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Protein Page:
eIF3-delta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF3-delta eukaryotic translation initiation factor 3 subunit 4. Binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. This subunit binds to the 18S rRNA. eIF-3 is composed of at least 12 different subunits. Contains 1 RNA recognition motif (RRM) domain. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component: eukaryotic translation initiation factor 3 complex; perinuclear region of cytoplasm; nucleus; cytosol
Molecular Function: protein binding; translation initiation factor activity; nucleotide binding
Biological Process: cellular protein metabolic process; translation; translational initiation; gene expression; formation of translation preinitiation complex; regulation of translational initiation
Reference #:  O75821 (UniProtKB)
Alt. Names/Synonyms: eIF-3 RNA-binding subunit; eIF-3-delta; eIF3 p42; eIF3 p44; eIF3-delta; EIF3-P42; eIF3-p44; EIF3G; EIF3S4; Eukaryotic translation initiation factor 3 RNA-binding subunit; Eukaryotic translation initiation factor 3 subunit 4; Eukaryotic translation initiation factor 3 subunit G; eukaryotic translation initiation factor 3 subunit p42; eukaryotic translation initiation factor 3, subunit 4 (delta, 44kD); eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa; eukaryotic translation initiation factor 3, subunit G
Gene Symbols: EIF3G
Molecular weight: 35,611 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Select Structure to View Below

eIF3-delta

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T3-p _____MPtGDFDskP
0 3 S8-p MPtGDFDskPsWADQ
0 1 K9-ub PtGDFDskPsWADQV
0 9 S11-p GDFDskPsWADQVEE
0 16 T38-p LKGIPLAtGDtsPEP
1 30 T41-p IPLAtGDtsPEPELL
1 44 S42-p PLAtGDtsPEPELLP
0 3 K65-ub EVINGNIkTVTEykI
0 5 Y70-p NIkTVTEykIDEDGK
0 1 K71-ac IkTVTEykIDEDGKk
0 1 K71-sc IkTVTEykIDEDGKk
0 1 K78-ac kIDEDGKkFKIVRtF
0 3 T84-p KkFKIVRtFRIETRK
0 1 S108-p NWKKFGNsEFDPPGP
0 2 S123-p NVATTTVsDDVsMTF
0 1 S127-p TTVsDDVsMTFITSK
0 1 K161-ac IVSCRICkGDHWTTR
0 1 K172-ac WTTRCPYkDTLGPMQ
0 3 K180-ub DTLGPMQkELAEQLG
0 2 S189-p LAEQLGLstGEkEkL
0 1 T190-p AEQLGLstGEkEkLP
0 1 K193-ac LGLstGEkEkLPGEL
0 1 K193-sc LGLstGEkEkLPGEL
0 2 K195-ub LstGEkEkLPGELEP
0 1 T206-p ELEPVQAtQNkTGKy
0 1 K209-ub PVQAtQNkTGKyVPP
0 3 Y213-p tQNkTGKyVPPsLRD
0 2 S217-p TGKyVPPsLRDGAsR
0 1 S223-p PsLRDGAsRRGESMQ
0 7 T240-p RRADDNAtIRVTNLS
0 1 T253 LSEDTRETDLQELFR
0 3 S264-p ELFRPFGsISRIYLA
0 1 K272-sc ISRIYLAkDKTTGQS
0 1 S286-p SKGFAFIsFHRREDA
  mouse

 
T3 _____MPTGDFDSKP
S8 MPTGDFDSKPSWADQ
K9 PTGDFDSKPSWADQV
S11 GDFDSKPSWADQVEE
T38-p LKGIPLPtGDtsPEP
T41-p IPLPtGDtsPEPELL
S42-p PLPtGDtsPEPELLP
K65-ub EVINGNIkTVTEYKI
Y70 NIkTVTEYKIEEDGK
K71 IkTVTEYKIEEDGKK
K71 IkTVTEYKIEEDGKK
K78 KIEEDGKKFKIVRTF
T84 KKFKIVRTFRIETRK
S108 NWKKFGNSEFDPPGP
S123 NVATTTVSDDVSMTF
S127 TTVSDDVSMTFITSK
K161 IVSCRICKGDHWTTR
K172 WTTRCPYKDTLGPMQ
K180-ub DTLGPMQkELAEQLG
S189 LAEQLGLSTGEKEkL
T190 AEQLGLSTGEKEkLP
K193 LGLSTGEKEkLPGEL
K193 LGLSTGEKEkLPGEL
K195-ub LSTGEKEkLPGELEP
A206 ELEPVQAAQSKTGKY
K209 PVQAAQSKTGKYVPP
Y213 AQSKTGKYVPPSLRD
S217 TGKYVPPSLRDGASR
S223 PSLRDGASRRGESMQ
T240 RRADDNATIRVTNLS
T253-p LSEDTREtDLQELFR
S264-p ELFRPFGsISRIYLA
K272 ISRIYLAKDKTTGQS
S286 SKGFAFISFHRREDA
  rat

 
T3 _____MPTGDFDSKP
S8 MPTGDFDSKPSWADQ
K9 PTGDFDSKPSWADQV
S11 GDFDSKPSWADQVEE
T38-p LKGIPLPtGDtsPEP
T41-p IPLPtGDtsPEPELL
S42-p PLPtGDtsPEPELLP
K65 EVINGNIKTVTEYKV
Y70 NIKTVTEYKVEEDGK
K71 IKTVTEYKVEEDGKK
K71 IKTVTEYKVEEDGKK
K78 KVEEDGKKFKIVRTF
T84 KKFKIVRTFRIETRK
S108 NWKKFGNSEFDPPGP
S123 NVATTTVSDDVSMTF
S127 TTVSDDVSMTFITSK
K161 IVSCRICKGDHWTTR
K172 WTTRCPYKDTLGPMQ
K180 DTLGPMQKELAEQLG
S189 LAEQLGLSTGEKEKL
T190 AEQLGLSTGEKEKLP
K193 LGLSTGEKEKLPGEL
K193 LGLSTGEKEKLPGEL
K195 LSTGEKEKLPGELEP
A206 ELEPVQAAQNKTGKY
K209 PVQAAQNKTGKYVPP
Y213 AQNKTGKYVPPSLRD
S217 TGKYVPPSLRDGASR
S223 PSLRDGASRRGESMQ
T240 RRADDNATIRVTNLS
T253 LSEDTRETDLQELFR
S264 ELFRPFGSISRIYLA
K272 ISRIYLAKDKTTGQS
S286 SKGFAFISFHRREDA
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