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Protein Page:
CISH (human)

Overview
CISH SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR). By a subset of cytokines including EPO/erythropoietin. Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: plasma membrane; cytosol
Molecular Function: protein binding
Biological Process: protein kinase C activation; protein ubiquitination; regulation of cell growth; negative regulation of signal transduction
Reference #:  Q9NSE2 (UniProtKB)
Alt. Names/Synonyms: CIS; CIS-1; CISH; cytokine inducible SH2-containing protein; cytokine-inducible inhibitor of signaling type 1B; Cytokine-inducible SH2-containing protein; G18; Protein G18; SOCS; Suppressor of cytokine signaling
Gene Symbols: CISH
Molecular weight: 28,663 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CISH

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 S75 LCIAKTFSYLRESGW
0 1 S142-p DSSFRLDsNCLSRPR
0 1 S173-p SCTADTRsDsPDPAP
0 1 S175-p TADTRsDsPDPAPTP
  CISH iso3  
T16-p CPHHDDDtAMDTPLP
S92 LCIAKTFSYLRESGW
S159 DSSFRLDSNCLSRPR
S190 SCTADTRSDSPDPAP
S192 TADTRSDSPDPAPTP
  mouse

 
- gap
S75-p LCIAKTFsYLRESGW
S142 DSSFRLDSNCLSRPR
S173 SCAADTRSDSPDPAP
S175 AADTRSDSPDPAPTP
  rat

 
- gap
S74 LCIAKTFSYLRESGW
S141 DSSFRLDSNCLSRPR
S172 SCTADTRSDSPDPAP
S174 TADTRSDSPDPAPTP
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