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Protein Page:
USP7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
USP7 an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. Note: This description may include information from UniProtKB.
Protein type: Protease; EC 3.1.2.15; EC 3.4.19.12; Ubiquitin-specific protease; Ubiquitin conjugating system
Cellular Component: PML body; nucleus; cytosol
Molecular Function: protein C-terminus binding; ubiquitin thiolesterase activity; protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; transcription factor binding
Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; viral reproduction; regulation of transcription factor activity; maintenance of DNA methylation; inhibition of NF-kappaB transcription factor; transcription-coupled nucleotide-excision repair; multicellular organismal development
Reference #:  Q93009 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 7; HAUSP; Herpes virus-associated ubiquitin-specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF1; Ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7 (herpes virus-associated); Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; UBP7; USP7
Gene Symbols: USP7
Molecular weight: 128,302 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

USP7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 41 S18-p KAGEQQLsEPEDMEM
0 3 S49-p INGNVALsDGHNtAE
0 2 N53 VALsDGHNtAEEDME
0 5 T54-p ALsDGHNtAEEDMED
0 1 K98-ub FVRNLPWkIMVMPRF
0 4 K148-ub INYRDDEkSFSRRIS
0 1 S155 kSFSRRISHLFFHKE
0 1 S174 FSNFMAWSEVTDPEK
0 1 T177 FMAWSEVTDPEKGFI
0 2 K254-ub TEGDDSSkSVPLALQ
0 1 K272-ac YELQHSDkPVGTKKL
0 1 K322 CVEGTIPKLFRGKMV
0 1 Y331-p FRGKMVSyIQCKEVD
0 13 K355-ub YDIQLSIkGkKNIFE
0 4 K357-ub IQLSIkGkKNIFESF
0 1 Y379-p QLDGDNKyDAGEHGL
0 1 T397 EKGVKFLTLPPVLHL
0 19 K420-ub PQTDQNIkINDRFEF
0 2 K439-ub PLDEFLQkTDPKDPA
0 1 K479-ub KGDGKWCkFDDDVVS
0 1 T511 DLSVRHCTNAYMLVY
0 1 Y518 TNAYMLVYIRESKLS
0 1 S522 MLVYIRESKLSEVLQ
0 1 K595-ac KVKYTVFkVLKNSSL
0 1 T730-p RAGFIQDtSLILyEE
0 17 Y735-p QDtSLILyEEVKPNL
0 1 T743-p EEVKPNLtERIQDYD
0 1 K755-ub DYDVSLDkALDELMD
0 2 Y791-p KEYFRDLyHRVDVIF
0 3 K824-ub MNYFQVAkTVAQRLN
0 1 K841-ac PMLLQFFkSQGyRDG
0 4 K841-ub PMLLQFFkSQGyRDG
0 1 S842 MLLQFFkSQGyRDGP
0 3 Y845-p QFFkSQGyRDGPGNP
0 2 K869-ac RDLLQFFkPRQPKkL
0 11 K869-ub RDLLQFFkPRQPKkL
0 1 K875-ub FkPRQPKkLYYQQLk
0 1 Y877 PRQPKkLYYQQLkMK
0 1 Y878 RQPKkLYYQQLkMKI
0 7 K882-ub kLYYQQLkMKITDFE
0 13 K934-ub KAVELGEkASGKLRL
0 6 S963-p DELLECLsPATSRTF
0 1 K1033-ub SLLDIQEkEFEKFKF
0 1 Y1050-p VMMGRHQyINEDEyE
0 1 Y1056-p QyINEDEyEVNLKDF
0 1 K1084-ac LGLDHFNkAPKRSRy
0 4 Y1091-p kAPKRSRytyLEkAI
0 3 T1092-p APKRSRytyLEkAIK
0 5 Y1093-p PKRSRytyLEkAIKI
0 3 K1096-ac SRytyLEkAIKIHN_
0 38 K1096-ub SRytyLEkAIKIHN_
  mouse

 
S19-p KAGEQQLsEPEDMEM
S50-p INGNVTLsDGHsNAE
S54-p VTLsDGHsNAEEDME
N55 TLsDGHsNAEEDMED
K99 FVRNLPWKIMVMPRF
K149 INYRDDDKSFSRRIs
S156-p KSFSRRIsHLFFHEE
S175-p FSNFMAWsEVtDPEK
T178-p FMAWsEVtDPEKGFI
K255-ub TEGDDSSkSVPLALQ
K273 YELQHSDKPVGTKKL
K323-ub CVEGTIPkLFRGKMV
Y332 FRGKMVSYIQCKDVD
K356-ub YDIQLSIkGKKNIFE
K358 IQLSIkGKKNIFESF
Y380 QLDGDNKYDAGEHGL
T398-p EKGVKFLtLPPVLHL
K421-ub PQTDQNIkINDRFEF
K440-ub PLDEFLQkTDPKDPA
K480 KGDGKWCKFDDDVVS
T512-p DLSVRHCtNAYMLVy
Y519-p tNAYMLVyIREsKLS
S523-p MLVyIREsKLSEVLQ
K596 KVRYTVFKVLKNSSL
T731 RAGFIQDTSLILYEE
Y736 QDTSLILYEEVKPNL
T744 EEVKPNLTERIQDYD
K756 DYDVSLDKALDELMD
Y792 KEYFRDLYHRVDVIF
K825-ub MNYFQVAkTVAQRLN
K842 PMLLQFFKsQGyRDG
K842 PMLLQFFKsQGyRDG
S843-p MLLQFFKsQGyRDGP
Y846-p QFFKsQGyRDGPGNP
K870-ac RDLLQFFkPRQPKKL
K870-ub RDLLQFFkPRQPKKL
K876 FkPRQPKKLyyQQLk
Y878-p PRQPKKLyyQQLkMK
Y879-p RQPKKLyyQQLkMKI
K883-ub KLyyQQLkMKITDFE
K935 KAVELGDKASGRLRL
S964-p DELLECLsPATSRTF
K1034 SLLDIQEKEFEKFKF
Y1051 VMMGRHQYINEDEYE
Y1057 QYINEDEYEVNLKDF
K1085 LGLDHFNKAPKRSRY
Y1092 KAPKRSRYTYLEkAI
T1093 APKRSRYTYLEkAIK
Y1094 PKRSRYTYLEkAIKI
K1097 SRYTYLEKAIKIHN_
K1097-ub SRYTYLEkAIKIHN_
  rat

 
S19-p KAGEQQLsEPEDMEM
S50 INGNVALSDGHSNAE
S54 VALSDGHSNAEEDME
N55 ALSDGHSNAEEDMED
K99 FVRNLPWKIMVMPRF
K149 INYRDDDKSFSRRIS
S156 KSFSRRISHLFFHKE
S175 FSNFMAWSEVTDPEK
T178 FMAWSEVTDPEKGFI
K255 TEGDDSSKSVPLALQ
K273 YELQHSDKPVGTKKL
K323 CVEGTIPKLFRGKMV
Y332 FRGKMVSYIQCKEVD
K356 YDIQLSIKGKKNIFE
K358 IQLSIKGKKNIFESF
Y380 QLDGDNKYDAGEHGL
T398 EKGVKFLTLPPVLHL
K421 PQTDQNIKINDRFEF
K440 PLDEFLQKTDPKDPA
K480 KGDGKWCKFDDDVVS
T512 DLSVRHCTNAYMLVY
Y519 TNAYMLVYIRESKLS
S523 MLVYIRESKLSEVLQ
K596 KVRYTVFKVLKNSSL
T731 RAGFIQDTSLILYEE
Y736 QDTSLILYEEVKPNL
T744 EEVKPNLTERIQDYD
K756 DYDVSLDKALDELMD
Y792 KEYFRDLYHRVDVIF
K825 MNYFQVAKTVAQRLN
K842 PMLLQFFKSQGYRDG
K842 PMLLQFFKSQGYRDG
S843 MLLQFFKSQGYRDGP
Y846 QFFKSQGYRDGPGNP
K870 RDLLQFFKPRQPKKL
K870 RDLLQFFKPRQPKKL
K876 FKPRQPKKLYYQQLK
Y878 PRQPKKLYYQQLKMK
Y879 RQPKKLYYQQLKMKI
K883 KLYYQQLKMKITDFE
E935 KAVELGDEASGRLRL
S964 DELLECLSPATSRTF
K1034 SLLDIQEKEFEKFKF
Y1051 VMMGRHQYINEDEYE
Y1057 QYINEDEYEVNLKDF
K1085 LGLDHFNKAPKRSRY
Y1092 KAPKRSRYTYLEKAI
T1093 APKRSRYTYLEKAIK
Y1094 PKRSRYTYLEKAIKI
K1097 SRYTYLEKAIKIHN_
K1097 SRYTYLEKAIKIHN_
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