Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
PHF21A (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
PHF21A Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: nucleoplasm; histone deacetylase complex
Molecular Function: DNA binding; zinc ion binding; chromatin binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; suckling behavior; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; blood coagulation
Reference #:  Q96BD5 (UniProtKB)
Alt. Names/Synonyms: BHC80; BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex; BRAF35/HDAC2 complex (80 kDa); KIAA1696; PF21A; PHD finger protein 21A; PHF21A
Gene Symbols: PHF21A
Molecular weight: 74,854 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Select Structure to View Below

PHF21A

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T124 TASQKTVTTASMITT
0 1 T125 ASQKTVTTASMITTK
0 1 T208 TVTLVQATPPQPIKV
0 2 S277 TPTTLPTSQNSIHPV
0 1 R314-m1 VIATPGTrLAGPQtV
0 1 T320-p TrLAGPQtVQLSKPS
0 5 T350-p QTESRTItPPAAPKP
0 2 Y400-p RTTANPVySGAVFEP
0 3 Y416 RKKSAVTYLNSTMHP
0 1 T444-p VLGFGALtPTsPQSs
0 4 S447-p FGALtPTsPQSsHPD
0 1 S451-p tPTsPQSsHPDsPEN
0 3 S455-p PQSsHPDsPENEKTE
  PHF21A iso2  
T124 TASQKTVTTASMITT
T125 ASQKTVTTASMITTK
T209-p VTLQVQAtPPQPIKV
S278 TPTTLPTSQNSIHPV
R315 VIATPGTRLAGPQTV
T321 TRLAGPQTVQLSKPS
T351 QTESRTITPPAAPKP
Y401 RTTANPVYSGAVFEP
Y417 RKKSAVTYLNSTMHP
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
T132-gl TASQKTVttASMITT
T133-gl ASQKTVttASMITTK
T217 VTLQVQATPPQPIKV
S286-gl TPTTLPTsQNSIHPV
R323 VIATPGTRLAGPQTV
T329 TRLAGPQTVQLSKPS
- gap
Y380 RTTANPVYSGAVFEP
Y396 RKKSAVTYLNSTMHP
T424 VLGFGALTPTSPPSS
S427 FGALTPTSPPSSHPD
S431 TPTSPPSSHPDSPEN
S435 PPSSHPDSPENEKTE
  PHF21A iso2  
- under review  
- under review  
T133 ASQQVQATPPQPIKV
S202 TPTTLPTSQNSIHPV
R239 VIATPGTRLAGPQTV
T245 TRLAGPQTVQLSKPS
T275-p QAESRTVtPPAAPKP
Y325 RTTANPVYSGAVFEP
Y341 RKKSAVTYLNSTMHP
T369 VLGFGALTPTSPPSS
S372 FGALTPTSPPSSHPD
S376 TPTSPPSSHPDSPEN
S380 PPSSHPDSPENEKTE
  rat

 
T138 TASQKTVTTASMITT
T139 ASQKTVTTASMITTK
T223 VTLQVQATPPQPIKV
S292 TPTTLPTSQNSIHPV
R329 VIATPGTRLAGPQTV
T335 TRLAGPQTVQLSKPS
T365 QAESRTVTPPAAPKP
Y415 RTTANPVYSGAVFEP
Y431-p RKKSAVTyLNSTMHP
T459 VLGFGALTPTSPPSS
S462 FGALTPTSPPSSHPD
S466 TPTSPPSSHPDSPEN
S470 PPSSHPDSPENEKTE
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.