an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
Molecular Function: integrin binding; protein C-terminus binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SMAD binding
Biological Process: cellular morphogenesis during differentiation; pinocytosis; receptor-mediated endocytosis; Wnt receptor signaling pathway; in utero embryonic development; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of endocytosis; excretion; activation of JNK activity; cell proliferation; clathrin cage assembly; protein transport; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation; negative regulation of transcription, DNA-dependent; negative regulation of protein binding; positive regulation of receptor recycling; positive regulation of cell migration; negative regulation of apoptosis; endoderm development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.