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Protein Page:
Meg-3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Meg-3 a maternal imprinting gene. Absent in pituitary adenomas. May possess growth suppressor activity. Two major alternatively spliced isoforms have been described. forms. One form, Meg3-proximal ( Meg3p), contains exons 1-3. The second form, Meg3-distal ( Meg3d) did not contain exons 1-3 and was present in oocytes and in 1- and 2-cell embryos. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: adherens junction; cytoplasm; plasma membrane; nucleolus; cytosol; nucleus; actin cytoskeleton
Biological Process: negative regulation of apoptosis
Reference #:  Q96TA1 (UniProtKB)
Alt. Names/Synonyms: bA356B19.6; C9orf88; DKFZP434H0820; FAM129B; family with sequence similarity 129, member B; FLJ13518; FLJ22151; FLJ22298; Meg-3; MINERVA; Niban-like protein 1; NIBL1; OC58; Protein FAM129B
Gene Symbols: FAM129B
Molecular weight: 84,138 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Meg-3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K83 FQHQEDSKKWRNRFS
0 2 K84 QHQEDSKKWRNRFSL
0 1 Y101-p HNYGLVLyENkAAYE
0 1 K104-ac GLVLyENkAAYERQV
0 4 K104-ub GLVLyENkAAYERQV
0 1 T126-p SAGYKILtSVDQYLE
0 2 S138-p YLELIGNsLPGttAk
0 1 T142-p IGNsLPGttAkSGSA
0 1 T143-p GNsLPGttAkSGSAP
0 3 K145-ub sLPGttAkSGSAPIL
0 2 K153-ub SGSAPILkCPTQFPL
0 1 K203-ac NGIPEDSkVEGPAFT
0 1 S315-p DMDQIITskEHLASK
0 2 K316-ub MDQIITskEHLASKI
0 1 K384-ub INEGGIDkLGEyMEk
0 3 Y388-p GIDkLGEyMEkLSRL
0 1 K391-ub kLGEyMEkLSRLAyH
0 20 Y397-p EkLSRLAyHPLkMQS
0 3 K401-ub RLAyHPLkMQSCYEK
0 1 S427-p RFDVSSTsVFkQRAQ
0 3 K430-ub VSSTsVFkQRAQIHM
0 1 Y446-p EQMDNAVyTFEtLLH
0 1 T450-p NAVyTFEtLLHQELG
0 1 Y480-p LERVLKKyDyDsSSV
0 41 Y482-p RVLKKyDyDsSSVRK
0 1 S484-p LKKyDyDsSSVRKRF
0 1 K554-ub KDILQAVkEAAVQRk
0 1 K561-ub kEAAVQRkHNLyRDs
0 2 Y565-p VQRkHNLyRDsMVMH
0 3 S568-p kHNLyRDsMVMHNsD
0 4 S574-p DsMVMHNsDPNLHLL
0 1 Y593-p PIDWGEEySNSGGGG
0 1 S601-p SNSGGGGsPsPStPE
0 1 S603-p SGGGGsPsPStPEsA
0 4 T606-p GGsPsPStPEsATLS
0 1 S609-p PsPStPEsATLSEKR
0 2 S624-p RRAKQVVsVVQDEEV
0 5 S638-p VGLPFEAsPEsPPPA
0 10 S641-p PFEAsPEsPPPAsPD
0 2 - gap
0 14 S646-p PEsPPPAsPDGVtEI
0 4 - gap
0 3 T651-p PAsPDGVtEIRGLLA
0 26 S665-p AQGLRPEsPPPAGPL
0 2 - gap
0 3 - gap
0 16 S681-p NGAPAGEsPQPKAAP
0 14 S691-p PKAAPEAssPPAsPL
0 26 S692-p KAAPEAssPPAsPLQ
0 29 S696-p EAssPPAsPLQHLLP
0 2 S728-p EQVSSPSsHPALHTT
0 1 T736 HPALHTTTEDSAGVQ
  mouse

 
K83-ac FQYQEDNkkWRNRFS
K84-ac QYQEDNkkWRNRFSL
Y101 HNYGLVLYENkVAYE
K104 GLVLYENKVAYERQI
K104-ub GLVLYENkVAYERQI
T126 SAGYKVLTSVDQYLE
S138 YLELVGNSLPGTTSk
T142 VGNSLPGTTSkSGST
T143 GNSLPGTTSkSGSTP
K145-ub SLPGTTSkSGSTPIL
K153 SGSTPILKCPTQFPL
K203 NGIPENSKVEGPAFT
S315 DMDQIITSKEHLASK
K316 MDQIITSKEHLASKI
K384 INEGGIDKLGEYMEK
Y388 GIDKLGEYMEKLSQL
K391 KLGEYMEKLSQLAYH
Y397 EKLSQLAYHPLkMQS
K401-ub QLAYHPLkMQSCYEK
S427 RFDVSSTSVFkQRAQ
K430-ub VSSTSVFkQRAQIHM
Y446 EQMDNAVYTFETLLH
T450 NAVYTFETLLHQELG
Y480 LERVLKKYDYDSSSV
Y482 RVLKKYDYDSSSVRK
S484 LKKYDYDSSSVRKRF
K554 KDILQAVKEAAVQRK
K561 KEAAVQRKHNLyRDs
Y565-p VQRKHNLyRDsMVLH
S568-p KHNLyRDsMVLHNsD
S574-p DsMVLHNsDPNLHLL
Y593 PIDWGEQYGDSGDSG
S607-p GGGDSGGsPCPSEAA
- gap
- gap
- gap
S628 RRAKQVMSVVQDEES
- gap
- gap
S647-p EAGVEPPsPAsPDsV
S650-p VEPPsPAsPDsVTEL
S653-p PsPAsPDsVTELRGL
T655 PAsPDsVTELRGLLA
S669-p AQDLQAEssPPAsPL
S670-p QDLQAEssPPAsPLL
S674-p AEssPPAsPLLNGAP
S685 NGAPVQESSQPVAVP
S695-p PVAVPEAsPPAsPLR
- gap
S699-p PEAsPPAsPLRHLPP
S731-p EQVSSPGsRPPIHTT
T739-p RPPIHTTtEDSAGVQ
  rat

 
K83 FQYQEDNKKWRNRFS
K84 QYQEDNKKWRNRFSL
Y101 HNYGLVLYENKVAYE
K104 GLVLYENKVAYERQI
K104 GLVLYENKVAYERQI
T126 SAGYKVLTSLDQYLE
S138 YLELVGNSLPGTTSK
T142 VGNSLPGTTSKSGST
T143 GNSLPGTTSKSGSTP
K145 SLPGTTSKSGSTPIL
K153 SGSTPILKCPTQFPL
K203 NGIPENSKVEGPAFT
S315 DMDQIITSKEHLASK
K316 MDQIITSKEHLASKI
K384 INEGGIDKLGEYMEK
Y388 GIDKLGEYMEKLSQL
K391 KLGEYMEKLSQLAYH
Y397 EKLSQLAYHPLKMQS
K401 QLAYHPLKMQSCYEK
S427 RFDVSSTSVFKQRAQ
K430 VSSTSVFKQRAQIHM
Y446 EQMDNAVYTFETLLH
T450 NAVYTFETLLHQELG
Y480 LERVLKKYDYDSSSV
Y482 RVLKKYDYDSSSVRK
S484 LKKYDYDSSSVRKRF
K554 KDILQAVKEAAVQRK
K561 KEAAVQRKHNLYRDS
Y565 VQRKHNLYRDSVVLH
S568 KHNLYRDSVVLHNSD
S574 DSVVLHNSDPNLHLL
Y593 PIDWGEQYGDGGDGS
S605 DGSDSGGSPCPSEAA
- gap
- gap
- gap
S626 RRAKQVVSVVQDEES
- gap
- gap
S645 EAGSEPPSPAsPDNV
S648-p SEPPSPAsPDNVTEL
- gap
T653 PAsPDNVTELRGLLA
S667 AQDLQAESSPPASPL
S668 QDLQAESSPPASPLL
S672 AESSPPASPLLNGAP
S683 NGAPVQESPQPMTVL
S693-p PMTVLEAsPPAsPLR
- gap
S697-p LEAsPPAsPLRHLPP
S729 EKVSSPGSRPPIHTT
T737 RPPIHTTTEDSAGVQ
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