Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. Specifically binds 9-cis retinoic acid (9C-RA). Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Expressed in a variety of tumor cell lines. Belongs to the nuclear hormone receptor family. NR2 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; retinoid-X receptor activity; zinc ion binding; transcription coactivator activity; steroid hormone receptor activity; transcription factor activity
Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; in utero embryonic development; ventricular cardiac muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; gene expression; cardiac muscle cell proliferation; steroid hormone mediated signaling; transmembrane transport; maternal placenta development
Alt. Names/Synonyms: DAUDI6; H-2RIIBP; MGC1831; MHC class I promoter binding protein; NR2B2; Nuclear receptor subfamily 2 group B member 2; RCoR-1; Retinoic acid receptor RXR-beta; Retinoid X receptor beta; retinoid X receptor, beta; RXRB
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.