Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SAE2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SAE2 a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; Motility/polarity/chemotaxis; Ligase
Cellular Component: nucleoplasm; cytosol
Molecular Function: SUMO activating enzyme activity; protein binding; protein heterodimerization activity; metal ion binding; enzyme activator activity; transcription factor binding; ATP binding; ligase activity
Biological Process: positive regulation of catalytic activity; cellular protein metabolic process; protein sumoylation; SMT3-dependent protein catabolic process; post-translational protein modification
Reference #:  Q9UBT2 (UniProtKB)
Alt. Names/Synonyms: Anthracycline-associated resistance ARX; ARX; FLJ13058; HRIHFB2115; SAE2; SUMO-1 activating enzyme subunit 2; SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; UBA2; UBA2, ubiquitin-activating enzyme E1 homolog; Ubiquitin-like 1-activating enzyme E1B; ubiquitin-like modifier activating enzyme 2; UBLE1B
Gene Symbols: UBA2
Molecular weight: 71,224 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SAE2

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 R5 ___MALSRGLPRELA
0 1 R9 ALSRGLPRELAEAVA
0 2 K65-ub NRQFLFQkKHVGRSK
0 1 K77-ac RSKAQVAkESVLQFY
0 1 K77-ub RSKAQVAkESVLQFY
0 1 K86-ub SVLQFYPkANIVAYH
0 2 K152-ub LGQVTTIkkGVTECY
0 1 K153-ub GQVTTIkkGVTECYE
1 0 K190-sm IHCIVWAkYLFNQLF
0 5 S207-p EDADQEVsPDRADPE
0 1 S229-p AEARARAsNEDGDIk
0 1 K236-ac sNEDGDIkRISTkEW
2 0 K236-sm sNEDGDIkRISTkEW
0 1 K241-ac DIkRISTkEWAkSTG
0 1 K241-ub DIkRISTkEWAkSTG
0 2 K245-ub ISTkEWAkSTGyDPV
0 1 Y249-p EWAkSTGyDPVkLFT
0 14 K253-ac STGyDPVkLFTkLFK
0 2 K253-ub STGyDPVkLFTkLFK
0 2 K257-ub DPVkLFTkLFKDDIR
2 0 K257-sm DPVkLFTkLFKDDIR
0 1 Y265-p LFKDDIRyLLTMDkL
0 2 K271-ac RyLLTMDkLWRkRKP
0 1 K271-m1 RyLLTMDkLWRkRKP
0 1 K271-ub RyLLTMDkLWRkRKP
2 0 K271-sm RyLLTMDkLWRkRKP
1 0 K275-sm TMDkLWRkRKPPVPL
0 9 S289-p LDWAEVQsQGEEtNA
0 2 T294-p VQsQGEEtNASDQQN
0 2 K316-ub DQQVLDVkSYARLFS
0 1 K316-sc DQQVLDVkSYARLFS
0 1 K324-ac SYARLFSkSIEtLRV
0 2 K324-ub SYARLFSkSIEtLRV
0 1 T328-p LFSkSIEtLRVHLAE
0 1 K336-ac LRVHLAEkGDGAELI
0 2 K336-ub LRVHLAEkGDGAELI
0 1 K420-ub CRTIFLNkQPNPRKK
0 1 K467 TVLTLQDKIVKEkFA
0 1 K472-ub QDKIVKEkFAMVAPD
0 1 K505 TEANNHKKLsEFGIR
0 3 S507-p ANNHKKLsEFGIRNG
0 1 K540-sm LHSEDLGkDVEFEVV
0 10 A550 EFEVVGDAPEKVGPK
0 1 S577-p SDDGAQPstSTAQEQ
0 1 T578-p DDGAQPstSTAQEQD
0 1 T580 GAQPstSTAQEQDDV
0 9 S592-p DDVLIVDsDEEDSsN
0 1 S598-p DsDEEDSsNNADVSE
1 0 K611-sm SEEERSRkRkLDEkE
1 0 K613-sm EERSRkRkLDEkENL
0 1 K617-ac RkRkLDEkENLSAkR
1 0 K617-sm RkRkLDEkENLSAkR
0 1 S621 LDEkENLSAkRSRIE
0 86 K623-ac EkENLSAkRSRIEQk
2 0 K623-sm EkENLSAkRSRIEQk
2 0 K630-sm kRSRIEQkEELDDVI
  mouse

 
R5-m1 ___MALSrGLPrELA
R9-m1 ALSrGLPrELAEAVS
K65-ub NRQFLFQkKHVGRSK
K77 RSKAQVAKESVLQFH
K77 RSKAQVAKESVLQFH
Q86 SVLQFHPQANIEAHH
K152 LGQVTTIKKGVTECY
K153 GQVTTIKKGVTECYE
K190 IHCIVWAKYLFNQLF
S207-p EDADQEVsPDRADPE
S229 AEARARASNEDGDIK
K236 SNEDGDIKRISTKEW
K236 SNEDGDIKRISTKEW
K241 DIKRISTKEWAkSTG
K241 DIKRISTKEWAkSTG
K245-ub ISTKEWAkSTGYDPV
Y249 EWAkSTGYDPVkLFT
K253 STGYDPVKLFTkLFK
K253-ub STGYDPVkLFTkLFK
K257-ub DPVkLFTkLFKDDIR
K257 DPVkLFTKLFKDDIR
Y265 LFKDDIRYLLTMDKL
K271 RYLLTMDKLWRKRKP
K271 RYLLTMDKLWRKRKP
K271 RYLLTMDKLWRKRKP
K271 RYLLTMDKLWRKRKP
K275 TMDKLWRKRKPPVPL
S289 LDWAEVQSQGEANAD
N294 VQSQGEANADQQNEP
K314 DQQVLDVKSYASLFS
K314 DQQVLDVKSYASLFS
K322 SYASLFSKSIETLRV
K322-ub SYASLFSkSIETLRV
T326 LFSkSIETLRVHLAE
K334 LRVHLAEKGDGAELI
K334-ub LRVHLAEkGDGAELI
K418 CRTIFLNKQPNPRKK
K465-ub TVLTLQDkIVKEKFA
K470 QDkIVKEKFAMVAPD
K503-ub TEANNPKkLSDFGIR
S505 ANNPKkLSDFGIRNG
K538 LHSEDLGKDVEFEVV
S548-p EFEVVGDsPEKVGPK
S575-p SDDGAQPsTStAQEQ
T576 DDGAQPsTStAQEQD
T578-p GAQPsTStAQEQDDV
S590-p DDVLIVDsDEEGPSN
S596 DsDEEGPSNSTDCSG
K609 SGDDKARKRKLEENE
K611 DDKARKRKLEENEAA
N615 RKRKLEENEAAsTkK
N615 RKRKLEENEAAsTkK
S619-p LEENEAAsTkKCRLE
K621-ac ENEAAsTkKCRLEQM
K621 ENEAAsTKKCRLEQM
M628 kKCRLEQMEDPDDVI
  rat

 
R5 ___MSLSRGLPRELA
R9 SLSRGLPRELAEAVS
K65 NRQFLFQKKHVGRSK
K77 RSKAQVAKESVLQFH
K77 RSKAQVAKESVLQFH
Q86 SVLQFHPQANIEAHH
K152 LGQVTTIKKGVTECY
K153 GQVTTIKKGVTECYE
K190 IHCIVWAKYLFNQLF
S207 EDADQEVSPDRADPE
S229 AEARARASNEDGDIK
K236 SNEDGDIKRISTKEW
K236 SNEDGDIKRISTKEW
K241 DIKRISTKEWAKSTG
K241 DIKRISTKEWAKSTG
K245 ISTKEWAKSTGYDPV
Y249 EWAKSTGYDPVKLFT
K253 STGYDPVKLFTKLFK
K253 STGYDPVKLFTKLFK
K257 DPVKLFTKLFKDDIR
K257 DPVKLFTKLFKDDIR
Y265 LFKDDIRYLLTMDKL
K271 RYLLTMDKLWRKRKP
K271 RYLLTMDKLWRKRKP
K271 RYLLTMDKLWRKRKP
K271 RYLLTMDKLWRKRKP
K275 TMDKLWRKRKPPVPL
S289 LDWAEVQSQGEEANA
A294 VQSQGEEANADQQSE
K315 DQQVLDVKSYASLFS
K315 DQQVLDVKSYASLFS
K323 SYASLFSKSIETLRV
K323 SYASLFSKSIETLRV
T327 LFSKSIETLRVRLAE
K335 LRVRLAEKGDGAELI
K335 LRVRLAEKGDGAELI
K419 CRTIFLNKQPNPRKK
K466 TVLTLQDKIVKEKFA
K471 QDKIVKEKFAMVAPD
K504 TEANNPKKLSDFGIR
S506 ANNPKKLSDFGIRNG
K539 LHSEDLGKDVEFEVV
T549-p EFEVVGDtPEKVGPK
S576 SDDGAQPSTSTAQEQ
T577 DDGAQPSTSTAQEQD
T579 GAQPSTSTAQEQDDV
S591-p DDVLIVDsDEEGPSN
S597 DsDEEGPSNSADGSR
K610 SRDDRTRKRKLEENE
K612 DDRTRKRKLEENEGA
N616 RKRKLEENEGASTKK
N616 RKRKLEENEGASTKK
S620 LEENEGASTKKSRLE
K622 ENEGASTKKSRLEQV
K622 ENEGASTKKSRLEQV
V629 KKSRLEQVEDQDDVI
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.