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Protein Page:
RXRB (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RXRB Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Specifically binds 9-cis retinoic acid (9C-RA). Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Expressed in a variety of tumor cell lines. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; ligand-dependent nuclear receptor activity; retinoid-X receptor activity; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; in utero embryonic development; ventricular cardiac muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; cardiac muscle cell proliferation; gene expression; maternal placenta development
Reference #:  P28702 (UniProtKB)
Alt. Names/Synonyms: DAUDI6; H-2RIIBP; MGC1831; MHC class I promoter binding protein; NR2B2; Nuclear receptor subfamily 2 group B member 2; RCoR-1; Retinoic acid receptor RXR-beta; Retinoid X receptor beta; retinoid X receptor, beta; RXRB
Gene Symbols: RXRB
Molecular weight: 56,922 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RXRB

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 R25-m1 QCGPVGVrKEMHCGV
0 1 R35 MHCGVASRWRRRRPW
0 1 S82 DSGRDSRSPDSSSPN
0 4 K202-a PGGPGAGkRLCAICG
0 2 Y220-p SGKHYGVySCEGCKG
0 3 K452-u ILFNPDAkGLSNPSE
0 2 K488-u EQQGRFAkLLLRLPA
  mouse

 
R25 QCGPVGVRKEMHCGV
R35-m2 MHCGVASrWRRRRPW
S79-p DSGRDSRsPDSSSPN
K189 PGGPGAGKRLCAICG
Y207 SGKHYGVYSCEGCKG
K439-u ILFNPDAkGLSNPGE
K475-u EQQGRFAkLLLRLPA
  rat

 
- gap
- gap
S17 DTGRDSRSPDSSSPN
K127 PGGPGAGKRLCAICG
Y145 SGKHYGVYSCEGCKG
K377 ILFNPDAKGLSNPGE
K413 EQQGRFAKLLLRLPA
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