a transcriptional activator/repressor in the myeloid lineage. Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3. Stimulates the DNA binding of the transcriptional repressor protein YY1. Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and NPM. Associates with chromatin. Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; DNA binding
Biological Process: B cell receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of apoptosis; cellular defense response; negative regulation of B cell proliferation; response to DNA damage stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.