Home

MYL1 (human)

Overview MYL1 Regulatory light chain of myosin. Does not bind calcium. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Contractile protein Cellular Component: sarcomere; myofibril; muscle myosin complex; cytosol Molecular Function: structural constituent of muscle; calcium ion binding Biological Process: muscle development; muscle contraction; muscle filament sliding; cardiac muscle contraction Reference #:  P05976 (UniProtKB) Alt. Names/Synonyms: A1 catalytic; A2 catalytic; MLC1/MLC3; MLC1F; MLC1F/MLC3F; MLC3F; MYL1; Myosin light chain 1/3, skeletal muscle isoform; Myosin light chain A1/A2; Myosin light chain alkali 1/2; myosin, light chain 1, alkali; myosin, light polypeptide 1, alkali; skeletal, fast Gene Symbols: MYL1 Molecular weight: 21,145 Da Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states CST Pathways:  Regulation of Actin Dynamics

Select Structure to View Below MYL1

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		K8	MAPKKDVKKPVAAAA
0	2		K9	APKKDVKKPVAAAAA
0	2		K32	APAPAPAKPKEEKID
0	1		K32	APAPAPAKPKEEKID
0	2		K34	APAPAKPKEEKIDLS
0	2		K37	PAKPKEEKIDLSAIK
0	2		K44	KIDLSAIKIEFSKEQ
0	1		K44	KIDLSAIKIEFSKEQ
0	2		K49	AIKIEFSKEQQDEFK
0	1		K49	AIKIEFSKEQQDEFK
0	2		K56	KEQQDEFKEAFLLFD
0	2		K56	KEQQDEFKEAFLLFD
0	1		T65-p	AFLLFDRtGDsKITL
0	1		S68-p	LFDRtGDsKITLsQV
0	2		K69	FDRtGDsKITLsQVG
0	1		K69	FDRtGDsKITLsQVG
0	2		T71	RtGDsKITLsQVGDV
0	2		S73-p	GDsKITLsQVGDVLR
0	2		R92	NPTNAEVRKVLGNPs
0	1		R92	NPTNAEVRKVLGNPs
0	2		K93	PTNAEVRKVLGNPsN
0	2		S99-p	RKVLGNPsNEELNAK
0	2		K106	sNEELNAKKIEFEQF
0	2		K106	sNEELNAKKIEFEQF
0	2		K107	NEELNAKKIEFEQFL
0	1		K107	NEELNAKKIEFEQFL
0	1		K124	MQAISNNKDQATYED
0	1		Y129	NNKDQATYEDFVEGL
0	2		K141-u	EGLRVFDkEGNGTVM
0	9		K162-a	VLATLGEkMKEEEVE
0	1		K162	VLATLGEKMKEEEVE
0	1		K164	ATLGEkMKEEEVEAL
0	1		Y184	DSNGCINYEAFVKHI

	mouse
K8-u	MAPKKDVkkPAAAPA
K9-u	APKKDVkkPAAAPAP
K26-u	APAPAPAkPkEEkID
K26-a	APAPAPAkPkEEkID
K28-u	APAPAkPkEEkIDLS
K31-u	PAkPkEEkIDLSAIk
K38-u	kIDLSAIkIEFSkEQ
K38-a	kIDLSAIkIEFSkEQ
K43-u	AIkIEFSkEQQEDFk
K43-a	AIkIEFSkEQQEDFk
K50-a	kEQQEDFkEAFLLFD
K50-u	kEQQEDFkEAFLLFD
T59	AFLLFDRTGECkItL
C62	LFDRTGECkItLSQV
K63-u	FDRTGECkItLSQVG
K63-a	FDRTGECkItLSQVG
T65-p	RTGECkItLSQVGDV
S67	GECkItLSQVGDVLR
K86-a	NPTNAEVkkVLGNPS
K86-u	NPTNAEVkkVLGNPS
K87-u	PTNAEVkkVLGNPSN
S93	kkVLGNPSNEEMNAk
K100-a	SNEEMNAkkIEFEQF
K100-u	SNEEMNAkkIEFEQF
K101-u	NEEMNAkkIEFEQFL
K101-a	NEEMNAkkIEFEQFL
K118-u	MQAISNNkDQGGyED
Y123-p	NNkDQGGyEDFVEGL
K135-u	EGLRVFDkEGNGTVM
K156-a	VLATLGEkMkEEEVE
K156-u	VLATLGEkMkEEEVE
K158-u	ATLGEkMkEEEVEAL
Y178-p	DSNGCINyEAFVKHI

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.