSDPASQL
1	1		S582	LPFPADSSDPASQLS
2	2		T600-p	EVGGPFKtPIKETLP
4	4		T611-p	ETLPISStPSKSVLP
2	15		T620-p	SKSVLPRtPESWRLt
1	6		T627-p	tPESWRLtPPAKVGG
2	2		S638-p	KVGGLDFsPVQTSQG
0	1		S666	LSTTPLQSAPPLEsP
1	1		S672-p	QSAPPLEsPQRLLSS
0	1		S692-p	ISVPFGNssPSDIDV
0	1		S693-p	SVPFGNssPSDIDVP
1	2		S704-p	IDVPKPGsPEPQVSG
0	3		S717-p	SGLAANRsLTEGLVL
0	2		S730-p	VLDTMNDsLSKILLD
0	1		S739-p	SKILLDIsFPGLDED

	FOXM1 iso2
S4	____MKTSPRRPLIL
S35	SEEEPKRSPAQQESN
S191-p	IQWLRKMsSDGLGSR
S251-p	MIQFAINstERKRMT
T252-p	IQFAINstERKRMTL
Y272	WIEDHFPYFKHIAKP
S306-p	TSANGKVsFWTIHPS
-	gap
S361-p	PLLPRVSsYLVPIQF
S436	LLFGEGFSPLLPVQT
S474	PPLEEWPSPAPSFKE
S486	FKEESSHSWEDSSQS
S493	SWEDSSQSPTPRPKK
T495	EDSSQSPTPRPKKSY
S507	KSYSGLRSPTRCVSE
S566-p	ELPFPADssDPASQL
S567-p	LPFPADssDPASQLS
T585	EVGGPFKTPIKETLP
T596-p	ETLPISStPSKSVLP
T605	SKSVLPRTPESWRLT
T612	TPESWRLTPPAKVGG
S623-p	KVGGLDFsPVQTSQG
S651	LSTTPLQSAPPLESP
S657	QSAPPLESPQRLLSS
S677	ISVPFGNSSPSDIDV
S678	SVPFGNSSPSDIDVP
S689	IDVPKPGSPEPQVSG
S702	SGLAANRSLTEGLVL
S715	VLDTMNDSLSKILLD
S724	SKILLDISFPGLDED

	mouse
S4	____MRTSPRRPLIL
S35	SEEEAKRSPAQPEPA
S189	IQWLGKMSSDGLGPC
S249	MIQFAINSTERKRMT
T250	IQFAINSTERKRMTL
Y270-p	WIEDHFPyFKHIAKP
S304	TSANGKVSFWTIHPS
S329	FKPLEPGSPQSPEHL
S374	PLLPRVSSYLEPIQF
L450	LLGGEGLLPLLPIQS
S488	PPLEEWPSPCASLKE
S500	LKEELSNSWEDSSCS
S507	SWEDSSCSPTPKPKK
T509	EDSSCSPTPKPKKSY
S521	KSYCGLKSPTRCVSE
S578	AVELLAESSEPAPHL
S579	VELLAESSEPAPHLS
T597	EEGGPFKTPIKETLP
T608	ETLPVSSTPSKSVLS
D617	SKSVLSRDPESWRLT
T624	DPESWRLTPPAKVGG
S635-p	KVGGLDFsPVRTPQG
S663-p	LNTTPLKsGPLFDsP
S669-p	KsGPLFDsPRELLNS
P689	ASDPFGSPPPPHVEG
P690	SDPFGSPPPPHVEGP
S701	VEGPKPGSPELQIPS
S714-p	PSLSANRsLTEGLVL
S727-p	VLDTMNDsLSKILLD
S736	SKILLDISFPGLEED

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