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Protein Page:
XPC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
XPC a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; cytoplasm; nucleolus; plasma membrane; nucleus
Molecular Function: protein binding; damaged DNA binding; bubble DNA binding; single-stranded DNA binding; loop DNA binding
Biological Process: response to drug; nucleotide-excision repair, DNA damage recognition; intra-S DNA damage checkpoint; nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; DNA repair; response to UV-B
Reference #:  Q01831 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein complementing XP-C cells; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C; XP3; XPC; XPCC
Gene Symbols: XPC
Molecular weight: 105,953 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

XPC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 - gap
0 1 K44-a FEDEKPPkkSLLSkV
0 1 K45-a EDEKPPkkSLLSkVS
0 1 K50-a PkkSLLSkVSQGKRK
0 7 S61-p GKRKRGCsHPGGSAD
0 18 S94-p VIKDEALsDGDDLRD
0 3 S122-p GATMNEDsNEEEEEs
0 4 S129-p sNEEEEEsENDWEEV
0 37 K161-u SRSLLPVkPVEIEIE
0 11 T169-p PVEIEIEtPEQAkTR
0 14 K174-u IEtPEQAkTRERSEK
0 2 S347-p TADPGGSsETSsQVL
0 1 S351-p GGSsETSsQVLENHT
0 2 V353 SsETSsQVLENHTkP
0 1 K359-u QVLENHTkPKTSKGT
0 1 S363 NHTkPKTSKGTKQEE
0 2 A373 TKQEETFAKGTCRPS
0 11 S397-p RKKRSKPsssEEDEG
0 3 S398-p KKRSKPsssEEDEGP
0 9 S399-p KRSKPsssEEDEGPG
0 1 K650 NHPLYALKRHLLkYE
1 0 K655-s ALKRHLLkYEAIYPE
0 1 T663-p YEAIYPEtAAILGYC
0 2 Y676-p YCRGEAVySRDCVHT
0 1 K692 HSRDTWLKKARVVRL
0 5 K750-u PPVAVDGkVPRNEFG
0 1 K849-u KRALGNWkLLAKGLL
0 1 S869 KRRYGPKSEAAAPHt
0 4 T876-p SEAAAPHtDAGGGLs
0 43 S883-p tDAGGGLssDEEEGT
0 42 S884-p DAGGGLssDEEEGTs
0 1 S891-p sDEEEGTssQAEAAR
0 4 S892-p DEEEGTssQAEAARI
  mouse

 
S29 KVARHEESVADDFED
R43 DEKQKPRRKSSFPKV
K44 EKQKPRRKSSFPKVS
K49 RRKSSFPKVSQGKRK
S60-p GKRKRGCsDPGDPTN
S93-p VLKEEALsDGDDFRD
T121 SKVVDQGTDEDDSED
S126 QGTDEDDSEDDWEEV
K157 SPSDMPVKAVEIEIE
T165 AVEIEIETPQQAkER
K170-u IETPQQAkERERSEK
S343 VEGPGGSSELSSNsP
S347 GGSSELSSNsPESHN
S349-p SSELSSNsPESHNKP
K355 NsPESHNKPTTsRRI
S359-p SHNKPTTsRRIKEEE
S369-p IKEEETLsEGRGKAT
S395-p SRQRRKPsCsEGEEA
C396 RQRRKPsCsEGEEAE
S397-p QRRKPsCsEGEEAEQ
K643-u NHPLYALkRHLLKFQ
K648 ALkRHLLKFQAIYPE
T656 FQAIYPETAAVLGYC
Y669 YCRGEAVYSRDCVHT
K685-u HSRDTWLkQARVVRL
K743-u PPIAVDGkVPRNEFG
K842 KRALGNWKLLVRGLL
S862-p KLRYGAKsEAAAPHA
A869 sEAAAPHAAGGGLss
S875-p HAAGGGLssDEEEGT
S876-p AAGGGLssDEEEGTS
S883 sDEEEGTSSQAEAAR
S884 DEEEGTSSQAEAARV
  rat

 
S29-p KATRPEEsDADDFED
R43 DEKQKPPRKCFLPKV
K44 EKQKPPRKCFLPKVS
K49 PRKCFLPKVSQGKRK
S60 GKRKRDCSDPGDPTN
S93-p AVKEEALsDDGDDFR
T122-p REVVDQGtDEDDsED
S127-p QGtDEDDsEDDWEEV
K158 SRSDLPVKAVEIEIE
T166 AVEIEIETPEQAKAR
K171 IETPEQAKARERSEK
S344 LEGPGDSSEPSSNIP
S348 GDSSEPSSNIPESHN
I350 SSEPSSNIPESHNKP
K356 NIPESHNKPKTSKRI
S360 SHNKPKTSKRIKQEE
S370 IKQEETLSEGSGKAN
S396-p SRQQRKPsCsEGEEA
C397 RQQRKPsCsEGEEAK
S398-p QQRKPsCsEGEEAKQ
K644 NHPLYALKRHLLKFQ
K649 ALKRHLLKFQAIYPE
S657 FQAIYPESAAVLGYC
Y670 YCRGEAVYSRDCVHT
K686 HSRDTWLKQARVVRL
K744 PPVAVDGKVPRNEFG
K843 KRALGNWKLLVRGLL
S863 KLRYGAKSEAAAPHA
A870 SEAAAPHANAGGGLs
S877-p ANAGGGLssDEEEGT
S878-p NAGGGLssDEEEGTS
S885 sDEEEGTSSQAEAAR
S886 DEEEGTSSQAEAARV
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