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Protein Page:
SSRP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SSRP1 a subunit of the chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Transcription initiation complex
Cellular Component: nucleoplasm; cytoplasm; nucleolus; chromosome; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; viral reproduction; positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; gene expression; DNA repair; DNA replication
Reference #:  Q08945 (UniProtKB)
Alt. Names/Synonyms: Chromatin-specific transcription elongation factor 80 kDa subunit; cisplatin-DNA SSRP; facilitates chromatin remodeling 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; Facilitates chromatin transcription complex subunit SSRP1; FACT; FACT 80 kDa subunit; FACT complex subunit SSRP1; FACT80; FACTp80; high mobility group box; hSSRP1; Recombination signal sequence recognition protein 1; SSRP1; structure specific recognition protein 1; Structure-specific recognition protein 1; T160
Gene Symbols: SSRP1
Molecular weight: 81,075 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SSRP1
Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S510‑p, S657‑p, S688‑p
inhibition: S510‑p, S657‑p, S688‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 K15-u NDVYQEVkGsMNDGR
0 1 S17-p VYQEVkGsMNDGRLR
0 1 K33-a SRQGIIFkNSKTGkV
0 3 K39-u FkNSKTGkVDNIQAG
0 1 K63-u VALGHGLkLLTKNGH
0 3 K84-u FRESEFEkLSDFFkT
0 1 K90-a EkLSDFFkTHYRLEL
0 1 K90-u EkLSDFFkTHYRLEL
0 2 K100-u YRLELMEkDLCVkGW
0 14 K105-u MEkDLCVkGWNWGTV
0 1 S120 KFGGQLLSFDIGDQP
0 10 T170-p VRFYVPPtQEDGVDP
0 1 K228-u TFLHLHGkTFDYkIP
0 2 K233-a HGkTFDYkIPYTTVL
0 2 K233-u HGkTFDYkIPYTTVL
0 1 S258-p RQMFFVIsLDPPIKQ
0 1 Y270-p IKQGQTRyHFLILLF
0 1 S278-p HFLILLFsKDEDISL
0 2 K304-u RFEGRLTkNMSGsLy
0 1 S309-p LTkNMSGsLyEMVsR
0 35 Y311-p kNMSGsLyEMVsRVM
0 1 S315-p GsLyEMVsRVMkALV
0 1 K319-u EMVsRVMkALVNRKI
0 1 K413-a IEREEYGkLFDFVNA
0 3 S437-p LKEGMNPsyDEyADs
0 20 Y438-p KEGMNPsyDEyADsD
0 122 Y441-p MNPsyDEyADsDEDQ
0 289 S444-p syDEyADsDEDQHDA
0 44 Y452-p DEDQHDAyLERMKEE
1 0 S510-p SSSNEGDsDRDEKKR
0 1 K524 RKQLKKAKMAKDRKS
0 21 P535 DRKSRKKPVEVkKGk
0 17 V536 RKSRKKPVEVkKGkD
0 1 K539-a RKKPVEVkKGkDPNA
0 2 K542-a PVEVkKGkDPNAPkR
0 3 K548-a GkDPNAPkRPMSAYM
0 1 R549 kDPNAPkRPMSAYML
0 1 K566-u NASREKIkSDHPGIS
0 1 S578-p GISITDLsKKAGEIW
0 1 K612-a RDYEKAMkEyEGGRG
0 1 Y614-p YEKAMkEyEGGRGES
0 1 K623-a GGRGESSkRDKSKKK
0 1 S641-p KVKMEKKsTPsRGSS
0 1 S644-p MEKKsTPsRGSSSKS
0 3 S652-p RGSSSKSsSRQLsEs
1 5 S657-p KSsSRQLsEsFKsKE
0 9 S659-p sSRQLsEsFKsKEFV
0 1 S662-p QLsEsFKsKEFVssD
0 16 S667-p FKsKEFVssDEsssG
0 16 S668-p KsKEFVssDEsssGE
0 15 S671-p EFVssDEsssGENKs
0 17 S672-p FVssDEsssGENKsK
0 12 S673-p VssDEsssGENKsKK
0 1 S678-p sssGENKsKKKRRRS
1 0 S688-p KRRRSEDsEEEELAS
0 1 T696-p EEEELAStPPSSEDS
  mouse

 
K15 NDIFQEVKGSMNDGR
S17 IFQEVKGSMNDGRLR
K33 SRQGIIFKNSKTGkV
K39-u FKNSKTGkVDNIQAG
K63 VALGHGLKLLTKNGH
K84-u FRESEFEkLSDFFKT
K90 EkLSDFFKTHYRLEL
K90 EkLSDFFKTHYRLEL
K100-u YRLELMEkDLCVkGW
K105-u MEkDLCVkGWNWGTV
S120-p KFGGQLLsFDIGDQP
T170 VRFYVPPTQEDGVDP
K228 TFLHLHGKTFDYKIP
K233 HGKTFDYKIPYTTVL
K233 HGKTFDYKIPYTTVL
S258 RQMFFVISLDPPIKQ
Y270 IKQGQTRYHFLILLF
S278 HFLILLFSKDEDISL
K304 RFEGRLTKNMSGSLy
S309 LTKNMSGSLyEMVSR
Y311-p KNMSGSLyEMVSRVM
S315 GSLyEMVSRVMKALV
K319 EMVSRVMKALVNRKI
K413 IEREEYGKLFDFVNA
G437 LKEGINPGYDDyADs
Y438 KEGINPGYDDyADsD
Y441-p INPGYDDyADsDEDQ
S444-p GYDDyADsDEDQHDA
Y452-p DEDQHDAyLERMKEE
S510 SSSNEGDSDREEKKR
K524-a REQLKRAkMAKDRKS
S535-p DRKSRRKssEAkKGk
S536-p RKSRRKssEAkKGkD
K539-a RRKssEAkKGkDPNA
K542-a ssEAkKGkDPNAPkr
K548-a GkDPNAPkrPMSAYM
R549-m1 kDPNAPkrPMSAYML
K566 NASREKIKSDHPGIS
S578 GISITDLSKKAGEIW
K612 REYEKAMKEYEGGRG
Y614 YEKAMKEYEGGRGDS
K623 GGRGDSSKRDKSKKK
S641 KAKMEKKSTPSRGSS
S644 MEKKSTPSRGSSSKS
S652 RGSSSKSSSRQLsDs
S657-p KSSSRQLsDsFKSKE
S659-p SSRQLsDsFKSKEFV
S662 QLsDsFKSKEFVssD
S667-p FKSKEFVssDEsssG
S668-p KSKEFVssDEsssGE
S671-p EFVssDEsssGENKS
S672-p FVssDEsssGENKSK
S673-p VssDEsssGENKSKK
S678 sssGENKSKKKRRRS
S688 KRRRSEDSEEELAST
T695 SEEELASTPPSSEDS
  rat

 
K15 NDIFQEVKGSMNDGR
S17 IFQEVKGSMNDGRLR
K33 SRQGIIFKNSKTGKV
K39 FKNSKTGKVDNIQAG
K63 VALGHGLKLLTKNGH
K84 FRESEFEKLSDFFKT
K90 EKLSDFFKTHYRLEL
K90 EKLSDFFKTHYRLEL
K100 YRLELMEKDLCVKGW
K105 MEKDLCVKGWNWGTV
S120 KFGGQLLSFDIGDQP
T170 VRFYVPPTQEDGVDP
K228 TFLHLHGKTFDYKIP
K233 HGKTFDYKIPYTTVL
K233 HGKTFDYKIPYTTVL
S258 RQMFFVISLDPPIKQ
Y270 IKQGQTRYHFLILLF
S278 HFLILLFSKDEDISL
K304 RFEGRLTKNMSGSLY
S309 LTKNMSGSLYEMVSR
Y311 KNMSGSLYEMVSRVM
S315 GSLYEMVSRVMKALV
K319 EMVSRVMKALVNRKI
K413 IEREEYGKLFDFVNA
G437 LKEGINPGYDDYADs
Y438 KEGINPGYDDYADsD
Y441 INPGYDDYADsDEDQ
S444-p GYDDYADsDEDQHDA
Y452 DEDQHDAYLERMKEE
S510 SSSNEGDSDREEKKR
K524 RKQLKRAKMAKDRKS
S535 DRKSRKKSSEGKKGK
S536 RKSRKKSSEGKKGKD
K539 RKKSSEGKKGKDPNA
K542 SSEGKKGKDPNAPKR
K548 GKDPNAPKRPMSAYM
R549 KDPNAPKRPMSAYML
K566 NASREKIKSDHPGIS
S578 GISITDLSKKAGEIW
K612 REYEKAMKEYEGGRG
Y614 YEKAMKEYEGGRGDS
K623 GGRGDSSKRDKSKKK
S641 KAKLEKKSTPSRGSS
S644 LEKKSTPSRGSSSKS
S652 RGSSSKSSSRQLSDS
S657 KSSSRQLSDSFKSKE
S659 SSRQLSDSFKSKEFV
S662 QLSDSFKSKEFVSSD
S667 FKSKEFVSSDESSSG
S668 KSKEFVSSDESSSGE
S671 EFVSSDESSSGENKS
S672 FVSSDESSSGENKSK
S673 VSSDESSSGENKSKK
S678 SSSGENKSKKKRRRS
S688 KRRRSEDSDEEELAS
T696 DEEELASTPPSSEDS
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