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Protein Page:
MESP2 (human)

Overview
MESP2 Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defects in MESP2 are the cause of spondylocostal dysostosis type 2 (SCDO2). An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Transcription factor
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription factor activity
Biological Process: Notch signaling pathway; somitogenesis; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; mesodermal cell migration
Reference #:  Q0VG99 (UniProtKB)
Alt. Names/Synonyms: BHLHC6; Class C basic helix-loop-helix protein 6; mesoderm posterior 2 homolog (mouse); Mesoderm posterior protein 2; MESP2; SCDO2
Gene Symbols: MESP2
Molecular weight: 41,760 Da
Basal Isoelectric point: 7.05  Predict pI for various phosphorylation states
Select Structure to View Below

MESP2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T69 RAAEAAATTPRRART
0 2 Y131-p TLRLAIRyIGHLSAV
  mouse

 
T67-p STRTTQAtAPRRTRP
Y129 TLRLAIRYIGHLSAL
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