metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor
Molecular Function: protein binding; enzyme binding; zinc ion binding; transcription coactivator activity; chromatin binding; transcription factor activity; transcription corepressor activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; secretory granule organization and biogenesis; response to lipopolysaccharide; female pregnancy; signal transduction; regulation of gene expression, epigenetic; entrainment of circadian clock by photoperiod; locomotor rhythm; regulation of transcription, DNA-dependent; double-strand break repair; regulation of inflammatory response; circadian regulation of gene expression; response to ionizing radiation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.