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Protein Page:
DAB2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DAB2 an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; apical plasma membrane; nucleolus; plasma membrane; clathrin coated vesicle membrane; coated pit; clathrin coat of coated pit
Molecular Function: protein C-terminus binding; integrin binding; protein binding; phosphatidylinositol-4,5-bisphosphate binding; SMAD binding
Biological Process: pinocytosis; cellular morphogenesis during differentiation; receptor-mediated endocytosis; Wnt receptor signaling pathway; in utero embryonic development; apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of endocytosis; excretion; activation of JNK activity; clathrin cage assembly; cell proliferation; protein transport; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; positive regulation of receptor recycling; endoderm development; positive regulation of cell migration; negative regulation of apoptosis
Reference #:  P98082 (UniProtKB)
Alt. Names/Synonyms: DAB2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); DOC-2; DOC2; FLJ26626; mitogen-responsive phosphoprotein
Gene Symbols: DAB2
Molecular weight: 82,448 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DAB2

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S24‑p
intracellular localization: S24‑p
molecular association, regulation: S24‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsNEVETSA
4 1 S24-p QAAPKAPsKKEKKKG
0 1 P32 KKEKKKGPEKTDEYL
0 1 T35 KKKGPEKTDEYLLAR
0 1 K53 DGVKYKAKLIGIDDV
0 1 R64-m1 IDDVPDArGDkMSQD
0 1 K67-ac VPDArGDkMSQDSMM
0 1 K67 VPDArGDKMSQDSMM
0 1 S69 DArGDkMSQDSMMKL
0 1 S72 GDkMSQDSMMKLKGM
0 1 S98-p QRIWVNIsLsGIKII
0 1 S100-p IWVNIsLsGIKIIDE
0 1 T151-p HQFFAIKtGQQAEPL
0 1 K163-m1 EPLVVDLkDLFQVIy
0 1 K163 EPLVVDLKDLFQVIy
0 4 Y170-p kDLFQVIyNVkKKEE
0 1 K173-m1 FQVIyNVkKKEEEKK
0 1 K173 FQVIyNVKKKEEEKK
0 1 S193 SKAVENGSEALMILD
0 1 K205 ILDDQTNKLKsGVDQ
0 1 K207 DDQTNKLKsGVDQMD
0 1 S208-p DQTNKLKsGVDQMDL
1 11 T221-p DLFGDMStPPDLNsP
1 6 S227-p StPPDLNsPTEsKDI
0 1 T229 PPDLNsPTEsKDILL
0 2 S231-p DLNsPTEsKDILLVD
0 1 T307-p FTQPDQStPSSFDsL
0 1 S313-p StPSSFDsLKsPDQK
0 3 S316-p SSFDsLKsPDQKKEN
0 3 N323 sPDQKKENsssSstP
0 2 S324-p PDQKKENsssSstPL
0 2 S325-p DQKKENsssSstPLs
0 3 S326-p QKKENsssSstPLsN
0 1 S328-p KENsssSstPLsNGP
0 7 T329-p ENsssSstPLsNGPL
0 1 S332-p ssSstPLsNGPLNGD
0 1 V340 NGPLNGDVDyFGQQF
0 18 Y342-p PLNGDVDyFGQQFDQ
0 1 K356 QISNRTGKQEAQAGP
0 2 S390-p EREQNGFsVKssPNP
1 2 S393-p QNGFsVKssPNPFVG
1 5 S394-p NGFsVKssPNPFVGs
1 19 S401-p sPNPFVGsPPKGLsI
0 1 S407-p GsPPKGLsIQNGVKQ
0 2 S418-p GVKQDLEssVQssPH
0 1 S419-p VKQDLEssVQssPHD
0 1 S422-p DLEssVQssPHDsIA
1 2 S423-p LEssVQssPHDsIAI
0 1 S427-p VQssPHDsIAIIPPP
0 1 S436-p AIIPPPQstkPGRGR
0 2 T437-p IIPPPQstkPGRGRR
0 1 K438-ub IPPPQstkPGRGRRT
0 1 R441 PQstkPGRGRRTAKS
0 1 T473-p PSGQASPtGQPTALQ
0 1 T618 MHSSLLVTPPQPPPR
0 1 K630 PPRAGPPKDISSDAF
0 1 K649 PLGDKEIKDVKEMFK
0 1 K652 DKEIKDVKEMFKDFQ
0 1 K656 KDVKEMFKDFQLRQP
0 1 K670 PPAVPARKGEQTsSG
0 4 Q673 VPARKGEQTsSGTLS
0 1 S675-p ARKGEQTsSGTLSAF
0 1 S676 RKGEQTsSGTLSAFA
0 1 S684-p GTLSAFAsyFNSKVG
0 6 Y685-p TLSAFAsyFNSKVGI
0 3 S723-p KPAPRQVsLPVTkSt
0 1 K728-ub QVsLPVTkStDNAFE
0 7 S729 VsLPVTkStDNAFEN
0 1 T730-p sLPVTkStDNAFENP
0 2 A733 VTkStDNAFENPFFK
0 1 K740 AFENPFFKDSFGSSQ
0 4 Y761-p QPVSSEMyRDPFGNP
0 5 D763 VSSEMyRDPFGNPFA
  mouse

 
S2 ______MSNEVETST
S24-p QAAPKAPsKKEKKKG
S32-p KKEKKKGsEKtDEYL
T35-p KKKGsEKtDEYLLAR
K53-ub DGVKYKAkLIGIDDV
R64 IDDVPDARGDkMsQD
K67 VPDARGDKMsQDsMM
K67-ub VPDARGDkMsQDsMM
S69-p DARGDkMsQDsMMKL
S72-p GDkMsQDsMMKLKGM
S98 QRIWVNISLSGIKII
S100 IWVNISLSGIKIIDE
T151 HQFFAIKTGQQAEPL
K163 EPLVVDLKDLFQVIy
K163-ub EPLVVDLkDLFQVIy
Y170-p kDLFQVIyNVkKKEE
K173 FQVIyNVKKKEEDKK
K173-ub FQVIyNVkKKEEDKK
S193-p NKAEENGsEALMTLD
K205-ub TLDDQANkLkLGVDQ
K207-ub DDQANkLkLGVDQMD
L208 DQANkLkLGVDQMDL
T221-p DLFGDMStPPDLNsP
S227-p StPPDLNsPtEsKDI
T229-p PPDLNsPtEsKDILL
S231-p DLNsPtEsKDILLVD
A307 FAQPDQSAPSSFDSL
S313 SAPSSFDSLTSPDQK
S316 SSFDSLTSPDQKKAs
S323-p SPDQKKAsLssSStP
L324 PDQKKAsLssSStPQ
S325-p DQKKAsLssSStPQS
S326-p QKKAsLssSStPQSK
S328 KAsLssSStPQSKGP
T329-p AsLssSStPQSKGPL
S332 ssSStPQSKGPLNGD
T340-p KGPLNGDtDyFGQQF
Y342-p PLNGDtDyFGQQFDQ
K356-ub QLSNRTGkPEAQGGP
H390 EREQNGFHIKssPNP
S393-p QNGFHIKssPNPFVG
S394-p NGFHIKssPNPFVGs
S401-p sPNPFVGsPPKGLSV
S407 GsPPKGLSVPNGVKQ
S418 GVKQDLESSVQSSAH
S419 VKQDLESSVQSSAHD
S422 DLESSVQSSAHDSIA
S423 LESSVQSSAHDSIAI
S427 VQSSAHDSIAIIPPP
S436 AIIPPPQSTKPGrGR
T437 IIPPPQSTKPGrGRR
K438 IPPPQSTKPGrGRRT
R441-m1 PQSTKPGrGRRTAKS
T470-p PPGQMSPtGQPAVPQ
T616 MMSSVLATPPQPPPR
K628-ub PPRNGPLkDIPSDAF
K647-ub PLGDKEVkEVkEMFk
K650-ub DKEVkEVkEMFkDFQ
K654-ub kEVkEMFkDFQLRQP
K668-ub PPLVPSRkGEtPPsG
T671-p VPSRkGEtPPsGTSS
P673 SRkGEtPPsGTSSAF
S674-p RkGEtPPsGTSSAFS
S682 GTSSAFSSyFNNKVG
Y683-p TSSAFSSyFNNKVGI
V721 KPAPRQGVLLGTKsA
K726 QGVLLGTKsADNsLE
S727-p GVLLGTKsADNsLEN
A728 VLLGTKsADNsLENP
S731-p GTKsADNsLENPFSk
K738-ub sLENPFSkGFSSSNP
H757 QPASSDPHRsPFGNP
S759-p ASSDPHRsPFGNPFA
  rat

 
S2 ______MSNEVETST
S24-p QAAPKAPsKKEKKKG
S32 KKEKKKGSEKTDEYL
T35 KKKGSEKTDEYLLAR
K53 DGVKYKAKLIGIDDV
R64 IDDVPDARGDKMSQD
K67 VPDARGDKMSQDSMM
K67 VPDARGDKMSQDSMM
S69 DARGDKMSQDSMMKL
S72 GDKMSQDSMMKLKGM
S98 QRIWVNISLSGIKII
S100 IWVNISLSGIKIIDE
T151 HQFFAIKTGQQAEPL
K163 EPLVVDLKDLFQVIY
K163 EPLVVDLKDLFQVIY
Y170 KDLFQVIYNVKKKEE
K173 FQVIYNVKKKEEEKK
K173 FQVIYNVKKKEEEKK
S193 NKAEENGSEALMTLD
K205 TLDDQANKLKLGVDQ
K207 DDQANKLKLGVDQMD
L208 DQANKLKLGVDQMDL
T221 DLFGDMSTPPDLNNP
N227 STPPDLNNPTESRDI
T229 PPDLNNPTESRDILL
S231 DLNNPTESRDILLVD
A307 FAQPDQSAPSSFHSL
S313 SAPSSFHSLTSADQK
S316 SSFHSLTSADQKKAN
N323 SADQKKANPGSLSTP
P324 ADQKKANPGSLSTPQ
G325 DQKKANPGSLSTPQS
S326 QKKANPGSLSTPQSK
S328 KANPGSLSTPQSKGP
T329 ANPGSLSTPQSKGPL
S332 GSLSTPQSKGPLNGD
T340 KGPLNGDTDYFGQQF
Y342 PLNGDTDYFGQQFDQ
K356 QISNRTGKQEAQGGP
H390 EKEQNGFHIKSSPNP
S393 QNGFHIKSSPNPFVG
S394 NGFHIKSSPNPFVGs
S401-p SPNPFVGsPPKGLSV
S407 GsPPKGLSVPNGVKQ
S418 GVKQDLESSVQSSAH
S419 VKQDLESSVQSSAHD
S422 DLESSVQSSAHDSIA
S423 LESSVQSSAHDSIAI
S427 VQSSAHDSIAIIPPP
S436 AIIPPPQSTKPGRGR
T437 IIPPPQSTKPGRGRR
K438 IPPPQSTKPGRGRRT
R441 PQSTKPGRGRRTAKS
T470 PPGQMSPTGQPAVPQ
T618-p MMSSVLVtPPQPPPR
K630 PPRNGPLKDTLSDAF
K649 PLGDKEVKEVKEMFK
K652 DKEVKEVKEMFKDFQ
K656 KEVKEMFKDFQLRQP
K670 PPLVPSRKGETPSSG
T673 VPSRKGETPSSGTSS
S675 SRKGETPSSGTSSAF
S676 RKGETPSSGTSSAFS
S684 GTSSAFSSYFNNKVG
Y685 TSSAFSSYFNNKVGI
V723 KPAPRQGVLSGTKsA
K728 QGVLSGTKsADNSLE
S729-p GVLSGTKsADNSLEN
A730 VLSGTKsADNSLENP
S733 GTKsADNSLENPFSK
K740 SLENPFSKGFSSTNP
H759 QPASSDAHRSPFGNP
S761 ASSDAHRSPFGNPFA
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