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Protein Page:
MESDC2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MESDC2 Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Belongs to the MESD family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: endoplasmic reticulum; plasma membrane
Molecular Function: low-density lipoprotein receptor binding
Biological Process: Wnt receptor signaling pathway; protein folding; mesoderm development
Reference #:  Q14696 (UniProtKB)
Alt. Names/Synonyms: BOCA; KIAA0081; LDLR chaperone MESD; MESD; MESDC2; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61
Gene Symbols: MESDC2
Molecular weight: 26,077 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MESDC2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S88-ga LPEHKRPsAPVDFSK
0 2 K209-u KTKQDKGkkKKEGDL
0 2 K210-u TKQDKGkkKKEGDLK
  mouse

 
S79 LPEHKRPSAPIDFSK
K200 KTKPEKAKKKEGDPK
K201 TKPEKAKKKEGDPKP
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