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Protein Page:
MRE11A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MRE11A a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; DNA repair; Cell cycle regulation; Deoxyribonuclease
Cellular Component: nucleoplasm; chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; perinuclear region of cytoplasm; nuclear chromatin; nucleolus; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; nuclease activity; DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; manganese ion binding; double-stranded DNA binding; 3'-5' exonuclease activity; endodeoxyribonuclease activity
Biological Process: heart development; positive regulation of kinase activity; sister chromatid cohesion; negative regulation of DNA endoreduplication; telomere maintenance via telomerase; regulation of mitotic recombination; DNA repair; positive regulation of protein amino acid autophosphorylation; double-strand break repair via nonhomologous end joining; DNA duplex unwinding; double-strand break repair via homologous recombination; DNA recombination; cell proliferation; meiotic recombination; double-strand break repair; synapsis; cell cycle checkpoint; response to DNA damage stimulus
Reference #:  P49959 (UniProtKB)
Alt. Names/Synonyms: AT-like disease; ATLD; DNA recombination and repair protein; Double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; Meiotic recombination 11 homolog 1; Meiotic recombination 11 homolog A; MRE11; MRE11 homolog 1; MRE11 homolog A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); MRE11A; MRE11B
Gene Symbols: MRE11A
Molecular weight: 80,593 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Cell Cycle: G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MRE11A
Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S264‑p, T329‑p, S382‑p, T481‑p, S531‑p, S590‑p, S676‑p, S678‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 5 S2 ______MSTADALDD
0 1 A4 ____MSTADALDDEN
0 1 T74-p PSRKTLHtCLELLRK
0 1 S165-p SVEKIDIsPVLLQKG
0 1 S183-p IALYGLGsIPDERLy
0 1 Y190-p sIPDERLyRMFVNkk
0 8 K196-a LyRMFVNkkVTMLRP
0 8 K197-a yRMFVNkkVTMLRPK
2 0 S264-p EQQLFYIsQPGSSVV
0 1 T272-p QPGSSVVtsLsPGEA
0 1 S273-p PGSSVVtsLsPGEAV
0 1 S275-p SSVVtsLsPGEAVKK
1 0 T329-p NPDNPKVtQAIQSFC
1 0 S382-p PFSVLRFsQkFVDRV
0 1 K384-u SVLRFsQkFVDRVAN
0 1 K393-u VDRVANPkDIIHFFR
0 1 K416-u GEEINFGkLITKPSE
0 1 T426-p TKPSEGTtLRVEDLV
0 1 K434-u LRVEDLVkQYFQTAE
0 9 K442-u QYFQTAEkNVQLSLL
0 1 K464-u AVQEFVDkEEKDAIE
0 1 K475-u DAIEELVkYQLEktQ
0 1 K480-a LVkYQLEktQRFLKE
1 0 T481-p VkYQLEktQRFLKER
1 1 S531-p TRARALRsQSEESAS
0 6 S558-p AEQMANDsDDsISAA
0 2 S561-p MANDsDDsISAATNK
2 0 R570-m SAATNKGrGrGrGrr
2 0 R572-m ATNKGrGrGrGrrGG
2 0 R574-m NKGrGrGrGrrGGrG
2 0 R576-m GrGrGrGrrGGrGQN
2 0 R577-m rGrGrGrrGGrGQNS
2 0 R580-m GrGrrGGrGQNSASr
3 0 R587-m rGQNSASrGGsQrGr
1 0 S590-p NSASrGGsQrGrADt
2 0 R592-m ASrGGsQrGrADtGL
2 0 R594-m rGGsQrGrADtGLET
0 2 R594-m1 rGGsQrGrADtGLET
0 15 T597-p sQrGrADtGLETSTR
0 2 S619-p VSASRNMsIIDAFKS
0 1 K625 MsIIDAFKSTRQQPS
0 1 S641 NVTTKNYSEVIEVDE
1 15 S649-p EVIEVDEsDVEEDIF
0 4 T669-p TDQRWSStSsskIMs
0 1 S671-p QRWSStSsskIMsQs
0 1 S672-p RWSStSsskIMsQsQ
0 8 K673 WSStSssKIMsQsQV
0 1 K673-u WSStSsskIMsQsQV
1 14 S676-p tSsskIMsQsQVsKG
1 6 S678-p sskIMsQsQVsKGVD
0 2 S681-p IMsQsQVsKGVDFEs
0 27 S688-p sKGVDFEssEDDDDD
0 18 S689-p KGVDFEssEDDDDDP
0 1 S701-p DDPFMNTsSLRRNRR
4859 : Phospho-Mre11 (Ser676) Antibody
  MRE11A iso2  
S2 ______MSTADALDD
A4 ____MSTADALDDEN
T74 PSRKTLHTCLELLRK
S165 SVEKIDISPVLLQKG
S183 IALYGLGSIPDERLY
Y190 SIPDERLYRMFVNKK
K196 LYRMFVNKKVTMLRP
K197 YRMFVNKKVTMLRPK
S264 EQQLFYISQPGSSVV
T272 QPGSSVVTSLSPGEA
S273 PGSSVVTSLSPGEAV
S275 SSVVTSLSPGEAVKK
T329 NPDNPKVTQAIQSFC
S382 PFSVLRFSQKFVDRV
K384 SVLRFSQKFVDRVAN
K393 VDRVANPKDIIHFFR
K416 GEEINFGKLITKPSE
T426 TKPSEGTTLRVEDLV
K434 LRVEDLVKQYFQTAE
K442 QYFQTAEKNVQLSLL
K464 AVQEFVDKEEKDAIE
K475 DAIEELVKYQLEKTQ
K480 LVKYQLEKTQRFLKE
T481 VKYQLEKTQRFLKER
S531 TRARALRSQSEESAS
S558 AEQMANDSDDSISAA
S561 MANDSDDSISAATNK
R570 SAATNKGRGRGRGRR
R572 ATNKGRGRGRGRRGG
R574 NKGRGRGRGRRGGRG
R576 GRGRGRGRRGGRGQN
R577 RGRGRGRRGGRGQNS
R580 GRGRRGGRGQNSASR
R587 RGQNSASRGGSQRGR
S590 NSASRGGSQRGRAFk
R592 ASRGGSQRGRAFkST
R594 RGGSQRGRAFkSTRQ
R594 RGGSQRGRAFkSTRQ
- gap
- gap
K597-a SQRGRAFkSTRQQPS
S613 NVTTKNYSEVIEVDE
S621 EVIEVDESDVEEDIF
T641 TDQRWSSTSSSKIMS
S643 QRWSSTSSSKIMSQS
S644 RWSSTSSSKIMSQSQ
K645 WSSTSSSKIMSQSQV
K645 WSSTSSSKIMSQSQV
S648 TSSSKIMSQSQVSKG
S650 SSKIMSQSQVSKGVD
S653 IMSQSQVSKGVDFES
S660 SKGVDFESSEDDDDD
S661 KGVDFESSEDDDDDP
S673 DDPFMNTSSLRRNRR
  mouse

 
S2-p ______MsPtDPLDD
T4-p ____MsPtDPLDDED
S74 PSRKTLHSCLELLRK
S165 SVEKVDISPVLLQKG
S183 LALYGLGSIPDERLY
Y190 SIPDERLYRMFVNkk
K196-a LYRMFVNkkVTMLRP
K197-a YRMFVNkkVTMLRPK
S264 EQQLFYVSQPGSSVV
T272 QPGSSVVTSLSPGEA
S273 PGSSVVTSLSPGEAV
S275 SSVVTSLSPGEAVKK
T329 NPDNPKVTQAIQSFC
S382 PFNVLRFSQKFVDRV
K384 NVLRFSQKFVDRVAN
K393 VDRVANPKDVIHFFR
M416 GEEINFGMLITKPAS
T427 KPASEGATLRVEDLV
K435 LRVEDLVKQYFQTAE
K443-u QYFQTAEkNVQLSLL
K465 AVQEFVDKEEKDAIE
K476 DAIEELVKYQLEKTQ
K481 LVKYQLEKTQRFLKE
T482 VKYQLEKTQRFLKER
S532 SRARALRSQSETSTS
S558 SEQTANDSDDSLSAV
S561 TANDSDDSLSAVPSR
R570 SAVPSRGRGRGRGRR
R572 VPSRGRGRGRGRRGA
R574 SRGRGRGRGRRGARG
R576 GRGRGRGRRGARGQS
R577 RGRGRGRRGARGQSS
R580 GRGRRGARGQSSAPR
R587 RGQSSAPRGGSQRGR
S590 SSAPRGGSQRGRDTG
R592 APRGGSQRGRDTGLE
R594 RGGSQRGRDTGLEIT
R594 RGGSQRGRDTGLEIT
T596 GSQRGRDTGLEITTR
S618-p SSTSRNMsIIDAFRS
R624 MsIIDAFRSTRQQPS
S640-p NVAPKNYsETIEVDD
S648-p ETIEVDDsDEDDIFP
T667 ADQRWSGTTSSkRMS
S669 QRWSGTTSSkRMSQS
S670 RWSGTTSSkRMSQSQ
K671-a WSGTTSSkRMSQSQT
K671 WSGTTSSKRMSQSQT
S674 TTSSkRMSQSQTAKG
S676 SSkRMSQSQTAKGVD
A679 RMSQSQTAKGVDFEs
S686-p AKGVDFEsDEDDDDD
D687 KGVDFEsDEDDDDDP
S699 DDPFMSSSCPRRNRR
  rat

 
S2 ______MSPTDPLDD
T4 ____MSPTDPLDDED
S74 PSRKTLHSCLELLRK
S165 SVEKVDISPVLLQKG
S183 LALYGLGSIPDERLY
Y190 SIPDERLYRMFVNKK
K196 LYRMFVNKKVTMLRP
K197 YRMFVNKKVTMLRPK
S264 EQQLFYVSQPGSSVV
T272 QPGSSVVTALSPGET
A273 PGSSVVTALSPGETV
S275 SSVVTALSPGETVKK
T329 NPDNPKVTQAIQSFC
S382 PFNVLRFSQKFVDRV
K384 NVLRFSQKFVDRVAN
K393 VDRVANPKDVIHFFR
K416 GEEINFGKLIIKPAS
T427 KPASEGTTLRVEDLV
K435 LRVEDLVKQYFQTAE
K443 QYFQTAEKNVQLSLL
K465 AVQEFVDKEEKDAIE
K476 DAIEELVKYQLEKTQ
K481 LVKYQLEKTQRFLKE
T482 VKYQLEKTQRFLKER
S532 SRARALRSQSENAAS
S558 TEQTADDSDDSQSAV
S561 TADDSDDSQSAVPSR
R570 SAVPSRGRGRGRGRR
R572 VPSRGRGRGRGRRGG
R574 SRGRGRGRGRRGGRG
R576 GRGRGRGRRGGRGQS
R577 RGRGRGRRGGRGQST
R580 GRGRRGGRGQSTAPR
R587 RGQSTAPRGGSQRGR
S590 STAPRGGSQRGRDTG
R592 APRGGSQRGRDTGLG
R594 RGGSQRGRDTGLGIS
R594 RGGSQRGRDTGLGIS
T596 GSQRGRDTGLGISTR
S618 ASTSRNMSIIDAFRS
R624 MSIIDAFRSTRQQPS
S640 NVATKNYSETIEVDE
S648 ETIEVDESDDDDSFP
T667 ADQRWSGTAPSKRMS
P669 QRWSGTAPSKRMSQS
S670 RWSGTAPSKRMSQSQ
K671 WSGTAPSKRMSQSQT
K671 WSGTAPSKRMSQSQT
S674 TAPSKRMSQSQTAKG
S676 PSKRMSQSQTAKGVD
A679 RMSQSQTAKGVDFEs
S686-p AKGVDFEsDEDDDDD
D687 KGVDFEsDEDDDDDP
S699 DDPFMSGSCPRRNRR
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