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Protein Page:
BAP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BAP1 Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Highly expressed in testis, placenta and ovary. Expressed in breast. Belongs to the peptidase C12 family. BAP1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Tumor suppressor; Ubiquitin-specific protease; Protease; EC 3.4.19.12; Ubiquitin conjugating system
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: peptidase activity; ubiquitin thiolesterase activity; protein binding; ubiquitin-specific protease activity; chromatin binding
Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; protein deubiquitination; regulation of cell cycle; protein modification process; regulation of cell growth
Reference #:  Q92560 (UniProtKB)
Alt. Names/Synonyms: BAP1; BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; cerebral protein-6; DKFZp686N04275; FLJ35406; FLJ37180; HUCEP-13; hucep-6; KIAA0272; ubiquitin carboxy-terminal hydrolase; Ubiquitin carboxyl-terminal hydrolase BAP1; UCHL2
Gene Symbols: BAP1
Molecular weight: 80,362 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BAP1

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S592‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 S123-p KDFTKGFsPESKGYA
0 1 K139-ub GNAPELAkAHNSHAR
0 1 Y223-p LATAGEPyHDIRFNL
0 1 Y241-p VPDRRIKyEARLHVL
1 0 T273-p TQPELIQtHKsQESQ
1 1 S276-p ELIQtHKsQESQLPE
0 1 S287-p QLPEESKsAsNKsPL
0 3 S289-p PEESKsAsNKsPLVL
1 10 S292-p SKsAsNKsPLVLEAN
0 1 N308 APAASEGNHTDGAEE
0 1 T310 AASEGNHTDGAEEAA
0 1 A323 AAGSCAQAPsHsPPN
0 1 S325-p GSCAQAPsHsPPNKP
1 4 S327-p CAQAPsHsPPNKPKL
1 11 S369-p DNHNYAKsPMQEEED
0 1 S384-p LAAGVGRsRVPVRPP
0 7 Y394-p PVRPPQQysDDEDDy
1 22 S395-p VRPPQQysDDEDDyE
0 13 Y401-p ysDDEDDyEDDEEDD
0 2 S460-p KESQKDLsIPLsIKT
0 1 S464-p KDLsIPLsIKTSSGA
1 0 S485-p VPTHSQPsPtPsNES
1 1 T487-p THSQPsPtPsNESTD
0 1 S489-p SQPsPtPsNESTDTA
1 0 S505-p EIGSAFNsPLRsPIR
1 0 S509-p AFNsPLRsPIRsANP
1 2 S513-p PLRsPIRsANPtRPs
0 5 T517-p PIRsANPtRPssPVt
0 5 S520-p sANPtRPssPVtsHI
1 12 S521-p ANPtRPssPVtsHIS
0 2 T524-p tRPssPVtsHISKVL
0 1 S525-p RPssPVtsHISKVLF
0 1 S537-p VLFGEDDsLLRVDCI
1 0 S571-p LAEDGVLsPLALTEG
0 3 S582-p LTEGGKGssPsIRPI
1 8 S583-p TEGGKGssPsIRPIQ
1 1 S585-p GGKGssPsIRPIQGs
2 10 S592-p sIRPIQGsQGsssPV
0 7 S595-p PIQGsQGsssPVEKE
0 7 S596-p IQGsQGsssPVEKEV
1 12 S597-p QGsQGsssPVEKEVV
0 1 T607 EKEVVEATDsREKTG
0 2 S609-p EVVEATDsREKTGMV
0 1 K630-ub SGEKYSPkELLALLK
0 1 K656-m1 CLKEEVEkRkkFKID
0 1 K658-m1 KEEVEkRkkFKIDDQ
0 1 K659-m1 EEVEkRkkFKIDDQR
9373 : Phospho-BAP1 (Ser592) Antibody
  mouse

 
S123 KDFTKGFSPESKGYA
K139 GNAPELAKAHNSHAR
Y223 LATAGEPYHDIRFNL
Y241 VPDRRIKYETRLHVL
T273 TQPELIQTHKSQESQ
S276 ELIQTHKSQESQLPE
P287 QLPEESKPAsSKsPL
S289-p PEESKPAsSKsPLGL
S292-p SKPAsSKsPLGLEAG
T308-p TPVASECtQtDGAEE
T310-p VASECtQtDGAEEVA
T323-p VAGSCPQtTTHsPPS
T325 GSCPQtTTHsPPSKC
S327-p CPQtTTHsPPSKCKL
S369-p DNHNYAKsPMQEEED
S384 LAAGVGRSRVPVRAP
Y394 PVRAPQQYsEDEDDY
S395-p VRAPQQYsEDEDDYE
Y401 YsEDEDDYEDEDEDV
S459 QESQKDLSVPLSIKT
S463 KDLSVPLSIKTSSGA
S484 VPTHSQPSPTPSNES
T486 THSQPSPTPSNESTD
S488 SQPSPTPSNESTDTA
S504 EIGSAFNSPLRSPIR
S508 AFNSPLRSPIRsANP
S512-p PLRSPIRsANPtRPs
T516-p PIRsANPtRPssPVT
S519-p sANPtRPssPVTSHI
S520-p ANPtRPssPVTSHIS
T523 tRPssPVTSHISKVL
S524 RPssPVTSHISKVLF
S536 VLFGEDDSLLRVDCI
S570 LAEDGVLSPLALTEG
S581 LTEGGKGSSPSTRSS
S582 TEGGKGSSPSTRSSQ
S584 GGKGSSPSTRSSQGS
S591 STRSSQGSQGSSGLE
S594 SSQGSQGSSGLEEKE
S595 SQGSQGSSGLEEKEV
G596 QGSQGSSGLEEKEVV
T606-p EKEVVEVtEsRDKPG
S608-p EVVEVtEsRDKPGLN
K629 SGEKYSPKELLALLK
K655 CLKEEVEKRKKFKID
K657 KEEVEKRKKFKIDDQ
K658 EEVEKRKKFKIDDQR
  rat

 
S123 KDFTKGFSPESKGYA
K139 GNAPELAKAHNSHAR
Y223 LATAGEPYHDIRFNL
Y241 VPDRRVKYEARLHVL
T273 TQPELIQTHKSQESQ
S276 ELIQTHKSQESQLPE
P287 QLPEESKPASSKsPF
S289 PEESKPASSKsPFGL
S292-p SKPASSKsPFGLEAG
T308 TPAASECTHTDGAEE
T310 AASECTHTDGAEEVA
T323 VAGSCPQTTTHSPPS
T325 GSCPQTTTHSPPSKS
S327 CPQTTTHSPPSKSKL
S369 DNHNYAKSPMQEEED
S384 LAAGVGRSRVPVRPQ
Y393 VPVRPQQYsDDEEDY
S394-p PVRPQQYsDDEEDYE
Y400 YsDDEEDYEDEEEDV
S458-p QESQKDLsIPLSIKT
S462 KDLsIPLSIKTSSGA
S483 VPTHSQPSPTPSNES
T485 THSQPSPTPSNESTD
S487 SQPSPTPSNESTDTA
S503 EIGSAFNSPLRSPIR
S507 AFNSPLRSPIRSANP
S511 PLRSPIRSANPTRPS
T515 PIRSANPTRPSSPVT
S518 SANPTRPSSPVTSHI
S519 ANPTRPSSPVTSHIS
T522 TRPSSPVTSHISKVL
S523 RPSSPVTSHISKVLF
S535 VLFGEDDSLLRVDCI
S569 LAEDGVLSPLALTEG
S580 LTEGGKGSSPSTRSS
S581 TEGGKGSSPSTRSSQ
S583 GGKGSSPSTRSSQGS
S590 STRSSQGSQGSSSLE
S593 SSQGSQGSSSLEEKE
S594 SQGSQGSSSLEEKEV
S595 QGSQGSSSLEEKEVV
T605 EKEVVEVTDSRDKSG
S607 EVVEVTDSRDKSGLN
K628 SGEKYSPKELLALLK
K654 CLKEEVEKRKKFKID
K656 KEEVEKRKKFKIDDQ
K657 EEVEKRKKFKIDDQR
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