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Protein Page:
MYL1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MYL1 Regulatory light chain of myosin. Does not bind calcium. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Contractile protein; Motility/polarity/chemotaxis
Cellular Component: sarcomere; myofibril; muscle myosin complex; cytosol
Molecular Function: structural constituent of muscle; calcium ion binding
Biological Process: muscle contraction; cardiac muscle contraction; muscle filament sliding
Reference #:  P05976 (UniProtKB)
Alt. Names/Synonyms: A1 catalytic; A2 catalytic; MLC1/MLC3; MLC1F; MLC1F/MLC3F; MLC3F; MYL1; Myosin light chain 1/3, skeletal muscle isoform; Myosin light chain A1/A2; Myosin light chain alkali 1/2; myosin, light chain 1, alkali; myosin, light polypeptide 1, alkali; skeletal, fast
Gene Symbols: MYL1
Molecular weight: 21,145 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below

MYL1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K8 MAPKKDVKKPVAAAA
0 2 K9 APKKDVKKPVAAAAA
0 1 K32 APAPAPAKPKEEKID
0 2 K32 APAPAPAKPKEEKID
0 2 K34 APAPAKPKEEKIDLS
0 2 K37 PAKPKEEKIDLSAIK
0 1 K44 KIDLSAIKIEFSKEQ
0 2 K44 KIDLSAIKIEFSKEQ
0 1 K49 AIKIEFSKEQQDEFK
0 2 K49 AIKIEFSKEQQDEFK
0 2 K56 KEQQDEFKEAFLLFD
0 2 K56 KEQQDEFKEAFLLFD
0 1 T65-p AFLLFDRtGDsKITL
0 1 S68-p LFDRtGDsKITLsQV
0 1 K69 FDRtGDsKITLsQVG
0 2 K69 FDRtGDsKITLsQVG
0 2 T71 RtGDsKITLsQVGDV
0 2 S73-p GDsKITLsQVGDVLR
0 2 R92 NPTNAEVRKVLGNPs
0 2 K93 PTNAEVRKVLGNPsN
0 2 S99-p RKVLGNPsNEELNAK
0 2 K106 sNEELNAKKIEFEQF
0 2 K106 sNEELNAKKIEFEQF
0 1 K107 NEELNAKKIEFEQFL
0 2 K107 NEELNAKKIEFEQFL
0 2 K141-u EGLRVFDkEGNGTVM
0 9 K162-a VLATLGEkMKEEEVE
  mouse

 
K8-u MAPKKDVkkPAAAPA
K9-u APKKDVkkPAAAPAP
K26-a APAPAPAkPkEEkID
K26-u APAPAPAkPkEEkID
K28-u APAPAkPkEEkIDLS
K31-u PAkPkEEkIDLSAIk
K38-a kIDLSAIkIEFSkEQ
K38-u kIDLSAIkIEFSkEQ
K43-a AIkIEFSkEQQEDFk
K43-u AIkIEFSkEQQEDFk
K50-a kEQQEDFkEAFLLFD
K50-u kEQQEDFkEAFLLFD
T59 AFLLFDRTGECkItL
C62 LFDRTGECkItLSQV
K63-a FDRTGECkItLSQVG
K63-u FDRTGECkItLSQVG
T65-p RTGECkItLSQVGDV
S67 GECkItLSQVGDVLR
K86-a NPTNAEVkkVLGNPS
K87-u PTNAEVkkVLGNPSN
S93 kkVLGNPSNEEMNAk
K100-a SNEEMNAkkIEFEQF
K100-u SNEEMNAkkIEFEQF
K101-a NEEMNAkkIEFEQFL
K101-u NEEMNAkkIEFEQFL
K135-u EGLRVFDkEGNGTVM
K156-a VLATLGEkMKEEEVE
  rat

► Hide Isoforms
 
K8 MAPKKDVKKPAAAAP
K9 APKKDVKKPAAAAPA
K27 APAPAPAKPKEEKID
K27 APAPAPAKPKEEKID
K29 APAPAKPKEEKIDLS
K32 PAKPKEEKIDLSAIK
K39 KIDLSAIKIEFSKEQ
K39 KIDLSAIKIEFSKEQ
K44 AIKIEFSKEQQEEFK
K44 AIKIEFSKEQQEEFK
K51 KEQQEEFKEAFLLFD
K51 KEQQEEFKEAFLLFD
T60 AFLLFDRTGECKITL
C63 LFDRTGECKITLSQV
K64 FDRTGECKITLSQVG
K64 FDRTGECKITLSQVG
T66 RTGECKITLSQVGDV
S68 GECKITLSQVGDVLR
K87 NPTNAEVKKVLGNPS
K88 PTNAEVKKVLGNPSN
S94 KKVLGNPSNEEMNAK
K101 SNEEMNAKKIEFEQF
K101 SNEEMNAKKIEFEQF
K102 NEEMNAKKIEFEQFL
K102 NEEMNAKKIEFEQFL
K136 EGLRVFDKEGNGTVM
K157 VLATLGEKMKEEEVE
  MYL1 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
K13 ADQIAEFKEAFLLFD
K13 ADQIAEFKEAFLLFD
T22 AFLLFDRTGECKITL
C25 LFDRTGECKITLSQV
K26 FDRTGECKITLSQVG
K26 FDRTGECKITLSQVG
T28 RTGECKITLSQVGDV
S30 GECKITLSQVGDVLR
K49 NPTNAEVKKVLGNPS
K50 PTNAEVKKVLGNPSN
S56 KKVLGNPSNEEMNAK
K63 SNEEMNAKKIEFEQF
K63 SNEEMNAKKIEFEQF
K64 NEEMNAKKIEFEQFL
K64 NEEMNAKKIEFEQFL
K98 EGLRVFDKEGNGTVM
K119 VLATLGEKMKEEEVE
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