an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; EC 184.108.40.206; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: PML body; cytosol; nucleus
Molecular Function: protein C-terminus binding; ubiquitin thiolesterase activity; protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; transcription factor binding
Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of transcription factor activity; maintenance of DNA methylation; viral reproduction; inhibition of NF-kappaB transcription factor; multicellular organismal development; transcription-coupled nucleotide-excision repair
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.