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CDT1 (human)

Overview CDT1 an essential licensing protein for DNA replication. Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Elevated in all human tumor cell lines analyzed. May function as an oncogene in mammals. Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Motility/polarity/chemotaxis; DNA replication Cellular Component: nucleoplasm; nucleus; cytosol Molecular Function: protein binding; DNA binding Biological Process: regulation of S phase of mitotic cell cycle; regulation of DNA replication initiation; G1/S-specific transcription in mitotic cell cycle; M/G1 transition of mitotic cell cycle; mitotic cell cycle; S phase of mitotic cell cycle; DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle Reference #:  Q9H211 (UniProtKB) Alt. Names/Synonyms: CDT1; chromatin licensing and DNA replication factor 1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP; RIS2 Gene Symbols: CDT1 Molecular weight: 60,390 Da Basal Isoelectric point: 9.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CDT1 2LE8 - A=708-821 (human) 2WVR - C=1-546 (human) 1WLQ - C/F=172-368 (mouse) 2KLO - A=420-557 (mouse) 2RQQ - A=450-557 (mouse) 2ZXX - F/C=172-368 (mouse) 3A4C - A=452-557 (mouse)

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	Sites Implicated In
cell cycle regulation: T29‑p transcription, inhibited: T29‑p molecular association, regulation: T29‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K24	PPRIAPPKLACRtPs
2	6		T29-p	PPKLACRtPsPARPA
1	5		S31-p	KLACRtPsPARPALR
0	1		S42-p	PALRAPAsAtsGSRK
0	1		T44-p	LRAPAsAtsGSRKRA
0	1		S45-p	RAPAsAtsGSRKRAR
0	1		S73-p	ARRRLRLsVDEVSSP
0	2		T82-p	DEVSSPStPEAPDIP
1	3		S93-p	PDIPACPsPGQKIKK
0	1		T152-p	QDAGESCtPEAEGRP
0	2		K240-u	ECNVGQIkTVYPASY
0	1		K307-u	QKLVEHVkEHHKAFL
1	3		S318-p	KAFLASLsPAMVVPE
0	1		K356-u	PQPPATEkLTTAQEV
0	1		S372-p	ARARNLIsPRMEkAL
0	1		K377-u	LIsPRMEkALsQLAL
0	2		S380-p	PRMEkALsQLALRSA
0	1		S390-p	ALRSAAPssPGsPRP
2	3		S391-p	LRSAAPssPGsPRPA
1	5		S394-p	AAPssPGsPRPALPA
1	4		T402-p	PRPALPAtPPAtPPA
1	0		T406-p	LPAtPPAtPPAAsPs
1	0		S411-p	PAtPPAAsPsALkGV
0	1		S413-p	tPPAAsPsALkGVSQ
0	1		K416-u	AAsPsALkGVSQDLL
0	1		K433-u	IRAKEAQkQLAQMTR
1	0		S491-p	GSCCTIMsPGEMEKH
0	1		K522-u	IRTDTYVkLDKAADL
0	1		T533-p	AADLAHItARLAHQT

	mouse
K23-u	GLTTPRAkSICLtPs
T28-p	RAkSICLtPsPGGLV
S30-p	kSICLtPsPGGLVAP
F39	GGLVAPAFTRSSSRK
R41	LVAPAFTRSSSRKRA
S42	VAPAFTRSSSRKRAR
S78	GLDSCPSSLPEPSSP
P96	SPPADPSPPADPGSP
S107	PGSPVCPSPVKRTKS
T165	ENAVEPSTPDAKVPT
K253	ERNVGQIKTVYPTSY
K319	QNLVERVKEQHKVFL
N330	KVFLASLNPPMAVPD
K368	PQPPVTEKLTTAQEV
T384	ARARSLMTPKMEKAL
K389	LMTPKMEKALSNLAL
S392	PKMEKALSNLALRSA
G402	ALRSAEPGsPGTSTP
S403-p	LRSAEPGsPGTSTPP
T406	AEPGsPGTSTPPLPA
T414-p	STPPLPAtPPATPPA
T418	LPAtPPATPPAASPS
S423	PATPPAASPSALKGV
S425	TPPAASPSALKGVSQ
K428	AASPSALKGVSQALL
K445	IRAKEVQKQLARMTR
S503	DSCQTALSPGEMEKH
K534	IRTDTYVKLDKAVDL
T545	AVDLAGLTARLAHHV

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