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Protein Page:
UTX (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
UTX a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; EC 1.14.11.-
Cellular Component: histone methyltransferase complex; nucleus
Molecular Function: dioxygenase activity; metal ion binding
Biological Process: notochord morphogenesis; respiratory system process; in utero embryonic development; heart development; histone H3-K4 methylation; neural tube closure; mesodermal cell differentiation; Wnt receptor signaling pathway through beta-catenin; somite rostral/caudal axis specification
Reference #:  O15550 (UniProtKB)
Alt. Names/Synonyms: bA386N14.2; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); DKFZp686A03225; Histone demethylase UTX; KDM6A; lysine (K)-specific demethylase 6A; Lysine-specific demethylase 6A; MGC141941; Ubiquitously transcribed TPR protein on the X chromosome; Ubiquitously transcribed X chromosome tetratricopeptide repeat protein; ubiquitously-transcribed TPR gene on the X chromosome; UTX
Gene Symbols: KDM6A
Molecular weight: 154,177 Da
Basal Isoelectric point: 7.17  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Select Structure to View Below

UTX

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K225-ub QRKYHSAkEAYEQLL
0 1 T387-p RSKSCSNtsALAARI
0 1 S388-p SKSCSNtsALAARIK
0 1 K395 sALAARIKYLQAQLC
0 1 R519 PTGVAQVRSTGIPNG
0 1 T535-p TADSSLPtNSVsGQQ
0 1 S539-p SLPtNSVsGQQPQLA
0 1 R549 QPQLALTRVPsVSQP
0 1 S552-p LALTRVPsVSQPGVR
0 1 S554 LTRVPsVSQPGVRPA
0 1 K719 ITLTKESKPSGNILT
0 3 S769-p PSHGDSKsPGLLSSD
0 2 A806 KVNNIHPAVHTKTDN
0 1 T809 NIHPAVHTKTDNSVA
0 2 T811 HPAVHTKTDNSVASs
0 6 S818-p TDNSVASsPSSAIST
0 1 S824 SsPSSAISTAtPsPK
0 1 T825 sPSSAISTAtPsPKS
0 3 T827-p SSAISTAtPsPKSTE
0 9 S829-p AISTAtPsPKSTEQT
0 1 Y928-p PRPPSSPyPPLPKDK
0 1 S1055 REENEKRSHHKDHsD
0 3 S1061-p RSHHKDHsDSESTSS
0 1 S1091-p FGTNIDLsDDKKWKL
0 1 T1131-p HTILGMNtVQLYMKV
  mouse

 
K227 QRKYHSAKEAYEQLL
T389 RSKNCSNTSGLAARI
S390 SKNCSNTSGLAARIk
K397-ub SGLAARIkYLQAQLC
R519-m1 QTGVAQVrPTGILNG
T535 TVDSSLPTNSVSGQQ
S539 SLPTNSVSGQQPQLP
R549-m1 QPQLPLTrMPSVsQP
S552 LPLTrMPSVsQPGVH
S554-gl LTrMPSVsQPGVHTA
K719-ac ITLTKESkPSGNTLT
S769-p PSHGDSKsPGLLSSD
T806-p KVNNIHPtVHtKtDN
T809-p NIHPtVHtKtDNSVA
T811-p HPtVHtKtDNSVASs
S818-p tDNSVASsPSSAIst
S824-p SsPSSAIstAtPsPK
T825-p sPSSAIstAtPsPKS
T827-p SSAIstAtPsPKSTE
S829-p AIstAtPsPKSTEQT
Y928 PRPPSSPYPPLPKDK
S1055-p REENEKRsHHKDHsD
S1061-p RsHHKDHsDSESTSS
S1091 FGTNIDLSDDKKWKL
T1131 HTILGMNTVQLYMKV
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