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Scribble (human)

Overview Scribble may be involved in regulating neuroblast cortical polarity, cell size asymmetry and mitotic spindle asymmetry. A neoplastic tumor suppressor genes in Drosophila melanogaster. May play a role in the suppression of mammalian tumorigenesis. Gene ablation in the mouse causes severe neural tube defects. May be implicated in the etiology of human NTDs. Involved in the regulation of synaptic plasticity and synaptic vesicle dynamics. May be required to sustain synaptic vesicle concentrations at their sites of release. Targeted for ubiquitin-mediated degradation by the HPV E6 oncoprotein. Note: This description may include information from UniProtKB. Protein type: Cell adhesion; Motility/polarity/chemotaxis Cellular Component: presynaptic membrane; postsynaptic membrane; cell-cell adherens junction; basolateral plasma membrane; leading edge; plasma membrane; intercellular junction Molecular Function: protein binding Biological Process: cell migration; wound healing; positive regulation of apoptosis; activation of Rac GTPase; establishment of apical/basal cell polarity; asymmetric protein localization; cell proliferation; cell-cell adhesion; positive chemotaxis; virus-host interaction; synaptic vesicle endocytosis; neural tube closure; negative regulation of mitotic cell cycle; synaptic vesicle targeting; positive regulation of receptor recycling Reference #:  Q14160 (UniProtKB) Alt. Names/Synonyms: CRIB1; hScrib; KIAA0147; LAP4; Protein LAP4; Protein scribble homolog; SCRB1; SCRIB; SCRIB1; Scribble; scribbled homolog (Drosophila); VARTUL Gene Symbols: SCRIB Molecular weight: 174,885 Da Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Scribble 1UJU - A=1096-1193 (human) 1WHA - A=860-951 (human) 1X5Q - A=718-814 (human) 2W4F - A=725-815 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1UJU 1WHA 1X5Q 2W4F  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S23-p	SVDKRHCsLQAVPEE
0	1		Y32-p	QAVPEEIyRysRsLE
0	2		Y34-p	VPEEIyRysRsLEEL
0	3		S35-p	PEEIyRysRsLEELL
0	4		S37-p	EIyRysRsLEELLLD
0	2		K53-u	NQLRELPkPFFRLLN
0	1		K105	PESIKFCKALEIADF
0	3		K164-u	ELRENLLkSLPASLS
0	2		K266-u	PDGIGQLkQLSILkV
0	1		K272-u	LkQLSILkVDQNRLC
0	1		K313-u	RSLGKLTkLTNLNVD
0	1		S432	EDAGQQGSLSETWSD
0	1		S434	AGQQGSLSETWSDAP
0	1		K467-u	AEEAAAEkRGLQRRA
0	47		T475-p	RGLQRRAtPHPSELK
0	1		S479	RRAtPHPSELKVMKR
0	1		S487-p	ELKVMKRsIEGRRSE
0	1		S502	ACPCQPDSGsPLPAE
0	5		S504-p	PCQPDSGsPLPAEEE
0	5		L506	QPDSGsPLPAEEEKR
0	2		A508	DSGsPLPAEEEKRLS
0	2		Y564-p	EEDAEEDyQEPTVHF
0	4		I584	LPGDDREIEEGQPEA
0	2		T607-p	QRLIRKDtPHyKKHF
0	8		Y610-p	IRKDtPHyKKHFKIS
0	2		S668-p	EEEEEEGsPQEEEVE
0	6		S688-p	RAEEEEAstEEEDKE
0	6		T689-p	AEEEEAstEEEDKEG
0	2		S703-p	GAVVSAPsVKGVsFD
0	1		S708-p	APsVKGVsFDQANNL
0	1		T728-p	RIEEEELtLtILRQt
0	1		T730-p	EEEELtLtILRQtGG
0	1		T735-p	tLtILRQtGGLGIsI
0	8		S741-p	QtGGLGIsIAGGKGs
0	1		S748-p	sIAGGKGstPYKGDD
0	4		T749-p	IAGGKGstPYKGDDE
0	2		T824-p	VEPENAVtItPLRPE
0	6		T826-p	PENAVtItPLRPEDD
0	84		Y834-p	PLRPEDDysPRERRG
0	36		S835-p	LRPEDDysPRERRGG
0	9		S853-p	LPLLPPEsPGPLRQR
0	1		S875-p	SERGLGFsIAGGKGS
0	2		T883-p	IAGGKGStPYRAGDA
0	5		S939-p	VSLLTAAsPTIALLL
0	1		A950	ALLLEREAGGPLPPS
0	2		P953	LEREAGGPLPPSPLP
0	2		S957	AGGPLPPSPLPHSSP
0	3		S962	PPSPLPHSSPPTAAV
0	1		V969	SSPPTAAVATTSITT
0	1		S973	TAAVATTSITTATPG
0	1		T976	VATTSITTATPGVPG
0	2		A988	VPGLPSLAPSLLAAA
0	4		Y1000-p	AAALEGPyPVEEIRL
0	1		S1017-p	AGGPLGLsIVGGSDH
0	1		S1050-p	PRGLAARsGLRVGDR
0	1		K1138-u	DEGIFISkVsPTGAA
0	2		S1140-p	GIFISkVsPTGAAGR
0	25		S1220-p	AGIGHRNsLEsIssI
0	6		S1223-p	GHRNsLEsIssIDRE
0	2		S1225-p	RNsLEsIssIDRELs
0	8		S1226-p	NsLEsIssIDRELsP
0	6		S1232-p	ssIDRELsPEGPGKE
0	65		Y1268-p	LQPLKLDyRALAAVP
0	35		S1276-p	RALAAVPsAGsVQRV
0	15		S1279-p	AAVPsAGsVQRVPsG
0	152		S1285-p	GsVQRVPsGAAGGKM
0	6		S1298-p	KMAESPCsPSGQQPP
0	1		G1301	ESPCsPSGQQPPsPP
0	10		-	gap
0	7		S1306-p	PSGQQPPsPPsPDEL
0	15		S1309-p	QQPPsPPsPDELPAN
0	18		T1342-p	DAPAQPPtPGPAAsP
0	19		S1348-p	PtPGPAAsPEQLsFR
0	10		S1353-p	AAsPEQLsFRERQKy
0	26		Y1360-p	sFRERQKyFELEVRV
0	90		S1378-p	EGPPKRVsLVGADDL
0	2		S1437-p	DEQPPWAsPsPTsRQ
0	1		S1439-p	QPPWAsPsPTsRQsP
0	1		S1442-p	WAsPsPTsRQsPAsP
0	1		S1445-p	PsPTsRQsPAsPPPL
0	14		S1448-p	TsRQsPAsPPPLGGG
0	26		S1475-p	QERLRVQsPEPPAPE
0	9		S1486-p	PAPERALsPAELRAL
0	95		S1508-p	WRAARMKsLEQDALR
0	1		T1529	RSQEGRGTRGPLERL
0	2		S1541-p	ERLAEAPsPAPTPsP
0	2		T1545	EAPsPAPTPsPtPVE
0	5		S1547-p	PsPAPTPsPtPVEDL
0	3		T1549-p	PAPTPsPtPVEDLGP
0	1		T1558-p	VEDLGPQtstsPGRL
0	2		S1559-p	EDLGPQtstsPGRLs
0	3		T1560-p	DLGPQtstsPGRLsP
0	10		S1561-p	LGPQtstsPGRLsPD
0	2		-	gap
1	22		S1566-p	stsPGRLsPDFAEEL
0	3		S1581-p	RSLEPSPsPGPQEED
0	1		P1584	EPSPsPGPQEEDGEV

	Scribble iso2
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
K24	PESIKFCKALEIADF
K83	ELRENLLKSLPASLS
K185	PDGIGQLKQLSILKV
K191	LKQLSILKVDQNRLC
K232	RSLGKLTKLTNLNVD
S351	EDAGQQGSLSETWSD
S353	AGQQGSLSETWSDAP
K386	AEEAAAEKRGLQRRA
T394-p	RGLQRRAtPHPSELK
S398	RRAtPHPSELKVMKR
S406	ELKVMKRSIEGRRSE
S421	ACPCQPDSGSPLPAE
S423	PCQPDSGSPLPAEEE
L425	QPDSGSPLPAEEEKR
A427	DSGSPLPAEEEKRLS
Y483	EEDAEEDYQEPTVHF
I503	LPGDDREIEEGQPEA
T526	QRLIRKDTPHYKKHF
Y529	IRKDTPHYKKHFKIS
S587	EEEEEEGSPQEEEVE
S607	RAEEEEASTEEEDKE
T608	AEEEEASTEEEDKEG
S622	GAVVSAPSVKGVSFD
S627	APSVKGVSFDQANNL
T647	RIEEEELTLTILRQT
T649	EEEELTLTILRQTGG
T654	TLTILRQTGGLGISI
S660	QTGGLGISIAGGKGS
S667	SIAGGKGStPYKGDD
T668-p	IAGGKGStPYKGDDE
T743	VEPENAVTITPLRPE
T745	PENAVTITPLRPEDD
Y753	PLRPEDDYSPRERRG
S754	LRPEDDYSPRERRGG
S772	LPLLPPESPGPLRQR
S794	SERGLGFSIAGGKGS
T802	IAGGKGSTPYRAGDA
S858	VSLLTAASPTIALLL
A869	ALLLEREAGGPLPPS
P872	LEREAGGPLPPSPLP
S876	AGGPLPPSPLPHSSP
S881	PPSPLPHSSPPTAAV
V888	SSPPTAAVATTSITT
S892	TAAVATTSITTATPG
T895	VATTSITTATPGVPG
A907	VPGLPSLAPSLLAAA
Y919-p	AAALEGPyPVEEIRL
S936	AGGPLGLSIVGGSDH
S969	PRGLAARSGLRVGDR
K1057	DEGIFISKVSPTGAA
S1059	GIFISKVSPTGAAGR
S1139	AGIGHRNSLESISSI
S1142	GHRNSLESISSIDRE
S1144	RNSLESISSIDRELS
S1145	NSLESISSIDRELSP
S1151	SSIDRELSPEGPGKE
Y1187	LQPLKLDYRALAAVP
S1195	RALAAVPSAGSVQRV
S1198	AAVPSAGSVQRVPsG
S1204-p	GSVQRVPsGAAGGKM
S1217	KMAESPCSPSGQQPP
G1220	ESPCSPSGQQPPSPP
-	gap
S1225	PSGQQPPSPPSPDEL
S1228	QQPPSPPSPDELPAN
T1261	DAPAQPPTPGPAASP
S1267	PTPGPAASPEQLSFR
S1272	AASPEQLSFRERQKy
Y1279-p	SFRERQKyFELEVRV
S1297	EGPPKRVSLVGADDL
S1356	DEQPPWASPSPTSRQ
S1358	QPPWASPSPTSRQSP
S1361	WASPSPTSRQSPAsP
S1364	PSPTSRQSPAsPPPL
S1367-p	TSRQSPAsPPPLGGG
S1394	QERLRVQSPEPPAPE
S1405	PAPERALSPAELRAL
S1427-p	WRAARMKsLEQDALR
T1448	RSQEGRGTRGPLERL
S1460	ERLAEAPSPAPTPSP
T1464	EAPSPAPTPSPTPVE
S1466	PSPAPTPSPTPVEDL
T1468	PAPTPSPTPVEDLGP
T1477	VEDLGPQTSTSPGRL
S1478	EDLGPQTSTSPGRLS
T1479	DLGPQTSTSPGRLSP
S1480	LGPQTSTSPGRLSPD
-	gap
S1485	STSPGRLSPDFAEEL
S1500	RSLEPSPSPGPQEED
P1503	EPSPSPGPQEEDGEV

	Scribble iso3
S23	SVDKRHCSLQAVPEE
Y32	QAVPEEIYRYSRSLE
Y34	VPEEIYRYSRSLEEL
S35	PEEIYRYSRSLEELL
S37	EIYRYSRSLEELLLD
K53	NQLRELPKPFFRLLN
K105	PESIKFCKALEIADF
K164	ELRENLLKSLPASLS
K266	PDGIGQLKQLSILKV
K272	LKQLSILKVDQNRLC
K313	RSLGKLTKLTNLNVD
S432	EDAGQQGSLSETWSD
S434	AGQQGSLSETWSDAP
K467	AEEAAAEKRGLQRRA
T475-p	RGLQRRAtPHPSELK
S479	RRAtPHPSELKVMKR
S487	ELKVMKRSIEGRRSE
S502	ACPCQPDSGSPLPAE
S504	PCQPDSGSPLPAEEE
L506	QPDSGSPLPAEEEKR
A508	DSGSPLPAEEEKRLS
Y564	EEDAEEDYQEPTVHF
I584	LPGDDREIEEGQPEA
T607	QRLIRKDTPHYKKHF
Y610	IRKDTPHYKKHFKIS
S668	EEEEEEGSPQEEEVE
S688	RAEEEEASTEEEDKE
T689	AEEEEASTEEEDKEG
S703	GAVVSAPSVKGVSFD
S708	APSVKGVSFDQANNL
T728	RIEEEELTLTILRQT
T730	EEEELTLTILRQTGG
T735	TLTILRQTGGLGISI
S741	QTGGLGISIAGGKGS
S748	SIAGGKGSTPYKGDD
T749	IAGGKGSTPYKGDDE
T824	VEPENAVTITPLRPE
T826	PENAVTITPLRPEDD
Y834	PLRPEDDYSPRERRG
S835	LRPEDDYSPRERRGG
S853	LPLLPPESPGPLRQR
S875	SERGLGFSIAGGKGS
T883	IAGGKGSTPYRAGDA
S939	VSLLTAASPTIALLL
A950	ALLLEREAGGPLPPS
P953	LEREAGGPLPPSPLP
S957	AGGPLPPSPLPHSSP
S962	PPSPLPHSSPPTAAV
V969	SSPPTAAVATTSITT
S973	TAAVATTSITTATPG
T976	VATTSITTATPGVPG
A988	VPGLPSLAPSLLAAA
Y1000-p	AAALEGPyPVEEIRL
S1017	AGGPLGLSIVGGSDH
S1050	PRGLAARSGLRVGDR
K1138	DEGIFISKVSPTGAA
S1140	GIFISKVSPTGAAGR
S1220	AGIGHRNSLESISSI
S1223	GHRNSLESISSIDRE
S1225	RNSLESISSIDRELS
S1226	NSLESISSIDRELSP
S1232	SSIDRELSPEGPGKE
Y1268	LQPLKLDYRALAAVP
S1276	RALAAVPSAGSVQRV
S1279	AAVPSAGSVQRVPsG
S1285-p	GSVQRVPsGAAGGKM
S1298	KMAESPCSPSGQQPP
G1301	ESPCSPSGQQPPSPP
-	gap
S1306	PSGQQPPSPPSPDEL
S1309	QQPPSPPSPDELPAN
T1342	DAPAQPPTPGPAASP
S1348	PTPGPAASPEQLSFR
S1353	AASPEQLSFRERQKy
Y1360-p	SFRERQKyFELEVRV
S1378	EGPPKRVSLVGADDL
S1437	DEQPPWASPSPTSRQ
S1439	QPPWASPSPTSRQSP
S1442	WASPSPTSRQSPASP
S1445	PSPTSRQSPASPPPL
S1448	TSRQSPASPPPLGGG
S1475	QERLRVQSPEPPAPE
S1486	PAPERALSPAELRAL
S1508-p	WRAARMKsLEQDALR
T1529	RSQEGRGTRGPLERL
S1541	ERLAEAPSPAPTPsP
T1545	EAPSPAPTPsPTPVE
S1547-p	PSPAPTPsPTPVEDL
T1549	PAPTPsPTPVEDLGP
T1558	VEDLGPQTsTsPGRL
S1559-p	EDLGPQTsTsPGRLP
T1560	DLGPQTsTsPGRLPL
S1561-p	LGPQTsTsPGRLPLS
Y1587-p	LPSSRPVyDIQsPDF
S1591-p	RPVyDIQsPDFAEEL
S1606	RSLEPSPSPGPQEED
P1609	EPSPSPGPQEEDGEV

	mouse ► Hide Isoforms
S23-p	SVDKRHCsLQVVPEE
Y32	QVVPEEIYRYsRsLE
Y34	VPEEIYRYsRsLEEL
S35-p	PEEIYRYsRsLEELL
S37-p	EIYRYsRsLEELLLD
K53-u	NQLRELPkPFFRLLN
K105-u	PESIKFCkALEIADF
K164-u	ELRENLLkSLPASLS
K266	PEGIGQLKQLSILKV
K272	LKQLSILKVDQNRLC
K313	HSLGKLTKLTNLNVD
S432-p	EDAGQQSsPsESCSD
S434-p	AGQQSsPsESCSDAP
K467	AEEAAAEKRGLQRRA
T475-p	RGLQRRAtPHPsELK
S479-p	RRAtPHPsELKVMKR
G487	ELKVMKRGIEERRNE
S503-p	FVCKPDPsPPsPsEE
P504	VCKPDPsPPsPsEEE
S506-p	KPDPsPPsPsEEEKR
S508-p	DPsPPsPsEEEKRLS
Y563	EEYTEDDYNEPTVHF
S583-p	IPREDGEsEEGQPEA
T606	QRLIRKDTPHYKKHF
Y609	IRKDTPHYKKHFKIS
-	gap
T674-p	DEEEGEAttEEDDKE
T675-p	EEEGEAttEEDDKEE
S689	EAVASAPSVKGVSFD
S694	APSVKGVSFDQANNL
T714	RIEEEELTLTIVRQT
T716	EEEELTLTIVRQTGG
T721	TLTIVRQTGGLGISI
S727	QTGGLGISIAGGKGS
S734	SIAGGKGSTPYKGDD
T735	IAGGKGSTPYKGDDE
T810	VEPENAVTItPLRPE
T812-p	PENAVTItPLRPEDD
Y820-p	PLRPEDDysPREWRG
S821-p	LRPEDDysPREWRGG
T839	LPLLQPETPVSLRQR
S861	SEKGLGFSIAGGKGS
T869	IAGGKGSTPYRAGDG
S925-p	VSLLTAAsPTISLLL
T936-p	SLLLEREtGGtYPPs
T939-p	LEREtGGtYPPsPPP
S943-p	tGGtYPPsPPPHsSP
S948-p	PPsPPPHsSPTPAAt
T955-p	sSPTPAAtVAAtVSt
T959-p	PAAtVAAtVStAVPG
T962-p	tVAAtVStAVPGEPL
S974-p	EPLLPRLsPSLLATA
Y986-p	ATALEGPyPVEEICL
S1003	AGGPLGLSIVGGSDH
C1036	PRGLAARCGLRVGDR
K1124	DEGIFISKVSPTGAA
S1126	GIFISKVSPTGAAGR
S1206-p	AGLGHRNsLEsIssI
S1209-p	GHRNsLEsIssIDRE
S1211-p	RNsLEsIssIDRELs
S1212-p	NsLEsIssIDRELsP
S1218-p	ssIDRELsPEGPGKE
Y1254	LEPLKLDYRALAALP
S1262-p	RALAALPsAGsLQRG
S1265-p	AALPsAGsLQRGPSA
S1271	GsLQRGPSATTGGKT
S1284-p	KTTEAPCsPGsQQPP
S1287-p	EAPCsPGsQQPPsPD
-	gap
-	gap
S1292-p	PGsQQPPsPDELPAN
T1325	NSATQPPTPGPAAsP
S1331-p	PTPGPAAsPEQLSFR
S1336	AAsPEQLSFRERQKY
Y1343	SFRERQKYFELEVRV
S1361-p	EGPPKRVsLVGADDL
V1419	EAEQPWAVPsHAGGS
S1421-p	EQPWAVPsHAGGSSP
G1424	WAVPsHAGGSSPSSP
S1427	PsHAGGSSPSSPPPL
S1430	AGGSSPSSPPPLGGN
S1457-p	QERLRMQsPELPAPE
S1468-p	PAPERALsPAERRAL
S1490-p	WRAARMKsLEQDALR
K1511-a	KSQEGRGkRGPLERL
S1523-p	ERLAEAPsPAPtPsP
T1527-p	EAPsPAPtPsPtPLE
S1529-p	PsPAPtPsPtPLEDF
T1531-p	PAPtPsPtPLEDFGL
T1540	LEDFGLQTsAsPGRL
S1541-p	EDFGLQTsAsPGRLs
A1542	DFGLQTsAsPGRLsP
S1543-p	FGLQTsAsPGRLsPD
-	gap
S1548-p	sAsPGRLsPDFVEEL
S1563-p	RTLEASPsPGsQEED
S1566-p	EASPsPGsQEEDGEV

	Scribble iso3
S23	SVDKRHCSLQVVPEE
Y32	QVVPEEIYRYSRSLE
Y34	VPEEIYRYSRSLEEL
S35	PEEIYRYSRSLEELL
S37	EIYRYSRSLEELLLD
K53	NQLRELPKPFFRLLN
K105	PESIKFCKALEIADF
K164	ELRENLLKSLPASLS
K266	PEGIGQLKQLSILKV
K272	LKQLSILKVDQNRLC
K313	HSLGKLTKLTNLNVD
S432	EDAGQQSSPSESCSD
S434	AGQQSSPSESCSDAP
K467	AEEAAAEKRGLQRRA
T475	RGLQRRATPHPSELK
S479	RRATPHPSELKVMKR
G487	ELKVMKRGIEERRNE
S503	FVCKPDPSPPSPSEE
P504	VCKPDPSPPSPSEEE
S506	KPDPSPPSPSEEEKR
S508	DPSPPSPSEEEKRLS
Y563	EEYTEDDYNEPTVHF
S583	IPREDGESEEGQPEA
T606	QRLIRKDTPHYKKHF
Y609	IRKDTPHYKKHFKIS
-	gap
T674	DEEEGEATTEEDDKE
T675	EEEGEATTEEDDKEE
S689	EAVASAPSVKGVSFD
S694	APSVKGVSFDQANNL
T714	RIEEEELTLTIVRQT
T716	EEEELTLTIVRQTGG
T721	TLTIVRQTGGLGISI
S727	QTGGLGISIAGGKGS
S734	SIAGGKGSTPYKGDD
T735	IAGGKGSTPYKGDDE
T810	VEPENAVTITPLRPE
T812	PENAVTITPLRPEDD
Y820	PLRPEDDYSPREWRG
S821	LRPEDDYSPREWRGG
T839	LPLLQPETPVSLRQR
S861	SEKGLGFSIAGGKGS
T869	IAGGKGSTPYRAGDG
S925	VSLLTAASPTISLLL
T936	SLLLERETGGTYPPS
T939	LERETGGTYPPSPPP
S943	TGGTYPPSPPPHSSP
S948	PPSPPPHSSPTPAAT
T955	SSPTPAATVAATVST
T959	PAATVAATVSTAVPG
T962	TVAATVSTAVPGEPL
S974	EPLLPRLSPSLLATA
Y986	ATALEGPYPVEEICL
S1003	AGGPLGLSIVGGSDH
C1036	PRGLAARCGLRVGDR
K1124	DEGIFISKVSPTGAA
S1126	GIFISKVSPTGAAGR
S1206	AGLGHRNSLESISSI
S1209	GHRNSLESISSIDRE
S1211	RNSLESISSIDRELS
S1212	NSLESISSIDRELSP
S1218	SSIDRELSPEGPGKE
Y1254	LEPLKLDYRALAALP
S1262	RALAALPSAGSLQRG
S1265	AALPSAGSLQRGPSA
S1271	GSLQRGPSATTGGKT
S1284	KTTEAPCSPGSQQTK
S1287	EAPCSPGSQQTKPGV
R1312-m1	NSPAPRGrGGPCsPP
S1317-p	RGrGGPCsPPsPDEL
S1320-p	GGPCsPPsPDELPAN
T1353	NSATQPPTPGPAASP
S1359	PTPGPAASPEQLSFR
S1364	AASPEQLSFRERQKY
Y1371	SFRERQKYFELEVRV
S1389	EGPPKRVSLVGADDL
V1447	EAEQPWAVPSHAGGS
S1449	EQPWAVPSHAGGSSP
G1452	WAVPSHAGGSSPSSP
S1455	PSHAGGSSPSSPPPL
S1458	AGGSSPSSPPPLGGN
S1485	QERLRMQSPELPAPE
S1496	PAPERALSPAERRAL
S1518	WRAARMKSLEQDALR
K1539	KSQEGRGKRGPLERL
S1551	ERLAEAPSPAPTPSP
T1555	EAPSPAPTPSPTPLE
S1557	PSPAPTPSPTPLEDF
T1559	PAPTPSPTPLEDFGL
T1568	LEDFGLQTSASPGRL
S1569	EDFGLQTSASPGRLP
A1570	DFGLQTSASPGRLPL
S1571	FGLQTSASPGRLPLS
Y1597	LPSSRPVYDIQsPDF
S1601-p	RPVYDIQsPDFVEEL
S1616	RTLEASPSPGSQEED
S1619	EASPSPGSQEEDGEV

	rat
S23	SVDKRHCSLQVVPEE
Y32	QVVPEEIYRYSRSLE
Y34	VPEEIYRYSRSLEEL
S35	PEEIYRYSRSLEELL
S37	EIYRYSRSLEELLLD
K53	NQLRELPKPFFRLLN
K105	PESIKFCKALEIADF
K164	ELRENLLKSLPASLS
K266	PEGIGQLKQLSILKV
K272	LKQLSILKVDQNRLC
K313	RSLGKLTKLTNLNVD
S432	EDPGQQSSPSESCSD
S434	PGQQSSPSESCSDAP
K467	AEEAAAEKRGLQRRA
T475	RGLQRRATPHPSELK
S479	RRATPHPSELKVMKR
G487	ELKVMKRGIEERRNE
S503	FVCKPDPSPPSPSEE
P504	VCKPDPSPPSPSEEE
S506	KPDPSPPSPSEEERR
S508	DPSPPSPSEEERRLS
Y563	EEYPEEDYNEPTVHF
G583	IPREDGEGEEGQPEA
T606	QRLIRKDTPHYKKHF
Y609	IRKDTPHYKKHFKIS
-	gap
S672	DEEEGEASMEEDDKE
M673	EEEGEASMEEDDKEE
S687	EAVASAPSVKGVSFD
S692	APSVKGVSFDQANNL
T712	RIEEEELTLTIVRQT
T714	EEEELTLTIVRQTGG
T719	TLTIVRQTGGLGISI
S725	QTGGLGISIAGGKGS
S732	SIAGGKGSTPYKGDD
T733	IAGGKGSTPYKGDDE
T808	VEPENAVTITPLRPE
T810	PENAVTITPLRPEDD
Y818	PLRPEDDYSPREWRG
S819	LRPEDDYSPREWRGG
T837	LPLLQPETPVPLRQR
S859	SEKGLGFSIAGGKGS
T867	IAGGKGSTPYRAGDA
S923	VSLLTAASTTISLLL
T934	SLLLERETGGAYPPS
A937	LERETGGAYPPSPPP
S941	TGGAYPPSPPPHSSS
S946	PPSPPPHSSSTPTAT
T953	SSSTPTATVAATMTT
T957	PTATVAATMTTAIPG
T960	TVAATMTTAIPGEPL
S972	EPLLPRLSPSLLATA
Y984	ATALEGPYPVEEICL
S1001	AGGPLGLSIVGGSDH
C1034	PRGLAARCGLRVGDR
K1122	DEGIFISKVSPTGAA
S1124	GIFISKVSPTGAAGR
S1204	AGLGHRNSLESISSI
S1207	GHRNSLESISSIDRE
S1209	RNSLESISSIDRELS
S1210	NSLESISSIDRELSP
S1216	SSIDRELSPEGPGKE
Y1252	QEPLKLDYRVLAAVP
S1260	RVLAAVPSAGSLQRG
S1263	AAVPSAGSLQRGPCA
C1269	GSLQRGPCATTGGKM
S1282	KMTEAPSSPGSQQTK
S1285	EAPSSPGSQQTKPGV
R1310	DSPAPRGRDGPCSPP
S1315	RGRDGPCSPPSPDEL
S1318	DGPCSPPSPDELPAN
T1351	NSATQPPTPGPAASP
S1357	PTPGPAASPEQLSFR
S1362	AASPEQLSFRERQKY
Y1369	SFRERQKYFELEVRV
S1387	EGPPKRVSLVGADDL
G1445	EAEQPWAGPSHAGGL
S1447	EQPWAGPSHAGGLSP
G1450	WAGPSHAGGLSPSSP
S1453	PSHAGGLSPSSPTPL
S1456	AGGLSPSSPTPLGGS
S1483	QERLRMQSPELPAPE
S1494	PAPERALSPAERRAL
S1516	WRAARMKSLEQDALR
K1537	KSQEGRGKRGPLERL
S1549	ERLAEAPSPAPTPSP
T1553	EAPSPAPTPSPTPLE
S1555	PSPAPTPSPTPLEDF
T1557	PAPTPSPTPLEDFGL
T1566	LEDFGLQTSTSPGRL
S1567	EDFGLQTSTSPGRLP
T1568	DFGLQTSTSPGRLPL
S1569	FGLQTSTSPGRLPLS
Y1595	LPSSRPVYDIQSPDF
S1599	RPVYDIQSPDFVEEL
S1614	RTLDPSPSPGPQEED
P1617	DPSPSPGPQEEDGEV

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