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Protein Page:
DAB2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DAB2 an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: apical plasma membrane; clathrin coated vesicle membrane; coated pit; nucleus
Molecular Function: protein C-terminus binding; protein binding; SMAD binding
Biological Process: pinocytosis; receptor-mediated endocytosis; cellular morphogenesis during differentiation; Wnt receptor signaling pathway; apoptosis; in utero embryonic development; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of endocytosis; excretion; cell proliferation; protein transport; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein amino acid phosphorylation; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; negative regulation of protein binding; negative regulation of apoptosis
Reference #:  P98082 (UniProtKB)
Alt. Names/Synonyms: DAB2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); DOC-2; DOC2; FLJ26626; mitogen-responsive phosphoprotein
Gene Symbols: DAB2
Molecular weight: 82,448 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DAB2
Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S24‑p
intracellular localization: S24‑p
molecular association, regulation: S24‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
4 0 S24-p QAAPKAPsKKEKKKG
0 1 K53 DGVKYKAKLIGIDDV
0 1 R64-m1 IDDVPDArGDkMSQD
0 1 K67-a VPDArGDkMSQDSMM
0 1 K67 VPDArGDKMSQDSMM
0 1 S69 DArGDkMSQDSMMKL
0 1 S72 GDkMSQDSMMKLKGM
0 1 S98-p QRIWVNIsLsGIKII
0 1 S100-p IWVNIsLsGIKIIDE
0 1 T151-p HQFFAIKtGQQAEPL
0 1 K163-m1 EPLVVDLkDLFQVIy
0 1 K163 EPLVVDLKDLFQVIy
0 3 Y170-p kDLFQVIyNVkKKEE
0 1 K173-m1 FQVIyNVkKKEEEKK
0 1 K173 FQVIyNVKKKEEEKK
0 1 S193 SKAVENGSEALMILD
0 1 K205 ILDDQTNKLKSGVDQ
0 1 K207 DDQTNKLKSGVDQMD
1 9 T221-p DLFGDMStPPDLNsP
1 3 S227-p StPPDLNsPTESKDI
0 2 S316-p SSFDSLKsPDQKKEN
0 2 N323 sPDQKKENsSsSStP
0 1 S324-p PDQKKENsSsSStPL
0 1 S326-p QKKENsSsSStPLSN
0 5 T329-p ENsSsSStPLSNGPL
0 1 V340 NGPLNGDVDyFGQQF
0 18 Y342-p PLNGDVDyFGQQFDQ
0 1 K356 QISNRTGKQEAQAGP
1 1 S393-p QNGFSVKssPNPFVG
1 2 S394-p NGFSVKssPNPFVGs
1 12 S401-p sPNPFVGsPPKGLSI
1 1 S423-p LESSVQSsPHDSIAI
0 1 T437-p IIPPPQStkPGRGRR
0 1 K438-u IPPPQStkPGRGRRT
0 1 R441 PQStkPGRGRRTAKS
0 1 K630 PPRAGPPKDISSDAF
0 1 K649 PLGDKEIKDVKEMFK
0 1 K652 DKEIKDVKEMFKDFQ
0 1 K656 KDVKEMFKDFQLRQP
0 1 K670 PPAVPARKGEQTSSG
0 3 Q673 VPARKGEQTSSGTLS
0 5 Y685-p TLSAFASyFNSKVGI
0 1 S723-p KPAPRQVsLPVTkSt
0 1 K728-u QVsLPVTkStDNAFE
0 6 S729 VsLPVTkStDNAFEN
0 1 T730-p sLPVTkStDNAFENP
0 2 A733 VTkStDNAFENPFFK
0 1 K740 AFENPFFKDSFGSSQ
0 4 Y761-p QPVSSEMyRDPFGNP
0 4 D763 VSSEMyRDPFGNPFA
  mouse

 
S24-p QAAPKAPsKKEKKKG
K53-u DGVKYKAkLIGIDDV
R64 IDDVPDARGDkMsQD
K67 VPDARGDKMsQDsMM
K67-u VPDARGDkMsQDsMM
S69-p DARGDkMsQDsMMKL
S72-p GDkMsQDsMMKLKGM
S98 QRIWVNISLSGIKII
S100 IWVNISLSGIKIIDE
T151 HQFFAIKTGQQAEPL
K163 EPLVVDLKDLFQVIy
K163-u EPLVVDLkDLFQVIy
Y170-p kDLFQVIyNVkKKEE
K173 FQVIyNVKKKEEDKK
K173-u FQVIyNVkKKEEDKK
S193-p NKAEENGsEALMTLD
K205-u TLDDQANkLkLGVDQ
K207-u DDQANkLkLGVDQMD
T221-p DLFGDMStPPDLNSP
S227 StPPDLNSPTESKDI
S316 SSFDSLTSPDQKKAs
S323-p SPDQKKAsLSSSSTP
L324 PDQKKAsLSSSSTPQ
S326 QKKAsLSSSSTPQSK
T329 AsLSSSSTPQSKGPL
T340-p KGPLNGDtDyFGQQF
Y342-p PLNGDtDyFGQQFDQ
K356-u QLSNRTGkPEAQGGP
S393-p QNGFHIKsSPNPFVG
S394 NGFHIKsSPNPFVGs
S401-p SPNPFVGsPPKGLSV
S423 LESSVQSSAHDSIAI
T437 IIPPPQSTKPGrGRR
K438 IPPPQSTKPGrGRRT
R441-m1 PQSTKPGrGRRTAKS
K628-u PPRNGPLkDIPSDAF
K647-u PLGDKEVkEVkEMFk
K650-u DKEVkEVkEMFkDFQ
K654-u kEVkEMFkDFQLRQP
K668-u PPLVPSRkGEtPPSG
T671-p VPSRkGEtPPSGTSS
Y683-p TSSAFSSyFNNKVGI
V721 KPAPRQGVLLGTKsA
K726 QGVLLGTKsADNsLE
S727-p GVLLGTKsADNsLEN
A728 VLLGTKsADNsLENP
S731-p GTKsADNsLENPFSk
K738-u sLENPFSkGFSSSNP
H757 QPASSDPHRsPFGNP
S759-p ASSDPHRsPFGNPFA
  rat

 
S24-p QAAPKAPsKKEKKKG
K53 DGVKYKAKLIGIDDV
R64 IDDVPDARGDKMSQD
K67 VPDARGDKMSQDSMM
K67 VPDARGDKMSQDSMM
S69 DARGDKMSQDSMMKL
S72 GDKMSQDSMMKLKGM
S98 QRIWVNISLSGIKII
S100 IWVNISLSGIKIIDE
T151 HQFFAIKTGQQAEPL
K163 EPLVVDLKDLFQVIY
K163 EPLVVDLKDLFQVIY
Y170 KDLFQVIYNVKKKEE
K173 FQVIYNVKKKEEEKK
K173 FQVIYNVKKKEEEKK
S193 NKAEENGSEALMTLD
K205 TLDDQANKLKLGVDQ
K207 DDQANKLKLGVDQMD
T221 DLFGDMSTPPDLNNP
N227 STPPDLNNPTESRDI
S316 SSFHSLTSADQKKAN
N323 SADQKKANPGSLSTP
P324 ADQKKANPGSLSTPQ
S326 QKKANPGSLSTPQSK
T329 ANPGSLSTPQSKGPL
T340 KGPLNGDTDYFGQQF
Y342 PLNGDTDYFGQQFDQ
K356 QISNRTGKQEAQGGP
S393 QNGFHIKSSPNPFVG
S394 NGFHIKSSPNPFVGS
S401 SPNPFVGSPPKGLSV
S423 LESSVQSSAHDSIAI
T437 IIPPPQSTKPGRGRR
K438 IPPPQSTKPGRGRRT
R441 PQSTKPGRGRRTAKS
K630 PPRNGPLKDTLSDAF
K649 PLGDKEVKEVKEMFK
K652 DKEVKEVKEMFKDFQ
K656 KEVKEMFKDFQLRQP
K670 PPLVPSRKGETPSSG
T673 VPSRKGETPSSGTSS
Y685 TSSAFSSYFNNKVGI
V723 KPAPRQGVLSGTKsA
K728 QGVLSGTKsADNSLE
S729-p GVLSGTKsADNSLEN
A730 VLSGTKsADNSLENP
S733 GTKsADNSLENPFSK
K740 SLENPFSKGFSSTNP
H759 QPASSDAHRSPFGNP
S761 ASSDAHRSPFGNPFA
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