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Protein Page:
XPC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
XPC a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 3p25
Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleolus; nucleus
Molecular Function: protein binding; damaged DNA binding; bubble DNA binding; single-stranded DNA binding; loop DNA binding
Biological Process: response to drug; nucleotide-excision repair, DNA damage recognition; intra-S DNA damage checkpoint; nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; DNA repair; response to UV-B
Reference #:  Q01831 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein complementing XP-C cells; p125; RAD4; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C; XP3; XPC; XPCC
Gene Symbols: XPC
Molecular weight: 105,953 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

XPC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 - gap
0 1 K44-ac FEDEKPPkkSLLSkV
0 1 K45-ac EDEKPPkkSLLSkVS
0 1 K50-ac PkkSLLSkVSQGKRK
0 8 S61-p GKRKRGCsHPGGSAD
0 1 T79-p KKKVAKVtVKSENLK
0 26 S94-p VIKDEALsDGDDLRD
0 3 S104-p DDLRDFPsDLKKAHH
0 4 S122-p GATMNEDsNEEEEEs
0 5 S129-p sNEEEEEsENDWEEV
0 1 S140-p WEEVEELsEPVLGDV
0 1 S150-p VLGDVREsTAFsRsL
0 1 S154-p VREsTAFsRsLLPVk
0 1 S156-p EsTAFsRsLLPVkPV
0 37 K161-ub sRsLLPVkPVEIEIE
0 13 T169-p PVEIEIEtPEQAkTR
0 14 K174-ub IEtPEQAkTRERSEK
0 1 L339 KKPSKERLtADPGGs
0 1 T340-p KPSKERLtADPGGss
0 1 S346-p LtADPGGssEtssQV
0 4 S347-p tADPGGssEtssQVL
0 2 T349-p DPGGssEtssQVLEN
0 1 S350-p PGGssEtssQVLENH
0 3 S351-p GGssEtssQVLENHT
0 3 V353 ssEtssQVLENHTkP
0 1 K359-ub QVLENHTkPKTSKGT
0 1 S363 NHTkPKTSKGTKQEE
0 2 A373 TKQEETFAKGTCRPS
0 14 S397-p RKKRSKPsssEEDEG
0 5 S398-p KKRSKPsssEEDEGP
0 11 S399-p KRSKPsssEEDEGPG
0 1 S453-p ELSSGEAsDPSDEDs
0 1 S460-p sDPSDEDsEPGPPKQ
0 2 S496-p GSHRKDPsLPAAssS
0 1 S501-p DPsLPAAssSSSssK
0 1 S502-p PsLPAAssSSSssKR
0 1 S506-p AAssSSSssKRGKKM
0 1 S507-p AssSSSssKRGKKMC
0 1 K619-ub SPFMDREkKEDLEFQ
0 1 K650 NHPLYALKRHLLkYE
1 0 K655-sm ALKRHLLkYEAIyPE
0 1 Y660-p LLkYEAIyPEtAAIL
0 1 T663-p YEAIyPEtAAILGyC
0 1 Y669-p EtAAILGyCRGEAVy
0 2 Y676-p yCRGEAVysRDCVHT
0 1 S677-p CRGEAVysRDCVHTL
0 1 K692 HSRDTWLKKARVVRL
0 5 K750-ub PPVAVDGkVPRNEFG
0 1 K785-ub NLHRVARkLDIDCVQ
0 1 K849-ub KRALGNWkLLAKGLL
0 1 S869 KRRYGPKSEAAAPHt
0 5 T876-p SEAAAPHtDAGGGLs
0 47 S883-p tDAGGGLssDEEEGt
0 47 S884-p DAGGGLssDEEEGts
0 1 T890-p ssDEEEGtssQAEAA
0 1 S891-p sDEEEGtssQAEAAR
0 5 S892-p DEEEGtssQAEAARI
0 2 S903-p AARILAAsWPQNRED
  mouse

 
S29 KVARHEESVADDFED
R43 DEKQKPRRKSSFPKV
K44 EKQKPRRKSSFPKVS
K49 RRKSSFPKVSQGKRK
S60-p GKRKRGCsDPGDPTN
T78 KKKVAKATAKSKNLK
S93-p VLKEEALsDGDDFRD
A103 DDFRDSPADCKKAKK
T121 SKVVDQGTDEDDSED
S126 QGTDEDDSEDDWEEV
T137 WEEVEELTEPVLDMG
N146 PVLDMGENSATSPSD
S150 MGENSATSPSDMPVK
S152 ENSATSPSDMPVKAV
K157 SPSDMPVKAVEIEIE
T165 AVEIEIETPQQAkER
K170-ub IETPQQAkERERSEK
S335-p RKSSKETsVEGPGGS
V336 KSSKETsVEGPGGSS
S342 sVEGPGGSSELSSNs
S343 VEGPGGSSELSSNsP
L345 GPGGSSELSSNsPES
S346 PGGSSELSSNsPESH
S347 GGSSELSSNsPESHN
S349-p SSELSSNsPESHNKP
K355 NsPESHNKPTTsRRI
S359-p SHNKPTTsRRIKEEE
S369-p IKEEETLsEGRGKAT
S395-p SRQRRKPsCsEGEEA
C396 RQRRKPsCsEGEEAE
S397-p QRRKPsCsEGEEAEQ
Q446 EPSSGEGQHSSDEDC
C453 QHSSDEDCEPGPRKQ
S489 GSQCEPSSFPEASSS
S494 PSSFPEASSSSSGCK
S495 SSFPEASSSSSGCKR
G499 EASSSSSGCKRGKKV
C500 ASSSSSGCKRGKKVS
K612 SLLTEREKKEDQEFQ
K643-ub NHPLYALkRHLLKFQ
K648 ALkRHLLKFQAIYPE
Y653 LLKFQAIYPETAAVL
T656 FQAIYPETAAVLGYC
Y662 ETAAVLGYCRGEAVY
Y669 YCRGEAVYSRDCVHT
S670 CRGEAVYSRDCVHTL
K685-ub HSRDTWLkQARVVRL
K743-ub PPIAVDGkVPRNEFG
K778 NLNRVARKLGIDCVQ
K842 KRALGNWKLLVRGLL
S862-p KLRYGAKsEAAAPHA
A869 sEAAAPHAAGGGLss
S875-p HAAGGGLssDEEEGT
S876-p AAGGGLssDEEEGTS
T882 ssDEEEGTSSQAEAA
S883 sDEEEGTSSQAEAAR
S884 DEEEGTSSQAEAARV
S895 AARVLAASWPQNRED
  rat

 
S29-p KATRPEEsDADDFED
R43 DEKQKPPRKCFLPKV
K44 EKQKPPRKCFLPKVS
K49 PRKCFLPKVSQGKRK
S60 GKRKRDCSDPGDPTN
T78 KKKVAKATTKSKNLK
S93-p AVKEEALsDDGDDFR
S104 DDFRDSLSNCRKAKK
T122-p REVVDQGtDEDDsED
S127-p QGtDEDDsEDDWEEV
T138 WEEVEELTEPVLDMG
N147 PVLDMGENSATSRSD
S151 MGENSATSRSDLPVK
S153 ENSATSRSDLPVKAV
K158 SRSDLPVKAVEIEIE
T166 AVEIEIETPEQAKAR
K171 IETPEQAKARERSEK
S336 KKSSKETSLEGPGDS
- under review  
S343 SLEGPGDSSEPSSNI
S344 LEGPGDSSEPSSNIP
P346 GPGDSSEPSSNIPES
S347 PGDSSEPSSNIPESH
S348 GDSSEPSSNIPESHN
I350 SSEPSSNIPESHNKP
K356 NIPESHNKPKTSKRI
S360 SHNKPKTSKRIKQEE
S370 IKQEETLSEGSGKAN
S396-p SRQQRKPsCsEGEEA
C397 RQQRKPsCsEGEEAK
S398-p QQRKPsCsEGEEAKQ
Q447 ELSSGEGQHSSDEDC
C454 QHSSDEDCKPGPRKQ
S490 GSQWEPPSFSVASSS
S495 PPSFSVASSSSSACK
S496 PSFSVASSSSSACKR
A500 VASSSSSACKRGKKI
C501 ASSSSSACKRGKKIS
K613 SPLTEREKKEDQEFQ
K644 NHPLYALKRHLLKFQ
K649 ALKRHLLKFQAIYPE
Y654 LLKFQAIYPESAAVL
S657 FQAIYPESAAVLGYC
Y663 ESAAVLGYCRGEAVY
Y670 YCRGEAVYSRDCVHT
S671 CRGEAVYSRDCVHTL
K686 HSRDTWLKQARVVRL
K744 PPVAVDGKVPRNEFG
K779 NLHRVARKLGIDCVQ
K843 KRALGNWKLLVRGLL
S863 KLRYGAKSEAAAPHA
A870 SEAAAPHANAGGGLs
S877-p ANAGGGLssDEEEGT
S878-p NAGGGLssDEEEGTS
T884 ssDEEEGTSSQAEAA
S885 sDEEEGTSSQAEAAR
S886 DEEEGTSSQAEAARV
S897 AARVLAASWPQNRET
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