Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix; Secreted, signal peptide; Secreted; Protease; EC 220.127.116.11
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; proteolysis; regulation of cell migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.