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Protein Page:
LAMP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAMP2 Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: phagocytic vesicle membrane; membrane; lysosomal membrane; late endosome membrane; lysosome; late endosome; integral to membrane; plasma membrane; platelet dense granule membrane
Molecular Function: enzyme binding
Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation
Reference #:  P13473 (UniProtKB)
Alt. Names/Synonyms: CD107 antigen-like family member B; CD107b; LAMP-2; LAMP2; LAMPB; LGP110; lysosomal-associated membrane protein 2; Lysosome-associated membrane glycoprotein 2; Lysosome-associated membrane protein 2
Gene Symbols: LAMP2
Molecular weight: 44,961 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
Select Structure to View Below

LAMP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T63-p TTNKTYKtVtIsDHG
0 1 T65-p NKTYKtVtIsDHGTV
0 1 S67-p TYKtVtIsDHGTVTY
0 1 S195-ga LCDKDKTstVAPtIH
0 1 T196-ga CDKDKTstVAPtIHt
0 1 T200-ga KTstVAPtIHttVPS
0 1 T203-ga tVAPtIHttVPSPtt
0 1 T204-ga VAPtIHttVPSPttt
0 1 T209-ga HttVPSPtttPtPKE
0 1 T210-ga ttVPSPtttPtPKEK
0 1 T211-ga tVPSPtttPtPKEKP
0 1 T213-ga PSPtttPtPKEKPEA
0 1 S267-p HSTGSCRsHtALLRL
0 1 T269-p TGSCRsHtALLRLNS
0 2 Y281-p LNSSTIKyLDFVFAV
0 1 Y407 LKHHHAGYEQF____
0 1 - gap
0 16 - gap
  LAMP2 iso2  
T63 TTNKTYKTVTISDHG
T65 NKTYKTVTISDHGTV
S67 TYKTVTISDHGTVTY
S195 LCDKDKTSTVAPTIH
T196 CDKDKTSTVAPTIHT
T200 KTSTVAPTIHTTVPS
T203 TVAPTIHTTVPSPTT
T204 VAPTIHTTVPSPTTT
T209 HTTVPSPTTTPTPKE
T210 TTVPSPTTTPTPKEK
T211 TVPSPTTTPTPKEKP
T213 PSPTTTPTPKEKPEA
S267 HSTGSCRSHTALLRL
T269 TGSCRSHTALLRLNS
Y281 LNSSTIKYLDFVFAV
- under review  
K402-ub AYVIGRRkSYAGyQT
Y407-p RRkSYAGyQTL____
  mouse

► Hide Isoforms
 
T59 TTNQTNKTITIAVPD
T61 NQTNKTITIAVPDKA
A63 TNKTITIAVPDKATH
T192 CEEDQTPTTVAPIIH
T193 EEDQTPTTVAPIIHT
I197 TPTTVAPIIHTTAPS
T200 TVAPIIHTTAPSTTT
T201 VAPIIHTTAPSTTTT
T206 HTTAPSTTTTLTPTS
T207 TTAPSTTTTLTPTST
T208 TAPSTTTTLTPTSTP
T218 PTSTPTPTPTPTPTV
P272 NFTGSCQPQSAQLRL
S274 TGSCQPQSAQLRLNN
Y286-p LNNSQIKyLDFIFAV
Y412-p LKRHHTGyEQF____
- gap
- gap
  LAMP2 iso3  
T59 TTNQTNKTITIAVPD
T61 NQTNKTITIAVPDKA
A63 TNKTITIAVPDKATH
T192 CEEDQTPTTVAPIIH
T193 EEDQTPTTVAPIIHT
I197 TPTTVAPIIHTTAPS
T200 TVAPIIHTTAPSTTT
T201 VAPIIHTTAPSTTTT
T206 HTTAPSTTTTLTPTS
T207 TTAPSTTTTLTPTST
T208 TAPSTTTTLTPTSTP
T218 PTSTPTPTPTPTPTV
P272 NFTGSCQPQSAQLRL
S274 TGSCQPQSAQLRLNN
Y286 LNNSQIKYLDFIFAV
- under review  
K407 AYLIGRRKTYAGyQT
Y412-p RRKTYAGyQTL____
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