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Protein Page:
CDT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CDT1 an essential licensing protein for DNA replication. Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Elevated in all human tumor cell lines analyzed. May function as an oncogene in mammals. Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Motility/polarity/chemotaxis; DNA replication
Cellular Component: nucleoplasm; cytosol; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: G1/S-specific transcription in mitotic cell cycle; regulation of DNA replication initiation; mitotic cell cycle; DNA replication checkpoint; DNA replication; regulation of DNA replication during S phase; G1/S transition of mitotic cell cycle
Reference #:  Q9H211 (UniProtKB)
Alt. Names/Synonyms: CDT1; chromatin licensing and DNA replication factor 1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP; RIS2
Gene Symbols: CDT1
Molecular weight: 60,390 Da
Basal Isoelectric point: 9.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CDT1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: T29‑p
transcription, inhibited: T29‑p
molecular association, regulation: T29‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K24 PPRIAPPKLACRtPs
2 8 T29-p PPKLACRtPsPARPA
1 7 S31-p KLACRtPsPARPALR
0 1 S42-p PALRAPAsAtsGSRK
0 1 T44-p LRAPAsAtsGSRKRA
0 1 S45-p RAPAsAtsGSRKRAR
0 1 S73-p ARRRLRLsVDEVSSP
0 2 T82-p DEVSSPStPEAPDIP
1 3 S93-p PDIPACPsPGQKIKK
0 1 T112-p AGQPPHLtSAQDQDT
0 1 T152-p QDAGESCtPEAEGRP
0 2 K240-ub ECNVGQIkTVYPASY
0 1 K307-ub QKLVEHVkEHHKAFL
1 4 S318-p KAFLASLsPAMVVPE
0 1 K356-ub PQPPATEkLTTAQEV
0 4 S372-p ARARNLIsPRMEkAL
0 1 K377-ub LIsPRMEkALsQLAL
0 3 S380-p PRMEkALsQLALRSA
0 1 S390-p ALRSAAPssPGsPRP
2 5 S391-p LRSAAPssPGsPRPA
1 7 S394-p AAPssPGsPRPALPA
1 5 T402-p PRPALPAtPPAtPPA
1 0 T406-p LPAtPPAtPPAAsPs
1 0 S411-p PAtPPAAsPsALkGV
0 1 S413-p tPPAAsPsALkGVSQ
0 1 K416-ub AAsPsALkGVSQDLL
0 1 K433-ub IRAKEAQkQLAQMTR
1 0 S491-p GSCCTIMsPGEMEKH
0 1 K522-ub IRTDTYVkLDKAADL
0 1 T533-p AADLAHItARLAHQT
  mouse

 
K23-ub GLTTPRAkSICLtPs
T28-p RAkSICLtPsPGGLV
S30-p kSICLtPsPGGLVAP
F39 GGLVAPAFTRSSSRK
R41 LVAPAFTRSSSRKRA
S42 VAPAFTRSSSRKRAR
S78 GLDSCPSSLPEPSSP
P96 SPPADPSPPADPGSP
S107 PGSPVCPSPVKRTKS
- gap
T165 ENAVEPSTPDAKVPT
K253 ERNVGQIKTVYPTSY
K319 QNLVERVKEQHKVFL
N330 KVFLASLNPPMAVPD
K368 PQPPVTEKLTTAQEV
T384 ARARSLMTPKMEKAL
K389 LMTPKMEKALSNLAL
S392 PKMEKALSNLALRSA
G402 ALRSAEPGsPGtSTP
S403-p LRSAEPGsPGtSTPP
T406-p AEPGsPGtSTPPLPA
T414-p STPPLPAtPPATPPA
T418 LPAtPPATPPAASPS
S423 PATPPAASPSALKGV
S425 TPPAASPSALKGVSQ
K428 AASPSALKGVSQALL
K445 IRAKEVQKQLARMTR
S503 DSCQTALSPGEMEKH
K534 IRTDTYVKLDKAVDL
T545 AVDLAGLTARLAHHV
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