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Protein Page:
NT5E (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NT5E Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleotide Metabolism - pyrimidine; EC 3.1.3.5; Membrane protein, GPI anchor; Nucleotide Metabolism - purine; Membrane protein, integral; Phosphatase (non-protein); Cofactor and Vitamin Metabolism - nicotinate and nicotinamide
Cellular Component: membrane; cytoplasm; plasma membrane
Molecular Function: 5'-nucleotidase activity; metal ion binding; nucleotide binding
Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; adenosine biosynthetic process; negative regulation of inflammatory response; purine nucleotide catabolic process; DNA metabolic process; purine base metabolic process; AMP catabolic process
Reference #:  P21589 (UniProtKB)
Alt. Names/Synonyms: 5' nucleotidase (CD73); 5'-NT; 5'-nucleotidase; 5'-nucleotidase, ecto (CD73); 5NTD; CD73; E5NT; Ecto-5'-nucleotidase; eN; eNT; NT; NT5; NT5E; NTE; Purine 5-Prime-Nucleotidase
Gene Symbols: NT5E
Molecular weight: 63,368 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NT5E

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 G17 ATLLLALGAVLWPAA
0 1 K133-ub GLIEPLLkEAKFPIL
0 1 S152-p KAKGPLAsQIsGLyL
0 1 S155-p GPLAsQIsGLyLPYK
0 1 Y158-p AsQIsGLyLPYKVLP
0 1 K262-ub SKEVPAGkYPFIVTS
0 1 S319-p SSIPEDPsIkADINK
0 1 K321-ub IPEDPsIkADINKWR
0 1 Y484 TKCRVPSYDPLKMDE
0 1 S520-p DELLRHDsGDQDINV
  mouse

 
S17-p KWLLLALsALLPQWP
R135 GLIDPLLRNVKFPIL
H154 KARGPLAHQISGLFL
S157 GPLAHQISGLFLPSK
F160 AHQISGLFLPSKVLS
K264 SKEVPAGKYPFIVTA
T321 SSIPEDATIKADINQ
K323 IPEDATIKADINQWR
Y486 TKCRVPIYEPLEMDK
S522 DELLKHDSGDQDISV
  rat

 
S17 KWLLLALSALLPLWP
R135 GLIDPLLRNVKFPIL
P154 KARGPLAPQISGLYL
S157 GPLAPQISGLYLPYK
Y160 APQISGLYLPYKVLS
K264 SKEVPAGKYPFIVTS
A321 STIREDAAIKADINQ
K323 IREDAAIKADINQWR
Y486-p TKCRVPIyEPLEMDK
S522 DELLKHDSGDQDISV
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