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Protein Page:
ataxin-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ataxin-1 spinocerebellar ataxia type 1 (SCA1) protein. Expansion of CAG repeats in the SCA1 gene results in an abnormally long polyglutamine tract in the protein, causing polyglutamine-induced neurodegeneration. 14-3-3 and Akt kinase stabilize both wild-type and mutant forms of ataxin-1. The expansion of the polyglutamine tract may alter this function. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Nuclear export
Cellular Component: nucleoplasm; nuclear RNA export factor complex; nuclear matrix; intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus; nuclear inclusion body
Molecular Function: protein C-terminus binding; identical protein binding; protein binding; DNA binding; protein self-association; poly(U) binding; poly(rG) binding
Biological Process: cell death; RNA processing; transcription, DNA-dependent; adult locomotory behavior; nuclear export; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; visual learning; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of excitatory postsynaptic membrane potential
Reference #:  P54253 (UniProtKB)
Alt. Names/Synonyms: ataxin 1; Ataxin-1; ATX1; ATXN1; D6S504E; SCA1; Spinocerebellar ataxia type 1 protein
Gene Symbols: ATXN1
Molecular weight: 86,923 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ataxin-1

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S775‑p
intracellular localization: S775‑p
molecular association, regulation: S775‑p
protein degradation: S775‑p
protein stabilization: S775‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K16-sm NECLPPKkREIPATS
0 1 P62 HGGGRHGPAGTSVEL
0 3 S82 IGLHKALSTGLDYsP
0 1 S82 IGLHKALSTGLDYsP
0 6 S88-p LSTGLDYsPPSAPRS
1 0 K194-sm LSQTPGHkAEQQQQQ
1 1 T235-p SRAPGLItPGsPPPA
1 12 S238-p PGLItPGsPPPAQQN
0 3 A242 tPGsPPPAQQNQyVH
0 1 Y247-p PPAQQNQyVHISSSP
0 1 S252 NQyVHISSSPQNtGR
0 1 S253 QyVHISSSPQNtGRT
0 2 T257-p ISSSPQNtGRTASPP
0 1 S312-p ATKKAESsRLQQAIQ
0 3 S406-p QATHREAsPSTLNDK
1 0 K609-sm AEISNDLkIDSSTVE
1 0 K696-sm NLKNGSVkKGQPVDP
0 1 K709 DPASVLLKHsKADGL
0 3 S711-p ASVLLKHsKADGLAG
1 0 K745-sm LSENGELkFPEKMGL
13 17 S775-p ATRKRRWsAPESRKL
  mouse

 
K16 NECLPPKKREIPATS
S62-p HGGGRHGsAGTSGEH
S81-p MGLHKALsAGLDYsP
S81-gl MGLHKALsAGLDYsP
S87-p LsAGLDYsPPSAPRS
K193 LSQAPGHKVEPPPQQ
N210 SRAAGLVNPGsPPPP
S213-p AGLVNPGsPPPPtQQ
T218-p PGsPPPPtQQNQYIH
Y223 PPtQQNQYIHISssP
S228-p NQYIHISssPQSsGR
S229-p QYIHISssPQSsGRA
S233-p ISssPQSsGRATSPP
S288 STKKAESSRLQQAMQ
S382-p QTTHREAsPSTLNDK
K585 AEISNDLKIDSSTVE
K672 NLKNGSVKKGQPVDP
K685-ub DPASVLLkQAKTDSL
A687 ASVLLkQAKTDSLAG
K721 LSENGELKFPEKIGL
S751-p ATRKRRWsAPETRKL
  rat

 
K16 NECLPPKKREIPATS
P62 HGGGRHGPAGTSGEH
S81 MGLHKALSAGLDYSP
S81 MGLHKALSAGLDYSP
S87 LSAGLDYSPPSAPRS
K193 LSQAPGHKVEPPPQQ
N210 GRAAGLVNPGsPPPt
S213-p AGLVNPGsPPPtQQN
T217-p NPGsPPPtQQNQYIH
Y222 PPtQQNQYIHISSSP
S227 NQYIHISSSPQSSGR
S228 QYIHISSSPQSSGRA
S232 ISSSPQSSGRATSPP
S286 STKKAESSRLQQAMQ
S380-p QATHREAsPSTLNDK
K583 AEISNDLKIDSSTVE
K670 NLKNGSVKKGQPVDP
K683 DPASALLKHAKTDSL
A685 ASALLKHAKTDSLAG
K719 LSENGELKFPEKIGL
S749 ATRKRRWSAPETRKL
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