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Protein Page:
NLRX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NLRX1 Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Interacts with MAVS. Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji, and Jurkat cell lines. Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: mitochondrial outer membrane
Molecular Function: protein binding; ATP binding
Biological Process: viral reproduction; negative regulation of innate immune response; negative regulation of inflammatory response; negative regulation of interleukin-6 production; innate immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interferon type I production; negative regulation of interferon-beta production
Reference #:  Q86UT6 (UniProtKB)
Alt. Names/Synonyms: Caterpiller protein 11.3; CLR11.3; DLNB26; FLJ21478; MGC131937; MGC21025; NLR family member X1; NLR family, X1; NLRX1; NOD-like receptor X1; NOD26; NOD5; NOD9; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain, leucine rich repeat containing X1
Gene Symbols: NLRX1
Molecular weight: 107,616 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NLRX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S34-p IPFLIHWsWPLQGER
0 1 S285-p KYMLPQAsILVTTRP
0 1 S293-p ILVTTRPsAIGRIPS
0 2 T428-p LMAYAARtMGKLAYE
0 1 T514-p VLGLRKTtLQKVGKE
0 1 S600-p VLDQMGAsILGVEGP
0 1 K659 LENAQAIKKKLGKLG
0 1 K768-ac SLGPEACkDLRDLLL
0 1 S943-p LLRDLEDsRGAtLNP
0 1 T947-p LEDsRGAtLNPWRKA
  NLRX1 iso2  
S34 IPFLIHWSWPLQGER
S285 KYMLPQASILVTTRP
S293 ILVTTRPSAIGRIPS
T428 LMAYAARTMGKLAYE
T514 VLGLRKTTLQKVGKE
S600 VLDQMGASILGVEGP
K659 LENAQAIKKKLGKLG
K768 SLGPEACKDLRDLLL
- gap
- gap
  mouse

 
S34 ISFLIQWSWPFKGVH
S285 KYMLPEASILVTTRP
S293 ILVTTRPSTISRIPS
T428 LMSYAARTMGKLAYE
A514 VLGLRKTALQRVGKE
S600 VLDQMGASILGVEGP
K659-sc LENAQAIkKKLGKLG
R768 NLGPEACRDLRDLLL
S943 LLRDLEDSRGATLNP
T947 LEDSRGATLNPWRKA
  rat

 
S31 DELRIQSSWPFKGVH
S283 KYMLPEASILVTTRP
S291 ILVTTRPSAIGRIPS
T426 LMSYAARTMGKLAYE
A512 VLGLRKTALQRVGKE
S598 VLDQMGASILGVEGP
K657 LENAQAIKKKLGKMG
R766 NLGPEACRDLRDLLL
S941 LLRDLEDSRGATLNP
T945 LEDSRGATLNPWRKA
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