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Protein Page:
NOD2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NOD2 Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). BS is a rare autosomal dominant disorder characterized by early-onset granulomatous arthritis, uveitis and skin rash. Defects in NOD2 are a cause of susceptibility to inflammatory bowel disease type 1 (IBD1). IBD1 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Defects in NOD2 are the cause of sarcoidosis early-onset (EOS). EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early- onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Cellular Component: signalosome; cell surface; protein complex; cytoskeleton; cytoplasm; plasma membrane; cytosol; vesicle
Molecular Function: protein binding; peptidoglycan binding; enzyme binding; CARD domain binding; protein kinase binding; ATP binding; muramyl dipeptide binding
Biological Process: activation of MAPK activity; maintenance of gastrointestinal epithelium; positive regulation of dendritic cell antigen processing and presentation; stress-activated MAPK cascade; response to lipopolysaccharide; positive regulation of interleukin-1 beta secretion; toll-like receptor 3 signaling pathway; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; negative regulation of interleukin-2 production; toll-like receptor 5 signaling pathway; positive regulation of gamma-delta T cell activation; positive regulation of phagocytosis; JNK cascade; detection of muramyl dipeptide; cytokine production during immune response; detection of biotic stimulus; toll-like receptor 4 signaling pathway; positive regulation of oxidoreductase activity; positive regulation of interleukin-17 production; negative regulation of interleukin-12 production; positive regulation of T-helper 2 type immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of dendritic cell cytokine production; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; protein oligomerization; toll-like receptor 2 signaling pathway; negative regulation of interleukin-18 production; defense response to Gram-positive bacterium; positive regulation of peptidyl-tyrosine phosphorylation; innate immune response in mucosa; inhibition of NF-kappaB transcription factor; response to muramyl dipeptide; positive regulation of B cell activation; defense response to bacterium; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; positive regulation of epithelial cell proliferation; negative regulation of T cell mediated immunity; microglial cell activation during immune response; positive regulation of nitric-oxide synthase biosynthetic process; detection of bacterium; positive regulation of interleukin-12 production; pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity; positive regulation of JNK cascade; defense response; positive regulation of stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; response to exogenous dsRNA; negative regulation of interferon-gamma production; negative regulation of inflammatory response to antigenic stimulus; positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria; response to nutrient; positive regulation of Notch signaling pathway; positive regulation of humoral immune response mediated by circulating immunoglobulin; MyD88-independent toll-like receptor signaling pathway; negative regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase activity; negative regulation of tumor necrosis factor production; immunoglobulin production during immune response; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-1 beta production; regulation of inflammatory response; toll-like receptor signaling pathway; innate immune response
Reference #:  Q9HC29 (UniProtKB)
Alt. Names/Synonyms: ACUG; BLAU; CARD15; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; CD; CLR16.3; IBD1; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NLRC2; NOD-like receptor C2; NOD2; NOD2B; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2; PSORAS1
Gene Symbols: NOD2
Molecular weight: 115,283 Da
Basal Isoelectric point: 6.3  Predict pI for various phosphorylation states
Select Structure to View Below

NOD2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T189-p RRLLDLAtVKANGLA
0 1 S238-p SAQSRFLstYDGAET
0 2 T239-p AQSRFLstYDGAETL
0 1 S402-p CSPTDPTsVQTLLFN
0 1 T424-p KNARKVVtsRPAAVS
0 1 S425-p NARKVVtsRPAAVSA
0 1 S477-p IRLLQETsALHGLCH
0 1 S493-p PVFSWMVsKCHQELL
0 1 K655-ub CIQASEGkDSSVAAL
0 1 K717-ac CLARSLRkHFHSIPP
0 1 K731-ac PAAPGEAkSVHAMPG
0 1 S983-p AEGLKKNssLKILKL
0 1 S984-p EGLKKNssLKILKLS
0 1 T1022-p EVWLRGNtFsLEEVD
0 1 S1024-p WLRGNtFsLEEVDKL
  mouse

 
A169 RRLLDLAAVKANGLA
S218 LTQSRFLSTYDGSEN
T219 TQSRFLSTYDGSENL
S382 CSPIDPTSVQTLLFN
T404 KNACKVLTSRPDAVS
S405 NACKVLTSRPDAVSA
S457 IQLIQATSALHGLCH
S473 PVFSWMVSRCHRELL
K635 CIQGSRVKKGSEAAL
E697 CLAHSLREHFHSIPP
K711 PAVPGETKSMHAMPG
S963 AEGLKRNSTLKFLKL
T964 EGLKRNSTLKFLKLS
T1002 EVWLRGNTFSLEEIQ
S1004 WLRGNTFSLEEIQTL
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