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Protein Page:
K12 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
K12 May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity. Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD); also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Belongs to the intermediate filament family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein
Cellular Component: intermediate filament
Molecular Function: structural molecule activity
Biological Process: visual perception
Reference #:  Q99456 (UniProtKB)
Alt. Names/Synonyms: CK-12; Cytokeratin-12; K12; K1C12; keratin 12; Keratin, type I cytoskeletal 12; Keratin-12; KRT12
Gene Symbols: KRT12
Molecular weight: 53,511 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
Select Structure to View Below

K12

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 77 Y139-p LNDRLASyLDkVRAL
0 6 K142-ub RLASyLDkVRALEEA
0 1 Y161-p ENKIREWyEtRGTGT
0 1 T163-p KIREWyEtRGTGTAD
0 2 Y429-p LELEIETyRRLLDGE
  mouse

 
Y133 LNDRLASYLGKVRSL
K136 RLASYLGKVRSLEEA
Y155 ENKIREWYETRRTRD
T157 KIREWYETRRTRDAG
Y422 LEMEIETYRRLLEGD
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