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MESDC2 (human)

Overview MESDC2 Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Belongs to the MESD family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide Cellular Component: endoplasmic reticulum; plasma membrane Molecular Function: low-density lipoprotein receptor binding Biological Process: Wnt receptor signaling pathway; protein folding; mesoderm development Reference #:  Q14696 (UniProtKB) Alt. Names/Synonyms: BOCA; KIAA0081; LDLR chaperone MESD; MESD; MESDC2; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61 Gene Symbols: MESDC2 Molecular weight: 26,077 Da Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MESDC2 2I9S - A=89-184 (mouse) 2KGL - A=30-224 (mouse) 2KMI - A=41-185 (mouse) 2RQK - A=45-184 (mouse) 2RQM - A=45-184 (mouse) 3OFH - A/B=98-183 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y58-p	KKKDIRDyNDADMAR
0	1		T113-p	KMTKKGKtLMMFVTV
0	1		T125-p	VTVSGSPtEKETEEI
0	1		K207-u	KNKTKQDkGkkkKEG
0	2		K209-u	KTKQDkGkkkKEGDL
0	2		K210-u	TKQDkGkkkKEGDLK
0	1		K211-u	KQDkGkkkKEGDLKS

	mouse
Y49	KKKDIRDYNDADMAR
T104	KMTKKGKTLMMFVTV
T116	VTVSGNPTEKETEEI
K198	KNKTKPEKAKKKEGD
K200	KTKPEKAKKKEGDPK
K201	TKPEKAKKKEGDPKP
K202	KPEKAKKKEGDPKPR

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