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Protein Page:
UTX (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UTX a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Oxidoreductase
Chromosomal Location of Human Ortholog: Xp11.2
Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus
Molecular Function: identical protein binding; dioxygenase activity; metal ion binding
Biological Process: heart morphogenesis; respiratory system process; notochord morphogenesis; establishment and/or maintenance of chromatin architecture; regulation of gene expression; in utero embryonic development; multicellular organism growth; neural tube closure; histone H3-K4 methylation; mesodermal cell differentiation; Wnt receptor signaling pathway through beta-catenin; somite rostral/caudal axis specification
Disease: Kabuki Syndrome 2; Kabuki Syndrome 1
Reference #:  O15550 (UniProtKB)
Alt. Names/Synonyms: bA386N14.2; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); DKFZp686A03225; Histone demethylase UTX; KDM6A; lysine (K)-specific demethylase 6A; Lysine-specific demethylase 6A; MGC141941; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; UTX
Gene Symbols: KDM6A
Molecular weight: 154,177 Da
Basal Isoelectric point: 7.17  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UTX

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K225-ub QRKYHSAkEAYEQLL
0 1 T387-p RSKSCSNtsALAARI
0 1 S388-p SKSCSNtsALAARIK
0 1 K395 sALAARIKYLQAQLC
0 1 R519 PTGVAQVRSTGIPNG
0 1 T535-p TADSSLPtNSVsGQQ
0 1 S539-p SLPtNSVsGQQPQLA
0 1 R549 QPQLALTRVPsVSQP
0 1 S552-p LALTRVPsVSQPGVR
0 1 S554 LTRVPsVSQPGVRPA
0 1 K719 ITLTKESKPSGNILT
0 4 S769-p PSHGDSKsPGLLSSD
0 2 A806 KVNNIHPAVHTKtDN
0 1 T809 NIHPAVHTKtDNSVA
0 3 T811-p HPAVHTKtDNSVASs
0 7 S818-p tDNSVASsPSSAIST
0 1 S824 SsPSSAISTAtPsPK
0 1 T825 sPSSAISTAtPsPKS
0 4 T827-p SSAISTAtPsPKSTE
0 12 S829-p AISTAtPsPKSTEQT
0 1 S926-p PPPRPPSsPyPPLPK
0 2 Y928-p PRPPSsPyPPLPKDK
0 1 S1055 REENEKRSHHKDHsD
0 3 S1061-p RSHHKDHsDSESTSS
0 1 S1091-p FGTNIDLsDDKKWKL
0 1 T1131-p HTILGMNtVQLYMKV
  mouse

 
K227 QRKYHSAKEAYEQLL
T389 RSKNCSNTSGLAARI
S390 SKNCSNTSGLAARIk
K397-ub SGLAARIkYLQAQLC
R519-m1 QTGVAQVrPTGILNG
T535 TVDSSLPTNSVSGQQ
S539 SLPTNSVSGQQPQLP
R549-m1 QPQLPLTrMPSVsQP
S552 LPLTrMPSVsQPGVH
S554-gl LTrMPSVsQPGVHTA
K719-ac ITLTKESkPSGNTLT
S769-p PSHGDSKsPGLLSSD
T806-p KVNNIHPtVHtKtDN
T809-p NIHPtVHtKtDNSVA
T811-p HPtVHtKtDNSVASs
S818-p tDNSVASsPSSAIst
S824-p SsPSSAIstAtPsPK
T825-p sPSSAIstAtPsPKS
T827-p SSAIstAtPsPKSTE
S829-p AIstAtPsPKSTEQT
S926 PPPRPPSSPYPPLPK
Y928 PRPPSSPYPPLPKDK
S1055-p REENEKRsHHKDHsD
S1061-p RsHHKDHsDSESTSS
S1091 FGTNIDLSDDKKWKL
T1131 HTILGMNTVQLYMKV
  rat

 
K224 QRKYHSAKEAYEQLL
T386 RSKNCSNTSGLAARI
S387 SKNCSNTSGLAARIK
K394 SGLAARIKYLQAQLC
R518 QTGVAQVRPTGIPNG
T534 TADSSLPTNSASGQQ
S538 SLPTNSASGQQPQLP
R548 QPQLPLTRMPSVSQP
S551 LPLTRMPSVSQPGVQ
S553 LTRMPSVSQPGVQPA
K718 ITLTKESKPSGNTLT
S768 PSHGDSKSPGLLSSD
T805 IVNNIHPTVHTKTDN
T808 NIHPTVHTKTDNSVA
T810 HPTVHTKTDNSVASS
S817 TDNSVASSPSSAIST
S823 SSPSSAISTATPSPK
T824 SPSSAISTATPSPKS
T826 SSAISTATPSPKSTE
S828 AISTATPSPKSTEQT
S925 PPPRPPSSPYPPLPK
Y927 PRPPSSPYPPLPKDK
S1054 REENEKRSHHKDHSD
S1060 RSHHKDHSDSESTSS
Q1090 KSGMFVLQDLIRWKL
T1130 HTILGMNTVQLYMKV
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