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SLC17A7 (human)

Overview SLC17A7 Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. Note: This description may include information from UniProtKB. Protein type: Vesicle protein; Membrane protein, integral; Transporter Cellular Component: neuron projection; synaptic vesicle membrane; plasma membrane; integral to membrane; presynaptic active zone; excitatory synapse; cell junction Molecular Function: sodium:inorganic phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; L-glutamate transmembrane transporter activity Biological Process: synaptic transmission, glutamatergic; synaptic transmission; L-glutamate import; glutamate secretion; long-term memory; phosphate transport; neurotransmitter secretion; ion transport; regulation of excitatory postsynaptic membrane potential; sequestering of neurotransmitter; transmembrane transport Reference #:  Q9P2U7 (UniProtKB) Alt. Names/Synonyms: BNPI; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; brain-specific Na-dependent inorganic phosphate cotransporter; SLC17A7; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; Solute carrier family 17 member 7; solute carrier family 17, member 7; Vesicular glutamate transporter 1; VGLU1; VGLUT1 Gene Symbols: SLC17A7 Molecular weight: 61,613 Da Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SLC17A7

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S36	GAETLELSADGRPVT
0	24		Y169	PSAARVHYGCVIFVR
0	1		T186	QGLVEGVTYPACHGI
0	7		Y187	GLVEGVTYPACHGIW
0	4		K272	SISEEERKYIEDAIG
0	2		S281	IEDAIGESAKLMNPL
0	1		K283	DAIGESAKLMNPLTK
0	1		T289	AKLMNPLTKFSTPWR
0	1		K290	KLMNPLTKFSTPWRR
0	1		T293	NPLTKFSTPWRRFFT
0	1		S519	GHDQLAGSDDSEMED
0	1		S522	QLAGSDDSEMEDEAE
0	1		Y560	PPPPVRDY_______

	mouse
S36-p	GAETLELsADGRPVT
Y169-p	PSAARVHyGCVIFVR
T186	QGLVEGVTyPACHGI
Y187-p	GLVEGVTyPACHGIW
K272-u	SISEEERkYIEDAIG
S281-p	IEDAIGEsAkLMNPV
K283-u	DAIGEsAkLMNPVtk
T289-p	AkLMNPVtkFNtPWR
K290-u	kLMNPVtkFNtPWRR
T293-p	NPVtkFNtPWRRFFT
S519-p	GHDQLAGsDEsEMED
S522-p	QLAGsDEsEMEDEAE
Y560-p	PPPPVRDy_______

	rat
S36	GAETLELSADGRPVT
Y169-p	PSAARVHyGCVIFVR
T186-p	QGLVEGVtyPACHGI
Y187-p	GLVEGVtyPACHGIW
K272	SISEEERKYIEDAIG
S281	IEDAIGESAKLMNPV
K283	DAIGESAKLMNPVTK
T289	AKLMNPVTKFNTPWR
K290	KLMNPVTKFNTPWRR
T293	NPVTKFNTPWRRFFT
S519	GHDQLAGSDESEMED
S522	QLAGSDESEMEDEVE
Y560	PPPPVRDY_______

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