a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. Alternative splicing results in two different isoforms. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; DNA repair; Cell cycle regulation; Deoxyribonuclease
Cellular Component: nucleoplasm; chromosome, telomeric region; condensed nuclear chromosome; Mre11 complex; perinuclear region of cytoplasm; nuclear chromatin; nucleolus; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; nuclease activity; DNA binding; single-stranded DNA specific endodeoxyribonuclease activity; manganese ion binding; double-stranded DNA binding; 3'-5' exonuclease activity; endodeoxyribonuclease activity
Biological Process: heart development; positive regulation of kinase activity; sister chromatid cohesion; negative regulation of DNA endoreduplication; telomere maintenance via telomerase; regulation of mitotic recombination; DNA repair; positive regulation of protein amino acid autophosphorylation; double-strand break repair via nonhomologous end joining; DNA duplex unwinding; double-strand break repair via homologous recombination; DNA recombination; cell proliferation; meiotic recombination; double-strand break repair; synapsis; cell cycle checkpoint; response to DNA damage stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.