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Protein Page:
DAB2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DAB2 an adaptor protein that interacts with Grb2, myosin VI, SMAD2/3, DIP1/2, Dvl-3, the integrin betasubunit, and c-Src. Negatively regulates canonical Wnt signaling by stabilizing the beta-catenin degradation complex. A component of the CSF-1 signal transduction pathway. Phosphorylated DAB2 inhibits adhesion and integrin signaling. Two alternatively spliced isoforms are described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; apical plasma membrane; plasma membrane; nucleolus; clathrin coated vesicle membrane; coated pit; clathrin coat of coated pit
Molecular Function: protein C-terminus binding; integrin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; SMAD binding
Biological Process: pinocytosis; cellular morphogenesis during differentiation; Wnt receptor signaling pathway; apoptosis; in utero embryonic development; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of endocytosis; excretion; activation of JNK activity; clathrin cage assembly; cell proliferation; protein transport; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of transcription, DNA-dependent; positive regulation of receptor recycling; endoderm development; positive regulation of cell migration; negative regulation of apoptosis
Reference #:  P98082 (UniProtKB)
Alt. Names/Synonyms: DAB2; Differentially-expressed protein 2; Disabled homolog 2; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); DOC-2; DOC2; FLJ26626; mitogen-responsive phosphoprotein
Gene Symbols: DAB2
Molecular weight: 82,448 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DAB2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
transcription, altered: S24‑p
intracellular localization: S24‑p
molecular association, regulation: S24‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S2-p ______MsNEVETSA
4 1 S24-p QAAPKAPsKKEKKKG
0 1 K53 DGVKYKAKLIGIDDV
0 1 R64-m1 IDDVPDArGDKMSQD
0 1 K67 VPDArGDKMSQDSMM
0 1 T151-p HQFFAIKtGQQAEPL
0 1 K163-m1 EPLVVDLkDLFQVIy
0 4 Y170-p kDLFQVIyNVkKKEE
0 1 K173-m1 FQVIyNVkKKEEEKK
0 1 K173 FQVIyNVKKKEEEKK
0 1 S193 SKAVENGSEALMILD
0 1 K205 ILDDQTNKLKSGVDQ
1 10 T221-p DLFGDMStPPDLNsP
1 3 S227-p StPPDLNsPTESKDI
0 2 S316-p SSFDSLKsPDQKKEN
0 2 N323 sPDQKKENSSSSStP
0 5 T329-p ENSSSSStPLSNGPL
0 1 V340 NGPLNGDVDyFGQQF
0 18 Y342-p PLNGDVDyFGQQFDQ
0 1 S390-p EREQNGFsVKssPNP
1 1 S393-p QNGFsVKssPNPFVG
1 3 S394-p NGFsVKssPNPFVGs
1 16 S401-p sPNPFVGsPPKGLSI
0 1 S418-p GVKQDLEsSVQSsPH
1 1 S423-p LEsSVQSsPHDSIAI
0 1 T437-p IIPPPQStKPGRGRR
0 1 K649 PLGDKEIKDVKEMFK
0 1 K652 DKEIKDVKEMFKDFQ
0 1 K656 KDVKEMFKDFQLRQP
0 3 Q673 VPARKGEQTsSGTLS
0 1 S675-p ARKGEQTsSGTLSAF
0 1 S684-p GTLSAFAsyFNSKVG
0 6 Y685-p TLSAFAsyFNSKVGI
0 2 S723-p KPAPRQVsLPVTKSt
0 7 S729 VsLPVTKStDNAFEN
0 1 T730-p sLPVTKStDNAFENP
0 2 A733 VTKStDNAFENPFFK
0 4 Y761-p QPVSSEMyRDPFGNP
0 5 D763 VSSEMyRDPFGNPFA
  mouse

 
S2 ______MSNEVETST
S24-p QAAPKAPsKKEKKKG
K53-u DGVKYKAkLIGIDDV
R64 IDDVPDARGDkMSQD
K67-u VPDARGDkMSQDSMM
T151 HQFFAIKTGQQAEPL
K163 EPLVVDLKDLFQVIy
Y170-p KDLFQVIyNVkKKEE
K173 FQVIyNVKKKEEDKK
K173-u FQVIyNVkKKEEDKK
S193-p NKAEENGsEALMTLD
K205-u TLDDQANkLKLGVDQ
T221-p DLFGDMStPPDLNsP
S227-p StPPDLNsPTESKDI
S316 SSFDSLTSPDQKKAs
S323-p SPDQKKAsLSSSStP
T329-p AsLSSSStPQSKGPL
T340-p KGPLNGDtDyFGQQF
Y342-p PLNGDtDyFGQQFDQ
H390 EREQNGFHIKssPNP
S393-p QNGFHIKssPNPFVG
S394-p NGFHIKssPNPFVGs
S401-p sPNPFVGsPPKGLSV
S418 GVKQDLESSVQSSAH
S423 LESSVQSSAHDSIAI
T437 IIPPPQSTKPGRGRR
K647-u PLGDKEVkEVkEMFk
K650-u DKEVkEVkEMFkDFQ
K654-u kEVkEMFkDFQLRQP
T671-p VPSRKGEtPPSGTSS
P673 SRKGEtPPSGTSSAF
S682 GTSSAFSSyFNNKVG
Y683-p TSSAFSSyFNNKVGI
V721 KPAPRQGVLLGTKsA
S727-p GVLLGTKsADNsLEN
A728 VLLGTKsADNsLENP
S731-p GTKsADNsLENPFSK
H757 QPASSDPHRsPFGNP
S759-p ASSDPHRsPFGNPFA
  rat

 
S2 ______MSNEVETST
S24-p QAAPKAPsKKEKKKG
K53 DGVKYKAKLIGIDDV
R64 IDDVPDARGDKMSQD
K67 VPDARGDKMSQDSMM
T151 HQFFAIKTGQQAEPL
K163 EPLVVDLKDLFQVIY
Y170 KDLFQVIYNVKKKEE
K173 FQVIYNVKKKEEEKK
K173 FQVIYNVKKKEEEKK
S193 NKAEENGSEALMTLD
K205 TLDDQANKLKLGVDQ
T221 DLFGDMSTPPDLNNP
N227 STPPDLNNPTESRDI
S316 SSFHSLTSADQKKAN
N323 SADQKKANPGSLSTP
T329 ANPGSLSTPQSKGPL
T340 KGPLNGDTDYFGQQF
Y342 PLNGDTDYFGQQFDQ
H390 EKEQNGFHIKSSPNP
S393 QNGFHIKSSPNPFVG
S394 NGFHIKSSPNPFVGs
S401-p SPNPFVGsPPKGLSV
S418 GVKQDLESSVQSSAH
S423 LESSVQSSAHDSIAI
T437 IIPPPQSTKPGRGRR
K649 PLGDKEVKEVKEMFK
K652 DKEVKEVKEMFKDFQ
K656 KEVKEMFKDFQLRQP
T673 VPSRKGETPSSGTSS
S675 SRKGETPSSGTSSAF
S684 GTSSAFSSYFNNKVG
Y685 TSSAFSSYFNNKVGI
V723 KPAPRQGVLSGTKsA
S729-p GVLSGTKsADNSLEN
A730 VLSGTKsADNSLENP
S733 GTKsADNSLENPFSK
H759 QPASSDAHRSPFGNP
S761 ASSDAHRSPFGNPFA
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