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Protein Page:
MTA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MTA1 metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Motility/polarity/chemotaxis
Cellular Component: intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; nucleolus; NuRD complex; nucleus
Molecular Function: protein binding; enzyme binding; zinc ion binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: regulation of transcription, DNA-dependent; secretory granule organization and biogenesis; signal transduction
Reference #:  Q13330 (UniProtKB)
Alt. Names/Synonyms: metastasis associated 1; metastasis associated gene 1 protein; metastasis associated protein; Metastasis-associated protein MTA1; MTA1
Gene Symbols: MTA1
Molecular weight: 80,786 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MTA1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 Y11-p NMYRVGDyVYFENSS
0 7 K32-ub RRIEELNkTANGNVE
0 1 S52 FYRRRDISSTLIALA
0 1 S53 YRRRDISSTLIALAD
0 1 K61 TLIALADKHATLSVC
0 2 K208-ub AHNPLTDkQIDQFLV
0 2 Y355-p ESKLKQVyIPNYNkP
0 2 K361-ub VyIPNYNkPNPNQIS
0 18 S386-p GTGAPGQsPGAGRAC
0 1 Y427-p CWTYWKKyGGLKMPT
0 5 S446-p ERPGPNRsNMsPHGL
0 29 S449-p GPNRsNMsPHGLPAR
0 2 S458-p HGLPARSsGsPKFAM
0 2 S460-p LPARSsGsPKFAMKT
1 0 K509-sm PINSAAIkAECTARL
0 4 S520-p TARLPEAsQsPLVLk
1 23 S522-p RLPEAsQsPLVLkQA
0 2 K527-ub sQsPLVLkQAVRkPL
1 0 K532-m1 VLkQAVRkPLEAVLR
1 0 K532-m2 VLkQAVRkPLEAVLR
0 1 V556 KPDPVKSVSSVLSsL
0 1 S557 PDPVKSVSSVLSsLt
0 1 S561 KSVSSVLSsLtPAKV
0 1 S562-p SVSSVLSsLtPAKVA
0 29 T564-p SSVLSsLtPAKVAPV
0 25 S576-p APVINNGsPtILGKR
0 8 T578-p VINNGsPtILGKRSY
0 1 R583 sPtILGKRSYEQHNG
0 2 R604-m1 KRLLMPSrGLANHGQ
0 1 R604 KRLLMPSRGLANHGQ
2 0 K626-ac RNLLLNGkSYPTKVR
0 1 R636 PTKVRLIRGGsLPPV
0 5 S639-p VRLIRGGsLPPVKRR
0 5 Y659-p DAPDDVFyMATEETR
0 1 S673-p RKIRKLLsSsEtKRA
0 1 S675-p IRKLLsSsEtKRAAR
0 1 T677-p KLLsSsEtKRAARRP
0 1 Y685-p KRAARRPyKPIALRQ
  MTA1 iso3  
Y11 NMYRVGDYVYFENSS
K32 RRIEELNKTANGNVE
S52 FYRRRDISSTLIALA
S53 YRRRDISSTLIALAD
K61-ub TLIALADkHAREIEE
K191 AHNPLTDKQIDQFLV
Y338 ESKLKQVYIPNYNKP
K344 VYIPNYNKPNPNQIS
S369 GTGAPGQSPGAGRAC
Y410 CWTYWKKYGGLKMPT
S429 ERPGPNRSNMSPHGL
S432 GPNRSNMSPHGLPAR
S441 HGLPARSSGSPKFAM
S443 LPARSSGSPKFAMKT
K492 PINSAAIKAECTARL
S503 TARLPEASQSPLVLK
S505 RLPEASQSPLVLKQA
K510 SQSPLVLKQAVRKPL
K515 VLKQAVRKPLEAVLR
K515 VLKQAVRKPLEAVLR
V539 KPDPVKSVSSVLSSL
S540 PDPVKSVSSVLSSLT
S544 KSVSSVLSSLTPAKV
S545 SVSSVLSSLTPAKVA
T547 SSVLSSLTPAKVAPV
S559 APVINNGSPTILGKR
T561 VINNGSPTILGKRSY
R566 SPTILGKRSYEQHNG
R587 KRLLMPSRGLANHGQ
R587 KRLLMPSRGLANHGQ
K609 RNLLLNGKSYPTKVR
R619 PTKVRLIRGGSLPPV
S622 VRLIRGGSLPPVKRR
Y642 DAPDDVFYMATEETR
S656 RKIRKLLSSSETKRA
S658 IRKLLSSSETKRAAR
T660 KLLSSSETKRAARRP
Y668 KRAARRPYKPIALRQ
  mouse

 
Y11 NMYRVGDYVYFENSS
K32-ub RRIEELNkTANGNVE
S52-p FYRRRDIssSLIALA
S53-p YRRRDIssSLIALAD
K61 SLIALADKHATLSVC
K208 AHNPLVDKQIDQFLV
Y355-p ESKLKQVyIPNYNkP
K361-ub VyIPNYNkPNPNQIS
S386-p GTGTPGQsPGAGRAC
Y427 CWTYWKKYGGLKMPT
N446 ERPGPNRNNMsPHGI
S449-p GPNRNNMsPHGIPAR
S458-p HGIPARSsGsPKFAM
S460-p IPARSsGsPKFAMKT
K509 PINSAAIKAECTARL
S520-p TARLPEAsQsPLVLk
S522-p RLPEAsQsPLVLkQV
K527-ub sQsPLVLkQVVRKPL
K532 VLkQVVRKPLEAVLR
K532 VLkQVVRKPLEAVLR
S556-p KPDPVKSssSVLssL
S557-p PDPVKSssSVLssLt
S561-p KSssSVLssLtPAKS
S562-p SssSVLssLtPAKSA
T564-p sSVLssLtPAKSAPV
S576-p APVINNGsPtILGKR
T578-p VINNGsPtILGKRSY
R583 sPtILGKRSYEQHNG
R604-m1 KRLLMPSrGLANHGQ
R604-m2 KRLLMPSrGLANHGQ
K626-ac RNLLLNGkSYPTKVR
R636 PTKVRLIRGGsLPPV
S639-p VRLIRGGsLPPVKRR
Y659 DAPDDVFYMATEETR
S673 RKIRKLLSSSETKRA
S675 IRKLLSSSETKRAAR
T677 KLLSSSETKRAARRP
Y685 KRAARRPYKPIALRQ
  rat

 
Y11 NMYRVGDYVYFENSS
K32 RRIEELNKTANGNVE
S52 FYRRRDISSSLIALA
S53 YRRRDISSSLIALAD
K61 SLIALADKHATLSVC
K208 AHNPLVDKQIDQFLV
Y355 ESKLKQVYIPNYNKP
K361 VYIPNYNKPNPNQIS
S386-p GTGTPGQsPGAGRAC
Y427 CWTYWKKYGGLKMPT
N446 ERPGPNRNNMsPHGI
S449-p GPNRNNMsPHGIPAR
S458 HGIPARSSGSPKFAM
S460 IPARSSGSPKFAMKT
K509 PINSAAIKAECTARL
S520 TARLPEASQsPLVLK
S522-p RLPEASQsPLVLKQV
K527 SQsPLVLKQVVRKPL
K532 VLKQVVRKPLEAVLR
K532 VLKQVVRKPLEAVLR
S556 KPDPVKSSSSVLSSL
S557 PDPVKSSSSVLSSLt
S561 KSSSSVLSSLtPAKS
S562 SSSSVLSSLtPAKSA
T564-p SSVLSSLtPAKSAPV
S576-p APVINNGsPTILGKr
T578 VINNGsPTILGKrSY
R583-m1 sPTILGKrSYEQHNG
- gap
- gap
K614 RNLLLNGKSYPTKVR
R624-m1 PTKVRLIrGGsLPPV
S627-p VRLIrGGsLPPVKRR
Y647 DAPDDVFYMATEETR
S661 RKIRKLLSSSETKRA
S663 IRKLLSSSETKRAAR
T665 KLLSSSETKRAARRP
Y673 KRAARRPYKPIALRQ
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