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NR6A1 (human)

Overview NR6A1 Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis. Homodimer. Interacts with UIMC1. Shows highest expression in the germ cells of the adult testis. Belongs to the nuclear hormone receptor family. NR6 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Nuclear receptor; DNA binding protein Cellular Component: nucleoplasm; transcription factor complex Molecular Function: ligand-dependent nuclear receptor activity; protein homodimerization activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity Biological Process: cell proliferation; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; gamete generation; gene expression; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter Reference #:  Q15406 (UniProtKB) Alt. Names/Synonyms: GCNF; GCNF1; Germ cell nuclear factor; hGCNF; hRTR; NR61; NR6A1; Nuclear receptor subfamily 6 group A member 1; nuclear receptor subfamily 6, group A, member 1; retinoic acid receptor-related testis-associated receptor; Retinoid receptor-related testis-specific receptor; RTR Gene Symbols: NR6A1 Molecular weight: 54,383 Da Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NR6A1

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S191-p	ASESNQPsPGSTLSS

	mouse
S206	ASESNQPSPGSTLSS

	rat
S162	VSESNQPSPGSTLSS

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