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Protein Page:
Meg-3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Meg-3 a maternal imprinting gene. Absent in pituitary adenomas. May possess growth suppressor activity. Two major alternatively spliced isoforms have been described. forms. One form, Meg3-proximal ( Meg3p), contains exons 1-3. The second form, Meg3-distal ( Meg3d) did not contain exons 1-3 and was present in oocytes and in 1- and 2-cell embryos. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 9q34.13
Cellular Component: nucleoplasm; adherens junction; cytoplasm; plasma membrane; nucleolus; cytosol; nucleus; actin cytoskeleton
Biological Process: negative regulation of apoptosis
Reference #:  Q96TA1 (UniProtKB)
Alt. Names/Synonyms: bA356B19.6; C9orf88; DKFZP434H0820; FAM129B; family with sequence similarity 129, member B; FLJ13518; FLJ22151; FLJ22298; Meg-3; MINERVA; Niban-like protein 1; NIBL1; OC58; Protein FAM129B
Gene Symbols: FAM129B
Molecular weight: 84,138 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Meg-3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 K83 FQHQEDSKKWRNRFS
0 2 K84 QHQEDSKKWRNRFSL
0 1 Y101-p HNYGLVLyENkAAYE
0 1 K104-ac GLVLyENkAAYERQV
0 4 K104-ub GLVLyENkAAYERQV
0 1 T126-p SAGYKILtSVDQYLE
0 2 S138-p YLELIGNsLPGttAk
0 1 T142-p IGNsLPGttAkSGSA
0 1 T143-p GNsLPGttAkSGSAP
0 3 K145-ub sLPGttAkSGSAPIL
0 2 K153-ub SGSAPILkCPTQFPL
0 1 K203-ac NGIPEDSkVEGPAFT
0 1 S315-p DMDQIITskEHLASK
0 2 K316-ub MDQIITskEHLASKI
0 1 K384-ub INEGGIDkLGEyMEk
0 3 Y388-p GIDkLGEyMEkLSRL
0 1 K391-ub kLGEyMEkLSRLAyH
0 20 Y397-p EkLSRLAyHPLkMQS
0 3 K401-ub RLAyHPLkMQSCYEK
0 1 S427-p RFDVSSTsVFkQRAQ
0 3 K430-ub VSSTsVFkQRAQIHM
0 1 Y446-p EQMDNAVyTFEtLLH
0 1 T450-p NAVyTFEtLLHQELG
0 1 K479-ac VLERVLKkyDyDsSS
0 1 Y480-p LERVLKkyDyDsSSV
0 41 Y482-p RVLKkyDyDsSSVRK
0 1 S484-p LKkyDyDsSSVRKRF
0 1 K507-ac SIPFLLKkLAPTCKS
0 1 K554-ub KDILQAVkEAAVQRk
0 1 K561-ub kEAAVQRkHNLyRDs
0 2 Y565-p VQRkHNLyRDsMVMH
0 3 S568-p kHNLyRDsMVMHNsD
0 5 S574-p DsMVMHNsDPNLHLL
0 2 Y593-p PIDWGEEySNSGGGG
0 2 S601-p SNSGGGGsPsPStPE
0 2 S603-p SGGGGsPsPStPEsA
0 5 T606-p GGsPsPStPEsATLS
0 1 S609-p PsPStPEsATLSEKR
0 4 S624-p RRAKQVVsVVQDEEV
0 7 S638-p VGLPFEAsPEsPPPA
0 1 P639 GLPFEAsPEsPPPAs
0 13 S641-p PFEAsPEsPPPAsPD
0 3 P643 EAsPEsPPPAsPDGV
0 19 S646-p PEsPPPAsPDGVtEI
0 4 G649 PPPAsPDGVtEIRGL
0 4 T651-p PAsPDGVtEIRGLLA
0 35 S665-p AQGLRPEsPPPAGPL
0 2 P666 QGLRPEsPPPAGPLL
0 4 G670 PEsPPPAGPLLNGAP
0 22 S681-p NGAPAGEsPQPKAAP
0 21 S691-p PKAAPEAssPPAsPL
0 33 S692-p KAAPEAssPPAsPLQ
0 41 S696-p EAssPPAsPLQHLLP
0 2 S728-p EQVSSPSsHPALHTT
0 1 T736 HPALHTTTEDSAGVQ
  Meg-3 iso2  
K70 FQHQEDSKKWRNRFS
K71 QHQEDSKKWRNRFSL
Y88 HNYGLVLYENKAAYE
K91 GLVLYENKAAYERQV
K91 GLVLYENKAAYERQV
T113 SAGYKILTSVDQYLE
S125 YLELIGNSLPGTTAK
T129 IGNSLPGTTAKSGSA
T130 GNSLPGTTAKSGSAP
K132 SLPGTTAKSGSAPIL
K140 SGSAPILKCPTQFPL
K190 NGIPEDSKVEGPAFT
S302 DMDQIITSKEHLASK
K303 MDQIITSKEHLASKI
K371 INEGGIDKLGEYMEK
Y375 GIDKLGEYMEKLSRL
K378 KLGEYMEKLSRLAYH
Y384 EKLSRLAYHPLKMQS
K388 RLAYHPLKMQSCYEK
S414 RFDVSSTSVFKQRAQ
K417 VSSTSVFKQRAQIHM
Y433 EQMDNAVYTFETLLH
T437 NAVYTFETLLHQELG
K466 VLERVLKKYDYDSSS
Y467 LERVLKKYDYDSSSV
Y469 RVLKKYDYDSSSVRK
S471 LKKYDYDSSSVRKRF
K494 SIPFLLKKLAPTCKS
K541 KDILQAVKEAAVQRK
K548 KEAAVQRKHNLYRDS
Y552 VQRKHNLYRDSMVMH
S555 KHNLYRDSMVMHNSD
S561 DSMVMHNSDPNLHLL
Y580 PIDWGEEYSNSGGGG
S588 SNSGGGGSPSPSTPE
S590 SGGGGSPSPSTPESA
T593 GGSPSPSTPESATLS
S596 PSPSTPESATLSEKR
S611 RRAKQVVSVVQDEEV
S625 VGLPFEASPESPPPA
P626 GLPFEASPESPPPAS
S628 PFEASPESPPPASPD
P630 EASPESPPPASPDGV
S633 PESPPPASPDGVTEI
G636 PPPASPDGVTEIRGL
T638 PASPDGVTEIRGLLA
S652 AQGLRPESPPPAGPL
P653 QGLRPESPPPAGPLL
G657 PESPPPAGPLLNGAP
S668 NGAPAGESPQPKAAP
S678 PKAAPEASSPPASPL
S679 KAAPEASSPPASPLQ
S683 EASSPPASPLQHLLP
S715 EQVSSPSSHPALHTT
T723 HPALHTTTEDSAGVQ
  mouse

 
K83-ac FQYQEDNkkWRNRFS
K84-ac QYQEDNkkWRNRFSL
Y101 HNYGLVLYENkVAYE
K104 GLVLYENKVAYERQI
K104-ub GLVLYENkVAYERQI
T126 SAGYKVLTSVDQYLE
S138 YLELVGNSLPGTTSk
T142 VGNSLPGTTSkSGST
T143 GNSLPGTTSkSGSTP
K145-ub SLPGTTSkSGSTPIL
K153 SGSTPILKCPTQFPL
K203 NGIPENSKVEGPAFT
S315 DMDQIITSKEHLASK
K316 MDQIITSKEHLASKI
K384 INEGGIDKLGEYMEK
Y388 GIDKLGEYMEKLSQL
K391 KLGEYMEKLSQLAYH
Y397 EKLSQLAYHPLkMQS
K401-ub QLAYHPLkMQSCYEK
S427 RFDVSSTSVFkQRAQ
K430-ub VSSTSVFkQRAQIHM
Y446 EQMDNAVYTFETLLH
T450 NAVYTFETLLHQELG
K479 ILERVLKKYDYDSSS
Y480 LERVLKKYDYDSSSV
Y482 RVLKKYDYDSSSVRK
S484 LKKYDYDSSSVRKRF
K507 TIPFLLKKLAPTCKS
K554 KDILQAVKEAAVQRK
K561 KEAAVQRKHNLyRDs
Y565-p VQRKHNLyRDsMVLH
S568-p KHNLyRDsMVLHNsD
S574-p DsMVLHNsDPNLHLL
Y593 PIDWGEQYGDSGDSG
S607-p GGGDSGGsPCPSEAA
- gap
- gap
- gap
S628 RRAKQVMSVVQDEES
G642 SGLPFEAGVEPPsPA
V643 GLPFEAGVEPPsPAs
P645 PFEAGVEPPsPAsPD
S647-p EAGVEPPsPAsPDsV
S650-p VEPPsPAsPDsVTEL
S653-p PsPAsPDsVTELRGL
T655 PAsPDsVTELRGLLA
S669-p AQDLQAEssPPAsPL
S670-p QDLQAEssPPAsPLL
S674-p AEssPPAsPLLNGAP
S685 NGAPVQESSQPVAVP
S695-p PVAVPEAsPPAsPLR
- gap
S699-p PEAsPPAsPLRHLPP
S731-p EQVSSPGsRPPIHTT
T739-p RPPIHTTtEDSAGVQ
  rat

 
K83 FQYQEDNKKWRNRFS
K84 QYQEDNKKWRNRFSL
Y101 HNYGLVLYENKVAYE
K104 GLVLYENKVAYERQI
K104 GLVLYENKVAYERQI
T126 SAGYKVLTSLDQYLE
S138 YLELVGNSLPGTTSK
T142 VGNSLPGTTSKSGST
T143 GNSLPGTTSKSGSTP
K145 SLPGTTSKSGSTPIL
K153 SGSTPILKCPTQFPL
K203 NGIPENSKVEGPAFT
S315 DMDQIITSKEHLASK
K316 MDQIITSKEHLASKI
K384 INEGGIDKLGEYMEK
Y388 GIDKLGEYMEKLSQL
K391 KLGEYMEKLSQLAYH
Y397 EKLSQLAYHPLKMQS
K401 QLAYHPLKMQSCYEK
S427 RFDVSSTSVFKQRAQ
K430 VSSTSVFKQRAQIHM
Y446 EQMDNAVYTFETLLH
T450 NAVYTFETLLHQELG
K479-ac ILERVLKkYDYDSSS
Y480 LERVLKkYDYDSSSV
Y482 RVLKkYDYDSSSVRK
S484 LKkYDYDSSSVRKRF
K507-ac TIPFLLKkLAPTCKS
K554 KDILQAVKEAAVQRK
K561 KEAAVQRKHNLYRDS
Y565 VQRKHNLYRDSVVLH
S568 KHNLYRDSVVLHNSD
S574 DSVVLHNSDPNLHLL
Y593 PIDWGEQYGDGGDGS
S605 DGSDSGGSPCPSEAA
- gap
- gap
- gap
S626-p RRAKQVVsVVQDEES
G640 SGLPFEAGsEPPsPA
S641-p GLPFEAGsEPPsPAs
P643 PFEAGsEPPsPAsPD
S645-p EAGsEPPsPAsPDNV
S648-p sEPPsPAsPDNVTEL
N651 PsPAsPDNVTELRGL
T653 PAsPDNVTELRGLLA
S667 AQDLQAESSPPAsPL
S668 QDLQAESSPPAsPLL
S672-p AESSPPAsPLLNGAP
S683 NGAPVQESPQPMTVL
S693-p PMTVLEAsPPAsPLR
- gap
S697-p LEAsPPAsPLRHLPP
S729 EKVSSPGSRPPIHTT
T737 RPPIHTTTEDSAGVQ
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