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MNDA
a transcriptional activator/repressor in the myeloid lineage. Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3. Stimulates the DNA binding of the transcriptional repressor protein YY1. Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and NPM. Associates with chromatin. Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia. Note: This description may include information from UniProtKB.
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| Protein type: DNA binding protein |
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Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleolus; nucleus
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Molecular Function: DNA binding
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Biological Process: B cell receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of apoptosis; cellular defense response; negative regulation of B cell proliferation; response to DNA damage stimulus
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Reference #:
P41218 (UniProtKB)
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| Alt. Names/Synonyms: MNDA; Myeloid cell nuclear differentiation antigen; PYHIN3 |
| Gene Symbols: MNDA |
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Molecular weight: 45,836 Da
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Basal Isoelectric point: 9.76
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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