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Protein Page:
Bcr/Abl (human)

Overview
Bcr/Abl an oncogenic fusion protein between the tyrosine kinase Abl and the BCR (breakpoint cluster region) protein. Results from a translocation between chromosome 9 and 22 t(9;22)(q34;q11), or the Philadelphia translocation (Ph). Found in 95% of people with chronic myelogenous leukemia (CML), 25-30% of adult cases and 2┬┐10% of pediatric cases of acute lymphoblastic leukemia (ALL), and occasionally in acute myelogenous leukemia (AML). Multiple isoforms resulting from varying locations of the BCR breakpoint have been reported. Three clinically important variants are the p190, p210 and p230 isoforms. p190 is generally associated with ALL, while p210 is generally associated with CML but can also be associated with ALL. p230 is usually associated with CML. The longest isoform is shown here. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Abl family
Reference #:  A9UF07 (UniProtKB)
Alt. Names/Synonyms: Abl; Abl1; ALL; BCR; BCR/ABL; BCR/ABL fusion protein isoform Y5; BCR1; breakpoint cluster region; CML; D22S11; D22S662; FLJ16453; PHL; renal carcinoma antigen NY-REN-26
Gene Symbols: BCR/ABL
Molecular weight: 196,572 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcr/Abl

Protein Structure Not Found.


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Sites Implicated In
cell growth, induced: Y177‑p
transcription, induced: Y177‑p
molecular association, regulation: Y177‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 663 Y177-p ADAEKPFyVNVEFHH
0 57 S354-p SGQSSRVsPsPTTyR
0 12 S356-p QSSRVsPsPTTyRMF
0 24 Y360-p VsPsPTTyRMFRDKS
0 42 T432-p DADGSFGtPPGYGCA
0 97 Y669-p DDESPGLyGFLNVIV
0 1 S1339-p ALRESGGsGFRSPHL
0 10 S1378-p KRFLRSCsASCVPHG
0 5 T1512-p PAAAEPVtPTSKAGS
  Bcr/Abl iso2  
Y177 ADAEKPFYVNVEFHH
S354 SGQSSRVSPSPTTYR
S356 QSSRVSPSPTTYRMF
Y360 VSPSPTTYRMFRDKS
T432 DADGSFGTPPGYGCA
- gap
S1193 ALRESGGSGFRSPHL
S1232 KRFLRSCSASCVPHG
T1366 PAAAEPVTPTSKAGS
  Bcr/Abl iso3  
Y122 ADAEKPFYVNVEFHH
S299 SGQSSRVSPSPTTYR
S301 QSSRVSPSPTTYRMF
Y305 VSPSPTTYRMFRDKS
- gap
- gap
- gap
- gap
- gap
  Bcr/Abl iso4  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
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