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USP7 (human)

Overview USP7 an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. Note: This description may include information from UniProtKB. Protein type: EC 3.1.2.15; Ubiquitin conjugating system; EC 3.4.19.12; Ubiquitin-specific protease; Protease Cellular Component: PML body; cytosol; nucleus Molecular Function: protein C-terminus binding; ubiquitin thiolesterase activity; protein binding; protein homodimerization activity; p53 binding; ubiquitin protein ligase binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; transcription factor binding Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; maintenance of DNA methylation; regulation of transcription factor activity; inhibition of NF-kappaB transcription factor; multicellular organismal development; virus-host interaction; transcription-coupled nucleotide-excision repair; induction of apoptosis; regulation of protein stability Reference #:  Q93009 (UniProtKB) Alt. Names/Synonyms: Deubiquitinating enzyme 7; HAUSP; Herpes virus-associated ubiquitin-specific protease; Herpesvirus-associated ubiquitin-specific protease; TEF1; Ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7 (herpes virus-associated); Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7; UBP7; USP7 Gene Symbols: USP7 Molecular weight: 128,302 Da Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below USP7 1NB8 - A/B=208-560 (human) 1NBF - A/B/E=208-560 (human) 1YY6 - A=54-205 (human) 1YZE - A/B/C=54-205 (human) 2F1W - A=53-206 (human) 2F1X - A/B=53-200 (human) 2F1Y - A=53-204 (human) 2F1Z - A/B=43-560 (human) 2FOJ - A=54-205 (human) 2FOO - A=54-205 (human) 2FOP - A=54-205 (human) 2KVR - A=537-664 (human) 2XXN - A=63-205 (human) 2YLM - A=560-1084 (human) 3MQR - A=54-205 (human) 3MQS - C=54-205 (human) 4JJQ - B=5-14 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	32		S18-p	KAGEQQLsEPEDMEM
0	3		S49-p	INGNVALsDGHNtAE
0	2		N53	VALsDGHNtAEEDME
0	4		T54-p	ALsDGHNtAEEDMED
0	1		K98-u	FVRNLPWkIMVMPRF
0	4		K148-u	INYRDDEkSFSRRIS
0	1		S155	kSFSRRISHLFFHKE
0	1		S174	FSNFMAWSEVTDPEK
0	1		T177	FMAWSEVTDPEKGFI
0	2		K254-u	TEGDDSSkSVPLALQ
0	1		K322	CVEGTIPKLFRGKMV
0	1		Y331-p	FRGKMVSyIQCKEVD
0	13		K355-u	YDIQLSIkGkKNIFE
0	4		K357-u	IQLSIkGkKNIFESF
0	1		Y379-p	QLDGDNKyDAGEHGL
0	1		T397	EKGVKFLTLPPVLHL
0	19		K420-u	PQTDQNIkINDRFEF
0	2		K439-u	PLDEFLQkTDPKDPA
0	1		K479-u	KGDGKWCkFDDDVVS
0	1		T511	DLSVRHCTNAYMLVY
0	1		Y518	TNAYMLVYIRESKLS
0	1		S522	MLVYIRESKLSEVLQ
0	1		K595-a	KVKYTVFkVLKNSSL
0	1		T730-p	RAGFIQDtSLILyEE
0	14		Y735-p	QDtSLILyEEVKPNL
0	1		T743-p	EEVKPNLtERIQDYD
0	1		K755-u	DYDVSLDkALDELMD
0	2		Y791-p	KEYFRDLyHRVDVIF
0	3		K824-u	MNYFQVAkTVAQRLN
0	4		K841-u	PMLLQFFkSQGyRDG
0	1		S842	MLLQFFkSQGyRDGP
0	3		Y845-p	QFFkSQGyRDGPGNP
0	1		K869-a	RDLLQFFkPRQPKkL
0	11		K869-u	RDLLQFFkPRQPKkL
0	1		K875-u	FkPRQPKkLYYQQLk
0	1		Y877	PRQPKkLYYQQLkMK
0	1		Y878	RQPKkLYYQQLkMKI
0	7		K882-u	kLYYQQLkMKITDFE
0	13		K934-u	KAVELGEkASGKLRL
0	5		S963-p	DELLECLsPATSRTF
0	1		K1033-u	SLLDIQEkEFEKFKF
0	1		Y1050-p	VMMGRHQyINEDEyE
0	1		Y1056-p	QyINEDEyEVNLKDF
0	1		K1084-a	LGLDHFNkAPKRSRy
0	2		Y1091-p	kAPKRSRytyLEkAI
0	3		T1092-p	APKRSRytyLEkAIK
0	5		Y1093-p	PKRSRytyLEkAIKI
0	3		K1096-a	SRytyLEkAIKIHN_
0	38		K1096-u	SRytyLEkAIKIHN_

	mouse
S19-p	KAGEQQLsEPEDMEM
S50-p	INGNVTLsDGHsNAE
S54-p	VTLsDGHsNAEEDME
N55	TLsDGHsNAEEDMED
K99	FVRNLPWKIMVMPRF
K149	INYRDDDKSFSRRIs
S156-p	KSFSRRIsHLFFHEE
S175-p	FSNFMAWsEVtDPEK
T178-p	FMAWsEVtDPEKGFI
K255-u	TEGDDSSkSVPLALQ
K323-u	CVEGTIPkLFRGKMV
Y332	FRGKMVSYIQCKDVD
K356-u	YDIQLSIkGKKNIFE
K358	IQLSIkGKKNIFESF
Y380	QLDGDNKYDAGEHGL
T398-p	EKGVKFLtLPPVLHL
K421-u	PQTDQNIkINDRFEF
K440-u	PLDEFLQkTDPKDPA
K480	KGDGKWCKFDDDVVS
T512-p	DLSVRHCtNAYMLVy
Y519-p	tNAYMLVyIREsKLS
S523-p	MLVyIREsKLSEVLQ
K596	KVRYTVFKVLKNSSL
T731	RAGFIQDTSLILYEE
Y736	QDTSLILYEEVKPNL
T744	EEVKPNLTERIQDYD
K756	DYDVSLDKALDELMD
Y792	KEYFRDLYHRVDVIF
K825-u	MNYFQVAkTVAQRLN
K842	PMLLQFFKsQGyRDG
S843-p	MLLQFFKsQGyRDGP
Y846-p	QFFKsQGyRDGPGNP
K870	RDLLQFFKPRQPKKL
K870-u	RDLLQFFkPRQPKKL
K876	FkPRQPKKLyyQQLk
Y878-p	PRQPKKLyyQQLkMK
Y879-p	RQPKKLyyQQLkMKI
K883-u	KLyyQQLkMKITDFE
K935	KAVELGDKASGRLRL
S964-p	DELLECLsPATSRTF
K1034	SLLDIQEKEFEKFKF
Y1051	VMMGRHQYINEDEYE
Y1057	QYINEDEYEVNLKDF
K1085	LGLDHFNKAPKRSRY
Y1092	KAPKRSRYTYLEkAI
T1093	APKRSRYTYLEkAIK
Y1094	PKRSRYTYLEkAIKI
K1097	SRYTYLEKAIKIHN_
K1097-u	SRYTYLEkAIKIHN_

	rat
S19-p	KAGEQQLsEPEDMEM
S50	INGNVALSDGHSNAE
S54	VALSDGHSNAEEDME
N55	ALSDGHSNAEEDMED
K99	FVRNLPWKIMVMPRF
K149	INYRDDDKSFSRRIS
S156	KSFSRRISHLFFHKE
S175	FSNFMAWSEVTDPEK
T178	FMAWSEVTDPEKGFI
K255	TEGDDSSKSVPLALQ
K323	CVEGTIPKLFRGKMV
Y332	FRGKMVSYIQCKEVD
K356	YDIQLSIKGKKNIFE
K358	IQLSIKGKKNIFESF
Y380	QLDGDNKYDAGEHGL
T398	EKGVKFLTLPPVLHL
K421	PQTDQNIKINDRFEF
K440	PLDEFLQKTDPKDPA
K480	KGDGKWCKFDDDVVS
T512	DLSVRHCTNAYMLVY
Y519	TNAYMLVYIRESKLS
S523	MLVYIRESKLSEVLQ
K596	KVRYTVFKVLKNSSL
T731	RAGFIQDTSLILYEE
Y736	QDTSLILYEEVKPNL
T744	EEVKPNLTERIQDYD
K756	DYDVSLDKALDELMD
Y792	KEYFRDLYHRVDVIF
K825	MNYFQVAKTVAQRLN
K842	PMLLQFFKSQGYRDG
S843	MLLQFFKSQGYRDGP
Y846	QFFKSQGYRDGPGNP
K870	RDLLQFFKPRQPKKL
K870	RDLLQFFKPRQPKKL
K876	FKPRQPKKLYYQQLK
Y878	PRQPKKLYYQQLKMK
Y879	RQPKKLYYQQLKMKI
K883	KLYYQQLKMKITDFE
E935	KAVELGDEASGRLRL
S964	DELLECLSPATSRTF
K1034	SLLDIQEKEFEKFKF
Y1051	VMMGRHQYINEDEYE
Y1057	QYINEDEYEVNLKDF
K1085	LGLDHFNKAPKRSRY
Y1092	KAPKRSRYTYLEKAI
T1093	APKRSRYTYLEKAIK
Y1094	PKRSRYTYLEKAIKI
K1097	SRYTYLEKAIKIHN_
K1097	SRYTYLEKAIKIHN_

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