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Protein Page:
CISH (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CISH SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate- recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Stably associated with the tyrosine-phosphorylated IL3 receptor beta chain and tyrosine-phosphorylated EPO receptor (EPOR). By a subset of cytokines including EPO/erythropoietin. Expressed in various epithelial tissues. Abundantly expressed in liver and kidney, and to a lesser extent in lung. The tissue distribution of isoforms 1 and 1B is distinct. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; protein kinase inhibitor activity
Biological Process: cytokine and chemokine mediated signaling pathway; protein kinase C activation; negative regulation of protein kinase activity; protein ubiquitination; negative regulation of insulin receptor signaling pathway; regulation of cell growth; negative regulation of JAK-STAT cascade
Disease: Mycobacterium Tuberculosis, Susceptibility To; Bacteremia, Susceptibility To, 2; Malaria, Susceptibility To
Reference #:  Q9NSE2 (UniProtKB)
Alt. Names/Synonyms: CIS; CIS-1; CISH; cytokine inducible SH2-containing protein; cytokine-inducible inhibitor of signaling type 1B; Cytokine-inducible SH2-containing protein; G18; Protein G18; SOCS; Suppressor of cytokine signaling
Gene Symbols: CISH
Molecular weight: 28,663 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CISH

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
1 0 K59 AQTESEPKVLDPEED
1 0 K72 EDLLCIAKTFSYLRE
0 1 S75 LCIAKTFSYLRESGW
1 0 K98 EARQHLQKMPEGTFL
1 0 K121 YLFTLSVKTTRGPTN
0 1 S142-p DSSFRLDsNCLSRPR
0 1 S173-p SCTADTRsDsPDPAP
0 1 S175-p TADTRsDsPDPAPTP
1 0 K188 TPALPMPKEDAPSDP
1 0 K209 PATAVHLKLVQPFVR
  CISH iso3  
T16-p CPHHDDDtAMDTPLP
K76 AQTESEPKVLDPEED
K89 EDLLCIAKTFSYLRE
S92 LCIAKTFSYLRESGW
K115 EARQHLQKMPEGTFL
K138 YLFTLSVKTTRGPTN
S159 DSSFRLDSNCLSRPR
S190 SCTADTRSDSPDPAP
S192 TADTRSDSPDPAPTP
K205 TPALPMPKEDAPSDP
K226 PATAVHLKLVQPFVR
  mouse

 
- gap
K59 VQAENEPKVLDPEGD
K72 GDLLCIAKTFsYLRE
S75-p LCIAKTFsYLRESGW
K98 EARQHLQKMPEGTFL
K121 YLFTLSVKTTRGPTN
S142 DSSFRLDSNCLSRPR
S173 SCAADTRSDSPDPAP
S175 AADTRSDSPDPAPTP
K188 TPALPMSKQDAPSDS
K208 VATAVHLKLVQPFVR
  rat

 
- gap
K58-ub VQSENEPkVLDPEGD
K71-ub GDLLCIAkTFSYLRE
S74 LCIAkTFSYLRESGW
K97-ub EARQHLQkMPEGTFL
K120-ub YLFTLSVkTTRGPTN
S141 DSSFRLDSNCLSRPR
S172 SCTADTRSDSPDPAP
S174 TADTRSDSPDPAPTP
K187-ub TPALPVSkPDAPGDP
K207-ub VATAVHLkLVQPFVR
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