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Protein Page:
Meg-3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Meg-3 a maternal imprinting gene. Absent in pituitary adenomas. May possess growth suppressor activity. Two major alternatively spliced isoforms have been described. forms. One form, Meg3-proximal ( Meg3p), contains exons 1-3. The second form, Meg3-distal ( Meg3d) did not contain exons 1-3 and was present in oocytes and in 1- and 2-cell embryos. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Cellular Component: adherens junction; nucleus; cytosol
Biological Process: negative regulation of apoptosis
Reference #:  Q96TA1 (UniProtKB)
Alt. Names/Synonyms: bA356B19.6; C9orf88; DKFZP434H0820; FAM129B; family with sequence similarity 129, member B; FLJ13518; FLJ22151; FLJ22298; Meg-3; MINERVA; Niban-like protein 1; NIBL1; OC58; Protein FAM129B
Gene Symbols: FAM129B
Molecular weight: 84,138 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Meg-3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K83 FQHQEDSKKWRNRFS
0 2 K84 QHQEDSKKWRNRFSL
0 4 K104-u GLVLYENkAAYERQV
0 1 T126-p SAGYKILtSVDQYLE
0 1 S138-p YLELIGNsLPGttAk
0 1 T142-p IGNsLPGttAkSGSA
0 1 T143-p GNsLPGttAkSGSAP
0 3 K145-u sLPGttAkSGSAPIL
0 2 K153-u SGSAPILkCPTQFPL
0 2 K316-u MDQIITSkEHLASKI
0 1 K384-u INEGGIDkLGEyMEk
0 3 Y388-p GIDkLGEyMEkLSRL
0 1 K391-u kLGEyMEkLSRLAyH
0 16 Y397-p EkLSRLAyHPLkMQS
0 3 K401-u RLAyHPLkMQSCYEK
0 3 K430-u VSSTSVFkQRAQIHM
0 1 Y446-p EQMDNAVyTFETLLH
0 44 Y482-p RVLKKYDyDSSSVRK
0 1 K554-u KDILQAVkEAAVQRK
0 2 Y565-p VQRKHNLyRDsMVMH
0 2 S568-p KHNLyRDsMVMHNsD
0 3 S574-p DsMVMHNsDPNLHLL
0 1 S601-p SNSGGGGsPsPStPE
0 1 S603-p SGGGGsPsPStPEsA
0 4 T606-p GGsPsPStPEsATLS
0 1 S609-p PsPStPEsATLSEKR
0 2 S624-p RRAKQVVsVVQDEEV
0 3 S638-p VGLPFEAsPEsPPPA
0 8 S641-p PFEAsPEsPPPAsPD
0 1 - gap
0 11 S646-p PEsPPPAsPDGVtEI
0 3 - gap
0 1 T651-p PAsPDGVtEIRGLLA
0 24 S665-p AQGLRPEsPPPAGPL
0 2 - gap
0 3 - gap
0 14 S681-p NGAPAGEsPQPKAAP
0 11 S691-p PKAAPEAssPPAsPL
0 23 S692-p KAAPEAssPPAsPLQ
0 25 S696-p EAssPPAsPLQHLLP
0 1 S728-p EQVSSPSsHPALHTT
  mouse

 
K83-a FQYQEDNkkWRNRFS
K84-a QYQEDNkkWRNRFSL
K104-u GLVLYENkVAYERQI
T126 SAGYKVLTSVDQYLE
S138 YLELVGNSLPGTTSk
T142 VGNSLPGTTSkSGST
T143 GNSLPGTTSkSGSTP
K145-u SLPGTTSkSGSTPIL
K153 SGSTPILKCPTQFPL
K316 MDQIITSKEHLASKI
K384 INEGGIDKLGEYMEK
Y388 GIDKLGEYMEKLSQL
K391 KLGEYMEKLSQLAYH
Y397 EKLSQLAYHPLkMQS
K401-u QLAYHPLkMQSCYEK
K430-u VSSTSVFkQRAQIHM
Y446 EQMDNAVYTFETLLH
Y482 RVLKKYDYDSSSVRK
K554 KDILQAVKEAAVQRK
Y565-p VQRKHNLyRDsMVLH
S568-p KHNLyRDsMVLHNsD
S574-p DsMVLHNsDPNLHLL
S607-p GGGDSGGsPCPSEAA
- gap
- gap
- gap
S628 RRAKQVMSVVQDEES
- gap
- gap
S647-p EAGVEPPsPAsPDsV
S650-p VEPPsPAsPDsVTEL
S653-p PsPAsPDsVTELRGL
T655 PAsPDsVTELRGLLA
S669-p AQDLQAEssPPAsPL
S670-p QDLQAEssPPAsPLL
S674-p AEssPPAsPLLNGAP
S685 NGAPVQESSQPVAVP
S695-p PVAVPEAsPPAsPLR
- gap
S699-p PEAsPPAsPLRHLPP
S731-p EQVSSPGsRPPIHTT
  rat

 
K83 FQYQEDNKKWRNRFS
K84 QYQEDNKKWRNRFSL
K104 GLVLYENKVAYERQI
T126 SAGYKVLTSLDQYLE
S138 YLELVGNSLPGTTSK
T142 VGNSLPGTTSKSGST
T143 GNSLPGTTSKSGSTP
K145 SLPGTTSKSGSTPIL
K153 SGSTPILKCPTQFPL
K316 MDQIITSKEHLASKI
K384 INEGGIDKLGEYMEK
Y388 GIDKLGEYMEKLSQL
K391 KLGEYMEKLSQLAYH
Y397 EKLSQLAYHPLKMQS
K401 QLAYHPLKMQSCYEK
K430 VSSTSVFKQRAQIHM
Y446 EQMDNAVYTFETLLH
Y482 RVLKKYDYDSSSVRK
K554 KDILQAVKEAAVQRK
Y565 VQRKHNLYRDSVVLH
S568 KHNLYRDSVVLHNSD
S574 DSVVLHNSDPNLHLL
S605 DGSDSGGSPCPSEAA
- gap
- gap
- gap
S626 RRAKQVVSVVQDEES
- gap
- gap
S645 EAGSEPPSPAsPDNV
S648-p SEPPSPAsPDNVTEL
- gap
T653 PAsPDNVTELRGLLA
S667 AQDLQAESSPPASPL
S668 QDLQAESSPPASPLL
S672 AESSPPASPLLNGAP
S683 NGAPVQESPQPMTVL
S693 PMTVLEASPPASPLR
- gap
S697 LEASPPASPLRHLPP
S729 EKVSSPGSRPPIHTT
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