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CISH (human)

Overview CISH SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR). By a subset of cytokines including EPO/erythropoietin. Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: cytosol Biological Process: protein ubiquitination; regulation of cell growth; negative regulation of signal transduction Reference #:  Q9NSE2 (UniProtKB) Alt. Names/Synonyms: CIS; CIS-1; CISH; cytokine inducible SH2-containing protein; cytokine-inducible inhibitor of signaling type 1B; Cytokine-inducible SH2-containing protein; G18; Protein G18; SOCS; Suppressor of cytokine signaling Gene Symbols: CISH Molecular weight: 28,663 Da Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CISH

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		-	gap
0	1		S75-p	LCIAKTFsYLRESGW
0	1		S173-p	SCTADTRsDsPDPAP
0	1		S175-p	TADTRsDsPDPAPTP

	CISH iso5
T16-p	CPHHDDDtAMDTPLP
S92	LCIAKTFSYLRESGW
S190	SCTADTRSDSPDPAP
S192	TADTRSDSPDPAPTP

	mouse
-	gap
S75-p	LCIAKTFsYLRESGW
S173	SCAADTRSDSPDPAP
S175	AADTRSDSPDPAPTP

	rat
-	gap
S74	LCIAKTFSYLRESGW
S172	SCTADTRSDSPDPAP
S174	TADTRSDSPDPAPTP

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