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Protein Page:
PHF21A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PHF21A Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: nucleoplasm; histone deacetylase complex
Molecular Function: DNA binding; zinc ion binding; chromatin binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; suckling behavior; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; blood coagulation
Reference #:  Q96BD5 (UniProtKB)
Alt. Names/Synonyms: BHC80; BHC80a; BM-006; BRAF35-HDAC complex protein BHC80; BRAF35/HDAC2 complex; BRAF35/HDAC2 complex (80 kDa); KIAA1696; PF21A; PHD finger protein 21A; PHF21A
Gene Symbols: PHF21A
Molecular weight: 74,854 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Select Structure to View Below

PHF21A

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S48-p QAKITALsEKQKRVV
0 1 T124 TASQKTVTTASMITT
0 1 T125 ASQKTVTTASMITTK
0 1 T208 TVTLVQATPPQPIKV
0 1 T273-p LTKFTPTtLPtsQNS
0 1 T276-p FTPTtLPtsQNSIHP
0 1 S277-p TPTtLPtsQNSIHPV
0 2 S277 TPTtLPtSQNSIHPV
0 1 R314-m1 VIATPGTrLAGPQtV
0 1 T320-p TrLAGPQtVQLSKPS
0 1 T339-p TVKSHTEtDEKQtES
0 1 T344-p TEtDEKQtESRTItP
0 6 T350-p QtESRTItPPAAPKP
0 2 Y400-p RTTANPVySGAVFEP
0 3 Y416 RKKSAVTYLNSTMHP
0 1 T444-p VLGFGALtPtsPQss
0 1 T446-p GFGALtPtsPQssHP
0 5 S447-p FGALtPtsPQssHPD
0 1 S450-p LtPtsPQssHPDsPE
0 2 S451-p tPtsPQssHPDsPEN
0 5 S455-p PQssHPDsPENEKTE
0 1 K566 KAAKEEEKQKLLKWS
0 1 K568 AKEEEKQKLLKWSSD
  PHF21A iso2  
S48 QAKITALSEKQKRVV
T124 TASQKTVTTASMITT
T125 ASQKTVTTASMITTK
T209-p VTLQVQAtPPQPIKV
T274 LTKFTPTTLPTSQNS
T277 FTPTTLPTSQNSIHP
S278 TPTTLPTSQNSIHPV
S278 TPTTLPTSQNSIHPV
R315 VIATPGTRLAGPQTV
T321 TRLAGPQTVQLSKPS
T340 TVKSHTETDEKQTES
T345 TETDEKQTESRTITP
T351 QTESRTITPPAAPKP
Y401 RTTANPVYSGAVFEP
Y417 RKKSAVTYLNSTMHP
- gap
- gap
- gap
- gap
- gap
- gap
K520 KAAKEEEKQKLLKWS
K522 AKEEEKQKLLKWSSD
  mouse

► Hide Isoforms
 
S48 QAKITALSEKQKRVV
T132-gl TASQKTVttASMITT
T133-gl ASQKTVttASMITTK
T217 VTLQVQATPPQPIKV
T282 LTKFTPTTLPTsQNS
T285 FTPTTLPTsQNSIHP
S286 TPTTLPTSQNSIHPV
S286-gl TPTTLPTsQNSIHPV
R323 VIATPGTRLAGPQTV
T329 TRLAGPQTVQLSKPS
R348 LNPTQKQRKNKQGLV
- gap
- gap
Y380 RTTANPVYSGAVFEP
Y396 RKKSAVTYLNSTMHP
T424 VLGFGALTPTSPPSS
T426 GFGALTPTSPPSSHP
S427 FGALTPTSPPSSHPD
S430 LTPTSPPSSHPDSPE
S431 TPTSPPSSHPDSPEN
S435 PPSSHPDSPENEKTE
K546-ac KAAKEEEkQkLLKWS
K548-ac AKEEEkQkLLKWSSD
  PHF21A iso2  
S48 QAKITALSEKQKRVV
- gap
- gap
T133 ASQQVQATPPQPIKV
T198 LTKFTPTTLPTSQNS
T201 FTPTTLPTSQNSIHP
S202 TPTTLPTSQNSIHPV
S202 TPTTLPTSQNSIHPV
R239 VIATPGTRLAGPQTV
T245 TRLAGPQTVQLSKPS
A264 TVKSHPEAEEKQAES
A269 PEAEEKQAESRTVtP
T275-p QAESRTVtPPAAPKP
Y325 RTTANPVYSGAVFEP
Y341 RKKSAVTYLNSTMHP
T369 VLGFGALTPTSPPSS
T371 GFGALTPTSPPSSHP
S372 FGALTPTSPPSSHPD
S375 LTPTSPPSSHPDSPE
S376 TPTSPPSSHPDSPEN
S380 PPSSHPDSPENEKTE
K491 KAAKEEEKQKLLKWS
K493 AKEEEKQKLLKWSSD
  rat

 
S48 QAKITALSEKQKRVV
T138 TASQKTVTTASMITT
T139 ASQKTVTTASMITTK
T223 VTLQVQATPPQPIKV
T288 LTKFTPTTLPTSQNS
T291 FTPTTLPTSQNSIHP
S292 TPTTLPTSQNSIHPV
S292 TPTTLPTSQNSIHPV
R329 VIATPGTRLAGPQTV
T335 TRLAGPQTVQLSKPS
A354 TVKSHTEAEEKQAES
A359 TEAEEKQAESRTVTP
T365 QAESRTVTPPAAPKP
Y415 RTTANPVYSGAVFEP
Y431-p RKKSAVTyLNSTMHP
T459 VLGFGALTPTSPPSS
T461 GFGALTPTSPPSSHP
S462 FGALTPTSPPSSHPD
S465 LTPTSPPSSHPDSPE
S466 TPTSPPSSHPDSPEN
S470 PPSSHPDSPENEKTE
K581 KAAKEEEKQKLLKWS
K583 AKEEEKQKLLKWSSD
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