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Protein Page:
LOR (human)

Overview
LOR Major keratinocyte cell envelope protein. Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK). Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques. Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI); also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm; cytoplasm; cornified envelope
Molecular Function: protein binding, bridging; protein binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process: keratinocyte differentiation; keratinization; peptide cross-linking
Reference #:  P23490 (UniProtKB)
Alt. Names/Synonyms: LOR; LORI; Loricrin; LRN; MGC111513
Gene Symbols: LOR
Molecular weight: 25,761 Da
Basal Isoelectric point: 8.5  Predict pI for various phosphorylation states
Select Structure to View Below

LOR

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y3-p _____MSyQKKQPTP
0 1 S242 SGGSGCFSSGGGGGS
0 1 S243 GGSGCFSSGGGGGSS
0 1 G248 FSSGGGGGSSGCGGG
  mouse

 
H3 _____MSHQKKQPTP
S395-p GGGGGCYssGGGGsS
S396-p GGGGCYssGGGGsSG
S401-p YssGGGGsSGGCGGG
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