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NT5E (human)

Overview NT5E Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Phosphatase (non-protein); Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - purine; Membrane protein, integral; EC 3.1.3.5; Nucleotide Metabolism - pyrimidine Cellular Component: membrane; cytoplasm; plasma membrane Molecular Function: 5'-nucleotidase activity; ferrous iron binding; nucleotide binding Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of inflammatory response; adenosine biosynthetic process; purine nucleotide catabolic process; purine nucleotide biosynthetic process; DNA metabolic process; purine base metabolic process; AMP catabolic process Reference #:  P21589 (UniProtKB) Alt. Names/Synonyms: 5' nucleotidase (CD73); 5'-NT; 5'-nucleotidase; 5'-nucleotidase, ecto (CD73); 5NTD; CD73; E5NT; Ecto-5'-nucleotidase; eN; eNT; NT; NT5; NT5E; NTE; Purine 5-Prime-Nucleotidase Gene Symbols: NT5E Molecular weight: 63,368 Da Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NT5E 4H1S - A/B=27-549 (human) 4H1Y - P=27-549 (human) 4H2B - A=27-549 (human) 4H2F - A=27-549 (human) 4H2G - A=27-549 (human) 4H2I - A=27-549 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 4H1S 4H1Y 4H2B 4H2F 4H2G 4H2I  |  ENZYME  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		G17	ATLLLALGAVLWPAA
0	1		K133-u	GLIEPLLkEAKFPIL
0	1		S152-p	KAKGPLAsQIsGLyL
0	1		S155-p	GPLAsQIsGLyLPYK
0	1		Y158-p	AsQIsGLyLPYKVLP
0	1		K262-u	SKEVPAGkYPFIVTS
0	1		K321-u	IPEDPSIkADINKWR
0	1		Y484	TKCRVPSYDPLKMDE
0	1		S520-p	DELLRHDsGDQDINV

	mouse
S17-p	KWLLLALsALLPQWP
R135	GLIDPLLRNVKFPIL
H154	KARGPLAHQISGLFL
S157	GPLAHQISGLFLPSK
F160	AHQISGLFLPSKVLS
K264	SKEVPAGKYPFIVTA
K323	IPEDATIKADINQWR
Y486	TKCRVPIYEPLEMDK
S522	DELLKHDSGDQDISV

	rat
S17	KWLLLALSALLPLWP
R135	GLIDPLLRNVKFPIL
P154	KARGPLAPQISGLYL
S157	GPLAPQISGLYLPYK
Y160	APQISGLYLPYKVLS
K264	SKEVPAGKYPFIVTS
K323	IREDAAIKADINQWR
Y486-p	TKCRVPIyEPLEMDK
S522	DELLKHDSGDQDISV

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