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Protein Page:
NT5E (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NT5E Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Phosphatase (non-protein); Nucleotide Metabolism - pyrimidine; EC 3.1.3.5; Nucleotide Metabolism - purine
Cellular Component: membrane; cytoplasm; plasma membrane
Molecular Function: 5'-nucleotidase activity; metal ion binding; nucleotide binding
Biological Process: pyrimidine nucleoside catabolic process; pyrimidine base metabolic process; dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; negative regulation of inflammatory response; adenosine biosynthetic process; purine nucleotide catabolic process; DNA metabolic process; purine base metabolic process; AMP catabolic process
Reference #:  P21589 (UniProtKB)
Alt. Names/Synonyms: 5' nucleotidase (CD73); 5'-NT; 5'-nucleotidase; 5'-nucleotidase, ecto (CD73); 5NTD; CD73; E5NT; Ecto-5'-nucleotidase; eN; eNT; NT; NT5; NT5E; NTE; Purine 5-Prime-Nucleotidase
Gene Symbols: NT5E
Molecular weight: 63,368 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NT5E

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  ENZYME  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K133-u GLIEPLLkEAKFPIL
0 1 K262-u SKEVPAGkYPFIVTS
0 1 K321-u IPEDPSIkADINKWR
  mouse

 
R135 GLIDPLLRNVKFPIL
K264 SKEVPAGKYPFIVTA
K323 IPEDATIKADINQWR
  rat

 
R135 GLIDPLLRNVKFPIL
K264 SKEVPAGKYPFIVTS
K323 IREDAAIKADINQWR
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