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Protein Page:
SLC17A7 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SLC17A7 Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Vesicle protein; Membrane protein, integral; Transporter
Cellular Component: neuron projection; synaptic vesicle membrane; presynaptic active zone; integral to membrane; plasma membrane; excitatory synapse; cell junction
Molecular Function: sodium:inorganic phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; L-glutamate transmembrane transporter activity
Biological Process: synaptic transmission, glutamatergic; L-glutamate import; synaptic transmission; glutamate secretion; phosphate transport; long-term memory; neurotransmitter secretion; ion transport; sequestering of neurotransmitter; regulation of excitatory postsynaptic membrane potential; transmembrane transport
Reference #:  Q9P2U7 (UniProtKB)
Alt. Names/Synonyms: BNPI; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; brain-specific Na-dependent inorganic phosphate cotransporter; SLC17A7; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; Solute carrier family 17 member 7; solute carrier family 17, member 7; Vesicular glutamate transporter 1; VGLU1; VGLUT1
Gene Symbols: SLC17A7
Molecular weight: 61,613 Da
Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC17A7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S36 GAETLELSADGRPVT
0 24 Y169 PSAARVHYGCVIFVR
0 7 Y187 GLVEGVTYPACHGIW
0 4 K272 SISEEERKYIEDAIG
0 2 S281 IEDAIGESAKLMNPL
0 1 K283 DAIGESAKLMNPLTK
0 1 T289 AKLMNPLTKFSTPWR
0 1 K290 KLMNPLTKFSTPWRR
0 1 T293 NPLTKFSTPWRRFFT
0 1 S519 GHDQLAGSDDSEMED
0 1 S522 QLAGSDDSEMEDEAE
0 1 Y560 PPPPVRDY_______
  mouse

 
S36-p GAETLELsADGRPVT
Y169-p PSAARVHyGCVIFVR
Y187-p GLVEGVTyPACHGIW
K272-u SISEEERkYIEDAIG
S281-p IEDAIGEsAkLMNPV
K283-u DAIGEsAkLMNPVtk
T289-p AkLMNPVtkFNtPWR
K290-u kLMNPVtkFNtPWRR
T293-p NPVtkFNtPWRRFFT
S519-p GHDQLAGsDEsEMED
S522-p QLAGsDEsEMEDEAE
Y560-p PPPPVRDy_______
  rat

 
S36 GAETLELSADGRPVT
Y169-p PSAARVHyGCVIFVR
Y187-p GLVEGVTyPACHGIW
K272 SISEEERKYIEDAIG
S281 IEDAIGESAKLMNPV
K283 DAIGESAKLMNPVTK
T289 AKLMNPVTKFNTPWR
K290 KLMNPVTKFNTPWRR
T293 NPVTKFNTPWRRFFT
S519 GHDQLAGSDESEMED
S522 QLAGSDESEMEDEVE
Y560 PPPPVRDY_______
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