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BAP1 (human)

Overview BAP1 Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'- linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. Component of the PR-DUB complex, at least composed of BAP1 and ASXL1. Interacts with BRCA1 (via the RING finger). Interacts (via HBM-like motif) with HCFC1. Highly expressed in testis, placenta and ovary. Expressed in breast. Belongs to the peptidase C12 family. BAP1 subfamily. Note: This description may include information from UniProtKB. Protein type: Ubiquitin conjugating system; EC 3.4.19.12; Protease; Ubiquitin-specific protease; Tumor suppressor Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus Molecular Function: peptidase activity; ubiquitin thiolesterase activity; protein binding; ubiquitin-specific protease activity; chromatin binding Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of cell proliferation; protein deubiquitination; regulation of cell cycle; protein modification process; regulation of cell growth Reference #:  Q92560 (UniProtKB) Alt. Names/Synonyms: BAP1; BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; cerebral protein-6; DKFZp686N04275; FLJ35406; FLJ37180; HUCEP-13; hucep-6; KIAA0272; ubiquitin carboxy-terminal hydrolase; Ubiquitin carboxyl-terminal hydrolase BAP1; UCHL2 Gene Symbols: BAP1 Molecular weight: 80,362 Da Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states

Select Structure to View Below BAP1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K139-u	GNAPELAkAHNSHAR
0	1		Y223-p	LATAGEPyHDIRFNL
0	1		Y241-p	VPDRRIKyEARLHVL
0	1		S287-p	QLPEESKsAsNKsPL
0	2		S289-p	PEESKsAsNKsPLVL
0	6		S292-p	SKsAsNKsPLVLEAN
0	1		N308	APAASEGNHTDGAEE
0	1		T310	AASEGNHTDGAEEAA
0	1		A323	AAGSCAQAPSHSPPN
0	2		S327	CAQAPSHSPPNKPKL
0	8		S369-p	DNHNYAKsPMQEEED
0	1		S384-p	LAAGVGRsRVPVRPP
0	7		Y394-p	PVRPPQQysDDEDDy
0	19		S395-p	VRPPQQysDDEDDyE
0	13		Y401-p	ysDDEDDyEDDEEDD
0	1		S464-p	KDLSIPLsIKTSSGA
0	1		T487-p	THSQPSPtPsNESTD
0	1		S489-p	SQPSPtPsNESTDTA
0	1		S513	PLRSPIRSANPtRPs
0	1		T517-p	PIRSANPtRPssPVT
0	1		S520-p	SANPtRPssPVTSHI
0	7		S521-p	ANPtRPssPVTSHIS
0	1		S582-p	LTEGGKGssPSIRPI
0	5		S583-p	TEGGKGssPSIRPIQ
0	9		S592-p	SIRPIQGsQGsssPV
0	7		S595-p	PIQGsQGsssPVEKE
0	7		S596-p	IQGsQGsssPVEKEV
0	9		S597-p	QGsQGsssPVEKEVV
0	1		T607	EKEVVEATDSREKTG
0	1		S609	EVVEATDSREKTGMV
0	1		K630-u	SGEKYSPkELLALLK
0	1		K656-m1	CLKEEVEkRkkFKID
0	1		K658-m1	KEEVEkRkkFKIDDQ
0	1		K659-m1	EEVEkRkkFKIDDQR

	mouse
K139	GNAPELAKAHNSHAR
Y223	LATAGEPYHDIRFNL
Y241	VPDRRIKYETRLHVL
P287	QLPEESKPAsSKsPL
S289-p	PEESKPAsSKsPLGL
S292-p	SKPAsSKsPLGLEAG
T308-p	TPVASECtQtDGAEE
T310-p	VASECtQtDGAEEVA
T323-p	VAGSCPQtTTHsPPS
S327-p	CPQtTTHsPPSKCKL
S369-p	DNHNYAKsPMQEEED
S384	LAAGVGRSRVPVRAP
Y394	PVRAPQQYsEDEDDY
S395-p	VRAPQQYsEDEDDYE
Y401	YsEDEDDYEDEDEDV
S463	KDLSVPLSIKTSSGA
T486	THSQPSPTPSNESTD
S488	SQPSPTPSNESTDTA
S512-p	PLRSPIRsANPTRPS
T516	PIRsANPTRPSsPVT
S519	sANPTRPSsPVTSHI
S520-p	ANPTRPSsPVTSHIS
S581	LTEGGKGSSPSTRSS
S582	TEGGKGSSPSTRSSQ
S591	STRSSQGSQGSSGLE
S594	SSQGSQGSSGLEEKE
S595	SQGSQGSSGLEEKEV
G596	QGSQGSSGLEEKEVV
T606-p	EKEVVEVtEsRDKPG
S608-p	EVVEVtEsRDKPGLN
K629	SGEKYSPKELLALLK
K655	CLKEEVEKRKKFKID
K657	KEEVEKRKKFKIDDQ
K658	EEVEKRKKFKIDDQR

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