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Protein Page:
eIF4G2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
eIF4G2 a general repressor of translation by forming translationally inactive complexes. Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Interacts with the protein kinases Mnk1 and -2. Binds EIF4A and EIF3. Cleaved by some caspases and viral proteases. Note: This description may include information from UniProtKB.
Protein type: Translation initiation; Translation
Cellular Component: eukaryotic translation initiation factor 4F complex; cytosol
Molecular Function: protein binding; DNA binding; translation factor activity, nucleic acid binding; translation initiation factor activity
Biological Process: cell death; RNA metabolic process; cytokine and chemokine mediated signaling pathway; cell cycle arrest; regulation of translational initiation
Reference #:  P78344 (UniProtKB)
Alt. Names/Synonyms: AAG1; aging-associated protein 1; DAP-5; DAP5; Death-associated protein 5; eIF-4-gamma 2; eIF-4G 2; eIF4G 2; EIF4G2; Eukaryotic translation initiation factor 4 gamma 2; eukaryotic translation initiation factor 4 gamma, 2; eukaryotic translation initiation factor 4G-like 1; FLJ41344; IF4G2; NAT1; p97
Gene Symbols: EIF4G2
Molecular weight: 102,362 Da
Basal Isoelectric point: 6.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

eIF4G2
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S3 _____MESAIAEGGA
0 3 S17-p ASRFSASsGGGGSRG
0 1 S22 ASsGGGGSRGAPQHY
0 1 K41-u GNSEFLGkTPGQNAQ
0 1 K71-u ANNSANEkERHDAIF
0 1 T89-p RGILNKLtPEKFDKL
0 7 K158-u AEGQPGQkQSTTFRR
0 13 K170-u FRRLLISkLQDEFEN
0 13 Y185-p RTRNVDVyDkRENPL
0 1 K187-u RNVDVyDkRENPLLP
0 1 S226-p KLDLIHEsILHKCIK
0 1 S283 QYFARMCSLMLSkEL
0 2 K288-u MCSLMLSkELPARIR
0 1 K332-u QIRQDAVkDLGVFIP
0 1 R360-m1 EGPFMPPrMKMDRDP
0 1 S381 MFGQMPGSGIGTGPG
0 10 S395-p GVIQDRFsPTMGRHR
0 1 T397 IQDRFsPTMGRHRSN
0 1 K431-u EMGGKFMkSQGLsQL
0 3 S436-p FMkSQGLsQLyHNQs
0 135 Y439-p SQGLsQLyHNQsQGL
0 21 S443-p sQLyHNQsQGLLsQL
0 1 S448-p NQsQGLLsQLQGQSK
0 1 S479-p ISLRPAQsFLMNKNQ
0 2 S500-p QITMIPPsAQPPrtQ
0 1 R505-m1 PPsAQPPrtQtPPLG
0 13 T506-p PsAQPPrtQtPPLGQ
0 61 T508-p AQPPrtQtPPLGQtP
0 8 T514-p QtPPLGQtPQLGLKT
0 1 K575-u VREMRAPkHFLPEML
0 2 K584-u FLPEMLSkVIILSLD
0 1 S602 EDKEKASSLIsLLKQ
0 2 S605-p EKASSLIsLLKQEGI
0 1 K640-u EVDIPLVksyLAQFA
0 1 S641-p VDIPLVksyLAQFAA
0 1 Y642-p DIPLVksyLAQFAAR
0 1 K698-u TELFQQSkVNMQKML
0 1 K732-u SFLFPLLkLEkELLk
0 1 K735-u FPLLkLEkELLkQIK
0 1 K739-u kLEkELLkQIKLDPS
0 28 Y751-p DPSPQTIyKWIKDNI
0 1 S811-p QEKQLLLsFkPVMQK
0 2 K813-u KQLLLsFkPVMQKFL
0 5 S902-p ETAEEEEsEEEAD__
  eIF4G2 iso2  
S3 _____MESAIAEGGA
S17 ASRFSASSGGGGSRG
S22 ASSGGGGSRGAPQHY
K41 GNSEFLGKTPGQNAQ
K71 ANNSANEKERHDAIF
T89 RGILNKLTPEKFDKL
K158 AEGQPGQKQSTTFRR
K170 FRRLLISKLQDEFEN
Y185 RTRNVDVYDKRENPL
K187 RNVDVYDKRENPLLP
S226 KLDLIHESILHKCIK
S283 QYFARMCSLMLSKEL
K288 MCSLMLSKELPARIR
K332 QIRQDAVKDLGVFIP
R360 EGPFMPPRMKMDRDP
S381 MFGQMPGSGIGTGPG
S395 GVIQDRFSPTMGRHR
T397 IQDRFSPTMGRHRSN
K431 EMGGKFMKSQISLRP
- gap
- gap
- gap
- gap
S441 ISLRPAQSFLMNKNQ
S462 QITMIPPSAQPPRTQ
R467 PPSAQPPRTQTPPLG
T468 PSAQPPRTQTPPLGQ
T470 AQPPRTQTPPLGQTP
T476 QTPPLGQTPQLGLKT
K537 VREMRAPKHFLPEML
K546 FLPEMLSKVIILSLD
S564 EDKEKASSLISLLKQ
S567 EKASSLISLLKQEGI
K602 EVDIPLVKSYLAQFA
S603 VDIPLVKSYLAQFAA
Y604 DIPLVKSYLAQFAAR
K660 TELFQQSKVNMQKML
K694 SFLFPLLKLEKELLK
K697 FPLLKLEKELLKQIK
K701 KLEKELLKQIKLDPS
Y713 DPSPQTIYKWIKDNI
S773 QEKQLLLSFKPVMQK
K775 KQLLLSFKPVMQKFL
S864 ETAEEEESEEEAD__
  mouse

 
S3-p _____MEsAIAEGGA
S17-p ASRFSASsGGGGsRG
S22-p ASsGGGGsRGAPQHY
K41 GNSEFLGKTPGQNAQ
K71 ANNSANEKERHDAIF
T89 RGILNKLTPEKFDKL
K158 AEGQPGQKQSTTFRR
K170 FRRLLISKLQDEFEN
Y185 RTRNVDVYDKRENPL
K187 RNVDVYDKRENPLLP
S226 KLDLIHESILHKCIK
S283-p QYFARMCsLMLSKEL
K288 MCsLMLSKELPARIR
K332 QIRQDAVKDLGVFIP
R359 EGPFMPPRMKMDRDP
S380-p MFGQMPGsGIGTGPG
S394-p GVIQDRFsPtMGRHR
T396-p IQDRFsPtMGRHRSN
K430 EMGGKFMKSQGLSQL
S435 FMKSQGLSQLYHNQs
Y438 SQGLSQLYHNQsQGL
S442-p SQLYHNQsQGLLSQL
S447 NQsQGLLSQLQGQSK
S478 ISLRPAQSFLMNKNQ
S499 QITMIPPSAQPPRtQ
R504 PPSAQPPRtQtPPLG
T505-p PSAQPPRtQtPPLGQ
T507-p AQPPRtQtPPLGQtP
T513-p QtPPLGQtPQLGLKT
K574 VREMRAPKHFLPEML
K583 FLPEMLSKVIILSLD
S601-p EDKEKASsLIsLLKQ
S604-p EKASsLIsLLKQEGI
K639 EVDIPLVKSYLAQFA
S640 VDIPLVKSYLAQFAA
Y641 DIPLVKSYLAQFAAR
K697 TELFQQSKVNMQKML
K731 SFLFPLLKLEKELLK
K734 FPLLKLEKELLKQIK
K738 KLEKELLKQIKLDPS
Y750 DPSPQTIYKWIKDNI
S810 QEKQLLLSFKPVMQK
K812 KQLLLSFKPVMQKFL
S901-p ETAEEEEsEEEAD__
  rat

 
S3 _____MESAIAEGGA
S17 ASRFSASSGGGGSRG
S22 ASSGGGGSRGAPQHY
K41 GNSEFLGKTPGQNAQ
K71 ANNSANEKERHDAIF
T89 RGILNKLTPEKFDKL
K158 AEGQPGQKQSTTFRR
K170 FRRLLISKLQDEFEN
Y185-p RTRNVDVyDKRENPL
K187 RNVDVyDKRENPLLP
S226 KLDLIHESILHKCIK
S283 QYFARMCSLMLSKEL
K288 MCSLMLSKELPARIR
K332 QIRQDAVKDLGVFIP
R359 EGPFMPPRMKMDRDP
S380 MFGQMPGSGIGTGPG
S394 GVIQDRFSPTMGRHR
T396 IQDRFSPTMGRHRSN
K430 EMGGKFMKSQGLSQL
S435 FMKSQGLSQLyHNQS
Y438-p SQGLSQLyHNQSQGL
S442 SQLyHNQSQGLLSQL
S447 NQSQGLLSQLQGQSK
S478 ISLRPAQSFLMNKNQ
S499 QITMIPPSAQPPRTQ
R504 PPSAQPPRTQtPPLG
T505 PSAQPPRTQtPPLGQ
T507-p AQPPRTQtPPLGQTP
T513 QtPPLGQTPQLGLKT
K574 VREMRAPKHFLPEML
K583 FLPEMLSKVIILSLD
S601 EDKEKASSLISLLKQ
S604 EKASSLISLLKQEGI
K639 EVDIPLVKSYLAQFA
S640 VDIPLVKSYLAQFAA
Y641 DIPLVKSYLAQFAAR
K697 TELFQQSKVNMQKML
K731 SFLFPLLKLEKELLK
K734 FPLLKLEKELLKQIK
K738 KLEKELLKQIKLDPS
Y750 DPSPQTIYKWIKDNI
S810 QEKQLLLSFKPVMQK
K812 KQLLLSFKPVMQKFL
S901 ETAEEEESEEEAD__
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